Description | Phosphatidylethanolamine (PE) is a lipid found in mammalian tissues, and is one of the main phospholipids constituent of the bilayer surrounding animal cells. PE in an abundant phospholipid in mammals, generally constituting 25% of cellular phospholipids. In the inner mitochondrial membrane Phosphatidylserine is decarboxylated resulting in the formation of PE. A membrane- associated N-acyltransferase transfers an acyl group from the sn- 1 position of a donor phospholipid to the amino group of PE. This enzyme is activated by calcium ions.
Phosphatidylethanolamine is a bioactive long-chain acylethanolamine from membrane glycerophospholipid essential in the formation of anandamide (the first discovered endocannabinoid, anendogenous ligand of cannabinoid receptors), a reaction that starts with the transfer of a fatty acyl chain from the sn-1 position of a glycerophospholipid to phosphatidylethanolamine by calcium-dependent N-acyltransferase, resulting in the generation of N-acylphosphatidylethanolamine. (PMID: 16880602, 10419193, 15974992, 15974992, 15914007, 17132865) |