Accession NumberHMDB02032
Common_Name8-Hydroxyguanine
DescriptionFormation of 8-hydroxyguanine (8-OHG), a mutagenic base which is a marker for OH-mediated DNA damage, requires peroxidase and halides and occurs in the presence of transition metal chelators (DTPA +/- desferrioxamine), and is inhibited by catalase, superoxide dismutase (SOD), and scavengers of hypohalous acids. (PMID 10820020) 8-Hydroxyguanine is an oxidative stress marker for diagnosis of Alzheimer's disease (AD). (PMID 15977989)
Chemical_IUPAC_Name2-amino-7,9-dihydro-3H-purine-6,8-dione
Chemical FormulaC5H5N5O2
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