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Showing Protein Proto-oncogene c-Fos (HMDBP14541)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP14541
Secondary Accession Numbers None
Name Proto-oncogene c-Fos
Synonyms
  1. Cellular oncogene fos
  2. G0/G1 switch regulatory protein 7
Gene Name FOS
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
Pathways
  • Amphetamine addiction
  • Apoptosis
  • B cell receptor signaling pathway
  • Breast cancer
  • cAMP signaling pathway
  • Chagas disease
  • Chemical carcinogenesis - reactive oxygen species
  • Chemical carcinogenesis - receptor activation
  • Choline metabolism in cancer
  • Cholinergic synapse
  • Circadian entrainment
  • Colorectal cancer
  • Coronavirus disease - COVID-19
  • Dopaminergic synapse
  • Endocrine resistance
  • Estrogen signaling pathway
  • Fluid shear stress and atherosclerosis
  • Growth hormone synthesis, secretion and action
  • Hepatitis B
  • Human immunodeficiency virus 1 infection
  • Human T-cell leukemia virus 1 infection
  • IL-17 signaling pathway
  • Kaposi sarcoma-associated herpesvirus infection
  • Leishmaniasis
  • Lipid and atherosclerosis
  • MAPK signaling pathway
  • Measles
  • Non-alcoholic fatty liver disease
  • Osteoclast differentiation
  • Oxytocin signaling pathway
  • Parathyroid hormone synthesis, secretion and action
  • Pathogenic Escherichia coli infection
  • PD-L1 expression and PD-1 checkpoint pathway in cancer
  • Pertussis
  • Prolactin signaling pathway
  • Relaxin signaling pathway
  • Rheumatoid arthritis
  • Salmonella infection
  • T cell receptor signaling pathway
  • Th1 and Th2 cell differentiation
  • Th17 cell differentiation
  • TNF signaling pathway
  • Toll-like receptor signaling pathway
  • Yersinia infection
Reactions Not Available
GO Classification
Biological Process
skeletal muscle cell differentiation
transcription from RNA polymerase II promoter
female pregnancy
response to gravity
cellular response to calcium ion
response to progesterone stimulus
cellular response to extracellular stimulus
Fc-epsilon receptor signaling pathway
cellular response to hormone stimulus
response to light stimulus
response to lipopolysaccharide
sleep
SMAD protein signal transduction
conditioned taste aversion
inflammatory response
response to drug
positive regulation of pri-miRNA transcription by RNA polymerase II
regulation of transcription from RNA polymerase II promoter
nervous system development
positive regulation of transcription, DNA-dependent
positive regulation of transcription from RNA polymerase II promoter
cellular response to cadmium ion
cellular response to reactive oxygen species
cytokine-mediated signaling pathway
positive regulation of osteoclast differentiation
positive regulation of neuron death
aging
response to corticosterone stimulus
transforming growth factor beta receptor signaling pathway
response to toxin
response to muscle stretch
response to immobilization stress
regulation of sequence-specific DNA binding transcription factor activity
DNA methylation
response to cAMP
response to cold
Cellular Component
cytosol
endoplasmic reticulum
nucleus
transcription factor AP-1 complex
nucleoplasm
protein-DNA complex
chromatin
membrane
neuron projection
Molecular Function
protein-containing complex binding
sequence-specific DNA binding transcription factor activity
R-SMAD binding
RNA polymerase II core promoter sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription factor binding
chromatin binding
DNA-binding transcription factor activity, RNA polymerase II-specific
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II activating transcription factor binding
sequence-specific double-stranded DNA binding
transcription regulatory region sequence-specific DNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 380
Molecular Weight 40694.855
Theoretical pI 4.861
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P01100
UniProtKB/Swiss-Prot Entry Name FOS_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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