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Showing Protein THO complex subunit 5 homolog (HMDBP14137)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP14137
Secondary Accession Numbers None
Name THO complex subunit 5 homolog
Synonyms
  1. Functional spliceosome-associated protein 79
  2. NF2/meningioma region protein pK1.3
  3. Placental protein 39.2
  4. hTREX90
  5. fSAP79
  6. PP39.2
Gene Name THOC5
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes.Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.
Pathways
  • Nucleocytoplasmic transport
Reactions Not Available
GO Classification
Biological Process
negative regulation of DNA damage checkpoint
positive regulation of DNA-templated transcription, elongation
primitive hemopoiesis
RNA export from nucleus
mRNA 3'-end processing
mRNA export from nucleus
RNA splicing
monocyte differentiation
intronless viral mRNA export from host nucleus
Cellular Component
THO complex
THO complex part of transcription export complex
cytoplasm
nucleus
nucleoplasm
transcription export complex
Molecular Function
mRNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 683
Molecular Weight 78507.24
Theoretical pI 6.876
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q13769
UniProtKB/Swiss-Prot Entry Name THOC5_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  13. Masuda S, Das R, Cheng H, Hurt E, Dorman N, Reed R: Recruitment of the human TREX complex to mRNA during splicing. Genes Dev. 2005 Jul 1;19(13):1512-7. [PubMed:15998806 ]
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  30. Viphakone N, Cumberbatch MG, Livingstone MJ, Heath PR, Dickman MJ, Catto JW, Wilson SA: Luzp4 defines a new mRNA export pathway in cancer cells. Nucleic Acids Res. 2015 Feb 27;43(4):2353-66. doi: 10.1093/nar/gkv070. Epub 2015 Feb 6. [PubMed:25662211 ]
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