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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2006-05-22 14:17:33 UTC
Update Date2023-02-21 17:16:05 UTC
HMDB IDHMDB0002040
Secondary Accession Numbers
  • HMDB02040
Metabolite Identification
Common Name4-Methoxycinnamic acid
Description4-Methoxycinnamic acid, also known as para-methoxycinnamate or O-methyl-p-coumarate, belongs to the class of organic compounds known as cinnamic acids. These are organic aromatic compounds containing a benzene and a carboxylic acid group forming 3-phenylprop-2-enoic acid. Outside of the human body, 4-Methoxycinnamic acid is found, on average, in the highest concentration within turmerics. 4-Methoxycinnamic acid has also been detected, but not quantified in cow milk and wild celeries. This could make 4-methoxycinnamic acid a potential biomarker for the consumption of these foods.
Structure
Data?1676999765
Synonyms
ValueSource
4-MethoxycinnamateGenerator
3-(4-Methoxyphenyl)acrylic acidChEMBL, HMDB
Para-methoxycinnamic acidChEMBL, HMDB
3-(4-Methoxyphenyl)acrylateGenerator, HMDB
Para-methoxycinnamateGenerator, HMDB
(e)-3-(4-Methoxyphenyl)acrylateHMDB
(e)-3-(4-Methoxyphenyl)acrylic acidHMDB
3-(4-Methoxy-phenyl)-acrylateHMDB
3-(4-Methoxy-phenyl)-acrylic acidHMDB
3-(4-Methoxyphenyl)-2-propenoateHMDB
3-(4-Methoxyphenyl)-2-propenoic acidHMDB
4-Methoxy cinnamateHMDB
4-Methoxy cinnamic acidHMDB
O-Methyl-P-coumarateHMDB
O-Methyl-P-coumaric acidHMDB
P-Hydroxy methyl cinnamateHMDB
P-Methoxy ciannamateHMDB
P-Methoxy ciannamic acidHMDB
P-MethoxycinnamateHMDB
P-Methoxycinnamic acidHMDB
trans-4-MethoxycinnamateHMDB
trans-4-Methoxycinnamic acidHMDB
4-Methoxycinnamate, aluminum saltMeSH, HMDB
4-Methoxycinnamate, (e)-isomerMeSH, HMDB
4-Methoxycinnamate, (Z)-isomerMeSH, HMDB
4-Methoxycinnamate, zinc saltMeSH, HMDB
4-Methoxycinnamate, zirconium saltMeSH, HMDB
e-P-Methoxycinnamic acidMeSH, HMDB
4-Methoxycinnamate, calcium saltMeSH, HMDB
4-Methoxycinnamate, magnesium saltMeSH, HMDB
4-Methoxycinnamate, potassium saltMeSH, HMDB
4-Methoxycinnamate, sodium saltMeSH, HMDB
(2E)-3-(4-Methoxyphenyl)prop-2-enoateGenerator, HMDB
4-Methoxycinnamic acidMeSH
(2E)-3-(4-Methoxyphenyl)-2-propenoic acidHMDB
(E)-3-(4-Methoxyphenyl)-2-propenoic acidHMDB
(E)-3-(4-Methoxyphenyl)acrylic acidHMDB
(E)-4-Methoxycinnamic acidHMDB
(E)-p-Methoxycinnamic acidHMDB
3-(4-Methoxyphenyl)propenoic acidHMDB
4'-Methoxycinnamic acidHMDB
4-Methyoxycinnamic acidHMDB
4’-Methoxycinnamic acidHMDB
O-Methyl-p-coumaric acidHMDB
p-Methoxycinnamic acidHMDB
trans-3-(4-Methoxyphenyl)-2-propenoic acidHMDB
trans-p-Methoxycinnamic acidHMDB
trans-p-MethoxycinnamateGenerator, HMDB
Chemical FormulaC10H10O3
Average Molecular Weight178.1846
Monoisotopic Molecular Weight178.062994186
IUPAC Name(2E)-3-(4-methoxyphenyl)prop-2-enoic acid
Traditional Namep-methoxy-cinnamic acid
CAS Registry Number943-89-5
SMILES
COC1=CC=C(\C=C\C(O)=O)C=C1
InChI Identifier
InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-4+
InChI KeyAFDXODALSZRGIH-QPJJXVBHSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as cinnamic acids. These are organic aromatic compounds containing a benzene and a carboxylic acid group forming 3-phenylprop-2-enoic acid.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassCinnamic acids and derivatives
Sub ClassCinnamic acids
Direct ParentCinnamic acids
Alternative Parents
Substituents
  • Cinnamic acid
  • Phenoxy compound
  • Anisole
  • Methoxybenzene
  • Styrene
  • Phenol ether
  • Alkyl aryl ether
  • Monocyclic benzene moiety
  • Benzenoid
  • Carboxylic acid derivative
  • Carboxylic acid
  • Ether
  • Monocarboxylic acid or derivatives
  • Organic oxygen compound
  • Carbonyl group
  • Organic oxide
  • Organooxygen compound
  • Hydrocarbon derivative
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available
Ontology
Physiological effectNot Available
Disposition
ProcessNot Available
Role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point173 - 175 °CNot Available
Boiling Point342.59 °C. @ 760.00 mm Hg (est)The Good Scents Company Information System
Water Solubility0.71 mg/mL at 25 °CNot Available
LogP2.68HANSCH,C ET AL. (1995)
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M-H]-MetCCS_train_neg146.27930932474
[M+H]+MetCCS_train_pos140.84930932474
[M-H]-Not Available146.279http://allccs.zhulab.cn/database/detail?ID=AllCCS00000433
[M+H]+Not Available141.375http://allccs.zhulab.cn/database/detail?ID=AllCCS00000433
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.55 g/LALOGPS
logP2.37ALOGPS
logP1.98ChemAxon
logS-2.5ALOGPS
pKa (Strongest Acidic)4.11ChemAxon
pKa (Strongest Basic)-4.8ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area46.53 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity49.52 m³·mol⁻¹ChemAxon
Polarizability18.34 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+142.3131661259
DarkChem[M-H]-141.87831661259
DeepCCS[M+H]+140.28830932474
DeepCCS[M-H]-137.91630932474
DeepCCS[M-2H]-173.13930932474
DeepCCS[M+Na]+148.4530932474
AllCCS[M+H]+138.232859911
AllCCS[M+H-H2O]+133.932859911
AllCCS[M+NH4]+142.232859911
AllCCS[M+Na]+143.332859911
AllCCS[M-H]-138.332859911
AllCCS[M+Na-2H]-139.132859911
AllCCS[M+HCOO]-140.032859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
4-Methoxycinnamic acidCOC1=CC=C(\C=C\C(O)=O)C=C13147.1Standard polar33892256
4-Methoxycinnamic acidCOC1=CC=C(\C=C\C(O)=O)C=C11638.9Standard non polar33892256
4-Methoxycinnamic acidCOC1=CC=C(\C=C\C(O)=O)C=C11776.5Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
4-Methoxycinnamic acid,1TMS,isomer #1COC1=CC=C(/C=C/C(=O)O[Si](C)(C)C)C=C11834.6Semi standard non polar33892256
4-Methoxycinnamic acid,1TBDMS,isomer #1COC1=CC=C(/C=C/C(=O)O[Si](C)(C)C(C)(C)C)C=C12088.7Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - 4-Methoxycinnamic acid GC-MS (1 TMS)splash10-03du-2920000000-dece72c3ca5c90bfc5472014-06-16HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 4-Methoxycinnamic acid EI-B (Non-derivatized)splash10-004i-0900000000-a59af9ca91b1d5bd71822017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 4-Methoxycinnamic acid EI-B (Non-derivatized)splash10-004i-7900000000-6075ede461ba4ee4c7cd2017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 4-Methoxycinnamic acid EI-B (Non-derivatized)splash10-004i-1900000000-e899894a8c3562db43a52017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 4-Methoxycinnamic acid GC-MS (Non-derivatized)splash10-03du-2920000000-dece72c3ca5c90bfc5472017-09-12HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 4-Methoxycinnamic acid GC-MS (Non-derivatized) - 70eV, Positivesplash10-03gi-1900000000-cc8f6e9174dff780d6432017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 4-Methoxycinnamic acid GC-MS (1 TMS) - 70eV, Positivesplash10-0080-9650000000-bb37ec4824ae491674e52017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 4-Methoxycinnamic acid GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - 4-Methoxycinnamic acid Quattro_QQQ 10V, Positive-QTOF (Annotated)splash10-03di-0900000000-12552bc1ab86525703a02012-07-25HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 4-Methoxycinnamic acid Quattro_QQQ 25V, Positive-QTOF (Annotated)splash10-00pi-5900000000-9632d41fa295f06b53812012-07-25HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 4-Methoxycinnamic acid Quattro_QQQ 40V, Positive-QTOF (Annotated)splash10-004u-9100000000-a6dac09530cfcfc288682012-07-25HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 4-Methoxycinnamic acid EI-B (HITACHI M-80) , Positive-QTOFsplash10-004i-0900000000-a59af9ca91b1d5bd71822012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 4-Methoxycinnamic acid EI-B (HITACHI M-80) , Positive-QTOFsplash10-004i-7900000000-8e025153eeb590c13daa2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 4-Methoxycinnamic acid LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative-QTOFsplash10-0fb9-0900000000-c6baccb046bfcd7d62822012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 4-Methoxycinnamic acid LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 30V, Negative-QTOFsplash10-014i-1900000000-3927439c287110a6a2f12012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 4-Methoxycinnamic acid LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive-QTOFsplash10-03e9-1900000000-03cba42101a868fcbdbb2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 4-Methoxycinnamic acid LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive-QTOFsplash10-03e9-1900000000-53a3d7a661e7d42fabbf2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 4-Methoxycinnamic acid LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 30V, Positive-QTOFsplash10-00mo-9600000000-b0e876994fe40230d56f2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 4-Methoxycinnamic acid LC-ESI-qTof , Positive-QTOFsplash10-00lr-1900000000-32372664024a7a1cba272017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 4-Methoxycinnamic acid LC-ESI-QTOF , negative-QTOFsplash10-0fb9-0900000000-c6baccb046bfcd7d62822017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 4-Methoxycinnamic acid LC-ESI-QTOF , negative-QTOFsplash10-014i-1900000000-3927439c287110a6a2f12017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 4-Methoxycinnamic acid LC-ESI-QTOF , positive-QTOFsplash10-03e9-1900000000-03cba42101a868fcbdbb2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 4-Methoxycinnamic acid LC-ESI-QTOF , positive-QTOFsplash10-03e9-1900000000-53a3d7a661e7d42fabbf2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 4-Methoxycinnamic acid LC-ESI-QTOF , positive-QTOFsplash10-00mo-9600000000-1dd0b8897a3d399d48fc2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 4-Methoxycinnamic acid , positive-QTOFsplash10-00lr-1900000000-32372664024a7a1cba272017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 4-Methoxycinnamic acid LC-ESI-QFT , positive-QTOFsplash10-03di-0900000000-2c4cab05840440c8ef922017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 4-Methoxycinnamic acid 35V, Positive-QTOFsplash10-03di-0900000000-3954121d114e7a1254012021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 4-Methoxycinnamic acid 10V, Positive-QTOFsplash10-03di-0900000000-f0f239b49fe3cc116d972017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 4-Methoxycinnamic acid 20V, Positive-QTOFsplash10-03e9-0900000000-d7031d18cf315b765cbf2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 4-Methoxycinnamic acid 40V, Positive-QTOFsplash10-0udi-9800000000-881ce76bbf7add1a81622017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 4-Methoxycinnamic acid 10V, Negative-QTOFsplash10-004i-0900000000-0d57f82612687cf62c682017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 4-Methoxycinnamic acid 20V, Negative-QTOFsplash10-057i-0900000000-c2111775e672e2666fbd2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 4-Methoxycinnamic acid 40V, Negative-QTOFsplash10-02u3-1900000000-295574bc9205dd1a7c792017-09-01Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Experimental 2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, CD3OD, experimental)2012-12-05Wishart LabView Spectrum

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-03FELIX labView Spectrum
Biological Properties
Cellular Locations
  • Membrane (predicted from logP)
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.693 +/- 0.228 uMAdult (>18 years old)Male
Normal
details
BloodDetected and Quantified0.475 +/- 0.218 uMAdult (>18 years old)Male
Normal
details
BloodDetected and Quantified0.752 +/- 0.225 uMAdult (>18 years old)Male
Normal
details
BloodDetected and Quantified0.762 +/- 0.324 uMAdult (>18 years old)Male
Normal
details
BloodDetected and Quantified0.52 +/- 0.192 uMAdult (>18 years old)Male
Normal
details
BloodDetected and Quantified0.555 +/- 0.17 uMAdult (>18 years old)Male
Normal
details
BloodDetected and Quantified0.435 +/- 0.204 uMAdult (>18 years old)Male
Normal
details
BloodDetected and Quantified2.941 +/- 2.612 uMAdult (>18 years old)Male
Normal
details
UrineDetected and Quantified0.02 +/- 0.006 umol/mmol creatinineAdult (>18 years old)Male
Normal
details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB002667
KNApSAcK IDNot Available
Chemspider ID609479
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN ID6453
PubChem Compound699414
PDB IDNot Available
ChEBI ID260249
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDrw1417131
References
Synthesis ReferencePuscaru, E.; Zotta, V.; Serper, Ana; Popescu, Margareta; Hociung, Jana; Gasmet, Ana; Spataru, Rodica. The N-methyl series of piperazine. II. Cinnamic acid derivatives. Farmacia (Bucharest, Romania) (1961), 9 345-50.
Material Safety Data Sheet (MSDS)Download (PDF)
General ReferencesNot Available

Enzymes

General function:
Involved in transferase activity, transferring hexosyl groups
Specific function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone.
Gene Name:
UGT1A1
Uniprot ID:
P22309
Molecular weight:
59590.91
Reactions
4-Methoxycinnamic acid → 3,4,5-trihydroxy-6-{[(2E)-3-(4-methoxyphenyl)prop-2-enoyl]oxy}oxane-2-carboxylic aciddetails