Human Metabolome Database: Showing Protein Anoctamin-8 (HMDBP07446)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 metabolites

Identification
HMDB Protein ID	HMDBP07446
Secondary Accession Numbers	13154
Name	Anoctamin-8
Synonyms	Transmembrane protein 16H
Gene Name	ANO8
Protein Type	Unknown
Biological Properties
General Function	Cell cycle control, cell division, chromosome partitioning
Specific Function	May act as a calcium-activated chloride channel
Pathways	Not Available
Reactions	Not Available
GO Classification	Not Available
Cellular Location	Membrane Multi-pass membrane protein (Potential)
Gene Properties
Chromosome Location	Chromosome:1
Locus	19p13.11
SNPs	ANO8
Gene Sequence	>3699 bp ATGGCCGAGGCCGCCTCCGGCGCCGGGGGCACGTCCCTGGAGGGCGAGCGTGGCAAGAGG CCCCCGCCGGAGGGCGAGCCTGCAGCCCCGGCGTCCGGAGTTCTGGATAAGCTTTTCGGA AAGCGGCTCCTGCAGGCTGGTCGCTACCTGGTGTCCCACAAGGCGTGGATGAAGACGGTG CCTACAGAGAACTGCGACGTGCTGATGACCTTCCCAGACACGACCGATGACCACACGCTG CTATGGCTGCTGAACCACATCCGCGTGGGCATTCCCGAGCTCATCGTGCAAGTCCGCCAC CACCGCCACACGCGTGCCTACGCCTTCTTTGTCACCGCCACGTATGAGAGCCTACTCCGA GGGGCCGACGAGCTGGGTCTGCGCAAAGCAGTGAAGGCCGAGTTTGGCGGGGGCACCCGC GGCTTCTCCTGCGAGGAGGACTTTATCTATGAGAATGTGGAGAGCGAGCTACGCTTCTTC ACCTCCCAGGAACGCCAGAGCATCATCCGCTTCTGGCTGCAGAATTTGCGTGCCAAGCAG GGAGAAGCACTCCACAACGTGCGCTTCCTGGAGGACCAGCCAATCATCCCGGAGCTGGCA GCACGTGGGATCATCCAGCAGGTGTTCCCTGTCCACGAGCAGCGTATTCTGAACCGCCTC ATGAAGTCATGGGTGCAGGCCGTGTGTGAAAACCAGCCTCTAGATGACATCTGTGATTAC TTTGGTGTGAAAATTGCCATGTACTTCGCCTGGCTGGGCTTCTACACGTCGGCTATGGTA TACCCAGCTGTCTTCGGGTCTGTCCTGTACACATTCACAGAGGCTGATCAGACAAGCCGG GATGTTTCCTGCGTGGTCTTTGCCCTCTTCAACGTGATCTGGTCGACGCTGTTCCTAGAG GAATGGAAGCGGAGAGGGGCTGAGCTGGCATATAAGTGGGGGACGCTGGACTCACCTGGG GAAGCCGTGGAGGAGCCACGCCCCCAGTTCAGGGGCGTGCGACGTATCAGCCCCATCACG CGGGCCGAGGAGTTCTACTACCCGCCCTGGAAGCGGCTGCTCTTCCAGCTGCTTGTGAGC CTCCCCCTGTGCCTGGCGTGCCTCGTCTGTGTCTTCTTGCTCATGCTTGGCTGCTTCCAG CTGCAGGAGCTGGTGCTGAGCGTGAAGGGGTTGCCCCGTCTCGCCCGATTCCTGCCTAAG GTCATGCTGGCCCTGCTTGTCAGTGTGAGTGCCGAGGGCTACAAGAAGCTAGCCATCTGG CTCAATGACATGGAAAATTACCGGCTGGAGAGCGCCTATGAGAAGCACCTCATCATCAAA GTTGTCCTGTTCCAGTTTGTCAACTCGTACCTGAGCCTCTTCTACATCGGTTTCTACCTC AAGGACATGGAGCGCTTGAAAGAGATGCTGGCCACGCTGCTGATCACCCGCCAGTTCCTC CAGAACGTGCGCGAGGTCCTGCAGCCGCACCTGTACCGGCGCCTGGGCCGCGGCGAGCTG GGCCTGCGGGCCGTCTGGGAGCTGGCCCGAGCCCTGCTTGGCCTCCTGAGCCTCCGGCGC CCTGCGCCCCGCCGCCTCGAACCCCAGGCGGATGAGGGCGGGGGCGGCGGCAGCGGGGGC GGGGGCCGCAGGTGCCTCAGCGGGGGCTGCGGGGCGCCGGAGGAGGAGGAGGAGGCGGCG CTGGTGGAGCGGCGGCGGGCGGGGGAAGGCGGGGAGGAGGGGGACGGGCCTCCAGGGGGC AAGGAGGAGGACGAGGACGACGAGGAGGAGGAGGACGAGGAGGAAGAGGAGGACGAGGAG GAGGGCGAGGAAGGGGGCCTCCTGGACTGCGGGCTCCGGCTGAAGAAGGTCAGCTTCGCT GAGCGCGGCGCGGGGCGGCGTCGGCCCGGCCCAAGCCCGGAGGCCCTCCTGGAGGAAGGG AGCCCCACTATGGTGGAGAAGGGGCTGGAGCCGGGAGTGTTCACCCTGGCCGAGGAGGAC GACGAGGCGGAGGGGGCTCCCGGCAGCCCTGAACGGGAGCCCCCGGCCATCTTGTTCCGC CGGGCCGGGGGCGAGGGCCGAGACCAGGGGCCCGACGGGGGCCCGGACCCGGAACCCGGC TCCAACAGCGATTCGACCCGTAGGCAGAGACGGCAGAACCGGTCGTCTTGGATTGACCCG CCGGAGGAGGAACACTCGCCCCAGCTCACCCAGGCAGAGCTGGAGAGCTGTATGAAGAAG TACGAGGACACGTTCCAGGACTACCAGGAGATGTTCGTGCAGTTCGGCTACGTTGTGCTC TTCTCGTCCGCCTTCCCCCTGGCGGCGCTGTGCGCCCTGGTCAACAACCTCATTGAGATC CGCAGCGACGCCTTCAAGCTGTGCACCGGGCTGCAGCGGCCCTTCGGCCAGCGCGTGGAA AGCATCGGCCAGTGGCAGAAGGTGATGGAGGCCATGGGTGTCCTAGCGATTGTGGTCAAC TGCTACTTAATCGGCCAGTGCGGGCAGCTGCAGCGCCTCTTCCCCTGGCTGAGCCCGGAG GCAGCCATCGTGTCGGTGGTAGTGCTCGAGCACTTCGCTCTGCTCCTCAAGTACCTCATC CACGTGGCCATCCCCGATATCCCGGGCTGGGTGGCCGAGGAAATGGCCAAGCTGGAGTAC CAGCGCCGCGAGGCCTTTAAGAGACACGAGCGCCAGGCCCAGCATCGCTACCAGCAGCAG CAGCGCAGGCGGCGGGAGGAGGAGGAGCGACAGCGCCATGCAGAGCACCATGCCCGGCGG GAGCATGATTCTGGTGGCCGAGAGGAGGCGAGGGCCGAGGGCTCTGGGCTGGACCCTGCC ACCTCCTCCGAGAAGGCCTCTGCCAAGGCCAAGGGCAGCACTGCGGGTGGCCACGGGCCT GAACGGCCCAAGCGCCCAGGGTCCCTGCTGGCACCCAACAACGTCATGAAGTTGAAGCAG ATCATCCCACTGCAGGGCAAATTCCTCTCGTCAGGGGCCACATCCTCACTGGCTGCTGCA GGGGCCGGAGCCACCACCCGGCCTCCCCCTGCCCAGTCACCCACAGGCAGCGACACCCGC CTGCCTGCCTTCCTCAGCTTCAAGTTCCTCAAGTCACCCGAGACCCGGCGGGACTCTGAG CGCAGCCACTCACCGCCCAAAGCCTTCCATGCTGGCAAGCTCTTCCCCTTTGGTGGCACC CGGGCTGAGCCTGGGTCCAACGGGGCGGGCGGGCAGGCCCGGCCAGATGGGACCCCCAGC AGTGGCAGCAGCCGGGTTCAGAGGAGTGGGCCGGTGGACGAGGCCCTGGCTGAGGAGCTG GAAGCCCCCCGGCCCGAAGAGGAAGGCTCAGGGACAGCGCTGGCCCCCGTGGGCGCCCCT GCCCTCCGCACCCGCCGCAGCCGGAGCCCCGCGCCGCCGCCGCCAATGCCGCTGCCCCGG CCCCCGACACCGCCCGCAGGCTGCTGGCAGTGGGACGGGCCCTGGGGCTGCGGGGGCGAG GGTGCCGCCCCCCGCCAGGCCCTGGCCGCTGCCGAGTGCCCACCCTGTGCCATGGCCGGG CCCCCACCCGCCCCCCAGCCCCTGCCGGGAGACGCCAGCTTTTACAGCCTCCCGCCCCCA CCGCTACCGCCCACCTCGGATCCCCTCGAGACCCCAGCGCCCTCCCCTAGCCCCAGCCCC AGCCCCCAGGCCGTGTGCTGGCCCAGCGGCTGGCATTAG
Protein Properties
Number of Residues	1232
Molecular Weight	136033.0
Theoretical pI	5.6
Pfam Domain Function	DUF590 (PF04547 )
Signals	None
Transmembrane Regions	245-265 282-302 357-377 401-421 438-458 751-771 808-828 842-862
Protein Sequence	>Anoctamin-8 MAEAASGAGGTSLEGERGKRPPPEGEPAAPASGVLDKLFGKRLLQAGRYLVSHKAWMKTV PTENCDVLMTFPDTTDDHTLLWLLNHIRVGIPELIVQVRHHRHTRAYAFFVTATYESLLR GADELGLRKAVKAEFGGGTRGFSCEEDFIYENVESELRFFTSQERQSIIRFWLQNLRAKQ GEALHNVRFLEDQPIIPELAARGIIQQVFPVHEQRILNRLMKSWVQAVCENQPLDDICDY FGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEADQTSRDVSCVVFALFNVIWSTLFLE EWKRRGAELAYKWGTLDSPGEAVEEPRPQFRGVRRISPITRAEEFYYPPWKRLLFQLLVS LPLCLACLVCVFLLMLGCFQLQELVLSVKGLPRLARFLPKVMLALLVSVSAEGYKKLAIW LNDMENYRLESAYEKHLIIKVVLFQFVNSYLSLFYIGFYLKDMERLKEMLATLLITRQFL QNVREVLQPHLYRRLGRGELGLRAVWELARALLGLLSLRRPAPRRLEPQADEGGGGGSGG GGRRCLSGGCGAPEEEEEAALVERRRAGEGGEEGDGPPGGKEEDEDDEEEEDEEEEEDEE EGEEGGLLDCGLRLKKVSFAERGAGRRRPGPSPEALLEEGSPTMVEKGLEPGVFTLAEED DEAEGAPGSPEREPPAILFRRAGGEGRDQGPDGGPDPEPGSNSDSTRRQRRQNRSSWIDP PEEEHSPQLTQAELESCMKKYEDTFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEI RSDAFKLCTGLQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWLSPE AAIVSVVVLEHFALLLKYLIHVAIPDIPGWVAEEMAKLEYQRREAFKRHERQAQHRYQQQ QRRRREEEERQRHAEHHARREHDSGGREEARAEGSGLDPATSSEKASAKAKGSTAGGHGP ERPKRPGSLLAPNNVMKLKQIIPLQGKFLSSGATSSLAAAGAGATTRPPPAQSPTGSDTR LPAFLSFKFLKSPETRRDSERSHSPPKAFHAGKLFPFGGTRAEPGSNGAGGQARPDGTPS SGSSRVQRSGPVDEALAEELEAPRPEEEGSGTALAPVGAPALRTRRSRSPAPPPPMPLPR PPTPPAGCWQWDGPWGCGGEGAAPRQALAAAECPPCAMAGPPPAPQPLPGDASFYSLPPP PLPPTSDPLETPAPSPSPSPSPQAVCWPSGWH
External Links
GenBank ID Protein	55741655
UniProtKB/Swiss-Prot ID	Q9HCE9
UniProtKB/Swiss-Prot Entry Name	ANO8_HUMAN
PDB IDs	Not Available
GenBank Gene ID	NM_020959.2
GeneCard ID	ANO8
GenAtlas ID	Not Available
HGNC ID	Not Available
References
General References	Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. DNA Res. 2002 Jun 30;9(3):99-106. [PubMed:12168954 ] Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM: The DNA sequence and biology of human chromosome 19. Nature. 2004 Apr 1;428(6982):529-35. [PubMed:15057824 ] Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O: Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 2000 Aug 31;7(4):273-81. [PubMed:10997877 ] Yang YD, Cho H, Koo JY, Tak MH, Cho Y, Shim WS, Park SP, Lee J, Lee B, Kim BM, Raouf R, Shin YK, Oh U: TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature. 2008 Oct 30;455(7217):1210-5. doi: 10.1038/nature07313. Epub 2008 Aug 24. [PubMed:18724360 ] Katoh M, Katoh M: Identification and characterization of TMEM16H gene in silico. Int J Mol Med. 2005 Feb;15(2):353-8. [PubMed:15647853 ]