Accession NumberHMDB03719
Common_NameL-2,4 diaminobutyric acid
DescriptionL-2,4 diaminobutyric acid (DAB) is a non-metabolizable cationic amino acid transported into cells by System A. Tumour cells are irreversibly damaged by incubation with DAB. The tumour cell-destroying effect of DAB is dose- and time-dependent. The presence of non-physiological amino acids in the incubation medium per se was not the cause of tumour cell destruction, since inclusion of other non-physiological aminoacids does not influence the viability of hepatoma cells; the tumour cell destructive effect of DAB is the result of a huge and unlimited uptake of DAB energized by the Na(+)-gradient and this uptake is not subjected to the law of saturation kinetics. DAB accumulates in malignant cells without saturation kinetics, leading to hyperosmosis and subsequently to cell lysis. DAB has been employed in the treatment of patients with inoperable malignant glioma by direct and continuous administration of DAB in tumour tissue employing a microdialysis technique. (PMID: 12820378, 11205257, 1561943)
Chemical_IUPAC_Name2,4-diaminobutanoic acid
Chemical FormulaC4H10N2O2
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Predicted 1H NMR SpectrumDownload
Predicted 1H NMR PeaklistDownload
Predicted 13C NMR SpectrumDownload
Predicted 13C NMR PeaklistDownload
Sample ConcentrationNot Available
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