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Identification Taxonomy Ontology Physical properties Spectra Biological properties Concentrations Links References enzymes (219) Show 219 proteins XML

Record Information

Version

5.0

Status

Detected and Quantified

Creation Date

2005-11-16 15:48:42 UTC

Update Date

2021-09-14 14:57:20 UTC

HMDB ID

HMDB0001487

Secondary Accession Numbers

HMDB01487

Metabolite Identification

Common Name

NADH

Description

Nicotinamide adenine dinucleotide (NAD) is a coenzyme central to metabolism. Found in all living cells, NAD is called a dinucleotide because it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine nucleobase and the other nicotinamide. NAD exists in two forms: an oxidized and reduced form, abbreviated as NAD+ and NADH (H for hydrogen) respectively. NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH. NAD (or nicotinamide adenine dinucleotide) is used extensively in glycolysis and the citric acid cycle of cellular respiration. The reducing potential stored in NADH can be either converted into ATP through the electron transport chain or used for anabolic metabolism. ATP "energy" is necessary for an organism to live. Green plants obtain ATP through photosynthesis, while other organisms obtain it via cellular respiration. NAD is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by a pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). NADP is formed through the addition of a phosphate group to the 2' position of the adenosyl nucleotide through an ester linkage.

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI


  Mrv1652309042000232D          

 44 48  0  0  0  0            999 V2000
 9995.5688 9998.0521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9997.3578 9998.0438    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9997.8653 9999.9046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.5818 9999.4911    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9999.2961 9999.9046    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
10000.0167 9999.5054    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10000.7302 9999.9168    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
10001.4459 9999.5054    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10002.1573 9999.9168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10002.6358 9998.0583    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10004.4258 9998.0663    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10007.0717 9999.5177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10007.7873 9999.9292    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
10007.0717 9998.6928    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10000.317810000.6318    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10001.142710000.6318    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9998.882710000.6194    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9999.707610000.6194    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10003.5378 9999.9992    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10002.8704 9999.5142    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
10003.1253 9998.7296    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
10003.9503 9998.7296    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
10004.2052 9999.5142    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
 9996.4809 9999.9854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9996.0684 9998.7158    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
 9996.8934 9998.7158    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9997.1483 9999.5004    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
10006.351610000.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10005.637110001.1544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10004.922610000.7419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10004.9225 9999.9170    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
10005.6370 9999.5044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10006.3516 9999.9170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9993.033010000.2714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9992.6975 9999.5178    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9993.1825 9998.8503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9994.0029 9998.9365    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9994.3385 9999.6901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9993.853510000.3577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9992.548010000.9388    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9995.1231 9999.9450    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9995.123110000.7700    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9994.338610001.0250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9995.7905 9999.4600    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5 17  2  0  0  0  0
  5 18  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7 15  2  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 19 20  1  0  0  0  0
 19 23  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 24 27  1  0  0  0  0
 25  1  1  1  0  0  0
 27  3  1  6  0  0  0
 26  2  1  1  0  0  0
 20  9  1  1  0  0  0
 22 11  1  6  0  0  0
 21 10  1  6  0  0  0
 28 29  1  0  0  0  0
 29 30  2  0  0  0  0
 32 33  2  0  0  0  0
 33 28  1  0  0  0  0
 33 12  1  0  0  0  0
 38 39  2  0  0  0  0
 39 34  1  0  0  0  0
 34 35  2  0  0  0  0
 35 36  1  0  0  0  0
 36 37  2  0  0  0  0
 37 38  1  0  0  0  0
 34 40  1  0  0  0  0
 42 43  2  0  0  0  0
 39 43  1  0  0  0  0
 41 42  1  0  0  0  0
 38 41  1  0  0  0  0
 44 41  1  6  0  0  0
 44 25  1  0  0  0  0
 24 44  1  0  0  0  0
  7 16  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 23 31  1  1  0  0  0
M  END

HMDB0001487
     RDKit          3D
NADH
 73 77  0  0  0  0  0  0  0  0999 V2000
   10.3397    1.2977   -1.0927 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.4943   -0.0219   -0.6209 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6284   -0.5421   -0.6237 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.3274   -0.7442   -0.1426 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1164   -0.2110   -0.1313 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9572   -0.8874    0.3283 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6666   -0.2399    0.3103 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.6390   -1.0838    0.6493 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4851   -0.4046    0.2821 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.3988   -1.4329   -0.0047 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2571   -0.7156   -0.3697 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0232   -1.7767   -0.7130 P   0  0  0  0  0  5  0  0  0  0  0  0
    0.3028   -2.6433   -1.9081 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2755   -2.7769    0.6197 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -0.8831   -0.9942 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8013   -0.0318    0.4149 P   0  0  0  0  0  5  0  0  0  0  0  0
   -1.9958   -1.0212    1.5352 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5244    0.9937    0.8689 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2239    0.8086    0.1817 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0867    1.7763   -0.8346 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4130    2.5157   -1.0087 C   0  0  1  0  0  0  0  0  0  0  0  0
   -5.3548    1.5866   -1.3519 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3916    1.6137   -0.4583 C   0  0  1  0  0  0  0  0  0  0  0  0
   -7.0070    0.3101   -0.3041 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3514   -0.8563   -0.3785 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2528   -1.8305   -0.1855 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4674   -1.3108    0.0100 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.7065   -1.8410    0.2468 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.8444   -3.2456    0.3206 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7856   -1.0569    0.4092 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.6215    0.2852    0.3331 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.4025    0.8276    0.0994 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3081    0.0651   -0.0665 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7985    2.1094    0.8400 C   0  0  2  0  0  0  0  0  0  0  0  0
   -6.7807    2.8112    1.5437 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7622    3.1036    0.3246 C   0  0  2  0  0  0  0  0  0  0  0  0
   -5.4183    4.3075    0.1142 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7933    0.3701   -0.9572 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.5676    1.7177   -0.7035 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2809    0.1604   -1.1197 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.9349    1.3316   -1.4914 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1312   -2.2148    0.7997 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3066   -2.7905    0.8107 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5150   -2.1186    0.3441 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8383    2.0799   -0.6386 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.7208    1.4866   -1.9021 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.0224    0.8091   -0.5004 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6250    0.6620    0.9496 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1644    0.2184    1.1393 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1804   -2.0492    0.8850 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7266   -2.1074   -0.8249 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0983   -2.3356    1.4201 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0853    1.3901    0.0966 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2552    2.4605   -0.6503 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8479    1.1987   -1.7585 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2855    3.2854   -1.7878 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1776    2.3457   -0.7454 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2769   -0.9878   -0.5630 H   0  0  0  0  0  0  0  0  0  0  0  0
   -9.9221   -3.7464    1.2127 H   0  0  0  0  0  0  0  0  0  0  0  0
   -9.8679   -3.7935   -0.5668 H   0  0  0  0  0  0  0  0  0  0  0  0
  -11.5015    0.8973    0.4665 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3249    1.3218    1.4349 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9507    2.4346    2.4302 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9119    3.1827    1.0056 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7490    4.4017   -0.8173 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2302    0.0097   -1.8431 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9066    2.2860   -1.4488 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.4699   -0.6800   -1.7983 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1254    1.2977   -2.4631 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.2372   -2.7509    1.1596 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.4057   -3.8222    1.1834 H   0  0  0  0  0  0  0  0  0  0  0  0
   10.0560   -2.7566   -0.3978 H   0  0  0  0  0  0  0  0  0  0  0  0
   10.2127   -2.0486    1.2228 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
 12 15  1  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 16 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 28 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 23 34  1  0
 34 35  1  0
 34 36  1  0
 36 37  1  0
  9 38  1  0
 38 39  1  0
 38 40  1  0
 40 41  1  0
  6 42  1  0
 42 43  2  0
 43 44  1  0
 44  4  1  0
 40  7  1  0
 36 21  1  0
 33 24  1  0
 33 27  1  0
  1 45  1  0
  1 46  1  0
  5 47  1  0
  7 48  1  1
  9 49  1  1
 10 50  1  0
 10 51  1  0
 14 52  1  0
 18 53  1  0
 20 54  1  0
 20 55  1  0
 21 56  1  6
 23 57  1  6
 25 58  1  0
 29 59  1  0
 29 60  1  0
 31 61  1  0
 34 62  1  1
 35 63  1  0
 36 64  1  1
 37 65  1  0
 38 66  1  6
 39 67  1  0
 40 68  1  6
 41 69  1  0
 42 70  1  0
 43 71  1  0
 44 72  1  0
 44 73  1  0
M  END


  Mrv1652309042000232D          

 44 48  0  0  0  0            999 V2000
 9995.5688 9998.0521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9997.3578 9998.0438    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9997.8653 9999.9046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.5818 9999.4911    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9999.2961 9999.9046    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
10000.0167 9999.5054    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10000.7302 9999.9168    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
10001.4459 9999.5054    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10002.1573 9999.9168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10002.6358 9998.0583    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10004.4258 9998.0663    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10007.0717 9999.5177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10007.7873 9999.9292    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
10007.0717 9998.6928    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10000.317810000.6318    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10001.142710000.6318    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9998.882710000.6194    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9999.707610000.6194    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10003.5378 9999.9992    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10002.8704 9999.5142    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
10003.1253 9998.7296    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
10003.9503 9998.7296    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
10004.2052 9999.5142    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
 9996.4809 9999.9854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9996.0684 9998.7158    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
 9996.8934 9998.7158    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9997.1483 9999.5004    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
10006.351610000.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10005.637110001.1544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10004.922610000.7419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10004.9225 9999.9170    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
10005.6370 9999.5044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10006.3516 9999.9170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9993.033010000.2714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9992.6975 9999.5178    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9993.1825 9998.8503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9994.0029 9998.9365    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9994.3385 9999.6901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9993.853510000.3577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9992.548010000.9388    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9995.1231 9999.9450    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9995.123110000.7700    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9994.338610001.0250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9995.7905 9999.4600    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5 17  2  0  0  0  0
  5 18  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7 15  2  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 19 20  1  0  0  0  0
 19 23  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 24 27  1  0  0  0  0
 25  1  1  1  0  0  0
 27  3  1  6  0  0  0
 26  2  1  1  0  0  0
 20  9  1  1  0  0  0
 22 11  1  6  0  0  0
 21 10  1  6  0  0  0
 28 29  1  0  0  0  0
 29 30  2  0  0  0  0
 32 33  2  0  0  0  0
 33 28  1  0  0  0  0
 33 12  1  0  0  0  0
 38 39  2  0  0  0  0
 39 34  1  0  0  0  0
 34 35  2  0  0  0  0
 35 36  1  0  0  0  0
 36 37  2  0  0  0  0
 37 38  1  0  0  0  0
 34 40  1  0  0  0  0
 42 43  2  0  0  0  0
 39 43  1  0  0  0  0
 41 42  1  0  0  0  0
 38 41  1  0  0  0  0
 44 41  1  6  0  0  0
 44 25  1  0  0  0  0
 24 44  1  0  0  0  0
  7 16  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 23 31  1  1  0  0  0
M  END
> <DATABASE_ID>
HMDB0001487

> <DATABASE_NAME>
hmdb

> <SMILES>
NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O

> <INCHI_IDENTIFIER>
InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1

> <INCHI_KEY>
BOPGDPNILDQYTO-NNYOXOHSSA-N

> <FORMULA>
C21H29N7O14P2

> <MOLECULAR_WEIGHT>
665.441

> <EXACT_MASS>
665.124771695

> <JCHEM_ACCEPTOR_COUNT>
16

> <JCHEM_ATOM_COUNT>
73

> <JCHEM_AVERAGE_POLARIZABILITY>
57.65419831221258

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
8

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy})phosphinic acid

> <ALOGPS_LOGP>
-1.45

> <JCHEM_LOGP>
-5.855536205936978

> <ALOGPS_LOGS>
-2.35

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-2

> <JCHEM_PKA>
3.187368832858877

> <JCHEM_PKA_STRONGEST_ACIDIC>
1.8536409122750466

> <JCHEM_PKA_STRONGEST_BASIC>
4.009033959582867

> <JCHEM_POLAR_SURFACE_AREA>
317.61999999999995

> <JCHEM_REFRACTIVITY>
142.99969999999996

> <JCHEM_ROTATABLE_BOND_COUNT>
11

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
2.95e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
NADH

> <JCHEM_VEBER_RULE>
0

$$$$

HMDB0001487
     RDKit          3D
NADH
 73 77  0  0  0  0  0  0  0  0999 V2000
   10.3397    1.2977   -1.0927 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.4943   -0.0219   -0.6209 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6284   -0.5421   -0.6237 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.3274   -0.7442   -0.1426 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1164   -0.2110   -0.1313 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9572   -0.8874    0.3283 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6666   -0.2399    0.3103 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.6390   -1.0838    0.6493 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4851   -0.4046    0.2821 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.3988   -1.4329   -0.0047 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2571   -0.7156   -0.3697 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0232   -1.7767   -0.7130 P   0  0  0  0  0  5  0  0  0  0  0  0
    0.3028   -2.6433   -1.9081 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2755   -2.7769    0.6197 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -0.8831   -0.9942 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8013   -0.0318    0.4149 P   0  0  0  0  0  5  0  0  0  0  0  0
   -1.9958   -1.0212    1.5352 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5244    0.9937    0.8689 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2239    0.8086    0.1817 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0867    1.7763   -0.8346 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4130    2.5157   -1.0087 C   0  0  1  0  0  0  0  0  0  0  0  0
   -5.3548    1.5866   -1.3519 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3916    1.6137   -0.4583 C   0  0  1  0  0  0  0  0  0  0  0  0
   -7.0070    0.3101   -0.3041 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3514   -0.8563   -0.3785 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2528   -1.8305   -0.1855 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4674   -1.3108    0.0100 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.7065   -1.8410    0.2468 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.8444   -3.2456    0.3206 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7856   -1.0569    0.4092 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.6215    0.2852    0.3331 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.4025    0.8276    0.0994 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3081    0.0651   -0.0665 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7985    2.1094    0.8400 C   0  0  2  0  0  0  0  0  0  0  0  0
   -6.7807    2.8112    1.5437 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7622    3.1036    0.3246 C   0  0  2  0  0  0  0  0  0  0  0  0
   -5.4183    4.3075    0.1142 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7933    0.3701   -0.9572 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.5676    1.7177   -0.7035 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2809    0.1604   -1.1197 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.9349    1.3316   -1.4914 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1312   -2.2148    0.7997 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3066   -2.7905    0.8107 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5150   -2.1186    0.3441 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8383    2.0799   -0.6386 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.7208    1.4866   -1.9021 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.0224    0.8091   -0.5004 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6250    0.6620    0.9496 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1644    0.2184    1.1393 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1804   -2.0492    0.8850 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7266   -2.1074   -0.8249 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0983   -2.3356    1.4201 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0853    1.3901    0.0966 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2552    2.4605   -0.6503 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8479    1.1987   -1.7585 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2855    3.2854   -1.7878 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1776    2.3457   -0.7454 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2769   -0.9878   -0.5630 H   0  0  0  0  0  0  0  0  0  0  0  0
   -9.9221   -3.7464    1.2127 H   0  0  0  0  0  0  0  0  0  0  0  0
   -9.8679   -3.7935   -0.5668 H   0  0  0  0  0  0  0  0  0  0  0  0
  -11.5015    0.8973    0.4665 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3249    1.3218    1.4349 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9507    2.4346    2.4302 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9119    3.1827    1.0056 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7490    4.4017   -0.8173 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2302    0.0097   -1.8431 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9066    2.2860   -1.4488 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.4699   -0.6800   -1.7983 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1254    1.2977   -2.4631 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.2372   -2.7509    1.1596 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.4057   -3.8222    1.1834 H   0  0  0  0  0  0  0  0  0  0  0  0
   10.0560   -2.7566   -0.3978 H   0  0  0  0  0  0  0  0  0  0  0  0
   10.2127   -2.0486    1.2228 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
 12 15  1  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 16 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 28 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 23 34  1  0
 34 35  1  0
 34 36  1  0
 36 37  1  0
  9 38  1  0
 38 39  1  0
 38 40  1  0
 40 41  1  0
  6 42  1  0
 42 43  2  0
 43 44  1  0
 44  4  1  0
 40  7  1  0
 36 21  1  0
 33 24  1  0
 33 27  1  0
  1 45  1  0
  1 46  1  0
  5 47  1  0
  7 48  1  1
  9 49  1  1
 10 50  1  0
 10 51  1  0
 14 52  1  0
 18 53  1  0
 20 54  1  0
 20 55  1  0
 21 56  1  6
 23 57  1  6
 25 58  1  0
 29 59  1  0
 29 60  1  0
 31 61  1  0
 34 62  1  1
 35 63  1  0
 36 64  1  1
 37 65  1  0
 38 66  1  6
 39 67  1  0
 40 68  1  6
 41 69  1  0
 42 70  1  0
 43 71  1  0
 44 72  1  0
 44 73  1  0
M  END

HEADER    PROTEIN                                 04-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-SEP-20         0                                  
HETATM    1  O   UNK     0    8658.3958663.031   0.000  0.00  0.00           O+0
HETATM    2  O   UNK     0    8661.7358663.015   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0    8662.6828666.489   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0    8664.0198665.717   0.000  0.00  0.00           O+0
HETATM    5  P   UNK     0    8665.3538666.489   0.000  0.00  0.00           P+0
HETATM    6  O   UNK     0    8666.6988665.743   0.000  0.00  0.00           O+0
HETATM    7  P   UNK     0    8668.0308666.511   0.000  0.00  0.00           P+0
HETATM    8  O   UNK     0    8669.3668665.743   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0    8670.6948666.511   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0    8671.5878663.042   0.000  0.00  0.00           O+0
HETATM   11  O   UNK     0    8674.9288663.057   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0    8679.8678665.766   0.000  0.00  0.00           C+0
HETATM   13  N   UNK     0    8681.2038666.535   0.000  0.00  0.00           N+0
HETATM   14  O   UNK     0    8679.8678664.227   0.000  0.00  0.00           O+0
HETATM   15  O   UNK     0    8667.2608667.846   0.000  0.00  0.00           O+0
HETATM   16  O   UNK     0    8668.8008667.846   0.000  0.00  0.00           O+0
HETATM   17  O   UNK     0    8664.5818667.823   0.000  0.00  0.00           O+0
HETATM   18  O   UNK     0    8666.1218667.823   0.000  0.00  0.00           O+0
HETATM   19  O   UNK     0    8673.2718666.665   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0    8672.0258665.760   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0    8672.5018664.295   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0    8674.0418664.295   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0    8674.5168665.760   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0    8660.0988666.639   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0    8659.3288664.269   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0    8660.8688664.269   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0    8661.3438665.734   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0    8678.5238668.052   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0    8677.1898668.822   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0    8675.8568668.052   0.000  0.00  0.00           C+0
HETATM   31  N   UNK     0    8675.8558666.512   0.000  0.00  0.00           N+0
HETATM   32  C   UNK     0    8677.1898665.742   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0    8678.5238666.512   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0    8653.6628667.173   0.000  0.00  0.00           C+0
HETATM   35  N   UNK     0    8653.0358665.767   0.000  0.00  0.00           N+0
HETATM   36  C   UNK     0    8653.9418664.521   0.000  0.00  0.00           C+0
HETATM   37  N   UNK     0    8655.4728664.681   0.000  0.00  0.00           N+0
HETATM   38  C   UNK     0    8656.0998666.088   0.000  0.00  0.00           C+0
HETATM   39  C   UNK     0    8655.1938667.334   0.000  0.00  0.00           C+0
HETATM   40  N   UNK     0    8652.7568668.419   0.000  0.00  0.00           N+0
HETATM   41  N   UNK     0    8657.5638666.564   0.000  0.00  0.00           N+0
HETATM   42  C   UNK     0    8657.5638668.104   0.000  0.00  0.00           C+0
HETATM   43  N   UNK     0    8656.0998668.580   0.000  0.00  0.00           N+0
HETATM   44  C   UNK     0    8658.8098665.659   0.000  0.00  0.00           C+0
CONECT    1   25                                                            
CONECT    2   26                                                            
CONECT    3    4   27                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6   17   18                                             
CONECT    6    5    7                                                       
CONECT    7    6    8   15   16                                             
CONECT    8    7    9                                                       
CONECT    9    8   20                                                       
CONECT   10   21                                                            
CONECT   11   22                                                            
CONECT   12   13   14   33                                                  
CONECT   13   12                                                            
CONECT   14   12                                                            
CONECT   15    7                                                            
CONECT   16    7                                                            
CONECT   17    5                                                            
CONECT   18    5                                                            
CONECT   19   20   23                                                       
CONECT   20   21   19    9                                                  
CONECT   21   20   22   10                                                  
CONECT   22   21   23   11                                                  
CONECT   23   22   19   31                                                  
CONECT   24   27   44                                                       
CONECT   25   26    1   44                                                  
CONECT   26   25   27    2                                                  
CONECT   27   26   24    3                                                  
CONECT   28   29   33                                                       
CONECT   29   28   30                                                       
CONECT   30   29   31                                                       
CONECT   31   30   32   23                                                  
CONECT   32   33   31                                                       
CONECT   33   32   28   12                                                  
CONECT   34   39   35   40                                                  
CONECT   35   34   36                                                       
CONECT   36   35   37                                                       
CONECT   37   36   38                                                       
CONECT   38   39   37   41                                                  
CONECT   39   38   34   43                                                  
CONECT   40   34                                                            
CONECT   41   42   38   44                                                  
CONECT   42   43   41                                                       
CONECT   43   42   39                                                       
CONECT   44   41   25   24                                                  
MASTER        0    0    0    0    0    0    0    0   44    0   96    0
END

COMPND    HMDB0001487
HETATM    1  N1  UNL     1      10.340   1.298  -1.093  1.00  0.00           N  
HETATM    2  C1  UNL     1      10.494  -0.022  -0.621  1.00  0.00           C  
HETATM    3  O1  UNL     1      11.628  -0.542  -0.624  1.00  0.00           O  
HETATM    4  C2  UNL     1       9.327  -0.744  -0.143  1.00  0.00           C  
HETATM    5  C3  UNL     1       8.116  -0.211  -0.131  1.00  0.00           C  
HETATM    6  N2  UNL     1       6.957  -0.887   0.328  1.00  0.00           N  
HETATM    7  C4  UNL     1       5.667  -0.240   0.310  1.00  0.00           C  
HETATM    8  O2  UNL     1       4.639  -1.084   0.649  1.00  0.00           O  
HETATM    9  C5  UNL     1       3.485  -0.405   0.282  1.00  0.00           C  
HETATM   10  C6  UNL     1       2.399  -1.433  -0.005  1.00  0.00           C  
HETATM   11  O3  UNL     1       1.257  -0.716  -0.370  1.00  0.00           O  
HETATM   12  P1  UNL     1      -0.023  -1.777  -0.713  1.00  0.00           P  
HETATM   13  O4  UNL     1       0.303  -2.643  -1.908  1.00  0.00           O  
HETATM   14  O5  UNL     1      -0.276  -2.777   0.620  1.00  0.00           O  
HETATM   15  O6  UNL     1      -1.409  -0.883  -0.994  1.00  0.00           O  
HETATM   16  P2  UNL     1      -1.801  -0.032   0.415  1.00  0.00           P  
HETATM   17  O7  UNL     1      -1.996  -1.021   1.535  1.00  0.00           O  
HETATM   18  O8  UNL     1      -0.524   0.994   0.869  1.00  0.00           O  
HETATM   19  O9  UNL     1      -3.224   0.809   0.182  1.00  0.00           O  
HETATM   20  C7  UNL     1      -3.087   1.776  -0.835  1.00  0.00           C  
HETATM   21  C8  UNL     1      -4.413   2.516  -1.009  1.00  0.00           C  
HETATM   22  O10 UNL     1      -5.355   1.587  -1.352  1.00  0.00           O  
HETATM   23  C9  UNL     1      -6.392   1.614  -0.458  1.00  0.00           C  
HETATM   24  N3  UNL     1      -7.007   0.310  -0.304  1.00  0.00           N  
HETATM   25  C10 UNL     1      -6.351  -0.856  -0.379  1.00  0.00           C  
HETATM   26  N4  UNL     1      -7.253  -1.830  -0.186  1.00  0.00           N  
HETATM   27  C11 UNL     1      -8.467  -1.311   0.010  1.00  0.00           C  
HETATM   28  C12 UNL     1      -9.707  -1.841   0.247  1.00  0.00           C  
HETATM   29  N5  UNL     1      -9.844  -3.246   0.321  1.00  0.00           N  
HETATM   30  N6  UNL     1     -10.786  -1.057   0.409  1.00  0.00           N  
HETATM   31  C13 UNL     1     -10.622   0.285   0.333  1.00  0.00           C  
HETATM   32  N7  UNL     1      -9.403   0.828   0.099  1.00  0.00           N  
HETATM   33  C14 UNL     1      -8.308   0.065  -0.066  1.00  0.00           C  
HETATM   34  C15 UNL     1      -5.799   2.109   0.840  1.00  0.00           C  
HETATM   35  O11 UNL     1      -6.781   2.811   1.544  1.00  0.00           O  
HETATM   36  C16 UNL     1      -4.762   3.104   0.325  1.00  0.00           C  
HETATM   37  O12 UNL     1      -5.418   4.308   0.114  1.00  0.00           O  
HETATM   38  C17 UNL     1       3.793   0.370  -0.957  1.00  0.00           C  
HETATM   39  O13 UNL     1       3.568   1.718  -0.704  1.00  0.00           O  
HETATM   40  C18 UNL     1       5.281   0.160  -1.120  1.00  0.00           C  
HETATM   41  O14 UNL     1       5.935   1.332  -1.491  1.00  0.00           O  
HETATM   42  C19 UNL     1       7.131  -2.215   0.800  1.00  0.00           C  
HETATM   43  C20 UNL     1       8.307  -2.790   0.811  1.00  0.00           C  
HETATM   44  C21 UNL     1       9.515  -2.119   0.344  1.00  0.00           C  
HETATM   45  H1  UNL     1      10.838   2.080  -0.639  1.00  0.00           H  
HETATM   46  H2  UNL     1       9.721   1.487  -1.902  1.00  0.00           H  
HETATM   47  H3  UNL     1       8.022   0.809  -0.500  1.00  0.00           H  
HETATM   48  H4  UNL     1       5.625   0.662   0.950  1.00  0.00           H  
HETATM   49  H5  UNL     1       3.164   0.218   1.139  1.00  0.00           H  
HETATM   50  H6  UNL     1       2.180  -2.049   0.885  1.00  0.00           H  
HETATM   51  H7  UNL     1       2.727  -2.107  -0.825  1.00  0.00           H  
HETATM   52  H8  UNL     1       0.098  -2.336   1.420  1.00  0.00           H  
HETATM   53  H9  UNL     1      -0.085   1.390   0.097  1.00  0.00           H  
HETATM   54  H10 UNL     1      -2.255   2.460  -0.650  1.00  0.00           H  
HETATM   55  H11 UNL     1      -2.848   1.199  -1.758  1.00  0.00           H  
HETATM   56  H12 UNL     1      -4.285   3.285  -1.788  1.00  0.00           H  
HETATM   57  H13 UNL     1      -7.178   2.346  -0.745  1.00  0.00           H  
HETATM   58  H14 UNL     1      -5.277  -0.988  -0.563  1.00  0.00           H  
HETATM   59  H15 UNL     1      -9.922  -3.746   1.213  1.00  0.00           H  
HETATM   60  H16 UNL     1      -9.868  -3.794  -0.567  1.00  0.00           H  
HETATM   61  H17 UNL     1     -11.502   0.897   0.466  1.00  0.00           H  
HETATM   62  H18 UNL     1      -5.325   1.322   1.435  1.00  0.00           H  
HETATM   63  H19 UNL     1      -6.951   2.435   2.430  1.00  0.00           H  
HETATM   64  H20 UNL     1      -3.912   3.183   1.006  1.00  0.00           H  
HETATM   65  H21 UNL     1      -5.749   4.402  -0.817  1.00  0.00           H  
HETATM   66  H22 UNL     1       3.230   0.010  -1.843  1.00  0.00           H  
HETATM   67  H23 UNL     1       3.907   2.286  -1.449  1.00  0.00           H  
HETATM   68  H24 UNL     1       5.470  -0.680  -1.798  1.00  0.00           H  
HETATM   69  H25 UNL     1       6.125   1.298  -2.463  1.00  0.00           H  
HETATM   70  H26 UNL     1       6.237  -2.751   1.160  1.00  0.00           H  
HETATM   71  H27 UNL     1       8.406  -3.822   1.183  1.00  0.00           H  
HETATM   72  H28 UNL     1      10.056  -2.757  -0.398  1.00  0.00           H  
HETATM   73  H29 UNL     1      10.213  -2.049   1.223  1.00  0.00           H  
CONECT    1    2   45   46
CONECT    2    3    3    4
CONECT    4    5    5   44
CONECT    5    6   47
CONECT    6    7   42
CONECT    7    8   40   48
CONECT    8    9
CONECT    9   10   38   49
CONECT   10   11   50   51
CONECT   11   12
CONECT   12   13   13   14   15
CONECT   14   52
CONECT   15   16
CONECT   16   17   17   18   19
CONECT   18   53
CONECT   19   20
CONECT   20   21   54   55
CONECT   21   22   36   56
CONECT   22   23
CONECT   23   24   34   57
CONECT   24   25   33
CONECT   25   26   26   58
CONECT   26   27
CONECT   27   28   28   33
CONECT   28   29   30
CONECT   29   59   60
CONECT   30   31   31
CONECT   31   32   61
CONECT   32   33   33
CONECT   34   35   36   62
CONECT   35   63
CONECT   36   37   64
CONECT   37   65
CONECT   38   39   40   66
CONECT   39   67
CONECT   40   41   68
CONECT   41   69
CONECT   42   43   43   70
CONECT   43   44   71
CONECT   44   72   73
END

HMDB0001487
     RDKit          3D
NADH
 73 77  0  0  0  0  0  0  0  0999 V2000
   10.3397    1.2977   -1.0927 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.4943   -0.0219   -0.6209 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6284   -0.5421   -0.6237 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.3274   -0.7442   -0.1426 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1164   -0.2110   -0.1313 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9572   -0.8874    0.3283 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6666   -0.2399    0.3103 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.6390   -1.0838    0.6493 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4851   -0.4046    0.2821 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.3988   -1.4329   -0.0047 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2571   -0.7156   -0.3697 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0232   -1.7767   -0.7130 P   0  0  0  0  0  5  0  0  0  0  0  0
    0.3028   -2.6433   -1.9081 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2755   -2.7769    0.6197 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -0.8831   -0.9942 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8013   -0.0318    0.4149 P   0  0  0  0  0  5  0  0  0  0  0  0
   -1.9958   -1.0212    1.5352 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5244    0.9937    0.8689 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2239    0.8086    0.1817 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0867    1.7763   -0.8346 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4130    2.5157   -1.0087 C   0  0  1  0  0  0  0  0  0  0  0  0
   -5.3548    1.5866   -1.3519 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3916    1.6137   -0.4583 C   0  0  1  0  0  0  0  0  0  0  0  0
   -7.0070    0.3101   -0.3041 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3514   -0.8563   -0.3785 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2528   -1.8305   -0.1855 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4674   -1.3108    0.0100 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.7065   -1.8410    0.2468 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.8444   -3.2456    0.3206 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7856   -1.0569    0.4092 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.6215    0.2852    0.3331 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.4025    0.8276    0.0994 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3081    0.0651   -0.0665 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7985    2.1094    0.8400 C   0  0  2  0  0  0  0  0  0  0  0  0
   -6.7807    2.8112    1.5437 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7622    3.1036    0.3246 C   0  0  2  0  0  0  0  0  0  0  0  0
   -5.4183    4.3075    0.1142 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7933    0.3701   -0.9572 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.5676    1.7177   -0.7035 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2809    0.1604   -1.1197 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.9349    1.3316   -1.4914 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1312   -2.2148    0.7997 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3066   -2.7905    0.8107 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5150   -2.1186    0.3441 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8383    2.0799   -0.6386 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.7208    1.4866   -1.9021 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.0224    0.8091   -0.5004 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6250    0.6620    0.9496 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1644    0.2184    1.1393 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1804   -2.0492    0.8850 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7266   -2.1074   -0.8249 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0983   -2.3356    1.4201 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0853    1.3901    0.0966 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2552    2.4605   -0.6503 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8479    1.1987   -1.7585 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2855    3.2854   -1.7878 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1776    2.3457   -0.7454 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2769   -0.9878   -0.5630 H   0  0  0  0  0  0  0  0  0  0  0  0
   -9.9221   -3.7464    1.2127 H   0  0  0  0  0  0  0  0  0  0  0  0
   -9.8679   -3.7935   -0.5668 H   0  0  0  0  0  0  0  0  0  0  0  0
  -11.5015    0.8973    0.4665 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3249    1.3218    1.4349 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9507    2.4346    2.4302 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9119    3.1827    1.0056 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7490    4.4017   -0.8173 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2302    0.0097   -1.8431 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9066    2.2860   -1.4488 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.4699   -0.6800   -1.7983 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1254    1.2977   -2.4631 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.2372   -2.7509    1.1596 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.4057   -3.8222    1.1834 H   0  0  0  0  0  0  0  0  0  0  0  0
   10.0560   -2.7566   -0.3978 H   0  0  0  0  0  0  0  0  0  0  0  0
   10.2127   -2.0486    1.2228 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
 12 15  1  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 16 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 28 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 23 34  1  0
 34 35  1  0
 34 36  1  0
 36 37  1  0
  9 38  1  0
 38 39  1  0
 38 40  1  0
 40 41  1  0
  6 42  1  0
 42 43  2  0
 43 44  1  0
 44  4  1  0
 40  7  1  0
 36 21  1  0
 33 24  1  0
 33 27  1  0
  1 45  1  0
  1 46  1  0
  5 47  1  0
  7 48  1  1
  9 49  1  1
 10 50  1  0
 10 51  1  0
 14 52  1  0
 18 53  1  0
 20 54  1  0
 20 55  1  0
 21 56  1  6
 23 57  1  6
 25 58  1  0
 29 59  1  0
 29 60  1  0
 31 61  1  0
 34 62  1  1
 35 63  1  0
 36 64  1  1
 37 65  1  0
 38 66  1  6
 39 67  1  0
 40 68  1  6
 41 69  1  0
 42 70  1  0
 43 71  1  0
 44 72  1  0
 44 73  1  0
M  END

View in JSmol View NMR Assignments View Stereo Labels

Synonyms

Value	Source
1,4-DIHYDRONICOTINAMIDE adenine dinucleotide	ChEBI
DPNH	ChEBI
Nicotinamide adenine dinucleotide (reduced)	ChEBI
Reduced nicotinamide adenine dinucleotide	ChEBI
b-DPNH	HMDB
b-NADH	HMDB
beta-DPNH	HMDB
beta-NADH	HMDB
Dihydrocodehydrogenase I	HMDB
Dihydrocozymase	HMDB
Dihydronicotinamide adenine dinucleotide	HMDB
Dihydronicotinamide mononucleotide	HMDB
ENADA	HMDB
NADH2	HMDB
Reduced codehydrogenase I	HMDB
Reduced diphosphopyridine nucleotide	HMDB
Reduced nicotinamide adenine diphosphate	HMDB
Reduced nicotinamide-adenine dinucleotide	HMDB
Nadide	HMDB
Coenzyme I	HMDB
DPN	HMDB
Diphosphopyridine nucleotide	HMDB
Nicotinamide adenine dinucleotide	HMDB
Nicotinamide-adenine dinucleotide	HMDB
NAD	HMDB
Nucleotide, diphosphopyridine	HMDB
Adenine dinucleotide, dihydronicotinamide	HMDB
Dinucleotide, dihydronicotinamide adenine	HMDB
Dinucleotide, nicotinamide-adenine	HMDB

Chemical Formula

C₂₁H₂₉N₇O₁₄P₂

Average Molecular Weight

665.441

Monoisotopic Molecular Weight

665.124771695

IUPAC Name

[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy})phosphinic acid

Traditional Name

NADH

CAS Registry Number

58-68-4

SMILES

NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O

InChI Identifier

InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1

InChI Key

BOPGDPNILDQYTO-NNYOXOHSSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as (5'->5')-dinucleotides. These are dinucleotides where the two bases are connected via a (5'->5')-phosphodiester linkage.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

(5'->5')-dinucleotides

Sub Class

Not Available

Direct Parent

(5'->5')-dinucleotides

Alternative Parents

Substituents

(5'->5')-dinucleotide
Purine nucleotide sugar
Purine ribonucleoside diphosphate
Purine ribonucleoside monophosphate
Nicotinamide-nucleotide
Pentose phosphate
Pentose-5-phosphate
Glycosyl compound
N-glycosyl compound
6-aminopurine
Monosaccharide phosphate
N-substituted nicotinamide
Organic pyrophosphate
Imidazopyrimidine
Purine
Monoalkyl phosphate
Dihydropyridine
Aminopyrimidine
Pyrimidine
Imidolactam
Monosaccharide
N-substituted imidazole
Alkyl phosphate
Phosphoric acid ester
Hydropyridine
Organic phosphoric acid derivative
Heteroaromatic compound
Tetrahydrofuran
Imidazole
Vinylogous amide
Azole
Amino acid or derivatives
Primary carboxylic acid amide
Secondary alcohol
Carboxamide group
Organoheterocyclic compound
Enamine
Azacycle
Oxacycle
Carboxylic acid derivative
Hydrocarbon derivative
Alcohol
Organic nitrogen compound
Organonitrogen compound
Organooxygen compound
Carbonyl group
Organic oxygen compound
Organopnictogen compound
Primary amine
Amine
Organic oxide
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

NAD (CHEBI:16908 )
NAD(P)H (CHEBI:16908 )

Ontology

Not Available

Physical Properties

State

Solid

Experimental Molecular Properties

Property	Value	Reference
Melting Point	140.0 - 142.0 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct Type	Data Source	CCS Value (Å²)	Reference
[M-H]-	Astarita_neg	224.3	30932474

Predicted Molecular Properties

Property	Value	Source
Water Solubility	2.95 g/L	ALOGPS
logP	-1.4	ALOGPS
logP	-5.9	ChemAxon
logS	-2.4	ALOGPS
pKa (Strongest Acidic)	1.85	ChemAxon
pKa (Strongest Basic)	4.01	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	16	ChemAxon
Hydrogen Donor Count	8	ChemAxon
Polar Surface Area	317.62 Å²	ChemAxon
Rotatable Bond Count	11	ChemAxon
Refractivity	143 m³·mol⁻¹	ChemAxon
Polarizability	57.65 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Predicted Chromatographic Properties

Predicted Collision Cross Sections

Predictor	Adduct Type	CCS Value (Å²)	Reference
AllCCS	[M+H]+	231.937	32859911
AllCCS	[M-H]-	223.945	32859911
DeepCCS	[M+H]+	211.374	30932474
DeepCCS	[M-H]-	209.549	30932474
DeepCCS	[M-2H]-	243.417	30932474
DeepCCS	[M+Na]+	217.193	30932474
AllCCS	[M+H]+	231.9	32859911
AllCCS	[M+H-H2O]+	231.3	32859911
AllCCS	[M+NH4]+	232.5	32859911
AllCCS	[M+Na]+	232.7	32859911
AllCCS	[M-H]-	223.9	32859911
AllCCS	[M+Na-2H]-	225.8	32859911
AllCCS	[M+HCOO]-	227.9	32859911

Predicted Retention Times

Underivatized

Chromatographic Method	Retention Time	Reference
Measured using a Waters Acquity ultraperformance liquid chromatography (UPLC) ethylene-bridged hybrid (BEH) C18 column (100 mm × 2.1 mm; 1.7 μmparticle diameter). Predicted by Afia on May 17, 2022. Predicted by Afia on May 17, 2022.	2.52 minutes	32390414
Predicted by Siyang on May 30, 2022	10.7609 minutes	33406817
Predicted by Siyang using ReTip algorithm on June 8, 2022	9.1 minutes	32390414
AjsUoB = Accucore 150 Amide HILIC with 10mM Ammonium Formate, 0.1% Formic Acid	491.1 seconds	40023050
Fem_Long = Waters ACQUITY UPLC HSS T3 C18 with Water:MeOH and 0.1% Formic Acid	1090.0 seconds	40023050
Fem_Lipids = Ascentis Express C18 with (60:40 water:ACN):(90:10 IPA:ACN) and 10mM NH4COOH + 0.1% Formic Acid	213.1 seconds	40023050
Life_Old = Waters ACQUITY UPLC BEH C18 with Water:(20:80 acetone:ACN) and 0.1% Formic Acid	56.5 seconds	40023050
Life_New = RP Waters ACQUITY UPLC HSS T3 C18 with Water:(30:70 MeOH:ACN) and 0.1% Formic Acid	172.7 seconds	40023050
RIKEN = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid	71.8 seconds	40023050
Eawag_XBridgeC18 = XBridge C18 3.5u 2.1x50 mm with Water:MeOH and 0.1% Formic Acid	345.6 seconds	40023050
BfG_NTS_RP1 =Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) with Water:ACN and 0.1% Formic Acid	338.6 seconds	40023050
HILIC_BDD_2 = Merck SeQuant ZIC-HILIC with ACN(0.1% formic acid):water(16 mM ammonium formate)	839.1 seconds	40023050
UniToyama_Atlantis = RP Waters Atlantis T3 (2.1 x 150 mm, 5 um) with ACN:Water and 0.1% Formic Acid	645.7 seconds	40023050
BDD_C18 = Hypersil Gold 1.9µm C18 with Water:ACN and 0.1% Formic Acid	168.1 seconds	40023050
UFZ_Phenomenex = Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex with Water:MeOH and 0.1% Formic Acid	840.8 seconds	40023050
SNU_RIKEN_POS = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid	230.1 seconds	40023050
RPMMFDA = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid	290.4 seconds	40023050
MTBLS87 = Merck SeQuant ZIC-pHILIC column with ACN:Water and :ammonium carbonate	587.9 seconds	40023050
KI_GIAR_zic_HILIC_pH2_7 = Merck SeQuant ZIC-HILIC with ACN:Water and 0.1% FA	429.3 seconds	40023050
Meister zic-pHILIC pH9.3 = Merck SeQuant ZIC-pHILIC column with ACN:Water 5mM NH4Ac pH9.3 and 5mM ammonium acetate in water	608.4 seconds	40023050

Predicted Kovats Retention Indices

Underivatized

Metabolite	SMILES	Kovats RI Value	Column Type	Reference
NADH	NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O	5351.5	Standard polar	33892256
NADH	NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O	3535.4	Standard non polar	33892256
NADH	NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O	5949.2	Semi standard non polar	33892256

Spectra

Biological Properties

Cellular Locations

Mitochondria
Endoplasmic reticulum
Peroxisome

Biospecimen Locations

Blood

Tissue Locations

Bladder
Brain
Fibroblasts
Platelet
Skeletal Muscle

Pathways

Name	SMPDB/PathBank	KEGG
Histidine metabolism
Malate-Aspartate Shuttle		Not Available
Glycerolipid Metabolism
Nitrogen metabolism	Not Available
Glycolysis

Normal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Detected and Quantified	22.0 (14.0-40.0) uM	Adult (>18 years old)	Both	Normal	Geigy Scientific ...	details

Abnormal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Detected and Quantified	0.0081 uM	Infant (0-1 year old)	Female	Nicotinamide Adenine Dinucleotide Deficiency	28792876	details

Associated Disorders and Diseases

Disease References

Nicotinamide Adenine Dinucleotide Deficiency

Shi H, Enriquez A, Rapadas M, Martin EMMA, Wang R, Moreau J, Lim CK, Szot JO, Ip E, Hughes JN, Sugimoto K, Humphreys DT, McInerney-Leo AM, Leo PJ, Maghzal GJ, Halliday J, Smith J, Colley A, Mark PR, Collins F, Sillence DO, Winlaw DS, Ho JWK, Guillemin GJ, Brown MA, Kikuchi K, Thomas PQ, Stocker R, Giannoulatou E, Chapman G, Duncan EL, Sparrow DB, Dunwoodie SL: NAD Deficiency, Congenital Malformations, and Niacin Supplementation. N Engl J Med. 2017 Aug 10;377(6):544-552. doi: 10.1056/NEJMoa1616361. [PubMed:28792876 ]

Associated OMIM IDs

None

External Links

DrugBank ID

DB00157

Phenol Explorer Compound ID

Not Available

FooDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

Nicotinamide_adenine_dinucleotide

METLIN ID

3687

PubChem Compound

439153

PDB ID

Not Available

ChEBI ID

16908

Food Biomarker Ontology

Not Available

VMH ID

HC02112

MarkerDB ID

Not Available

Good Scents ID

Not Available

References

Synthesis Reference

Marek, Miroslav; Vrbova, Eva; Horakova, Irena; Musil, Petr; Kefurt, Karel. NADH manufacture with immobilized Candida formate dehydrogenase. Czech. (1992), 4 pp.

Material Safety Data Sheet (MSDS)

Download (PDF)

General References

Krotz F, Sohn HY, Gloe T, Zahler S, Riexinger T, Schiele TM, Becker BF, Theisen K, Klauss V, Pohl U: NAD(P)H oxidase-dependent platelet superoxide anion release increases platelet recruitment. Blood. 2002 Aug 1;100(3):917-24. [PubMed:12130503 ]
Yamamoto T, Moriwaki Y, Takahashi S, Suda M, Higashino K: Ethanol as a xanthine dehydrogenase inhibitor. Metabolism. 1995 Jun;44(6):779-85. [PubMed:7783663 ]
Nadlinger K, Westerthaler W, Storga-Tomic D, Birkmayer JG: Extracellular metabolisation of NADH by blood cells correlates with intracellular ATP levels. Biochim Biophys Acta. 2002 Nov 14;1573(2):177-82. [PubMed:12399028 ]
Saada A, Bar-Meir M, Belaiche C, Miller C, Elpeleg O: Evaluation of enzymatic assays and compounds affecting ATP production in mitochondrial respiratory chain complex I deficiency. Anal Biochem. 2004 Dec 1;335(1):66-72. [PubMed:15519572 ]
Heiman-Patterson TD, Argov Z, Chavin JM, Kalman B, Alder H, DiMauro S, Bank W, Tahmoush AJ: Biochemical and genetic studies in a family with mitochondrial myopathy. Muscle Nerve. 1997 Oct;20(10):1219-24. [PubMed:9324076 ]
Mintun MA, Vlassenko AG, Rundle MM, Raichle ME: Increased lactate/pyruvate ratio augments blood flow in physiologically activated human brain. Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):659-64. Epub 2004 Jan 2. [PubMed:14704276 ]
Yeo SF, Zhang Y, Schafer D, Campbell S, Wong B: A rapid, automated enzymatic fluorometric assay for determination of D-arabinitol in serum. J Clin Microbiol. 2000 Apr;38(4):1439-43. [PubMed:10747122 ]
Uppal A, Ghosh N, Datta A, Gupta PK: Fluorimetric estimation of the concentration of NADH from human blood samples. Biotechnol Appl Biochem. 2005 Feb;41(Pt 1):43-7. [PubMed:15035655 ]
Yamamoto T, Moriwaki Y, Takahashi S, Suda M, Higashino K: Xylitol-induced increase in the concentration of oxypurines and its mechanism. Int J Clin Pharmacol Ther. 1995 Jun;33(6):360-5. [PubMed:7582389 ]
Helge JW, Fraser AM, Kriketos AD, Jenkins AB, Calvert GD, Ayre KJ, Storlien LH: Interrelationships between muscle fibre type, substrate oxidation and body fat. Int J Obes Relat Metab Disord. 1999 Sep;23(9):986-91. [PubMed:10490806 ]
Fulco M, Schiltz RL, Iezzi S, King MT, Zhao P, Kashiwaya Y, Hoffman E, Veech RL, Sartorelli V: Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol Cell. 2003 Jul;12(1):51-62. [PubMed:12887892 ]
Li D, Gan Y, Wientjes MG, Badalament RA, Au JL: Distribution of DT-diaphorase and reduced nicotinamide adenine dinucleotide phosphate: cytochrome p450 oxidoreductase in bladder tissues and tumors. J Urol. 2001 Dec;166(6):2500-5. [PubMed:11696818 ]
Desir G, Bratusch-Marrain P, DeFronzo RA: Effect of hyperketonemia on renal ammonia excretion in man. Metabolism. 1986 Aug;35(8):736-43. [PubMed:3736414 ]
Odland LM, Heigenhauser GJ, Spriet LL: Effects of high fat provision on muscle PDH activation and malonyl-CoA content in moderate exercise. J Appl Physiol (1985). 2000 Dec;89(6):2352-8. [PubMed:11090589 ]
Rani K, Garg P, Pundir CS: Measurement of bile acid in serum and bile with arylamine-glass-bound 3alpha-hydroxysteroid dehydrogenase and diaphorase. Anal Biochem. 2004 Sep 1;332(1):32-7. [PubMed:15301946 ]
Nomura H, Koike F, Tsuruta Y, Iwaki A, Iwaki T: Autopsy case of autosomal recessive hereditary spastic paraplegia with reference to the muscular pathology. Neuropathology. 2001 Sep;21(3):212-7. [PubMed:11666018 ]
Orallo F, Alvarez E, Camina M, Leiro JM, Gomez E, Fernandez P: The possible implication of trans-Resveratrol in the cardioprotective effects of long-term moderate wine consumption. Mol Pharmacol. 2002 Feb;61(2):294-302. [PubMed:11809853 ]
Jawed S, Stevens CR, Harrison R, Blake DR: Elevated circulating plasma NADH oxidising activity of xanthine oxidoreductase in plasma. Biochem Soc Trans. 1997 Aug;25(3):531S. [PubMed:9388747 ]
Harbord MG, Hwang PA, Robinson BH, Becker LE, Hunjan A, Murphy EG: Infant-onset progressive myoclonus epilepsy. J Child Neurol. 1991 Apr;6(2):134-42. [PubMed:1904460 ]
Mayevsky A, Meilin S, Manor T, Ornstein E, Zarchin N, Sonn J: Multiparametric monitoring of brain oxygen balance under experimental and clinical conditions. Neurol Res. 1998;20 Suppl 1:S76-80. [PubMed:9584930 ]
Biellmann JF, Lapinte C, Haid E, Weimann G: Structure of lactate dehydrogenase inhibitor generated from coenzyme. Biochemistry. 1979 Apr 3;18(7):1212-7. [PubMed:218616 ]
Lin SJ, Guarente L: Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. Curr Opin Cell Biol. 2003 Apr;15(2):241-6. [PubMed:12648681 ]
Belenky P, Bogan KL, Brenner C: NAD+ metabolism in health and disease. Trends Biochem Sci. 2007 Jan;32(1):12-9. Epub 2006 Dec 11. [PubMed:17161604 ]
Pollak N, Dolle C, Ziegler M: The power to reduce: pyridine nucleotides--small molecules with a multitude of functions. Biochem J. 2007 Mar 1;402(2):205-18. [PubMed:17295611 ]
Khan JA, Forouhar F, Tao X, Tong L: Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery. Expert Opin Ther Targets. 2007 May;11(5):695-705. [PubMed:17465726 ]
Brunk E, Sahoo S, Zielinski DC, Altunkaya A, Drager A, Mih N, Gatto F, Nilsson A, Preciat Gonzalez GA, Aurich MK, Prlic A, Sastry A, Danielsdottir AD, Heinken A, Noronha A, Rose PW, Burley SK, Fleming RMT, Nielsen J, Thiele I, Palsson BO: Recon3D enables a three-dimensional view of gene variation in human metabolism. Nat Biotechnol. 2018 Mar;36(3):272-281. doi: 10.1038/nbt.4072. Epub 2018 Feb 19. [PubMed:29457794 ]
WholeHealthMD [Link]

Only showing the first 10 proteins. There are 219 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details

1. Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

General function:: Involved in catalytic activity
Specific function:: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:: PDHB
Uniprot ID:: P11177
Molecular weight:: 39233.1

Enzyme Details

2. Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

General function:: Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Specific function:: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:: PDHA1
Uniprot ID:: P08559
Molecular weight:: 43295.255

Reactions

Coenzyme A + NAD + Pyruvic acid → Carbon dioxide + Hydrogen Ion + NADH + Acetyl-CoA	details

Enzyme Details

3. Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial

General function:: Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Specific function:: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:: PDHA2
Uniprot ID:: P29803
Molecular weight:: 42932.855

Enzyme Details

4. Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

General function:: Involved in oxidoreductase activity
Specific function:: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.
Gene Name:: ALDH6A1
Uniprot ID:: Q02252
Molecular weight:: 57839.31

Reactions

2-Methyl-3-oxopropanoic acid + Coenzyme A + Water + NAD → Propionyl-CoA + Hydrogen carbonate + NADH	details
Malonic semialdehyde + Coenzyme A + NAD → Acetyl-CoA + Carbon dioxide + NADH + Hydrogen Ion	details
(S)-Methylmalonic acid semialdehyde + Coenzyme A + NAD → Propionyl-CoA + Carbon dioxide + NADH + Hydrogen Ion	details
(S)-Methylmalonic acid semialdehyde + Coenzyme A + NAD → Methylmalonyl-CoA + NADH + Hydrogen Ion	details

Enzyme Details

5. Dihydrolipoyl dehydrogenase, mitochondrial

General function:: Involved in oxidoreductase activity
Specific function:: Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.
Gene Name:: DLD
Uniprot ID:: P09622
Molecular weight:: 54176.91

Reactions

Protein N(6)-(dihydrolipoyl)lysine + NAD → protein N(6)-(lipoyl)lysine + NADH	details
Dihydrolipoamide + NAD → Lipoamide + NADH + Hydrogen Ion	details
Dihydrolipoylprotein + NAD → Lipoylprotein + NADH + Hydrogen Ion	details
Enzyme N6-(dihydrolipoyl)lysine + NAD → Enzyme N6-(lipoyl)lysine + NADH + Hydrogen Ion	details
Coenzyme A + NAD + Pyruvic acid → Carbon dioxide + Hydrogen Ion + NADH + Acetyl-CoA	details

Enzyme Details

6. Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

General function:: Involved in acyltransferase activity
Specific function:: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:: DLAT
Uniprot ID:: P10515
Molecular weight:: 68996.03

Reactions

Coenzyme A + NAD + Pyruvic acid → Carbon dioxide + Hydrogen Ion + NADH + Acetyl-CoA	details

Enzyme Details

7. Aldo-keto reductase family 1 member C4

General function:: Involved in oxidoreductase activity
Specific function:: Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
Gene Name:: AKR1C4
Uniprot ID:: P17516
Molecular weight:: 37094.57

Reactions

Androsterone + NAD → Androstanedione + NADH + Hydrogen Ion	details
Etiocholanolone + NAD → Etiocholanedione + NADH + Hydrogen Ion	details
3a,7a-Dihydroxy-5b-cholestane + NAD → 7a-Hydroxy-5b-cholestan-3-one + NADH + Hydrogen Ion	details
5beta-Cholestane-3alpha,7alpha,12alpha-triol + NAD → 7a,12a-Dihydroxy-5b-cholestan-3-one + NADH + Hydrogen Ion	details
Tetrahydrocortisone + NAD → 17a,21-Dihydroxy-5b-pregnane-3,11,20-trione + NADH + Hydrogen Ion	details
Tetrahydrocortisol + NAD → Dihydrocortisol + NADH + Hydrogen Ion	details
3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al + NAD → 11b,21-Dihydroxy-3,20-oxo-5b-pregnan-18-al + NADH + Hydrogen Ion	details
Tetrahydrocorticosterone + NAD → 11b,21-Dihydroxy-5b-pregnane-3,20-dione + NADH + Hydrogen Ion	details
3a,21-Dihydroxy-5b-pregnane-11,20-dione + NAD → 21-Hydroxy-5b-pregnane-3,11,20-trione + NADH + Hydrogen Ion	details
3a-Hydroxy-5b-pregnane-20-one + NAD → 5a-Pregnane-3,20-dione + NADH + Hydrogen Ion	details

Enzyme Details

8. 15-hydroxyprostaglandin dehydrogenase [NAD(+)]

General function:: Involved in oxidoreductase activity
Specific function:: Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.
Gene Name:: HPGD
Uniprot ID:: P15428
Molecular weight:: 28977.105

Reactions

(5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD → (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH	details

Enzyme Details

9. Tyrosinase

General function:: Involved in oxidoreductase activity
Specific function:: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
Gene Name:: TYR
Uniprot ID:: P14679
Molecular weight:: 60392.69

Reactions

Tyramine + Oxygen + NADH + Hydrogen Ion → Dopamine + NAD + Water	details

Enzyme Details

10. Aldose reductase

General function:: Involved in oxidoreductase activity
Specific function:: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Gene Name:: AKR1B1
Uniprot ID:: P15121
Molecular weight:: 35853.125

Reactions

Glycerol + NAD → Glyceraldehyde + NADH + Hydrogen Ion	details
beta-D-Galactose + NADH + Hydrogen Ion → Galactitol + NAD	details
L-Arabitol + NAD → L-Arabinose + NADH + Hydrogen Ion	details
Lactaldehyde + NAD → Pyruvaldehyde + NADH + Hydrogen Ion	details

Only showing the first 10 proteins. There are 219 proteins in total.

Show all enzymes and transporters

Showing metabocard for NADH (HMDB0001487)

MOL for HMDB0001487 (NADH)

3D MOL for HMDB0001487 (NADH)

3D SDF for HMDB0001487 (NADH)

3D-SDF for HMDB0001487 (NADH)

PDB for HMDB0001487 (NADH)

3D PDB for HMDB0001487 (NADH)

SMILES for HMDB0001487 (NADH)

INCHI for HMDB0001487 (NADH)

Structure for HMDB0001487 (NADH)

3D Structure for HMDB0001487 (NADH)

Experimental Collision Cross Sections

Predicted Collision Cross Sections

Predicted Retention Times

Underivatized

Predicted Kovats Retention Indices

Underivatized

Enzymes

Reactions

Reactions

Reactions

Reactions

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Reactions