Accession NumberHMDB03601
Common_Name(S)-Reticuline
Description(S)-reticuline is an endogenous precursors of morphine. (PMID 15383669) (S)-Reticuline is a key intermediate in the synthesis of morphine, the major active metabolite of opium poppy. "Endogenous morphine" has been long isolated and authenticated by mass spectrometry in trace amounts from animal and human specific tissue or fluids. (PMID: 15874902) Recently, human neuroblastoma cells (SH-SY5Y) were shown capable of synthesizing morphine as well. (S)-reticuline undergoes a change of configuration at C-1 during its transformation to salutaridinol and thebaine. From thebaine, there is a bifurcate pathway leading to morphine proceeding via codeine or oripavine, in both plants and mammals. (PMID 15937106)
Chemical_IUPAC_Name(1S)-1-[(3-hydroxy-4-methoxy-phenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol
Chemical FormulaC19H23NO4
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