| Identification |
|---|
| HMDB Protein ID
| HMDBP14614 |
| Secondary Accession Numbers
| None |
| Name
| Pro-MCH |
| Synonyms
|
Not Available
|
| Gene Name
| PMCH |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| MCH inhibits ACTH secretion at the end of the light on period which corresponds to the peak of the circadian rhythm in ACTH. Inhibits also stress induced ACTH release during the light off period of the cycle. Involved as a neurotransmitter or neuromodulator in a broad array of neuronal functions. Stimulates sexual behavior when injected into the ventromedial nucleus, this effect is antagonized by NEI. In the medial preoptic area, stimulates anxiety and sexual behavior. Antagonizes inhibitory effect of melanotropin alpha on exploration behavior.NEI can influence differentiation of neuronal processes in brain neurons. Affects the content of neurofilament protein in neuritogenesis (in vitro). May also be a neuromodulatory factor. In behavioral tests, it stimulates exploration and anxiety when injected into the ventromedial nucleus. Also stimulates grooming, locomotion and rearing. May antagonize the inhibitory effect of mch on ACTH release. Reduces dopamine and dopac release in the ventromedial nucleus. |
| Pathways
|
- Neuroactive ligand-receptor interaction
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| negative regulation of synaptic transmission, dopaminergic |
| learning or memory |
| elevation of cytosolic calcium ion concentration |
| negative regulation of blood pressure |
| drinking behavior |
| neuropeptide signaling pathway |
| positive regulation of circadian sleep/wake cycle, REM sleep |
| regulation of neuronal synaptic plasticity |
| feeding behavior |
| glucose homeostasis |
| lactation |
| response to cold |
| synaptic transmission |
| regulation of heart rate |
| Cellular Component |
| nucleus |
| synapse |
| extracellular space |
| Molecular Function |
| melanin-concentrating hormone activity |
| type 1 melanin-concentrating hormone receptor binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 165 |
| Molecular Weight
| 18481.93 |
| Theoretical pI
| 7.286 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P14200 |
| UniProtKB/Swiss-Prot Entry Name
| MCH_RAT |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Nahon JL, Presse F, Bittencourt JC, Sawchenko PE, Vale W: The rat melanin-concentrating hormone messenger ribonucleic acid encodes multiple putative neuropeptides coexpressed in the dorsolateral hypothalamus. Endocrinology. 1989 Oct;125(4):2056-65. doi: 10.1210/endo-125-4-2056. [PubMed:2477226 ]
- Thompson RC, Watson SJ: Nucleotide sequence and tissue-specific expression of the rat melanin concentrating hormone gene. DNA Cell Biol. 1990 Nov;9(9):637-45. doi: 10.1089/dna.1990.9.637. [PubMed:2261081 ]
- Vaughan JM, Fischer WH, Hoeger C, Rivier J, Vale W: Characterization of melanin-concentrating hormone from rat hypothalamus. Endocrinology. 1989 Sep;125(3):1660-5. doi: 10.1210/endo-125-3-1660. [PubMed:2759038 ]
- Hervieu G, Nahon JL: Pro-melanin concentrating hormone messenger ribonucleic acid and peptides expression in peripheral tissues of the rat. Neuroendocrinology. 1995 Apr;61(4):348-64. doi: 10.1159/000126857. [PubMed:7783849 ]
- Hervieu G, Volant K, Grishina O, Descroix-Vagne M, Nahon JL: Similarities in cellular expression and functions of melanin-concentrating hormone and atrial natriuretic factor in the rat digestive tract. Endocrinology. 1996 Feb;137(2):561-71. doi: 10.1210/endo.137.2.8593803. [PubMed:8593803 ]
- Takahashi K, Suzuki H, Totsune K, Murakami O, Satoh F, Sone M, Sasano H, Mouri T, Shibahara S: Melanin-concentrating hormone in human and rat. Neuroendocrinology. 1995 May;61(5):493-8. doi: 10.1159/000126872. [PubMed:7617126 ]
- Parkes D, Vale W: Secretion of melanin-concentrating hormone and neuropeptide-EI from cultured rat hypothalamic cells. Endocrinology. 1992 Oct;131(4):1826-31. doi: 10.1210/endo.131.4.1327720. [PubMed:1327720 ]
- Viale A, Ortola C, Hervieu G, Furuta M, Barbero P, Steiner DF, Seidah NG, Nahon JL: Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals. J Biol Chem. 1999 Mar 5;274(10):6536-45. doi: 10.1074/jbc.274.10.6536. [PubMed:10037747 ]
- Bluet-Pajot MT, Presse F, Voko Z, Hoeger C, Mounier F, Epelbaum J, Nahon JL: Neuropeptide-E-I antagonizes the action of melanin-concentrating hormone on stress-induced release of adrenocorticotropin in the rat. J Neuroendocrinol. 1995 Apr;7(4):297-303. doi: 10.1111/j.1365-2826.1995.tb00761.x. [PubMed:7647772 ]
- Gonzalez MI, Baker BI, Hole DR, Wilson CA: Behavioral effects of neuropeptide E-I (NEI) in the female rat: interactions with alpha-MSH, MCH and dopamine. Peptides. 1998;19(6):1007-16. doi: 10.1016/s0196-9781(98)00045-x. [PubMed:9700748 ]
- Kistler-Heer V, Schlumpf M, Lichtensteiger W: Melanocortin and MCH precursor-derived NEI effects on striatum-midbrain co-cultures. Peptides. 1998;19(8):1317-27. doi: 10.1016/s0196-9781(98)00076-x. [PubMed:9809645 ]
|
