Accession NumberHMDB05313
Common_NameDimyristoylphosphatidylethanolamine
DescriptionDimyristoylphosphatidylethanolamine is a diacylglycerophosphoethanolamine lipid of the glycerophospholipids class. The composition of the molecular species of diacylglycerophosphoethanolamine (PtdEtn) shows a specific pattern of phospholipid molecular species that undergo changes in myelin sheaths during brain development and maturation. PtdEtn are characterized by their low levels of disaturated species and a high content of saturated/monounsaturated and saturated/polyunsaturated species, of which those containing fatty acids of the n-3 series decreased, whereas those containing fatty acids of the n-6 series did not change during brain development. The levels of saturated/monounsaturated species increased in PtdEtn. Diacylglycerophosphoethanolamines are one of the major sources of arachidonate in stimulated cells. Deacylation of membrane of diacylglycerophosphoethanolamine by phospholipase A2 is selective for those molecular species of phospholipid containing arachidonic acid, suggesting that a certain proportion of arachidonoyl-containing molecular species of phospholipid are compartmentalized with the platelet membrane proximal to the site of action of this enzyme, demonstrating that the human platelet is a cell poised and specialized to release rapidly substantial amounts of arachidonic acid upon stimulation. Influence of diet has an strong influence in the content of n-3 fatty acids on macrophage glycerophospholipid molecular species. Diacylglycerophosphoethanolamine constitutes approximately the 20% of phospholipid fractions of peripheral blood lymphocytes. (PMID: 3118499, 1940643, 8139401, 3111541)
Chemical_IUPAC_Name[1-(2-aminoethoxy-hydroxyphosphoryl)oxy-3-tetradecanoyloxypropan-2-yl] tetradecanoate
Chemical FormulaC33H66NO8P
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