Accession NumberHMDB04698
Common_Name12(R)-HETE
Description12(R)-HETE is a naturally occurring hydroxyeicosatetraenoic acid eicosanoid that has been isolated from several tissues in mammals. Human and bovine corneal epithelial cytochrome P450 convert arachidonic acid to 12(R)-HETE, a metabolite with inflammatory properties including vasodilatation and breakdown of the blood-aqueous barrier. Increased amounts of 12(R)-HETE are found in the lesional skin of patients with the skin disease psoriasis when compared to clinically normal skin. 12(R)-HETE is a chemoattractant for human polymorphonuclear leucocytes in vitro. (PMID: 1709873, 3707572, 3317516)
Chemical_IUPAC_Name(5Z,8Z,10E,12R,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid
Chemical FormulaC20H32O3
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Predicted 13C NMR PeaklistDownload
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