Accession NumberHMDB04224
Common_NameN-(omega)-Hydroxyarginine
DescriptionN(omega)-hydroxyarginine is a product of the arginine-Nitric Oxide pathway, and is the first intermediate in the process catalyzed by nitric oxide synthase (EC 1.14.13.99, NOS, a heme protein that catalyzes the oxygenation of L-arginine in the presence of NADPH to form nitric oxide + citrulline). N(omega)-hydroxyarginine appears to interfere with cell proliferation/cell growth by inhibiting arginase (EC 3.5.3.1, a binuclear Mn (2+) metalloenzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea), and that has 6R-tetrahydrobiopterin (H4B) as an enzyme-bound cofactor. (PMID: 11259671, 11258880, 14504282, 9735327)
Chemical_IUPAC_Name2-amino-5-[[amino-(hydroxyamino)methylidene]amino]pentanoic acid
Chemical FormulaC6H14N4O3
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