Hmdb loader
Identification
HMDB Protein ID HMDBP02018
Secondary Accession Numbers
  • 7474
  • HMDBP08484
Name Molybdenum cofactor biosynthesis protein 1
Synonyms
  1. MOCS1A
  2. Cell migration-inducing gene 11 protein
  3. Molybdenum cofactor biosynthesis protein A
  4. Molybdenum cofactor biosynthesis protein C
  5. Molybdenum cofactor synthesis-step 1 protein A-B
Gene Name MOCS1
Protein Type Unknown
Biological Properties
General Function Coenzyme transport and metabolism
Specific Function Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z).
Pathways
  • Folate biosynthesis
  • molybdopterin biosynthesis
  • Sulfur relay system
Reactions
Guanosine triphosphate → Cyclic pyranopterin monophosphate + Pyrophosphate details
Guanosine triphosphate + Water → Cyclic pyranopterin monophosphate + Pyrophosphate details
GO Classification
Biological Process
water-soluble vitamin metabolic process
Mo-molybdopterin cofactor biosynthetic process
Cellular Component
cytosol
molybdopterin synthase complex
nucleus
Component
molybdopterin synthase complex
macromolecular complex
protein complex
unlocalized protein complex
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
metal cluster binding
iron-sulfur cluster binding
iron ion binding
4 iron, 4 sulfur cluster binding
Molecular Function
metal ion binding
4 iron, 4 sulfur cluster binding
GTP binding
catalytic activity
Process
metabolic process
cellular metabolism
cofactor metabolism
coenzyme metabolism
coenzyme biosynthetic process
cellular metabolic process
physiological process
metabolism
cofactor metabolic process
coenzyme metabolic process
mo-molybdopterin cofactor biosynthetic process
coenzyme biosynthesis
mo-molybdopterin cofactor biosynthesis
Cellular Location
  1. Cytoplasm
Gene Properties
Chromosome Location 6
Locus 6p21.3
SNPs MOCS1
Gene Sequence
>1158 bp
ATGGCGGCGCGGCCACTGTCCCGGATGCTGCGGCGGCTTCTGAGGTCCAGCGCCCGGAGC
TGCAGCTCAGGGGCTCCGGTGACCCAGCCCTGCCCCGGGGAGTCCGCGCGAGCTGCCTCG
GAGGAGGTGTCCAGGCGGAGGCAGTTCCTGCGGGAGCATGCGGCCCCCTTCTCCGCCTTC
CTCACAGACAGCTTCGGCCGGCAGCACAGCTACCTGCGGATCTCCCTCACAGAGAAGTGC
AACCTCAGATGTCAGTACTGCATGCCCGAGGAGGGGGTCCCGCTGACCCCCAAAGCCAAC
CTGCTGACCACAGAGGAGATCCTGACCCTCGCCCGGCTCTTTGTGAAGGAAGGCATCGAC
AAGATCCGGCTCACAGGTGGAGAGCCGCTTATCCGGCCGGACGTGGTGGACATTGTGGCC
CAGCTCCAGCGGCTGGAAGGGCTGAGAACCATAGGTGTTACCACCAATGGCATCAACCTG
GCCCGGCTACTGCCCCAGCTTCAGAAGGCTGGTCTCAGTGCCATCAACATCAGCCTGGAC
ACCCTGGTGCCTGCCAAGTTTGAGTTCATTGTCCGCAGGAAAGGCTTCCACAAGGTCATG
GAGGGCATCCACAAGGCCATCGAGCTGGGCTACAACCCTGTGAAGGTGAACTGTGTGGTG
ATGCGAGGCCTTAACGAGGATGAACTCCTGGACTTTGCGGCCTTGACTGAGGGCCACCCC
CTGGATGTGCGCTTCATAGAGTATATGCCCTTTGATGGCAACAAGTGGAACTTCAAGAAG
ATGGTCAGCTATAAGGAGATGCTAGACACTGTCCGGCAGCAGTGGCCAGAGCTGGAGAAG
GTGCCAGAGGAGGAATCCAGCACAGCCAAGGCCTTTAAAATCCCTGGCTTCCAAGGCCAG
ATCAGCTTCATCACATCCATGTCTGAGCATTTCTGTGGGACCTGCAACCGCCTGCGAATC
ACAGCTGATGGGAACCTCAAGGTCTGCCTCTTTGGAAACTCTGAGGTATCCCTGCGGGAT
CACCTGCGAGCTGGGGCCTCTGAGCAGGAGCTGCTGAGAATCATTGGGGCTGCTGTGGGC
AGGAAGAAGCGGCAGCATGCAGGCATGTTCAGTATTTCCCAGATGAAGAACCGGCCCATG
ATCCTCATCGGTGGGTGA
Protein Properties
Number of Residues 385
Molecular Weight 43087.69
Theoretical pI 9.291
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Molybdenum cofactor biosynthesis protein 1 A
MAARPLSRMLRRLLRSSARSCSSGAPVTQPCPGESARAASEEVSRRRQFLREHAAPFSAF
LTDSFGRQHSYLRISLTEKCNLRCQYCMPEEGVPLTPKANLLTTEEILTLARLFVKEGID
KIRLTGGEPLIRPDVVDIVAQLQRLEGLRTIGVTTNGINLARLLPQLQKAGLSAINISLD
TLVPAKFEFIVRRKGFHKVMEGIHKAIELGYNPVKVNCVVMRGLNEDELLDFAALTEGLP
LDVRFIEYMPFDGNKWNFKKMVSYKEMLDTVRQQWPELEKVPEEESSTAKAFKIPGFQGQ
ISFITSMSEHFCGTCNRLRITADGNLKVCLFGNSEVSLRDHLRAGASEQELLRIIGAAVG
RKKRQHAGMFSISQMKNRPMILIGG
GenBank ID Protein 2645879
UniProtKB/Swiss-Prot ID Q9NZB8
UniProtKB/Swiss-Prot Entry Name MOS1A_HUMAN
PDB IDs Not Available
GenBank Gene ID AF034374
GeneCard ID MOCS1
GenAtlas ID MOCS1
HGNC ID HGNC:7190
References
General References
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  10. Gray TA, Nicholls RD: Diverse splicing mechanisms fuse the evolutionarily conserved bicistronic MOCS1A and MOCS1B open reading frames. RNA. 2000 Jul;6(7):928-36. [PubMed:10917590 ]
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