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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2012-09-11 17:50:37 UTC
Update Date2023-02-21 17:22:25 UTC
HMDB IDHMDB0032582
Secondary Accession Numbers
  • HMDB32582
Metabolite Identification
Common Name2-Biphenylol
Description2-Biphenylol is found in lemon. It is an antifungal agent and preservative. 2-Biphenylol is used for post-harvest control of storage disease in apples, citrus fruit, stone fruit, tomatoes, cucumber and peppers through the use of impregnated wrapping materials or by direct application in a wax. 2-Biphenylol is used in food seasonings. Inhibitory to a wider range of moulds than Biphenyl HMJ12-A. The practical way of treatment is to immerse citrus fruit in an alkaline aqueous solution of the parent compound or its Na salt
Structure
Data?1677000145
Synonyms
ValueSource
2-HydroxybiphenylChEBI
2-PhenylphenolChEBI
O-DiphenylolChEBI
O-HydroxybiphenylChEBI
O-HydroxydiphenylChEBI
O-PhenylphenolChEBI
Orthophenyl phenolChEBI
AmocidKegg
2-HydroxydiphenylMeSH
2-Phenylphenol sodiumMeSH
DowicideMeSH
LyortholMeSH
O-PhenylphenateMeSH
Ortho-phenylphenateMeSH
OrthophenylphenolMeSH
Sodium O-phenylphenoateMeSH
Sodium ortho-phenylphenateMeSH
Sodium ortho-phenylphenolMeSH
(1,1'-Biphenyl)-2-olHMDB
(1,1-Biphenyl)-2-olHMDB
1,1'-Biphenyl-2-olHMDB
1-Hydroxy-2-phenylbenzeneHMDB
2-FenylfenolHMDB
2-Hydroxy biphenylHMDB
2-Hydroxy-1,1'-biphenylHMDB
2-Phenylphenol, bsi, isoHMDB
BiphenylolHMDB
Dowicide 1HMDB
e231HMDB
FEMA 3959HMDB
HBPHMDB
HydroxdiphenylHMDB
Hydroxy-2-phenylbenzeneHMDB
HydroxybiphenylHMDB
ManuseptHMDB
NectrylHMDB
Nipacide OPPHMDB
O-BiphenylolHMDB
O-Phenyl phenolHMDB
O-XenolHMDB
O-XonalHMDB
OPP?HMDB
ortho-PhenylphenolHMDB
OrthohydroxydipbenylHMDB
OrthohydroxydiphenylHMDB
OrthoxenolHMDB
PhenylphenolHMDB
RotolineHMDB
StelliseptHMDB
TorsiteHMDB
2-BiphenylolChEBI
Chemical FormulaC12H10O
Average Molecular Weight170.2072
Monoisotopic Molecular Weight170.073164942
IUPAC Name[1,1'-biphenyl]-2-ol
Traditional Nameo-phenylphenol
CAS Registry Number90-43-7
SMILES
OC1=CC=CC=C1C1=CC=CC=C1
InChI Identifier
InChI=1S/C12H10O/c13-12-9-5-4-8-11(12)10-6-2-1-3-7-10/h1-9,13H
InChI KeyLLEMOWNGBBNAJR-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBiphenyls and derivatives
Direct ParentBiphenyls and derivatives
Alternative Parents
Substituents
  • Biphenyl
  • 1-hydroxy-4-unsubstituted benzenoid
  • 1-hydroxy-2-unsubstituted benzenoid
  • Phenol
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Organooxygen compound
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
ProcessNot Available
Role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point56 °CNot Available
Boiling Point282.00 to 285.00 °C. @ 760.00 mm HgThe Good Scents Company Information System
Water Solubility0.7 mg/mL at 25 °CNot Available
LogP3.09Not Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.34 g/LALOGPS
logP3.21ALOGPS
logP3.32ChemAxon
logS-2.7ALOGPS
pKa (Strongest Acidic)9.69ChemAxon
pKa (Strongest Basic)-5.6ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area20.23 ŲChemAxon
Rotatable Bond Count1ChemAxon
Refractivity53.18 m³·mol⁻¹ChemAxon
Polarizability18.75 ųChemAxon
Number of Rings2ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+135.60431661259
DarkChem[M-H]-134.65931661259
DeepCCS[M+H]+133.47330932474
DeepCCS[M-H]-130.58730932474
DeepCCS[M-2H]-166.95830932474
DeepCCS[M+Na]+142.40930932474
AllCCS[M+H]+135.332859911
AllCCS[M+H-H2O]+130.632859911
AllCCS[M+NH4]+139.732859911
AllCCS[M+Na]+140.932859911
AllCCS[M-H]-135.432859911
AllCCS[M+Na-2H]-135.532859911
AllCCS[M+HCOO]-135.832859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
2-BiphenylolOC1=CC=CC=C1C1=CC=CC=C12472.7Standard polar33892256
2-BiphenylolOC1=CC=CC=C1C1=CC=CC=C11515.5Standard non polar33892256
2-BiphenylolOC1=CC=CC=C1C1=CC=CC=C11505.9Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
2-Biphenylol,1TMS,isomer #1C[Si](C)(C)OC1=CC=CC=C1C1=CC=CC=C11577.7Semi standard non polar33892256
2-Biphenylol,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC1=CC=CC=C1C1=CC=CC=C11855.6Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - 2-Biphenylol EI-B (Non-derivatized)splash10-00di-1900000000-f58c83912c81582962ec2017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 2-Biphenylol EI-B (Non-derivatized)splash10-00xr-1900000000-ba4f084280aee3b63cb92017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 2-Biphenylol EI-B (Non-derivatized)splash10-00xr-2900000000-0395543c94def63fbf1c2017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 2-Biphenylol GC-EI-TOF (Non-derivatized)splash10-03fr-1790000000-2fec91e9a3b831e4f6612017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 2-Biphenylol EI-B (Non-derivatized)splash10-00di-1900000000-f58c83912c81582962ec2018-05-18HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 2-Biphenylol EI-B (Non-derivatized)splash10-00xr-1900000000-ba4f084280aee3b63cb92018-05-18HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 2-Biphenylol EI-B (Non-derivatized)splash10-00xr-2900000000-0395543c94def63fbf1c2018-05-18HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 2-Biphenylol GC-EI-TOF (Non-derivatized)splash10-03fr-1790000000-2fec91e9a3b831e4f6612018-05-18HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 2-Biphenylol GC-MS (Non-derivatized) - 70eV, Positivesplash10-00di-0900000000-43bf1dee532a54447f412017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 2-Biphenylol GC-MS (1 TMS) - 70eV, Positivesplash10-00di-9760000000-5e1078b290b37f1d47bc2017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 2-Biphenylol GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
MSMass Spectrum (Electron Ionization)splash10-01bc-3900000000-adae00e9be0477f3901b2014-09-20Not AvailableView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Biphenylol LC-ESI-ITFT , positive-QTOFsplash10-0fml-0900000000-7b06dbf8c12560a092e62017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Biphenylol LC-ESI-ITFT , positive-QTOFsplash10-0fb9-0900000000-dc2a630f122797c0a30d2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Biphenylol LC-ESI-ITFT , positive-QTOFsplash10-0udl-0900000000-0058244c148d04bcffb92017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Biphenylol LC-ESI-ITFT , positive-QTOFsplash10-0udl-0900000000-28f041bf0b0faf02ccd52017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Biphenylol 60V, Negative-QTOFsplash10-00kf-9500000000-f6d4cbb6fefb881a66df2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Biphenylol 45V, Negative-QTOFsplash10-00kf-9500000000-645cd80d916513b7da2e2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Biphenylol 75V, Negative-QTOFsplash10-0006-9200000000-cb0f070ccdf943ac78cc2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Biphenylol 90V, Negative-QTOFsplash10-0006-9200000000-e74e7ad70d8227b5a7e92021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Biphenylol 90V, Positive-QTOFsplash10-0fb9-0900000000-6327145722d77a345d122021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Biphenylol 15V, Positive-QTOFsplash10-00di-0900000000-58d1482e199dc20e2e652021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Biphenylol 30V, Positive-QTOFsplash10-00di-0900000000-28311b68921ae494a0e82021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Biphenylol 60V, Positive-QTOFsplash10-0fb9-0900000000-931a5f59b51289796ad92021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Biphenylol 45V, Positive-QTOFsplash10-00dl-0900000000-85cbd30844e2c9d2b8cc2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Biphenylol 15V, Negative-QTOFsplash10-00kf-9600000000-6bdabf5fa4f9b4d076d02021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Biphenylol 30V, Negative-QTOFsplash10-00kf-9700000000-6e22867439b22f4327de2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Biphenylol 90V, Positive-QTOFsplash10-0fb9-0900000000-c230f5371d3e1af257882021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Biphenylol 75V, Positive-QTOFsplash10-0fb9-0900000000-665c01eb096b23432bf12021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Biphenylol 10V, Positive-QTOFsplash10-00di-0900000000-aa09c65297232074b1da2016-08-02Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Biphenylol 20V, Positive-QTOFsplash10-00di-1900000000-042a540d9a28eba4bb1e2016-08-02Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Biphenylol 40V, Positive-QTOFsplash10-0f96-9600000000-ee2a147f3a7a3bbc0bda2016-08-02Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Biphenylol 10V, Negative-QTOFsplash10-014i-0900000000-05ec524c3078c379ec6f2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Biphenylol 20V, Negative-QTOFsplash10-014i-1900000000-cf114607f489ee9543972016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Biphenylol 40V, Negative-QTOFsplash10-002f-9500000000-075a7f587e50b80d93c62016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Biphenylol 10V, Positive-QTOFsplash10-00di-0900000000-13ac4e364e8d0c6b9e7c2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Biphenylol 20V, Positive-QTOFsplash10-00di-0900000000-5e0bca337cd8a7eff74f2021-09-22Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)2023-02-04FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)2023-02-04FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-04FELIX labView Spectrum
Biological Properties
Cellular Locations
  • Membrane
Biospecimen Locations
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
UrineDetected and Quantified0.0000870 (0.0000731-0.000104) umol/mmol creatinineAdult (>18 years old)Not SpecifiedNormal
    • National Health a...
details
UrineDetected and Quantified0.000145 (0.000126-0.000169) umol/mmol creatinineChildren (1-13 years old)Not SpecifiedNormal
    • National Health a...
details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB010519
KNApSAcK IDNot Available
Chemspider ID13839012
KEGG Compound IDC02499
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkBiphenyl-2-ol
METLIN IDNot Available
PubChem Compound7017
PDB IDNot Available
ChEBI ID17043
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDrw1099421
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Shen DT, Crawford TB, Gorham JR, McGuire TC: Inactivation of equine infectious anemia virus by chemical disinfectants. Am J Vet Res. 1977 Aug;38(8):1217-9. [PubMed:199094 ]
  2. Johnson GD, Harsy SG, Geronimo J, Wise JM: Orthophenylphenol and phenylhydroquinone residues in citrus fruit and processed citrus products after postharvest fungicidal treatments with sodium orthophenylphenate in California and Florida. J Agric Food Chem. 2001 May;49(5):2497-502. [PubMed:11368626 ]
  3. Humphreys MJ, Allman R, Lloyd D: Determination of the viability of Trichomonas vaginalis using flow cytometry. Cytometry. 1994 Apr 1;15(4):343-8. [PubMed:8026224 ]
  4. HOPKINS EF, LOUCKS KW: Prevention of the phytotoxic action of sodium orthophenylphenate on citrus fruits by hexamine. Science. 1950 Dec 15;112(2920):720-1. [PubMed:14787507 ]
  5. Diaz Borras A, Vila Aguilar R, Hernandez Gimenez E: Synergistic effect of fungicides on resistant strains of Penicillium italicum and Penicillium digitatum. Int J Food Microbiol. 1988 Aug;7(1):79-85. [PubMed:3275313 ]
  6. Csermely P, Balint E, Grimley PM, Aszalos A: Protein kinase C is involved in the early signals of interferon-alpha but not of interferon-gamma in U937 cells. J Interferon Res. 1990 Dec;10(6):605-11. [PubMed:2128303 ]
  7. Reitz RH, Fox TR, Quast JF, Hermann EA, Watanabe PG: Biochemical factors involved in the effects of orthophenylphenol (OPP) and sodium orthophenylphenate (SOPP) on the urinary tract of male F344 rats. Toxicol Appl Pharmacol. 1984 Apr;73(2):345-9. [PubMed:6710533 ]
  8. Cinelli AR, Salzberg BM: Dendritic origin of late events in optical recordings from salamander olfactory bulb. J Neurophysiol. 1992 Sep;68(3):786-806. [PubMed:1432048 ]
  9. Evans JA, Darlington DN, Gann DS: A circulating factor(s) mediates cell depolarization in hemorrhagic shock. Ann Surg. 1991 Jun;213(6):549-56; discussion 556-7. [PubMed:2039285 ]
  10. Fangstrom B, Hovander L, Bignert A, Athanassiadis I, Linderholm L, Grandjean P, Weihe P, Bergman A: Concentrations of polybrominated diphenyl ethers, polychlonnated biphenyls, and polychlorobiphenylols in serum from pregnant Faroese women and their children 7 years later. Environ Sci Technol. 2005 Dec 15;39(24):9457-63. [PubMed:16475322 ]
  11. McDONOUGH ES: Inhibition of mold contamination in Drosophila food using sodium orthophenylphenate. Science. 1953 Oct 2;118(3066):388. [PubMed:13101762 ]
  12. Santhamma KR, Bhaduri A: Characterization of the respiratory chain of Leishmania donovani promastigotes. Mol Biochem Parasitol. 1995 Dec;75(1):43-53. [PubMed:8720174 ]
  13. Calori-Domingues MA, Fonseca H: Laboratory evaluation of chemical control of aflatoxin production in unshelled peanuts (Arachis hypogaea L.). Food Addit Contam. 1995 May-Jun;12(3):347-50. [PubMed:7664926 ]
  14. Ranzani MR, Fonseca H: Mycological evaluation of chemically-treated unshelled peanuts. Food Addit Contam. 1995 May-Jun;12(3):343-6. [PubMed:7664925 ]
  15. (). Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.. .