Accession NumberHMDB00890
Common_NameUroporphyrin IV
DescriptionUroporphyrin is the porphyrin produced by oxidation of the methylene bridges in uroporphyrinogen. They have four acetic acid and four propionic acid side chains attached to the pyrrole rings. Uroporphyrinogen I and III are formed from polypyrryl methane in the presence of uroporphyrinogen III cosynthetase and uroporphyrin I synthetase, respectively. They can yield uroporphyrins by autooxidation or coproporphyrinogens by decarboxylation. Excessive amounts of uroporphyrin I are excreted in congenital erythropoietic porphyria, and both types I and III are excreted in porphyria cutanea tarda. Uroporphyrin I and III are the most common isomemrs. Uroporphyrin IV is a rare isomer; Formed together with the other Uroporphyrin isomers by the nonenzymic acid-catalysed polymerisation and oxidn. of Porphobilinogen (Combined Chemical Dictionary)
Chemical_IUPAC_Name3,8,13,17-tetrakis(carboxymethyl)-21H,23H-Porphine-2,7,12,18-tetrapropanoic acid
Chemical FormulaC36H38N4O8
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Predicted 1H NMR SpectrumDownload
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