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Identification
HMDB Protein ID HMDBP14544
Secondary Accession Numbers None
Name Forkhead box protein H1
Synonyms
  1. Forkhead activin signal transducer 1
  2. Forkhead activin signal transducer 2
  3. Fast-1
  4. hFAST-1
  5. Fast-2
Gene Name FOXH1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
negative regulation of sequence-specific DNA binding transcription factor activity
secondary heart field specification
axial mesoderm development
embryonic heart tube anterior/posterior pattern specification
ventricular trabecula myocardium morphogenesis
cardiac right ventricle morphogenesis
positive regulation of transcription, DNA-dependent
nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
negative regulation of transcription from RNA polymerase II promoter
cellular response to cytokine stimulus
positive regulation of transcription from RNA polymerase II promoter
aorta morphogenesis
heart looping
outflow tract morphogenesis
negative regulation of intracellular estrogen receptor signaling pathway
transforming growth factor beta receptor signaling pathway
negative regulation of androgen receptor signaling pathway
Cellular Component
nucleus
nucleoplasm
chromatin
activin responsive factor complex
transcription factor complex
Molecular Function
sequence-specific DNA binding
sequence-specific DNA binding transcription factor activity
co-SMAD binding
R-SMAD binding
DNA-binding transcription activator activity, RNA polymerase II-specific
androgen receptor binding
protein domain specific binding
DNA-binding transcription factor activity, RNA polymerase II-specific
core promoter proximal region sequence-specific DNA binding
transcription regulatory region sequence-specific DNA binding
SMAD binding
bHLH transcription factor binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 365
Molecular Weight 39256.61
Theoretical pI 9.514
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O75593
UniProtKB/Swiss-Prot Entry Name FOXH1_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B: Characterization of human FAST-1, a TGF beta and activin signal transducer. Mol Cell. 1998 Jul;2(1):121-7. [PubMed:9702198 ]