Accession Number | HMDB02342 |
Common_Name | 14,15-Dihydroxyeicosatrienoic acid |
Description | 14,15-Dihydroxyeicosatrienoic acid (14,15-DHET) is a metabolite of arachidonic acid metabolism. 14,15-DHET is the main product of 14,15-epoxyeicosatrienoic acid (14,15-EET) metabolism in intact human blood vessels. Epoxyeicosatrienoic acids (EETs) are potent regulators of vascular homeostasis and are bound by cytosolic fatty acid-binding proteins (FABPs); FABPs are potent inhibitors of 14,15-EET conversion to 14,15-DHET. Endothelial cells, but not smooth muscle cells, convert 14,15-EET to 14,15-DHET, and this conversion results in a loss of vasodilator activity. 14,15-DHET is a potent activator of peroxisome proliferator-activated receptor alpha (PPARalpha). (PMID: 6798994, 6792198, 17431031, 15284062, 14529287, 11959628) |
Chemical_IUPAC_Name | (5E,8E,11E)-14,15-dihydroxyicosa-5,8,11-trienoic acid |
Chemical Formula | C20H34O4 |
Sample Concentration | Not Available |
Mass Value | Not Available |
Mass Unit | Not Available |
Manufacturer | Not Available |
Analyzer | Not Available |
Delivery | Not Available |
Ionization | Not Available |
Predicted 1H NMR Spectrum | Download |
Predicted 1H NMR Peaklist | Download |
Predicted 13C NMR Spectrum | Download |
Predicted 13C NMR Peaklist | Download |
Sample Concentration | Not Available |
Mass Value | Not Available |
Mass Unit | Not Available |
Manufacturer | Not Available |
Frequency | Not Available |
1H NMR Spectrum | Not Available |
Sample Concentration | Not Available |
Mass Value | Not Available |
Mass Unit | Not Available |
Manufacturer | Not Available |
Frequency | Not Available |
13C NMR Spectrum | Not Available |
Low Energy Voltage | Not Available |
Low Energy Spectrum | Not Available |
Low Energy Peaklist | Not Available |
Medium Energy Spectrum | Not Available |
Hight Energy Spectrum | Not Available |