Human Metabolome Database: Showing Protein Inositol 1,4,5-trisphosphate receptor type 1 (HMDBP02849)

Identification Biological properties Gene properties Protein properties External links References XML Show 4 metabolites

Identification

HMDB Protein ID

HMDBP02849

Secondary Accession Numbers

8356

Name

Inositol 1,4,5-trisphosphate receptor type 1

Synonyms

IP3 receptor isoform 1
IP3R 1
InsP3R1
Type 1 InsP3 receptor
Type 1 inositol 1,4,5-trisphosphate receptor

Gene Name

ITPR1

Protein Type

Unknown

Biological Properties

General Function

Involved in calcium channel activity

Specific Function

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate

Pathways

Acebutolol Action Pathway
Acrivastine H1-Antihistamine Action
Activation of PKC through G protein coupled receptor
Alcaftadine H1-Antihistamine Action
Alimemazine H1-Antihistamine Action
Alprenolol Action Pathway
Amiodarone Action Pathway
Amlodipine Action Pathway
Antazoline H1-Antihistamine Action
Arbutamine Action Pathway
Astemizole H1-Antihistamine Action
Atenolol Action Pathway
Azatadine H1-Antihistamine Action
Azelastine H1-Antihistamine Action
Bamipine H1-Antihistamine Action
Bepotastine H1-Antihistamine Action
Betahistine H1-Antihistamine Action
Betaxolol Action Pathway
Bevantolol Action Pathway
Bilastine H1-Antihistamine Action
Bisoprolol Action Pathway
Bopindolol Action Pathway
Bromodiphenhydramine H1-Antihistamine Action
Brompheniramine H1-Antihistamine Action
Buclizine H1-Antihistamine Action
Bupranolol Action Pathway
Carbinoxamine H1-Antihistamine Action
Carteolol Action Pathway
Carvedilol Action Pathway
Cetirizine H1-Antihistamine Action
Chlorcyclizine H1-Antihistamine Action
Chloropyramine H1-Antihistamine Action
Chlorphenamine H1-Antihistamine Action
Chlorphenoxamine H1-Antihistamine Action
Cinnarizine H1-Antihistamine Action
Clemastine H1-Antihistamine Action
Clocinizine H1-Antihistamine Action
Cyclizine H1-Antihistamine Action
Cyproheptadine H1-Antihistamine Action
Deptropine H1-Antihistamine Action
Desloratadine H1-Antihistamine Action
Dexbrompheniramine H1-Antihistamine Action
Dexchlorpheniramine H1-Antihistamine Action
Diltiazem Action Pathway
Dimetindene H1-Antihistamine Action
Diphenhydramine H1-Antihistamine Action
Diphenylpyraline H1-Antihistamine Action
Disopyramide Action Pathway
Dobutamine Action Pathway
Doxepin H1-Antihistamine Action
Doxylamine H1-Antihistamine Action
Ebastine H1-Antihistamine Action
Embramine H1-Antihistamine Action
Emedastine H1-Antihistamine Action
Epinastine H1-Antihistamine Action
Epinephrine Action Pathway
Esmolol Action Pathway
Felodipine Action Pathway
Fenethazine H1-Antihistamine Action
Fexofenadine H1-Antihistamine Action
Flecainide Action Pathway
Flunarizine H1-Antihistamine Action
Fosphenytoin (Antiarrhythmic) Action Pathway
Histamine H1 Receptor Activation
Histapyrrodine H1-Antihistamine Action
Homochlorcyclizine H1-Antihistamine Action
Hydroxyethylpromethazine H1-Antihistamine Action
Hydroxyzine H1-Antihistamine Action
Ibutilide Action Pathway
Isoprenaline Action Pathway
Isothipendyl H1-Antihistamine Action
Isradipine Action Pathway
Ketotifen H1-Antihistamine Action
Labetalol Action Pathway
Latrepirdine H1-Antihistamine Action
Levobunolol Action Pathway
Levocabastine H1-Antihistamine Action
Levocetirizine H1-Antihistamine Action
Lidocaine (Antiarrhythmic) Action Pathway
Loratadine H1-Antihistamine Action
Lysophosphatidic Acid LPA1 Signalling
Lysophosphatidic Acid LPA2 Signalling
Lysophosphatidic Acid LPA3 Signalling
Lysophosphatidic Acid LPA4 Signalling
Lysophosphatidic Acid LPA5 Signalling
Mebhydrolin H1-Antihistamine Action
Meclizine H1-Antihistamine Action
Mepyramine H1-Antihistamine Action
Mequitazine H1-Antihistamine Action
Methapyrilene H1-Antihistamine Action
Methdilazine H1-Antihistamine Action
Metipranolol Action Pathway
Metoprolol Action Pathway
Mexiletine Action Pathway
Mirtazapine H1-Antihistamine Action
Mizolastine H1-Antihistamine Action
Muscle/Heart Contraction
Nadolol Action Pathway
Nebivolol Action Pathway
Nifedipine Action Pathway
Nimodipine Action Pathway
Nisoldipine Action Pathway
Nitrendipine Action Pathway
Olopatadine H1-Antihistamine Action
Orphenadrine H1-Antihistamine Action
Oxatomide H1-Antihistamine Action
Oxomemazine H1-Antihistamine Action
Oxprenolol Action Pathway
Penbutolol Action Pathway
Phenbenzamine H1-Antihistamine Action
Phenindamine H1-Antihistamine Action
Pheniramine H1-Antihistamine Action
Phenyltoloxamine H1-Antihistamine Action
Phenytoin (Antiarrhythmic) Action Pathway
Pimethixene H1-Antihistamine Action
Pindolol Action Pathway
Practolol Action Pathway
Procainamide (Antiarrhythmic) Action Pathway
Promethazine H1-Antihistamine Action
Propiomazine H1-Antihistamine Action
Propranolol Action Pathway
Pyrrobutamine H1-Antihistamine Action
Quetiapine H1-Antihistamine Action
Quifenadine H1-Antihistamine Action
Quinidine Action Pathway
Rupatadine H1-Antihistamine Action
Sotalol Action Pathway
Talastine H1-Antihistamine Action
Temelastine H1-Antihistamine Action
Terfenadine H1-Antihistamine Action
Thenalidine H1-Antihistamine Action
Thenyldiamine H1-Antihistamine Action
Thiazinamium H1-Antihistamine Action
Thonzylamine H1-Antihistamine Action
Timolol Action Pathway
Tocainide Action Pathway
Tolpropamine H1-Antihistamine Action
Tripelennamine H1-Antihistamine Action
Triprolidine H1-Antihistamine Action
Tritoqualine H1-Antihistamine Action
Verapamil Action Pathway

Reactions

Not Available

GO Classification

Component
membrane
cell part
endoplasmic reticulum
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
Function
intracellular ligand-gated ion channel activity
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
cation channel activity
calcium channel activity
ligand-gated ion channel activity
Process
di-, tri-valent inorganic cation transport
divalent metal ion transport
calcium ion transport
establishment of localization
transport
transmembrane transport
ion transport
cation transport

Cellular Location

Endoplasmic reticulum membrane
Multi-pass membrane protein

Gene Properties

Chromosome Location

Chromosome:3

Locus

3p26.1

SNPs

ITPR1

Gene Sequence

>8088 bp
ATGTCTGACAAAATGTCTAGCTTCCTACATATTGGAGACATTTGTTCTCTGTACGCGGAG
GGATCGACAAATGGATTTATTAGCACCTTGGGCCTGGTTGATGATCGTTGTGTTGTACAG
CCAGAAACCGGGGACCTTAACAATCCACCTAAGAAATTCAGAGACTGCCTCTTTAAGCTA
TGTCCCATGAACCGCTACTCTGCCCAAAAGCAGTTCTGGAAAGCCGCTAAGCCTGGGGCC
AACAGCACCACAGACGCAGTGCTACTCAACAAACTGCACCACGCTGCAGACTTGGAAAAG
AAGCAGAATGAGACAGAAAACAGGAAATTGCTGGGGACCGTAATCCAGTATGGCAATGTG
ATCCAGCTCCTGCATTTGAAAAGTAATAAATACCTAACAGTGAATAAGAGGCTTCCTGCT
CTGTTGGAGAAGAATGCCATGAGAGTCACATTGGACGAGGCTGGAAATGAAGGGTCCTGG
TTTTATATTCAGCCATTCTACAAGCTGCGATCCATTGGAGACAGCGTGGTCATAGGTGAC
AAGGTGGTTCTGAACCCCGTCAATGCTGGTCAGCCCCTACATGCTAGCAGCCATCAACTG
GTAGATAACCCAGGCTGCAATGAGGTCAATTCCGTCAACTGCAATACAAGCTGGAAAATA
GTCCTTTTCATGAAATGGAGTGATAACAAAGACGACATATTAAAGGGGGGTGACGTGGTG
AGGCTGTTTCATGCTGAGCAGGAGAAGTTTCTCACCTGTGACGAACACAGGAAGAAGCAG
CACGTCTTCCTGAGAACCACGGGCCGGCAGTCGGCCACATCTGCCACCAGTTCAAAAGCC
CTGTGGGAGGTGGAGGTGGTCCAGCATGACCCATGTCGGGGCGGAGCAGGGTATTGGAAC
AGCCTTTTCCGTTTCAAGCATCTGGCCACGGGGCATTACTTGGCAGCAGAGGTGGACCCT
GATCAGGACGCCTCTCGAAGTAGGTTGCGGAATGCCCAAGAAAAGATGGTATACTCCCTG
GTCTCTGTGCCTGAAGGCAATGACATCTCCTCCATTTTCGAGCTAGATCCCACCACTCTG
CGTGGAGGTGACAGCCTTGTCCCAAGGAACTCTTATGTTCGGCTCAGACACCTATGTACT
AATACCTGGGTTCACAGCACAAATATTCCTATTGACAAGGAAGAAGAAAAGCCCGTGATG
CTGAAAATTGGCACCTCTCCTGTGAAGGAGGATAAGGAAGCATTTGCCATAGTTCCGGTT
TCTCCTGCTGAAGTTCGGGACCTGGACTTTGCCAATGATGCCAGCAAGGTGCTGGGCTCC
ATTGCTGGGAAGCTAGAGAAGGGCACCATCACCCAGAATGAAAGGAGGTCTGTAACCAAG
CTGCTAGAAGATTTGGTTTACTTCGTCACTGGTGGAACTAATTCTGGTCAAGATGTTCTC
GAAGTTGTCTTCTCCAAGCCCAACAGAGAACGGCAGAAACTGATGAGAGAACAGAATATT
CTCAAGCAGATCTTCAAGTTGTTACAAGCCCCATTCACAGACTGCGGTGATGGCCCAATG
CTTCGGCTGGAAGAGCTCGGGGACCAGCGGCACGCTCCTTTCAGACACATCTGCCGGCTC
TGCTACAGGGTGCTGAGACACTCGCAGCAAGACTACAGGAAGAACCAGGAGTATATAGCC
AAGCAGTTTGGCTTCATGCAGAAGCAGATTGGCTATGATGTGTTGGCTGAAGACACTATC
ACTGCCCTGCTCCACAATAATCGGAAACTCCTGGAAAAACACATTACCGCGGCAGAGATT
GACACATTTGTCAGCCTGGTGCGAAAGAACAGGGAGCCCAGATTCTTAGATTACCTCTCC
GACCTCTGTGTCTCCATGAACAAATCAATTCCAGTGACCCAGGAACTGATATGTAAAGCT
GTGCTGAACCCCACCAACGCTGACATCCTGATTGAGACCAAGTTGGTTCTTTCTCGTTTT
GAATTTGAAGGTGTCTCTTCCACTGGAGAGAATGCTCTGGAGGCAGGAGAAGACGAGGAA
GAGGTGTGGCTGTTTTGGAGGGACAGCAACAAAGAGATTCGCAGCAAGAGTGTGAGGGAA
TTGGCTCAGGATGCTAAAGAAGGGCAGAAGGAGGACCGAGACGTTCTCAGCTACTACAGA
TATCAGCTGAACCTCTTTGCGAGGATGTGTCTGGACCGCCAATACCTGGCCATCAACGAA
ATCTCAGGCCAGCTGGATGTCGATCTCATTCTCCGCTGCATGTCTGACGAGAACCTGCCC
TATGACCTCAGGGCGTCCTTCTGCCGCCTCATGCTTCACATGCATGTGGACCGAGATCCC
CAGGAACAAGTCACCCCCGTGAAATATGCCCGCCTCTGGTCGGAGATTCCCTCGGAGATC
GCCATTGACGACTATGATAGTAGTGGAGCTTCCAAAGATGAAATTAAGGAGAGATTTGCT
CAGACCATGGAGTTTGTGGAGGAGTATTTAAGAGATGTGGTTTGTCAGAGGTTCCCTTTC
TCTGATAAAGAGAAGAATAAGCTTACGTTTGAGGTTGTAAATTTAGCTAGGAATCTCATA
TACTTTGGTTTCTACAACTTCTCTGACCTTCTACGATTAACTAAGATCCTTCTGGCCATA
TTGGACTGTGTACATGTGACAACAATCTTCCCCATTAGCAAGATGGCGAAAGGAGAAGAG
AATAAAGGCAGTAACGTGATGAGATCTATTCATGGCGTGGGAGAGCTGATGACCCAGGTG
GTGCTCCGGGGAGGAGGCTTTTTGCCCATGACTCCCATGGCTGCTGCCCCTGAAGGCAAT
GTGAAGCAGGCAGAGCCTGAGAAGGAGGACATCATGGTCATGGACACCAAGCTGAAGATC
ATTGAGATACTCCAGTTTATTTTGAATGTGAGGTTGGATTATAGGATCTCCTGCCTCCTG
TGTATATTTAAGCGAGAGTTTGATGAAAGCAATTCCCAGACTTCAGAAACATCCTCCGGA
AACAGCAGCCAAGAAGGGCCAAGTAATGTACCAGGTGCTCTTGACTTTGAACACATTGAA
GAACAAGCAGAAGGCATCTTTGGAGGAAGTGAGGAGAACACCCCACTGGACTTGGATGAC
CACGGCGGCAGAACCTTTCTCCGTGTCCTGCTCCACTTGACGATGCATGACTACCCACCC
CTGGTGTCAGGGGCCCTGCAGCTCCTCTTCCGGCACTTCAGCCAGAGGCAGGAGGTGCTC
CAGGCCTTCAAACAGGTTCAACTGCTGGTTACCAGCCAAGATGTGGACAACTACAAACAG
ATCAAACAAGACTTGGATCAACTGAGGTCCATCGTGGAAAAGTCAGAGCTTTGGGTGTAC
AAAGGGCAGGGCCCCGATGAGACTATGGATGGTGCATCTGGAGAAAATGAACATAAGAAA
ACGGAGGAGGGAAATAACAAGCCACAAAAGCATGAAAGCACCAGCAGCTACAACTACAGA
GTGGTCAAAGAGATTTTGATTCGGCTTAGCAAACTCTGTGTTCAAGAGAGTGCCTCAGTG
AGAAAGAGCAGGAAGCAGCAACAGCGTCTGCTCCGGAACATGGGCGCGCACGCCGTGGTG
CTGGAGCTGCTGCAGATTCCCTATGAGAAGGCCGAAGATACCAAGATGCAAGAGATAATG
AGGTTGGCTCATGAATTTTTGCAGAATTTCTGCGCAGGCAACCAGCAGAATCAAGCTTTG
CTACATAAACACATAAACCTGTTTCTCAACCCAGGGATCCTGGAGGCAGTAACCATGCAG
CACATCTTCATGAACAATTTCCAGCTTTGCAGTGAGATCAACGAGAGAGTTGTTCAGCAC
TTCGTTCACTGCATAGAGACTCACGGTCGGAATGTCCAGTATATAAAGTTCTTACAGACA
ATTGTCAAGGCAGAAGGGAAATTTATTAAAAAATGCCAAGACATGGTTATGGCCGAGCTG
GTCAATTCGGGAGAGGATGTCCTCGTGTTCTACAACGACAGAGCCTCTTTCCAGACTCTG
ATCCAGATGATGCGGTCAGAACGGGATCGGATGGATGAGAACAGCCCTCTCATGTACCAC
ATCCACTTGGTCGAGCTCCTGGCTGTGTGCACGGAGGGTAAGAATGTCTACACAGAGATC
AAGTGCAACTCCCTGCTCCCGCTGGATGACATCGTTCGCGTGGTGACCCACGAGGACTGC
ATCCCTGAGGTTAAAATTGCATACATTAACTTCCTGAATCACTGCTATGTGGATACAGAG
GTGGAAATGAAGGAGATTTATACCAGCAATCACATGTGGAAATTGTTTGAGAATTTCCTT
GTAGACATCTGCAGGGCCTGTAACAACACTAGTGACAGGAAACATGCAGACTCGATTTTG
GAGAAGTATGTCACCGAAATCGTCATGAGTATTGTTACTACTTTCTTCAGCTCTCCCTTC
TCAGACCAGAGTACGACTTTGCAGACTCGCCAGCCTGTCTTTGTGCAACTGCTGCAAGGC
GTGTTCAGGGTTTACCACTGCAACTGGTTAATGCCAAGCCAAAAAGCCTCCGTGGAGAGC
TGTATTCGGGTGCTGTCTGATGTAGCCAAGAGCCGGGCCATTGCCATTCCCGTGGACCTG
GACAGCCAAGTCAACAACCTCTTTCTCAAGTCCCACAGCATTGTGCAGAAAACAGCCATG
AACTGGCGGCTCTCAGCCCGCAATGCCGCACGCAGGGACTCTGTTCTGGCAGCTTCCAGA
GACTACCGGAATATCATTGAGAGATTGCAGGACATCGTCTCCGCGCTGGAGGACCGTCTC
AGGCCCCTGGTGCAGGCAGAGTTATCTGTGCTCGTGGATGTTCTCCACAGACCCGAGCTG
CTTTTCCCAGAGAACACAGACGCCAGAAGGAAATGTGAAAGTGGCGGTTTCATTTGCAAG
TTAATAAAGCATACAAAACAGCTGCTAGAAGAAAATGAAGAGAAGCTCTGCATTAAGGTC
CTACAGACCCTGAGGGAAATGATGACCAAAGATAGAGGCTATGGAGAAAAGGGTGAGGCG
CTCAGGCAAGTTCTGGTCAACCGTTACTATGGAAACGTCAGACCTTCGGGACGAAGAGAG
AGCCTTACCAGCTTTGGCAATGGCCCACTGTCAGCAGGAGGACCCGGCAAGCCCGGGGGA
GGAGGGGGAGGTTCCGGATCCAGCTCTATGAGCAGGGGTGAGATGAGTCTGGCCGAGGTT
CAGTGTCACCTTGACAAGGAGGGGGCTTCCAATCTAGTTATCGACCTCATCATGAACGCA
TCCAGTGACCGAGTGTTCCATGAAAGCATTCTCCTGGCCATTGCCCTTCTGGAAGGAGGC
AACACCACCATCCAGCACTCCTTTTTCTGTCGCTTGACAGAAGATAAGAAGTCAGAGAAA
TTCTTTAAGGTGTTTTATGACCGGATGAAGGTGGCCCAGCAAGAAATCAAAGCAACAGTG
ACAGTGAACACCAGTGACTTGGGAAATAAAAAGAAAGACGATGAGGTAGACAGGGATGCC
CCATCACGGAAAAAAGCTAAAGAGCCCACAACACAGATAACAGAAGAGGTCCGGGATCAG
CTCCTGGAGGCCTCCGCTGCCACCAGGAAAGCCTTCACCACTTTCAGGAGGGAGGCTGAT
CCCGACGACCACTACCAGCCTGGAGAGGGCACCCAGGCCACTGCCGACAAGGCCAAGGAC
GACCTGGAGATGAGCGCGGTCATCACCATCATGCAGCCCATCCTCCGCTTCCTTCAGCTC
CTGTGTGAAAACCACAACCGAGACCTGCAGAACTTCCTCCGTTGCCAAAATAACAAGACC
AACTACAATTTGGTATGTGAGACCCTGCAGTTTCTGGACTGTATTTGTGGAAGCACAACT
GGAGGCCTTGGTCTTCTGGGCTTGTATATAAATGAAAAGAACGTAGCGCTTATCAACCAA
ACCCTGGAAAGTCTGACCGAATACTGTCAAGGACCTTGCCATGAGAACCAGAACTGCATA
GCCACCCATGAATCCAATGGCATTGACATCATCACAGCCCTGATCCTCAATGATATCAAT
CCTTTGGGAAAGAAGAGGATGGACCTTGTGTTAGAACTGAAGAACAATGCCTCGAAGTTG
CTCCTGGCCATCATGGAAAGCAGGCACGACAGTGAAAACGCAGAGAGGATACTTTATAAC
ATGAGGCCCAAGGAACTGGTGGAAGTGATCAAGAAAGCCTACATGCAAGGTGAAGTGGAA
TTTGAGGATGGAGAAAACGGTGAGGATGGGGCGGCGTCCCCCAGGAACGTGGGGCACAAC
ATCTACATATTAGCCCATCAGTTGGCTCGGCATAACAAAGAACTTCAGAGCATGCTGAAA
CCTGGTGGCCAAGTGGACGGAGATGAAGCCCTGGAGTTTTATGCCAAGCACACGGCGCAG
ATAGAGATTGTCAGATTAGACCGAACAATGGAACAGATAGTCTTTCCCGTGCCCAGCATA
TGTGAATTCCTAACCAAGGAGTCAAAACTACGAATTTACTATACTACAGAGAGAGACGAA
CAAGGCAGCAAAATCAATGATTTCTTTCTGCGGTCTGAAGACCTCTTCAATGAAATGAAT
TGGCAGAAGAAACTGAGAGCCCAGCCCGTGTTGTACTGGTGTGCCCGCAACATGTCTTTC
TGGAGCAGCATTTCGTTTAACCTGGCCGTCCTGATGAACCTGCTGGTGGCGTTTTTCTAC
CCGTTTAAGGGAGTCCGAGGAGGAACCCTGGAGCCCCACTGGTCGGGACTCCTGTGGACA
GCCATGCTCATCTCTCTGGCCATCGTCATTGCCCTCCCCAAGCCCCATGGCATCCGGGCC
TTAATTGCCTCCACAATTCTACGACTGATATTTTCAGTCGGGTTACAACCCACGTTGTTT
CTTCTGGGCGCTTTCAATGTATGCAATAAAATCATCTTTCTAATGAGCTTTGTGGGCAAC
TGTGGGACATTCACAAGAGGCTACCGAGCCATGGTTCTGGATGTTGAGTTCCTCTATCAT
TTGTTGTATCTGGTGATCTGTGCCATGGGGCTCTTTGTCCATGAATTCTTCTACAGTCTG
CTGCTTTTTGATTTAGTGTACAGAGAAGAGACTTTGCTTAATGTCATTAAAAGTGTCACT
CGCAATGGACGGTCCATCATCCTGACAGCAGTTCTGGCTCTGATCCTCGTTTACCTGTTC
TCAATAGTGGGCTATCTTTTCTTCAAGGATGACTTTATCTTGGAAGTAGATAGGCTGCCC
AATGAAACAGCTGTTCCAGAAACCGGCGAGAGTTTGGCAAGCGAGTTCCTGTTCTCCGAT
GTGTGTAGGGTGGAGAGTGGGGAGAACTGCTCCTCTCCTGCACCCAGAGAAGAGCTGGTC
CCTGCAGAAGAGACGGAACAGGATAAAGAGCACACATGTGAGACGCTGCTGATGTGCATT
GTCACTGTGCTGAGTCACGGGCTGCGGAGCGGGGGTGGAGTAGGAGATGTACTCAGGAAG
CCGTCCAAAGAGGAACCCCTGTTTGCTGCTAGAGTTATTTATGACCTCTTGTTCTTCTTC
ATGGTCATCATCATTGTTCTTAACCTGATTTTTGGGGTTATCATTGACACTTTTGCTGAC
CTGAGGAGTGAGAAGCAGAAGAAGGAAGAGATCTTGAAGACCACGTGCTTTATCTGTGGC
TTGGAAAGAGACAAGTTTGACAACAAGACTGTCACCTTTGAAGAGCACATCAAGGAAGAA
CACAACATGTGGCACTATCTGTGCTTCATCGTCCTGGTGAAAGTAAAGGACTCCACCGAA
TATACTGGGCCTGAGAGTTACGTGGCAGAAATGATCAAGGAAAGAAACCTTGACTGGTTC
CCCAGGATGAGAGCCATGTCATTGGTCAGCAGTGATTCTGAAGGAGAACAGAATGAGCTG
AGAAACCTGCAGGAGAAGCTGGAGTCCACCATGAAACTTGTCACGAACCTTTCTGGCCAG
CTGTCGGAATTAAAGGATCAGATGACAGAACAAAGGAAGCAGAAACAAAGAATTGGTCTT
CTAGGACATCCTCCTCACATGAATGTCAACCCACAACAACCAGCATAA

Protein Properties

Number of Residues

2758

Molecular Weight

313942.4

Theoretical pI

5.91

Pfam Domain Function

MIR (PF02815 )
Ion_trans (PF00520 )
Ins145_P3_rec (PF08709 )
RIH_assoc (PF08454 )
RYDR_ITPR (PF01365 )

Signals

None

Transmembrane Regions

2283-2303
2315-2335
2362-2382
2406-2426
2449-2469
2578-2598

Protein Sequence

>Inositol 1,4,5-trisphosphate receptor type 1
MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKL
CPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNV
IQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD
KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVV
RLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWN
SLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMVYSLVSVPE
GNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGT
SPVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDL
VYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEE
LGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLH
NNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPT
NADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDA
KEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRA
SFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEF
VEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVH
VTTIFPISKMAKGEENKGNNDVEKLKSSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAA
PEGNVKQAEPEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSE
TSSGNSSQEGPSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMH
DYPPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSE
LWVYKGQGPDETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQE
SASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQ
NQALLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIK
FLQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSP
LMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCY
VDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFF
SSPFSDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAI
PVDLDSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSAL
EDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKL
CIKVLQTLREMMTKDRGYGEKLISIDELDNAELPPAPDSENSTEELEPSPPLRQLEDHKR
GEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGSGSSSMSRGEMSL
AEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKK
SEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEV
RDQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRF
LQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVAL
INQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILNDINPLGKKRMDLVLELKNNA
SKLLLAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEFEDGENGEDGAASPRNV
GHNIYILAHQLARHNKELQSMLKPGGQVDGDEALEFYAKHTAQIEIVRLDRTMEQIVFPV
PSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARN
MSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLISLAIVIALPKPHG
IRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEF
LYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILV
YLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSPAPRE
ELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLL
FFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHI
KEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRAMSLVSSDSEGEQ
NELRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPPHMNVNPQQPA

External Links

GenBank ID Protein

269954692

UniProtKB/Swiss-Prot ID

Q14643

UniProtKB/Swiss-Prot Entry Name

ITPR1_HUMAN

PDB IDs

1N4K

GenBank Gene ID

Not Available

GeneCard ID

ITPR1

GenAtlas ID

ITPR1

HGNC ID

HGNC:6180

References

General References

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