Accession NumberHMDB00443
Common_Name1-Oleoyl-lysophosphatidic acid
Description1-Oleoyl-lysophosphatidic acid is a phospholipid mediator with multiple biological functions and is implicated in various human diseases. 1-Oleoyl-lysophosphatidic acid is produced in various conditions both in cells and in biological fluids, where multiple synthetic reactions occur. In serum and plasma, 1-Oleoyl-lysophosphatidic acid is mainly converted from lysophospholipids, whereas in platelets and some cancer cells is converted from phosphatidic acid. In each pathway, at least two phospholipase activities are required: phospholipase A1 (PLA1)/PLA2 plus lysophospholipase D (lysoPLD) activities are involved in the first pathway and phospholipase D (PLD) plus PLA1/PLA2 activities are involved in the second pathway. (PMID 15271293) The biological actions of the lysolipid agonists sphingosine 1-phosphate and lysophosphatidic acid, in addition to other bioactive lipid phosphates such as phosphatidic acid and ceramide 1-phosphate, can be influenced by a family of lipid phosphate phosphatases (LPP), including LPP1, LPP2, LPP3, the Drosophila homologues Wunen (Wun) and Wunen2 (Wun2) and sphingosine 1-phosphate phosphatases 1 and 2 (SPP1, SPP2). (PMID 15271294) 1-Oleoyl-lysophosphatidic acid is a phospholipid mediator with multiple biological functions and is implicated in various human diseases. 1-Oleoyl-lysophosphatidic acid is produced in various conditions both in cells and in biological fluids, where multiple synthetic reactions occur. In serum and plasma, 1-Oleoyl-lysophosphatidic acid is mainly converted from lysophospholipids, whereas in platelets and some cancer cells is converted from phosphatidic acid. In each pathway, at least two phospholipase activities are required: phospholipase A1 (PLA1)/PLA2 plus lysophospholipase D (lysoPLD) activities are involved in the first pathway and phospholipase D (PLD) plus PLA1/PLA2 activities are involved in the second pathway. (PMID 15271293) The biological actions of the lysolipid agonists sphingosine 1-phosphate and lysophosphatidic acid, in addition to other bioactive lipid phosphates such as phosphatidic acid and ceramide 1-phosphate, can be influenced by a family of lipid phosphate phosphatases (LPP), including LPP1, LPP2, LPP3, the Drosophila homologues Wunen (Wun) and Wunen2 (Wun2) and sphingosine 1-phosphate phosphatases 1 and 2 (SPP1, SPP2). (PMID 15271294) Lysophospholipids are small lipid molecules defined by a 3-carbon backbone to which an acyl chain having variable length and saturation is attached and represent one class of lipids that has many important actions mediated by G protein-coupled receptors. (PMID 16099390)
Chemical_IUPAC_Name(2-hydroxy-3-phosphonooxypropyl) (E)-octadec-9-enoate
Chemical FormulaC21H41O7P
Sample ConcentrationNot Available
Mass ValueNot Available
Mass UnitNot Available
ManufacturerNot Available
AnalyzerNot Available
DeliveryNot Available
IonizationNot Available
Predicted 1H NMR SpectrumDownload
Predicted 1H NMR PeaklistDownload
Predicted 13C NMR SpectrumDownload
Predicted 13C NMR PeaklistDownload
Sample ConcentrationNot Available
Mass ValueNot Available
Mass UnitNot Available
ManufacturerNot Available
FrequencyNot Available
1H NMR SpectrumNot Available
Sample ConcentrationNot Available
Mass ValueNot Available
Mass UnitNot Available
ManufacturerNot Available
FrequencyNot Available
13C NMR SpectrumNot Available
Low Energy VoltageNot Available
Low Energy SpectrumNot Available
Low Energy PeaklistNot Available
Medium Energy SpectrumNot Available
Hight Energy SpectrumNot Available