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Showing Protein Apoptosis-associated speck-like protein containing a CARD (HMDBP13951)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP13951
Secondary Accession Numbers None
Name Apoptosis-associated speck-like protein containing a CARD
Synonyms
  1. hASC
  2. Caspase recruitment domain-containing protein 5
  3. PYD and CARD domain-containing protein
  4. Target of methylation-induced silencing 1
Gene Name PYCARD
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory form of cell death and is the major constituent of the ASC pyroptosome which forms upon potassium depletion and rapidly recruits and activates caspase-1. In innate immune response believed to act as an integral adapter in the assembly of the inflammasome which activates caspase-1 leading to processing and secretion of proinflammatory cytokines. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Required for recruitment of caspase-1 to inflammasomes containing certain pattern recognition receptors, such as NLRP2, NLRP3, AIM2 and probably IFI16. In the NLRP1 and NLRC4 inflammasomes seems not be required but facilitates the processing of procaspase-1. In cooperation with NOD2 involved in an inflammasome activated by bacterial muramyl dipeptide leading to caspase-1 activation. May be involved in DDX58-triggered proinflammatory responses and inflammasome activation. Isoform 2 may have a regulating effect on the function as inflammasome adapter. Isoform 3 seems to inhibit inflammasome-mediated maturation of interleukin-1 beta. In collaboration with AIM2 which detects cytosolic double-stranded DNA may also be involved in a caspase-1-independent cell death that involves caspase-8. In adaptive immunity may be involved in maturation of dendritic cells to stimulate T-cell immunity and in cytoskeletal rearrangements coupled to chemotaxis and antigen uptake may be involved in post-transcriptional regulation of the guanine nucleotide exchange factor DOCK2; the latter function is proposed to involve the nuclear form. Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome; this function may involve AP-1, NF-kappa-B, MAPK and caspase-8 signaling pathways. For regulation of NF-kappa-B activating and inhibiting functions have been reported. Modulates NF-kappa-B induction at the level of the IKK complex by inhibiting kinase activity of CHUK and IKBK. Proposed to compete with RIPK2 for association with CASP1 thereby down-regulating CASP1-mediated RIPK2-dependent NF-kappa-B activation and activating interleukin-1 beta processing. Modulates host resistance to DNA virus infection, probably by inducing the cleavage of and inactivating CGAS in presence of cytoplasmic double-stranded DNA (PubMed:28314590).
Pathways
  • C-type lectin receptor signaling pathway
  • Cytosolic DNA-sensing pathway
  • Influenza A
  • Legionellosis
  • Lipid and atherosclerosis
  • Necroptosis
  • NOD-like receptor signaling pathway
  • Pathogenic Escherichia coli infection
  • Pertussis
  • Salmonella infection
  • Shigellosis
  • Yersinia infection
Reactions Not Available
GO Classification
Biological Process
negative regulation of cytokine production involved in inflammatory response
signal transduction
positive regulation of chemokine production
regulation of inflammatory response
positive regulation of apoptotic process
neutrophil degranulation
positive regulation of interleukin-10 production
positive regulation of interleukin-8 production
activation of cysteine-type endopeptidase activity involved in apoptotic process
myeloid dendritic cell activation involved in immune response
apoptotic process
activation of cysteine-type endopeptidase activity
macropinocytosis
negative regulation of interferon-beta production
positive regulation of cysteine-type endopeptidase activity
positive regulation of T cell activation
positive regulation of T cell migration
purinergic nucleotide receptor signaling pathway
regulation of intrinsic apoptotic signaling pathway
myeloid dendritic cell activation
positive regulation of release of cytochrome c from mitochondria
positive regulation of extrinsic apoptotic signaling pathway
negative regulation of I-kappaB kinase/NF-kappaB cascade
inflammatory response
regulation of tumor necrosis factor-mediated signaling pathway
activation of innate immune response
regulation of autophagy
cellular response to tumor necrosis factor
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of phagocytosis
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to lipopolysaccharide
cellular response to interleukin-1
positive regulation of ERK1 and ERK2 cascade
regulation of protein stability
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of antigen processing and presentation of peptide antigen via MHC class II
defense response to virus
innate immune response
negative regulation of NF-kappaB transcription factor activity
intrinsic apoptotic signaling pathway by p53 class mediator
protein homooligomerization
positive regulation of defense response to virus by host
positive regulation of interferon-gamma production
negative regulation of protein serine/threonine kinase activity
tumor necrosis factor-mediated signaling pathway
positive regulation of tumor necrosis factor production
regulation of GTPase activity
positive regulation of JNK cascade
defense response to Gram-negative bacterium
positive regulation of actin filament polymerization
positive regulation of interleukin-1 beta production
positive regulation of interleukin-6 production
positive regulation of NF-kappaB transcription factor activity
positive regulation of activated T cell proliferation
positive regulation of adaptive immune response
Cellular Component
cytosol
protein-containing complex
cytoplasm
endoplasmic reticulum
IkappaB kinase complex
mitochondrion
NLRP1 inflammasome complex
nucleolus
nucleus
nucleoplasm
AIM2 inflammasome complex
NLRP3 inflammasome complex
extracellular region
azurophil granule lumen
neuronal cell body
secretory granule lumen
Golgi membrane
Molecular Function
protease binding
BMP receptor binding
cysteine-type endopeptidase activity involved in apoptotic process
interleukin-6 receptor binding
myosin I binding
Pyrin domain binding
tropomyosin binding
ion channel binding
protein homodimerization activity
enzyme binding
cysteine-type endopeptidase activator activity involved in apoptotic process
identical protein binding
protein dimerization activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 195
Molecular Weight 21626.57
Theoretical pI 6.346
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9ULZ3
UniProtKB/Swiss-Prot Entry Name ASC_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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