Accession NumberHMDB06528
Common_Nameclupanodonic acid
DescriptionClupanodonic acid is one of the essential fatty acid(EFA) which is prevalent in fish oils. It belongs to one of the families of essential fatty acids, Linolenic acid There are three functions of clupanodonic acid. The most important is as part of phospholipids in all animal cellular membranes: in deficiency of clupanodonic acid faulty membranes are formed. A second is in the transport and oxidation of cholesterol: clupanodonic acid tend to lower plasma cholesterol. A third function is as precursors of prostanoids which are only formed from clupanodonic acid. Deficiency of this in experimental animals causes lesions mainly attributable to faulty cellular membranes: sudden failure of growth, lesions of skin and kidney and connective tissue, erythrocyte fragility, impaired fertility, uncoupling of oxidation and phosphorylation. In man pure deficiency of clupanodonic acid has been studied particularly in persons fed intravenously. A relative deficiency (that is, a low ratio in the body of clupanodonic to long-chain saturated fatty acids and isomers of clupanodonic) is common on Western diets and plays an important part in the causation of atherosclerosis, coronary thrombosis, multiple sclerosis, the triopathy of diabetes mellitus, hypertension and certain forms of malignant disease. Various factors affect the dietary requirement of clupanodonic acid. (PMID: 6469703)
Chemical_IUPAC_Name(4E,8E,11E,15E)-octadeca-4,8,11,15-tetraenoic acid
Chemical FormulaC18H28O2
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Predicted 1H NMR SpectrumDownload
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