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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:51 UTC
Update Date2022-03-07 02:51:56 UTC
HMDB IDHMDB0015315
Secondary Accession Numbers
  • HMDB15315
Metabolite Identification
Common NameDomperidone
DescriptionDomperidone is only found in individuals that have used or taken this drug. It is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. [PubChem]Domperidone acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Domperidone facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting
Structure
Data?1582753282
Synonyms
ValueSource
1-(3-(4-(5-Chloro-2-oxo-2,3-dihydrobenzo[D]imidazol-1-yl)piperidin-1-yl)propyl)-1H-benzo[D]imidazol-2(3H)-oneChEBI
5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinoneChEBI
5-Chloro-1-(1-(3-(2-oxo-2,3-dihydrobenzo[D]imidazol-1-yl)propyl)piperidin-4-yl)-1H-benzo[D]imidazol-2(3H)-oneChEBI
5-Chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-oneChEBI
DomperidonaChEBI
DomperidonumChEBI
MotiliumKegg
Domperidon hexalHMDB
Domperidon tevaHMDB
Domperidon-tevaHMDB
Domperidone monohydrochlorideHMDB
GastrocureHMDB
Novopharm brand OF domperidone maleateHMDB
PMS-DomperidoneHMDB
Ratiopharm brand OF domperidone maleateHMDB
Apo domperidoneHMDB
DomperidonHMDB
Domperidon alHMDB
Domperidon stadaHMDB
Domperidona gamirHMDB
Domperidone maleateHMDB
Gry brand OF domperidone maleateHMDB
NauzelinHMDB
Nu-pharm brand OF domperidone maleateHMDB
Rottapharm brand OF domperidoneHMDB
Stadapharm brand OF domperidone maleateHMDB
Taxandria brand OF domperidone maleateHMDB
Ratio domperidoneHMDB
DomidonHMDB
Domperidone maleate (1:1)HMDB
Hexal, domperidonHMDB
Monohydrochloride, domperidoneHMDB
Novo domperidoneHMDB
Nu pharm brand OF domperidone maleateHMDB
PMS DomperidoneHMDB
Pharmascience brand OF domperidone maleateHMDB
Pierre fabre brand OF domperidoneHMDB
Teva brand OF domperidone maleateHMDB
Ratio-domperidoneHMDB
Aliud brand OF domperidone maleateHMDB
Apo-domperidoneHMDB
Apotex brand OF domperidone maleateHMDB
Gamir, domperidonaHMDB
Hexal brand OF domperidone maleateHMDB
Janssen brand OF domperidoneHMDB
Maleate, domperidoneHMDB
Novo-domperidoneHMDB
Nu domperidoneHMDB
Nu-domperidoneHMDB
PéridysHMDB
Stada, domperidonHMDB
Chemical FormulaC22H24ClN5O2
Average Molecular Weight425.911
Monoisotopic Molecular Weight425.161852744
IUPAC Name5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)propyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
Traditional Namemotilium
CAS Registry Number57808-66-9
SMILES
ClC1=CC2=C(C=C1)N(C1CCN(CCCN3C(=O)NC4=CC=CC=C34)CC1)C(=O)N2
InChI Identifier
InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)
InChI KeyFGXWKSZFVQUSTL-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as benzimidazoles. These are organic compounds containing a benzene ring fused to an imidazole ring (five member ring containing a nitrogen atom, 4 carbon atoms, and two double bonds).
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzimidazoles
Sub ClassNot Available
Direct ParentBenzimidazoles
Alternative Parents
Substituents
  • Benzimidazole
  • Aryl chloride
  • Aryl halide
  • N-substituted imidazole
  • Piperidine
  • Benzenoid
  • Azole
  • Imidazole
  • Heteroaromatic compound
  • Tertiary aliphatic amine
  • Tertiary amine
  • Urea
  • Azacycle
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Organic oxide
  • Organopnictogen compound
  • Amine
  • Organic oxygen compound
  • Organic nitrogen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
ProcessNot Available
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point242.5 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.092 g/LNot Available
LogP2.4Not Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.092 g/LALOGPS
logP3.7ALOGPS
logP2.9ChemAxon
logS-3.7ALOGPS
pKa (Strongest Acidic)12.52ChemAxon
pKa (Strongest Basic)7.03ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area67.92 ŲChemAxon
Rotatable Bond Count5ChemAxon
Refractivity119.37 m³·mol⁻¹ChemAxon
Polarizability45.61 ųChemAxon
Number of Rings5ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DeepCCS[M-2H]-228.31430932474
DeepCCS[M+Na]+203.54230932474
AllCCS[M+H]+197.532859911
AllCCS[M+H-H2O]+195.432859911
AllCCS[M+NH4]+199.532859911
AllCCS[M+Na]+200.132859911
AllCCS[M-H]-194.532859911
AllCCS[M+Na-2H]-194.432859911
AllCCS[M+HCOO]-194.532859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
DomperidoneClC1=CC2=C(C=C1)N(C1CCN(CCCN3C(=O)NC4=CC=CC=C34)CC1)C(=O)N24847.5Standard polar33892256
DomperidoneClC1=CC2=C(C=C1)N(C1CCN(CCCN3C(=O)NC4=CC=CC=C34)CC1)C(=O)N23716.1Standard non polar33892256
DomperidoneClC1=CC2=C(C=C1)N(C1CCN(CCCN3C(=O)NC4=CC=CC=C34)CC1)C(=O)N24335.3Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Domperidone,1TMS,isomer #1C[Si](C)(C)N1C(=O)N(CCCN2CCC(N3C(=O)[NH]C4=CC(Cl)=CC=C43)CC2)C2=CC=CC=C213769.4Semi standard non polar33892256
Domperidone,1TMS,isomer #1C[Si](C)(C)N1C(=O)N(CCCN2CCC(N3C(=O)[NH]C4=CC(Cl)=CC=C43)CC2)C2=CC=CC=C213386.1Standard non polar33892256
Domperidone,1TMS,isomer #1C[Si](C)(C)N1C(=O)N(CCCN2CCC(N3C(=O)[NH]C4=CC(Cl)=CC=C43)CC2)C2=CC=CC=C214930.1Standard polar33892256
Domperidone,1TMS,isomer #2C[Si](C)(C)N1C(=O)N(C2CCN(CCCN3C(=O)[NH]C4=CC=CC=C43)CC2)C2=CC=C(Cl)C=C213756.8Semi standard non polar33892256
Domperidone,1TMS,isomer #2C[Si](C)(C)N1C(=O)N(C2CCN(CCCN3C(=O)[NH]C4=CC=CC=C43)CC2)C2=CC=C(Cl)C=C213416.5Standard non polar33892256
Domperidone,1TMS,isomer #2C[Si](C)(C)N1C(=O)N(C2CCN(CCCN3C(=O)[NH]C4=CC=CC=C43)CC2)C2=CC=C(Cl)C=C214971.0Standard polar33892256
Domperidone,2TMS,isomer #1C[Si](C)(C)N1C(=O)N(CCCN2CCC(N3C(=O)N([Si](C)(C)C)C4=CC(Cl)=CC=C43)CC2)C2=CC=CC=C213792.6Semi standard non polar33892256
Domperidone,2TMS,isomer #1C[Si](C)(C)N1C(=O)N(CCCN2CCC(N3C(=O)N([Si](C)(C)C)C4=CC(Cl)=CC=C43)CC2)C2=CC=CC=C213403.0Standard non polar33892256
Domperidone,2TMS,isomer #1C[Si](C)(C)N1C(=O)N(CCCN2CCC(N3C(=O)N([Si](C)(C)C)C4=CC(Cl)=CC=C43)CC2)C2=CC=CC=C214536.6Standard polar33892256
Domperidone,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)N1C(=O)N(CCCN2CCC(N3C(=O)[NH]C4=CC(Cl)=CC=C43)CC2)C2=CC=CC=C213897.6Semi standard non polar33892256
Domperidone,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)N1C(=O)N(CCCN2CCC(N3C(=O)[NH]C4=CC(Cl)=CC=C43)CC2)C2=CC=CC=C213570.7Standard non polar33892256
Domperidone,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)N1C(=O)N(CCCN2CCC(N3C(=O)[NH]C4=CC(Cl)=CC=C43)CC2)C2=CC=CC=C214917.2Standard polar33892256
Domperidone,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)N1C(=O)N(C2CCN(CCCN3C(=O)[NH]C4=CC=CC=C43)CC2)C2=CC=C(Cl)C=C213894.1Semi standard non polar33892256
Domperidone,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)N1C(=O)N(C2CCN(CCCN3C(=O)[NH]C4=CC=CC=C43)CC2)C2=CC=C(Cl)C=C213600.9Standard non polar33892256
Domperidone,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)N1C(=O)N(C2CCN(CCCN3C(=O)[NH]C4=CC=CC=C43)CC2)C2=CC=C(Cl)C=C214963.7Standard polar33892256
Domperidone,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)N1C(=O)N(CCCN2CCC(N3C(=O)N([Si](C)(C)C(C)(C)C)C4=CC(Cl)=CC=C43)CC2)C2=CC=CC=C214074.6Semi standard non polar33892256
Domperidone,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)N1C(=O)N(CCCN2CCC(N3C(=O)N([Si](C)(C)C(C)(C)C)C4=CC(Cl)=CC=C43)CC2)C2=CC=CC=C213740.7Standard non polar33892256
Domperidone,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)N1C(=O)N(CCCN2CCC(N3C(=O)N([Si](C)(C)C(C)(C)C)C4=CC(Cl)=CC=C43)CC2)C2=CC=CC=C214543.0Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Domperidone GC-MS (Non-derivatized) - 70eV, Positivesplash10-08mj-2692000000-9daf8802fe5fc021ea4f2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Domperidone GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Domperidone LC-ESI-qTof , Positive-QTOFsplash10-004i-0300900000-912de932579a7a2a6e2f2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Domperidone LC-ESI-QFT , negative-QTOFsplash10-00xr-0700900000-fbaf0980af220c88125f2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Domperidone , positive-QTOFsplash10-004i-0300900000-912de932579a7a2a6e2f2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Domperidone LC-ESI-QFT , positive-QTOFsplash10-004i-0900300000-877326ac38180c1229cd2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Domperidone 50V, Positive-QTOFsplash10-002b-0900000000-c28877fb980fa886a6062021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Domperidone 10V, Positive-QTOFsplash10-004i-0000900000-90c1af73e4aead615fec2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Domperidone 30V, Positive-QTOFsplash10-004i-0900300000-6df2864601f7af858ef12021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Domperidone 20V, Positive-QTOFsplash10-004i-0100900000-1a1ca493695b3d8e70c62021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Domperidone 40V, Positive-QTOFsplash10-004j-0900000000-3680b79b1b5bcdc66d602021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Domperidone 50V, Positive-QTOFsplash10-002b-0900000000-0431b44f33deef2ed82c2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Domperidone 35V, Positive-QTOFsplash10-004i-0900300000-3bd92bca9e67f74beb8f2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Domperidone 35V, Negative-QTOFsplash10-00xr-0700900000-fbaf0980af220c88125f2021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Domperidone 10V, Positive-QTOFsplash10-004i-0220900000-320024dacd7b3666a2932016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Domperidone 20V, Positive-QTOFsplash10-004r-0950500000-c8c3833dfb87847d975b2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Domperidone 40V, Positive-QTOFsplash10-014r-2940000000-3f7966be585ce22c8c862016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Domperidone 10V, Negative-QTOFsplash10-00di-0100900000-a3ae8ff94e1811fc95ae2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Domperidone 20V, Negative-QTOFsplash10-0089-0911500000-6cf625cae563f06d7a952016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Domperidone 40V, Negative-QTOFsplash10-00lr-1900000000-6a827fec8d00d10897d82016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Domperidone 10V, Positive-QTOFsplash10-004i-0000900000-164bcaf83a844bfb13ca2021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Domperidone 20V, Positive-QTOFsplash10-0059-0018900000-1a73c208d5dee5a156fe2021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Domperidone 40V, Positive-QTOFsplash10-003s-1927200000-d47116c34282e11f03392021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Domperidone 10V, Negative-QTOFsplash10-00di-0000900000-d0f9c41f28982aef98a22021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Domperidone 20V, Negative-QTOFsplash10-00di-1006900000-8c0370be45df6f7f085c2021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Domperidone 40V, Negative-QTOFsplash10-00lr-5912300000-1e39d4bb8c5a8a77c0392021-10-11Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB01184 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB01184 details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB01184
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID3039
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkDomperidone
METLIN IDNot Available
PubChem Compound3151
PDB IDNot Available
ChEBI ID31515
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Silvers D, Kipnes M, Broadstone V, Patterson D, Quigley EM, McCallum R, Leidy NK, Farup C, Liu Y, Joslyn A: Domperidone in the management of symptoms of diabetic gastroparesis: efficacy, tolerability, and quality-of-life outcomes in a multicenter controlled trial. DOM-USA-5 Study Group. Clin Ther. 1998 May-Jun;20(3):438-53. [PubMed:9663360 ]

Enzymes

General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular weight:
57255.585
References
  1. Chang SY, Fancher RM, Zhang H, Gan J: Mechanism-based inhibition of human cytochrome P4503A4 by domperidone. Xenobiotica. 2010 Feb;40(2):138-45. doi: 10.3109/00498250903406762. [PubMed:20082577 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Simard C, Michaud V, Gibbs B, Masse R, Lessard E, Turgeon J: Identification of the cytochrome P450 enzymes involved in the metabolism of domperidone. Xenobiotica. 2004 Nov-Dec;34(11-12):1013-23. [PubMed:15801545 ]
General function:
Involved in monooxygenase activity
Specific function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular weight:
55768.94
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular weight:
56277.81
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular weight:
57108.065
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular weight:
57525.03
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular weight:
58406.915
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular weight:
55824.275
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase
Gene Name:
DRD2
Uniprot ID:
P14416
Molecular weight:
50618.9
References
  1. Cavallotti C, Nuti F, Bruzzone P, Mancone M: Age-related changes in dopamine D2 receptors in rat heart and coronary vessels. Clin Exp Pharmacol Physiol. 2002 May-Jun;29(5-6):412-8. [PubMed:12010185 ]
  2. Osinski MA, Uchic ME, Seifert T, Shaughnessy TK, Miller LN, Nakane M, Cox BF, Brioni JD, Moreland RB: Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets. Pharmacol Biochem Behav. 2005 May;81(1):211-9. [PubMed:15894081 ]
  3. de Mey C, Enterling D, Meineke I, Yeulet S: Interactions between domperidone and ropinirole, a novel dopamine D2-receptor agonist. Br J Clin Pharmacol. 1991 Oct;32(4):483-8. [PubMed:1683559 ]
  4. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  5. Ali I, Gupta VK, Singh P, Pant HV: Screening of domperidone in wastewater by high performance liquid chromatography and solid phase extraction methods. Talanta. 2006 Jan 15;68(3):928-31. doi: 10.1016/j.talanta.2005.06.027. Epub 2005 Jul 22. [PubMed:18970411 ]
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation
Gene Name:
DRD3
Uniprot ID:
P35462
Molecular weight:
44224.3
References
  1. Freedman SB, Patel S, Marwood R, Emms F, Seabrook GR, Knowles MR, McAllister G: Expression and pharmacological characterization of the human D3 dopamine receptor. J Pharmacol Exp Ther. 1994 Jan;268(1):417-26. [PubMed:8301582 ]

Transporters

General function:
Involved in ATP binding
Specific function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular weight:
141477.3
References
  1. Faassen F, Vogel G, Spanings H, Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. [PubMed:12954186 ]
  2. Schinkel AH, Wagenaar E, Mol CA, van Deemter L: P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest. 1996 Jun 1;97(11):2517-24. [PubMed:8647944 ]