Accession NumberHMDB01127
Common_Name6-Phosphonoglucono-D-lactone
Description6-phosphoglucono-delta-lactone (d-6PGL) is the immediate product of the Glucose-6-phosphate dehydrogenase (G-6-PD), the first enzyme of the hexose monophosphate pathway. (PMID 3711719) The pentose-phosphate pathway provides reductive power and nucleotide precursors to the cell through oxidative and nonoxidative branches. 6-Phosphogluconolactonase is the second enzyme of the oxidative branch and catalyzes the hydrolysis of 6-phosphogluconolactones, the products of glucose 6-phosphate oxidation by glucose-6-phosphate dehydrogenase. By efficiently catalyzing the hydrolysis of d-6PGL, 6-phosphogluconolactonase prevents the reaction between d-6PGL and intracellular nucleophiles; such a reaction would interrupt the functioning of the pentose-phosphate pathway. (PMID 11457850)
Chemical_IUPAC_Name(3,4,5-trihydroxy-6-oxo-oxan-2-yl)methoxyphosphonic acid
Chemical FormulaC6H11O9P
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Predicted 1H NMR SpectrumDownload
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Predicted 13C NMR PeaklistDownload
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