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Showing Protein Myelin-associated glycoprotein (HMDBP14367)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP14367
Secondary Accession Numbers None
Name Myelin-associated glycoprotein
Synonyms
  1. Siglec-4a
Gene Name MAG
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity).
Pathways
  • Cell adhesion molecules
Reactions Not Available
GO Classification
Biological Process
cell-cell adhesion via plasma-membrane adhesion molecules
leukocyte migration
negative regulation of neuron apoptotic process
cell adhesion
negative regulation of axonogenesis
axon regeneration
negative regulation of axon extension
positive regulation of astrocyte differentiation
positive regulation of myelination
substantia nigra development
transmission of nerve impulse
negative regulation of neuron projection development
central nervous system myelination
cellular response to mechanical stimulus
negative regulation of neuron differentiation
Cellular Component
membrane raft
cytoplasm
plasma membrane
myelin sheath adaxonal region
Schmidt-Lanterman incisure
compact myelin
mesaxon
paranode region of axon
myelin sheath
integral to plasma membrane
Molecular Function
protein kinase binding
carbohydrate binding
receptor binding
ganglioside GT1b binding
protein homodimerization activity
sialic acid binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 626
Molecular Weight 69067.885
Theoretical pI 5.033
Pfam Domain Function
Signals
  • 1-19;
Transmembrane Regions
  • 517-536;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P20916
UniProtKB/Swiss-Prot Entry Name MAG_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  11. Roda RH, FitzGibbon EJ, Boucekkine H, Schindler AB, Blackstone C: Neurologic syndrome associated with homozygous mutation at MAG sialic acid binding site. Ann Clin Transl Neurol. 2016 Jun 23;3(8):650-4. doi: 10.1002/acn3.329. eCollection 2016 Aug. [PubMed:27606346 ]