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Showing metabocard for 1-Methylhistamine (HMDB0000898)

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enzymes (3) Show 3 proteins
Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-02-21 17:15:17 UTC
HMDB IDHMDB0000898
Secondary Accession Numbers
  • HMDB0000976
  • HMDB00898
  • HMDB00976
Metabolite Identification
Common Name1-Methylhistamine
Description1-Methylhistamine, also known as H137, belongs to the class of organic compounds known as 2-arylethylamines. These are primary amines that have the general formula RCCNH2, where R is an organic group. 1-Methylhistamine exists in all living organisms, ranging from bacteria to humans. Within humans, 1-methylhistamine participates in a number of enzymatic reactions. In particular, S-adenosylhomocysteine and 1-methylhistamine can be biosynthesized from S-adenosylmethionine and histamine; which is mediated by the enzyme histamine N-methyltransferase. In addition, 1-methylhistamine can be converted into methylimidazole acetaldehyde through its interaction with the enzyme amine oxidase [flavin-containing] a. In humans, 1-methylhistamine is involved in histidine metabolism. 1-Methylhistamine is a potentially toxic compound.
Structure
Data?1676999717
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0000898 (1-Methylhistamine)


  Mrv1652305261923512D          

  9  9  0  0  0  0            999 V2000
    0.2425    0.2652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1820    0.2652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2425   -0.5569    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8258    0.8486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1820   -0.5569    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4735   -0.9699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6214    0.6364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2995   -1.1554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2048    1.2198    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  1  0  0  0  0
  1  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  5  6  1  0  0  0  0
M  END
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3D MOL for HMDB0000898 (1-Methylhistamine)

HMDB0000898
     RDKit          3D
1-Methylhistamine
 20 20  0  0  0  0  0  0  0  0999 V2000
    3.1329   -0.6104   -0.5612 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9001   -0.0808   -0.0100 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7193    0.2096    1.2927 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4604    0.6833    1.4701 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1699    0.6981    0.2811 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5694    1.1532    0.0672 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5472   -0.0041    0.2193 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2260   -1.0270   -0.7647 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7488    0.2166   -0.6286 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6059   -1.2435    0.2194 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8450    0.1859   -0.8105 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9038   -1.1825   -1.4806 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4562    0.0843    2.0626 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6226    1.5226   -0.9778 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8507    1.9855    0.7202 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5680    0.3856    0.0340 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5366   -0.4046    1.2423 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6049   -0.7230   -1.6998 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6535   -1.9417   -0.5309 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5762    0.0928   -1.6885 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  5  9  2  0
  9  2  1  0
  1 10  1  0
  1 11  1  0
  1 12  1  0
  3 13  1  0
  6 14  1  0
  6 15  1  0
  7 16  1  0
  7 17  1  0
  8 18  1  0
  8 19  1  0
  9 20  1  0
M  END
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3D SDF for HMDB0000898 (1-Methylhistamine)


  Mrv1652305261923512D          

  9  9  0  0  0  0            999 V2000
    0.2425    0.2652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1820    0.2652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2425   -0.5569    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8258    0.8486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1820   -0.5569    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4735   -0.9699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6214    0.6364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2995   -1.1554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2048    1.2198    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  1  0  0  0  0
  1  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  5  6  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0000898

> <DATABASE_NAME>
hmdb

> <SMILES>
CN1C=NC(CCN)=C1

> <INCHI_IDENTIFIER>
InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3

> <INCHI_KEY>
FHQDWPCFSJMNCT-UHFFFAOYSA-N

> <FORMULA>
C6H11N3

> <MOLECULAR_WEIGHT>
125.1716

> <EXACT_MASS>
125.095297367

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
20

> <JCHEM_AVERAGE_POLARIZABILITY>
14.241604820217898

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
2-(1-methyl-1H-imidazol-4-yl)ethan-1-amine

> <ALOGPS_LOGP>
-0.57

> <JCHEM_LOGP>
-0.47729507866666643

> <ALOGPS_LOGS>
-1.39

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_BASIC>
9.57278986154642

> <JCHEM_POLAR_SURFACE_AREA>
43.84

> <JCHEM_REFRACTIVITY>
36.56009999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
5.12e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
methylhistamine

> <JCHEM_VEBER_RULE>
0

$$$$
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3D-SDF for HMDB0000898 (1-Methylhistamine)

HMDB0000898
     RDKit          3D
1-Methylhistamine
 20 20  0  0  0  0  0  0  0  0999 V2000
    3.1329   -0.6104   -0.5612 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9001   -0.0808   -0.0100 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7193    0.2096    1.2927 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4604    0.6833    1.4701 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1699    0.6981    0.2811 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5694    1.1532    0.0672 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5472   -0.0041    0.2193 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2260   -1.0270   -0.7647 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7488    0.2166   -0.6286 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6059   -1.2435    0.2194 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8450    0.1859   -0.8105 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9038   -1.1825   -1.4806 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4562    0.0843    2.0626 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6226    1.5226   -0.9778 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8507    1.9855    0.7202 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5680    0.3856    0.0340 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5366   -0.4046    1.2423 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6049   -0.7230   -1.6998 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6535   -1.9417   -0.5309 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5762    0.0928   -1.6885 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  5  9  2  0
  9  2  1  0
  1 10  1  0
  1 11  1  0
  1 12  1  0
  3 13  1  0
  6 14  1  0
  6 15  1  0
  7 16  1  0
  7 17  1  0
  8 18  1  0
  8 19  1  0
  9 20  1  0
M  END
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PDB for HMDB0000898 (1-Methylhistamine)

HEADER    PROTEIN                                 26-MAY-19   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   26-MAY-19         0                                  
HETATM    1  C   UNK     0       0.453   0.495   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -2.206   0.495   0.000  0.00  0.00           C+0
HETATM    3  N   UNK     0       0.453  -1.040   0.000  0.00  0.00           N+0
HETATM    4  C   UNK     0       1.541   1.584   0.000  0.00  0.00           C+0
HETATM    5  N   UNK     0      -2.206  -1.040   0.000  0.00  0.00           N+0
HETATM    6  C   UNK     0      -0.884  -1.810   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       3.027   1.188   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -4.292  -2.157   0.000  0.00  0.00           C+0
HETATM    9  N   UNK     0       4.116   2.277   0.000  0.00  0.00           N+0
CONECT    1    2    3    4                                                  
CONECT    2    1    5                                                       
CONECT    3    1    6                                                       
CONECT    4    1    7                                                       
CONECT    5    2    8    6                                                  
CONECT    6    3    5                                                       
CONECT    7    4    9                                                       
CONECT    8    5                                                            
CONECT    9    7                                                            
MASTER        0    0    0    0    0    0    0    0    9    0   18    0
END
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3D PDB for HMDB0000898 (1-Methylhistamine)

COMPND    HMDB0000898
HETATM    1  C1  UNL     1       3.133  -0.610  -0.561  1.00  0.00           C  
HETATM    2  N1  UNL     1       1.900  -0.081  -0.010  1.00  0.00           N  
HETATM    3  C2  UNL     1       1.719   0.210   1.293  1.00  0.00           C  
HETATM    4  N2  UNL     1       0.460   0.683   1.470  1.00  0.00           N  
HETATM    5  C3  UNL     1      -0.170   0.698   0.281  1.00  0.00           C  
HETATM    6  C4  UNL     1      -1.569   1.153   0.067  1.00  0.00           C  
HETATM    7  C5  UNL     1      -2.547  -0.004   0.219  1.00  0.00           C  
HETATM    8  N3  UNL     1      -2.226  -1.027  -0.765  1.00  0.00           N  
HETATM    9  C6  UNL     1       0.749   0.217  -0.629  1.00  0.00           C  
HETATM   10  H1  UNL     1       3.606  -1.243   0.219  1.00  0.00           H  
HETATM   11  H2  UNL     1       3.845   0.186  -0.811  1.00  0.00           H  
HETATM   12  H3  UNL     1       2.904  -1.183  -1.481  1.00  0.00           H  
HETATM   13  H4  UNL     1       2.456   0.084   2.063  1.00  0.00           H  
HETATM   14  H5  UNL     1      -1.623   1.523  -0.978  1.00  0.00           H  
HETATM   15  H6  UNL     1      -1.851   1.986   0.720  1.00  0.00           H  
HETATM   16  H7  UNL     1      -3.568   0.386   0.034  1.00  0.00           H  
HETATM   17  H8  UNL     1      -2.537  -0.405   1.242  1.00  0.00           H  
HETATM   18  H9  UNL     1      -2.605  -0.723  -1.700  1.00  0.00           H  
HETATM   19  H10 UNL     1      -2.653  -1.942  -0.531  1.00  0.00           H  
HETATM   20  H11 UNL     1       0.576   0.093  -1.689  1.00  0.00           H  
CONECT    1    2   10   11   12
CONECT    2    3    9
CONECT    3    4    4   13
CONECT    4    5
CONECT    5    6    9    9
CONECT    6    7   14   15
CONECT    7    8   16   17
CONECT    8   18   19
CONECT    9   20
END
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SMILES for HMDB0000898 (1-Methylhistamine)

CN1C=NC(CCN)=C1
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INCHI for HMDB0000898 (1-Methylhistamine)

InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3
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View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
ValueSource
1-Methyl-1H-imidazole-4-ethanamineChEBI
1-Methyl-4-(2-aminoethyl)imidazoleChEBI
3-MethylhistamineChEBI
4-(1-Aminoethyl)-1-methyl-1H-imidazoleChEBI
MethylhistamineChEBI
N-MethylhistamineChEBI
N(1)-MethylhistamineChEBI
Ntau-methylhistamineChEBI
tele-MethylhistamineChEBI
tele-Methylhistamine dihydrochlorideHMDB
1-Methyl-4-(beta-aminoethyl)imidazoleHMDB
1,4-MethylhistamineHMDB
N-tele MethylhistamineHMDB
1-Methyl-4-(b-aminoethyl)imidazoleHMDB
1-Methyl-4-histamineHMDB
2-(1-Methyl-1H-imidazol-4-yl)ethanamineHMDB
2-(1-Methyl-1H-imidazol-4-yl)ethylamineHMDB
4-(2-Aminoethyl)-1-methyl-imidazoleHMDB
4-(2-Aminoethyl)-1-methylimidazoleHMDB
H137HMDB
N( 1)-MethylhistamineHMDB
N(T)-MethylhistamineHMDB
N-tele-MethylhistamineHMDB
N-Telle-methylhistamineHMDB
N1-MethylhistamineHMDB
NT-MethylhistamineHMDB
Chemical FormulaC6H11N3
Average Molecular Weight125.1716
Monoisotopic Molecular Weight125.095297367
IUPAC Name2-(1-methyl-1H-imidazol-4-yl)ethan-1-amine
Traditional Namemethylhistamine
CAS Registry Number501-75-7
SMILES
CN1C=NC(CCN)=C1
InChI Identifier
InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3
InChI KeyFHQDWPCFSJMNCT-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as 2-arylethylamines. These are primary amines that have the general formula RCCNH2, where R is an organic group.
KingdomOrganic compounds
Super ClassOrganic nitrogen compounds
ClassOrganonitrogen compounds
Sub ClassAmines
Direct Parent2-arylethylamines
Alternative Parents
Substituents
  • 2-arylethylamine
  • Aralkylamine
  • N-substituted imidazole
  • Heteroaromatic compound
  • Imidazole
  • Azole
  • Azacycle
  • Organoheterocyclic compound
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Primary aliphatic amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Ontology
Not AvailableNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M+H]+Baker122.55530932474
[M+H]+MetCCS_train_pos121.30230932474
[M+H]+Not Available121.9http://allccs.zhulab.cn/database/detail?ID=AllCCS00000535
Predicted Molecular Properties
PropertyValueSource
Water Solubility5.12 g/LALOGPS
logP-0.57ALOGPS
logP-0.48ChemAxon
logS-1.4ALOGPS
pKa (Strongest Basic)9.57ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area43.84 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity36.56 m³·mol⁻¹ChemAxon
Polarizability14.24 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+126.15631661259
DarkChem[M+H]+126.15631661259
DarkChem[M-H]-123.86931661259
DarkChem[M-H]-123.86931661259
AllCCS[M+H]+127.18832859911
AllCCS[M-H]-127.17232859911
DeepCCS[M+H]+122.34830932474
DeepCCS[M-H]-119.10130932474
DeepCCS[M-2H]-155.74530932474
DeepCCS[M+Na]+130.91730932474
AllCCS[M+H]+127.232859911
AllCCS[M+H-H2O]+122.532859911
AllCCS[M+NH4]+131.532859911
AllCCS[M+Na]+132.832859911
AllCCS[M-H]-127.232859911
AllCCS[M+Na-2H]-129.432859911
AllCCS[M+HCOO]-131.932859911

Predicted Retention Times

Underivatized

Chromatographic MethodRetention TimeReference
Measured using a Waters Acquity ultraperformance liquid chromatography (UPLC) ethylene-bridged hybrid (BEH) C18 column (100 mm × 2.1 mm; 1.7 μmparticle diameter). Predicted by Afia on May 17, 2022. Predicted by Afia on May 17, 2022.1.81 minutes32390414
Predicted by Siyang on May 30, 20227.7922 minutes33406817
Predicted by Siyang using ReTip algorithm on June 8, 20226.24 minutes32390414
AjsUoB = Accucore 150 Amide HILIC with 10mM Ammonium Formate, 0.1% Formic Acid399.3 seconds40023050
Fem_Long = Waters ACQUITY UPLC HSS T3 C18 with Water:MeOH and 0.1% Formic Acid330.6 seconds40023050
Fem_Lipids = Ascentis Express C18 with (60:40 water:ACN):(90:10 IPA:ACN) and 10mM NH4COOH + 0.1% Formic Acid269.5 seconds40023050
Life_Old = Waters ACQUITY UPLC BEH C18 with Water:(20:80 acetone:ACN) and 0.1% Formic Acid57.8 seconds40023050
Life_New = RP Waters ACQUITY UPLC HSS T3 C18 with Water:(30:70 MeOH:ACN) and 0.1% Formic Acid178.6 seconds40023050
RIKEN = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid64.4 seconds40023050
Eawag_XBridgeC18 = XBridge C18 3.5u 2.1x50 mm with Water:MeOH and 0.1% Formic Acid265.1 seconds40023050
BfG_NTS_RP1 =Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) with Water:ACN and 0.1% Formic Acid222.2 seconds40023050
HILIC_BDD_2 = Merck SeQuant ZIC-HILIC with ACN(0.1% formic acid):water(16 mM ammonium formate)955.4 seconds40023050
UniToyama_Atlantis = RP Waters Atlantis T3 (2.1 x 150 mm, 5 um) with ACN:Water and 0.1% Formic Acid506.8 seconds40023050
BDD_C18 = Hypersil Gold 1.9µm C18 with Water:ACN and 0.1% Formic Acid35.9 seconds40023050
UFZ_Phenomenex = Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex with Water:MeOH and 0.1% Formic Acid484.6 seconds40023050
SNU_RIKEN_POS = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid184.9 seconds40023050
RPMMFDA = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid259.0 seconds40023050
MTBLS87 = Merck SeQuant ZIC-pHILIC column with ACN:Water and :ammonium carbonate789.5 seconds40023050
KI_GIAR_zic_HILIC_pH2_7 = Merck SeQuant ZIC-HILIC with ACN:Water and 0.1% FA678.6 seconds40023050
Meister zic-pHILIC pH9.3 = Merck SeQuant ZIC-pHILIC column with ACN:Water 5mM NH4Ac pH9.3 and 5mM ammonium acetate in water307.8 seconds40023050

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
1-MethylhistamineCN1C=NC(CCN)=C12150.0Standard polar33892256
1-MethylhistamineCN1C=NC(CCN)=C11375.0Standard non polar33892256
1-MethylhistamineCN1C=NC(CCN)=C11277.9Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
1-Methylhistamine,1TMS,isomer #1CN1C=NC(CCN[Si](C)(C)C)=C11513.1Semi standard non polar33892256
1-Methylhistamine,1TMS,isomer #1CN1C=NC(CCN[Si](C)(C)C)=C11559.5Standard non polar33892256
1-Methylhistamine,1TMS,isomer #1CN1C=NC(CCN[Si](C)(C)C)=C11930.0Standard polar33892256
1-Methylhistamine,2TMS,isomer #1CN1C=NC(CCN([Si](C)(C)C)[Si](C)(C)C)=C11793.8Semi standard non polar33892256
1-Methylhistamine,2TMS,isomer #1CN1C=NC(CCN([Si](C)(C)C)[Si](C)(C)C)=C11764.3Standard non polar33892256
1-Methylhistamine,2TMS,isomer #1CN1C=NC(CCN([Si](C)(C)C)[Si](C)(C)C)=C11892.4Standard polar33892256
1-Methylhistamine,1TBDMS,isomer #1CN1C=NC(CCN[Si](C)(C)C(C)(C)C)=C11743.8Semi standard non polar33892256
1-Methylhistamine,1TBDMS,isomer #1CN1C=NC(CCN[Si](C)(C)C(C)(C)C)=C11791.7Standard non polar33892256
1-Methylhistamine,1TBDMS,isomer #1CN1C=NC(CCN[Si](C)(C)C(C)(C)C)=C12045.2Standard polar33892256
1-Methylhistamine,2TBDMS,isomer #1CN1C=NC(CCN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C12147.2Semi standard non polar33892256
1-Methylhistamine,2TBDMS,isomer #1CN1C=NC(CCN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C12184.9Standard non polar33892256
1-Methylhistamine,2TBDMS,isomer #1CN1C=NC(CCN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C12060.7Standard polar33892256
Spectra
Biological Properties
Cellular Locations
  • Cytoplasm
Biospecimen Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Feces
  • Saliva
  • Urine
Tissue Locations
  • Bone Marrow
  • Brain
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.00034 (0.00021-0.00047) uMAdult (>18 years old)BothNormal details
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.002 +/- 0.0005 (0.0015 - 0.0025) uMAdult (>18 years old)BothNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.005 +/- 0.0006 (0.003-0.006) uMChildren (1-13 years old)BothNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.002209 +/- 0.000463 uMAdult (>18 years old)Not SpecifiedNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.00214 +/- 0.0001 uMNot SpecifiedNot SpecifiedNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified1.12 +/- 0.22 uMAdult (>18 years old)Both
Normal		 details
Cerebrospinal Fluid (CSF)Detected and Quantified0.007 +/- 0.0005 (0.006 - 0.008) uMChildren (1-13 years old)Not SpecifiedNormal details
FecesDetected but not QuantifiedNot QuantifiedChildren (6 - 18 years old)Not SpecifiedNormal details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal		 details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal		 details
SalivaDetected and Quantified0.0117 +/- 0.0359 uMAdult (>18 years old)BothNormal
    • Sugimoto et al. (...
 details
SalivaDetected and Quantified0.0125 +/- 0.0348 uMAdult (>18 years old)Both
Normal
    • Sugimoto et al. (...
 details
SalivaDetected and Quantified0.0301 +/- 0.0193 uMAdult (>18 years old)Both
Normal
    • Sugimoto et al. (...
 details
UrineDetected and Quantified0.065 (0.32-0.98) umol/mmol creatinineAdult (>18 years old)BothNormal details
UrineDetected and Quantified0.098 (0.032-0.18) umol/mmol creatinineAdult (>18 years old)BothNormal
    • Geigy Scientific ...
    • West Cadwell, N.J...
    • Basel, Switzerlan...
 details
UrineDetected and Quantified0.13 umol/mmol creatinineAdult (>18 years old)BothNormal details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.00078 (0.00055-0.00100) uMAdult (>18 years old)BothDermal fibroproliferative disorder (hypertrophic scarring) details
Cerebrospinal Fluid (CSF)Detected and Quantified0.002431 +/- 0.000461 uMAdult (>18 years old)Not Specifiedsporadic narcolepsy-cataplexy details
Cerebrospinal Fluid (CSF)Detected and Quantified0.00276 +/- 0.00013 uMAdult (>18 years old)Not SpecifiedAlzheimer's disease details
Cerebrospinal Fluid (CSF)Detected and Quantified2.90 +/- 0.27 uMAdult (>18 years old)Both
Schizophrenia		 details
Cerebrospinal Fluid (CSF)Detected and Quantified0.00290 +/- 0.00027 uMAdult (>18 years old)BothSchizophrenia details
FecesDetected but not QuantifiedNot QuantifiedChildren (6 - 18 years old)Not SpecifiedCrohns disease details
FecesDetected but not QuantifiedNot QuantifiedChildren (6 - 18 years old)Not SpecifiedUlcerative colitis details
FecesDetected but not QuantifiedNot QuantifiedChildren (6 - 18 years old)Not SpecifiedUnclassified IBD details
SalivaDetected and Quantified0.0203 +/- 0.0254 uMAdult (>18 years old)BothOral cavity disorders
    • Sugimoto et al. (...
 details
UrineDetected and Quantified0.73 umol/mmol creatinineAdult (>18 years old)BothMastocytosis details
Associated Disorders and Diseases
Disease References
Dermal fibroproliferative disorder
  1. Tredget EE, Iwashina T, Scott PG, Ghahary A: Determination of plasma Ntau-methylhistamine in vivo by isotope dilution using benchtop gas chromatography-mass spectrometry. J Chromatogr B Biomed Sci Appl. 1997 Jun 20;694(1):1-9. [PubMed:9234842 ]
Alzheimer's disease
  1. Motawaj M, Peoc'h K, Callebert J, Arrang JM: CSF levels of the histamine metabolite tele-methylhistamine are only slightly decreased in Alzheimer's disease. J Alzheimers Dis. 2010;22(3):861-71. doi: 10.3233/JAD-2010-100381. [PubMed:20858978 ]
Schizophrenia
  1. Prell GD, Green JP, Kaufmann CA, Khandelwal JK, Morrishow AM, Kirch DG, Linnoila M, Wyatt RJ: Histamine metabolites in cerebrospinal fluid of patients with chronic schizophrenia: their relationships to levels of other aminergic transmitters and ratings of symptoms. Schizophr Res. 1995 Jan;14(2):93-104. [PubMed:7711000 ]
Crohn's disease
  1. Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V: Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158. [PubMed:27609529 ]
Ulcerative colitis
  1. Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V: Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158. [PubMed:27609529 ]
Mastocytosis
  1. Martens-Lobenhoffer J, Neumann HJ: Determination of 1-methylhistamine and 1-methylimidazoleacetic acid in human urine as a tool for the diagnosis of mastocytosis. J Chromatogr B Biomed Sci Appl. 1999 Jan 8;721(1):135-40. [PubMed:10027644 ]
Associated OMIM IDs
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB022306
KNApSAcK IDNot Available
Chemspider ID3488
KEGG Compound IDC05127
BioCyc IDN-METHYL-HISTAMINE
BiGG ID45171
Wikipedia LinkMethylhistamine
METLIN ID5854
PubChem Compound3614
PDB IDNot Available
ChEBI ID29009
Food Biomarker OntologyNot Available
VMH IDMHISTA
MarkerDB IDMDB00000278
Good Scents IDNot Available
References
Synthesis ReferenceRothschild, Zuleika; Schayer, Richard W. Synthesis and metabolism of a histamine metabolite, 1-methyl-4-(b-aminoethyl)imidazole. Biochimica et Biophysica Acta (1958), 30 23-7.
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Ito C: The role of the central histaminergic system on schizophrenia. Drug News Perspect. 2004 Jul-Aug;17(6):383-7. [PubMed:15334189 ]
  2. Khandelwal JK, Hough LB, Morrishow AM, Green JP: Measurement of tele-methylhistamine and histamine in human cerebrospinal fluid, urine, and plasma. Agents Actions. 1982 Dec;12(5-6):583-90. [PubMed:7164933 ]
  3. Winterkamp S, Weidenhiller M, Otte P, Stolper J, Schwab D, Hahn EG, Raithel M: Urinary excretion of N-methylhistamine as a marker of disease activity in inflammatory bowel disease. Am J Gastroenterol. 2002 Dec;97(12):3071-7. [PubMed:12492192 ]
  4. Elmore BO, Bollinger JA, Dooley DM: Human kidney diamine oxidase: heterologous expression, purification, and characterization. J Biol Inorg Chem. 2002 Jun;7(6):565-79. Epub 2002 Feb 13. [PubMed:12072962 ]
  5. Robbins IM, Barst RJ, Rubin LJ, Gaine SP, Price PV, Morrow JD, Christman BW: Increased levels of prostaglandin D(2) suggest macrophage activation in patients with primary pulmonary hypertension. Chest. 2001 Nov;120(5):1639-44. [PubMed:11713147 ]
  6. O'Sullivan S, Roquet A, Dahlen B, Dahlen S, Kumlin M: Urinary excretion of inflammatory mediators during allergen-induced early and late phase asthmatic reactions. Clin Exp Allergy. 1998 Nov;28(11):1332-9. [PubMed:9824404 ]
  7. Martens-Lobenhoffer J, Neumann HJ: Determination of 1-methylhistamine and 1-methylimidazoleacetic acid in human urine as a tool for the diagnosis of mastocytosis. J Chromatogr B Biomed Sci Appl. 1999 Jan 8;721(1):135-40. [PubMed:10027644 ]
  8. Theoharides TC, Sant GR, el-Mansoury M, Letourneau R, Ucci AA Jr, Meares EM Jr: Activation of bladder mast cells in interstitial cystitis: a light and electron microscopic study. J Urol. 1995 Mar;153(3 Pt 1):629-36. [PubMed:7861501 ]
  9. Brumsen C, Papapoulos SE, Lentjes EG, Kluin PM, Hamdy NA: A potential role for the mast cell in the pathogenesis of idiopathic osteoporosis in men. Bone. 2002 Nov;31(5):556-61. [PubMed:12477568 ]
  10. Rozniecki JJ, Hauser SL, Stein M, Lincoln R, Theoharides TC: Elevated mast cell tryptase in cerebrospinal fluid of multiple sclerosis patients. Ann Neurol. 1995 Jan;37(1):63-6. [PubMed:7818259 ]
  11. Alakarppa K, Tupala E, Mantere T, Sarkioja T, Rasanen P, Tarhanen J, Tiihonen J, Tuomisto L: Effect of alcohol abuse on human brain histamine and tele-methylhistamine. Inflamm Res. 2002 Apr;51 Suppl 1:S40-1. [PubMed:12013402 ]
  12. Tredget EE, Iwashina T, Scott PG, Ghahary A: Determination of plasma Ntau-methylhistamine in vivo by isotope dilution using benchtop gas chromatography-mass spectrometry. J Chromatogr B Biomed Sci Appl. 1997 Jun 20;694(1):1-9. [PubMed:9234842 ]
  13. van Toorenenbergen AW, Oranje AP: Comparison of serum tryptase and urine N-methylhistamine in patients with suspected mastocytosis. Clin Chim Acta. 2005 Sep;359(1-2):72-7. [PubMed:15913591 ]
  14. Droogendijk HJ, Kluin-Nelemans HJ, van Doormaal JJ, Oranje AP, van de Loosdrecht AA, van Daele PL: Imatinib mesylate in the treatment of systemic mastocytosis: a phase II trial. Cancer. 2006 Jul 15;107(2):345-51. [PubMed:16779792 ]
  15. Oranje AP, Mulder PG, Heide R, Tank B, Riezebos P, van Toorenenbergen AW: Urinary N-methylhistamine as an indicator of bone marrow involvement in mastocytosis. Clin Exp Dermatol. 2002 Sep;27(6):502-6. [PubMed:12372095 ]
  16. Rinne JO, Anichtchik OV, Eriksson KS, Kaslin J, Tuomisto L, Kalimo H, Roytta M, Panula P: Increased brain histamine levels in Parkinson's disease but not in multiple system atrophy. J Neurochem. 2002 Jun;81(5):954-60. [PubMed:12065607 ]
  17. Fitzpatrick MF, Mackay T, Walters C, Tai PC, Church MK, Holgate ST, Douglas NJ: Circulating histamine and eosinophil cationic protein levels in nocturnal asthma. Clin Sci (Lond). 1992 Aug;83(2):227-32. [PubMed:1327639 ]
  18. Butterfield JH, Tefferi A, Kozuh GF: Successful treatment of systemic mastocytosis with high-dose interferon-alfa: long-term follow-up of a case. Leuk Res. 2005 Feb;29(2):131-4. [PubMed:15607359 ]
  19. Winterkamp S, Weidenhiller M, Wilken V, Donhauser N, Schultis HW, Buchwald F, Hahn EG, Raithel M: Standardised evaluation of urinary excretion of N-tele-methylhistamine in different periods of age in a healthy population. Inflamm Res. 2003 Apr;52 Suppl 1:S57-8. [PubMed:12755411 ]
  20. Coruzzi G, Morini G, Adami M, Grandi D: Role of histamine H3 receptors in the regulation of gastric functions. J Physiol Pharmacol. 2001 Dec;52(4 Pt 1):539-53. [PubMed:11787757 ]

Enzymes

Enzyme Details
1. Amine oxidase [flavin-containing] B
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
Gene Name:
MAOB
Uniprot ID:
P27338
Molecular weight:
58762.475
Reactions
1-Methylhistamine + Water + Oxygen → Methylimidazole acetaldehyde + Ammonia + Hydrogen peroxidedetails
Enzyme Details
2. Amine oxidase [flavin-containing] A
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
Gene Name:
MAOA
Uniprot ID:
P21397
Molecular weight:
59681.27
Reactions
1-Methylhistamine + Water + Oxygen → Methylimidazole acetaldehyde + Ammonia + Hydrogen peroxidedetails
Enzyme Details
3. Histamine N-methyltransferase
General function:
Involved in histamine N-methyltransferase activity
Specific function:
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
Gene Name:
HNMT
Uniprot ID:
P50135
Molecular weight:
6045.9
Reactions
S-Adenosylmethionine + Histamine → S-Adenosylhomocysteine + 1-Methylhistaminedetails