Accession NumberHMDB03818
Common_NameAndrost-5-ene-3beta,17beta-diol
DescriptionAndrostenediol is a term used to refer to two different steroids with molecular weights of 290.44: '4-androstenediol' (4-androstene-3beta,17beta-diol) and '5-androstenediol' (5-androstene-3beta,17beta-diol). 4-Androstenediol is closer to testosterone structurally, and has androgenic effects. 5-Androstenediol is a direct metabolite of the most abundant steroid produced by the human adrenal cortex, dehydroepiandrosterone (DHEA). 5-Androstenediol is less androgenic than 4-androstenediol, and stimulates the immune system. When administered to rats in vivo, 5-androstenediol has approximately 1/70 the androgenicity of DHEA, 1/185 the androgenicity of androstenedione, and 1/475 the androgenicity of testosterone (Coffey, 1988). Because it induces production of white blood cells and platelets, 5-androstenediol is being developed as a radiation countermeasure as Neumune(HE2100). An intermediate in testosterone biosynthesis, found in the testis or the adrenal. Androstenediol, derived from dehydroepiandrosterone by the reduction of the 17-keto group (17-fydroxysteroid dehydrogenaseS), is converted to testosterone by the oxidation of the 3-beta hydroxyl group to a 3-keto group (3-fydroxysteroid dehydrogenase).
Chemical_IUPAC_Name(3S,8R,9S,10R,13S,14S,17S)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol
Chemical FormulaC19H30O2
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