Accession NumberHMDB04670
Common_NameAlpha-dimorphecolic
DescriptionAlpha-dimorphecolic acid is an endogenous fatty acid PPARgamma agonist synthesized in the body from linoleic acid. Alpha-dimorphecolic activates Peroxisomal proliferator-activated receptor-gamma (PPAR)gamma in human endothelial cells increasing plasminogen activator inhibitor type-1 expression. Plasminogen activator inhibitor type-1 (PAI-1) is a major physiological inhibitor of fibrinolysis, with its plasma levels correlating with the risk for myocardial infarction and venous thrombosis. The regulation of PAI-1 transcription by endothelial cells (ECs), a major source of PAI-1, remains incompletely understood. Adipocytes also produce PAI-1, suggesting possible common regulatory pathways between adipocytes and ECs. Peroxisomal proliferator-activated receptor-gamma (PPAR)gamma is a ligand-activated transcription factor that regulates gene expression in response to various mediators such as 15-deoxy-Delta12, 14-prostaglandin J2 (15d-PGJ2) and oxidized linoleic acid (9- and 13-HODE). Alpha-dimorphecolic is a ligand of the G protein-coupled receptor G2A. (PMID: 10073956, 16647253, 16236715)
Chemical_IUPAC_Name(9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid
Chemical FormulaC18H32O3
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