| Identification |
|---|
| HMDB Protein ID
| HMDBP07655 |
| Secondary Accession Numbers
| |
| Name
| Desmocollin-1 |
| Synonyms
|
- Cadherin family member 1
- DG2/DG3
- Desmosomal glycoprotein 2/3
|
| Gene Name
| DSC1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| membrane |
| cell part |
| membrane part |
| plasma membrane |
| intrinsic to membrane |
| integral to membrane |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
- Cell junction
- desmosome
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 18q12.2|18q12.1 |
| SNPs
| DSC1 |
| Gene Sequence
|
>2685 bp
ATGGCTCTGGCCTCTGCTGCCCCAGGGAGCATCTTCTGTAAGCAGCTCCTTTTCTCTCTC
CTGGTTTTAACATTACTTTGCGATGCTTGTCAGAAAGTTTATCTTCGAGTTCCTTCTCAT
CTTCAGGCTGAAACACTTGTAGGCAAAGTGAATCTGGAGGAGTGTCTCAAGTCGGCCAGC
CTAATCCGGTCCAGTGACCCTGCCTTCAGAATTCTAGAAGATGGCTCAATTTACACAACA
CATGACCTCATTTTGTCTTCTGAAAGGAAAAGTTTTTCCATTTTCCTTTCAGATGGTCAG
AGACGGGAACAACAAGAGATAAAAGTTGTACTGTCAGCAAGAGAAAACAAGTCTCCTAAG
AAGAGACATACCAAAGACACAGCCCTCAAGCGCAGCAAGAGACGATGGGCTCCTATTCCA
GCTTCATTGATGGAGAACTCGTTGGGTCCATTTCCACAACACGTTCAGCAGATCCAATCT
GATGCTGCACAGAATTACACCATCTTTTATTCCATAAGTGGGCCAGGCGTGGACAAAGAA
CCCTTCAATTTGTTTTACATAGAGAAAGACACTGGGGATATCTTTTGTACAAGGAGCATT
GACCGTGAGAAATACGAACAGTTTGCGTTATATGGCTATGCAACAACTGCAGATGGCTAT
GCACCAGAATATCCACTCCCTTTGATCATCAAAATTGAAGATGATAATGATAACGCCCCA
TATTTTGAACACAGAGTGACTATCTTTACTGTGCCTGAAAATTGCCGATCCGGAACTTCA
GTGGGAAAAGTGACCGCCACAGACCTTGACGAACCTGACACTCTCCATACTCGTCTGAAA
TATAAAATCTTACAACAAATCCCAGATCATCCAAAGCATTTCTCCATACACCCAGATACC
GGTGTCATCACCACAACTACACCTTTTCTGGATAGAGAAAAATGTGATACTTACCAGTTA
ATAATGGAAGTGCGAGACATGGGTGGTCAGCCTTTCGGTTTATTTAATACAGGAACAATT
ACTATTTCACTTGAGGATGAAAATGACAATCCACCATCTTTCACAGAAACTTCTTATGTT
ACAGAAGTAGAAGAAAACAGAATTGACGTGGAGATTTTGCGAATGAAGGTACAGGATCAG
GATTTGCCAAACACTCCTCACTCAAAGGCTGTATACAAAATCTTACAAGGAAATGAAAAT
GGAAACTTCATAATTAGCACAGATCCAAATACAAATGAAGGAGTGCTGTGTGTTGTCAAG
CCATTGAACTATGAAGTCAATCGCCAAGTTATTTTGCAAGTTGGTGTCATTAACGAGGCA
CAATTCTCTAAAGCAGCGAGCTCACAAACTCCTACAATGTGCACTACAACTGTCACCGTT
AAAATTATAGACAGTGATGAGGGCCCTGAATGCCACCCTCCAGTGAAAGTTATTCAGAGT
CAAGATGGCTTCCCAGCTGGCCAAGAACTCCTTGGATACAAAGCACTGGACCCGGAAATA
TCCAGTGGTGAAGGCTTAAGGTATCAGAAGTTAGGGGATGAAGATAACTGGTTTGAAATT
AATCAACACACTGGCGACTTGAGAACTCTAAAAGTACTAGATAGAGAATCCAAATTTGTA
AAAAACAACCAATACAATATTTCAGTTGTTGCAGTGGATGCAGTTGGCCGATCTTGCACT
GGAACATTAGTAGTTCATTTGGATGATTACAACGATCACGCACCTCAAATTGACAAAGAA
GTGACCATTTGTCAGAATAATGAGGATTTTGCTGTTCTGAAACCTGTAGATCCAGATGGA
CCTGAAAATGGACCACCTTTTCAATTCTTTCTGGATAATTCTGCCAGTAAAAACTGGAAC
ATAGAAGAAAAGGATGGTAAAACTGCCATTCTTCGTCAACGGCAAAATCTTGATTATAAC
TATTATTCTGTGCCTATTCAAATAAAAGACAGGCATGGTTTAGTTGCAACACATATGTTA
ACAGTGAGAGTATGTGACTGTTCAACTCCATCTGAGTGTAGAATGAAGGATAAAAGTACA
AGAGACGTTAGACCAAATGTAATACTTGGAAGATGGGCTATTCTTGCTATGGTGTTGGGT
TCTGTATTGTTATTATGTATTCTGTTTACATGTTTCTGTGTCACTGCTAAGAGAACAGTC
AAGAAATGTTTTCCAGAAGACATAGCCCAGCAAAATTTAATTGTATCAAATACTGAAGGA
CCTGGAGAAGAAGTAACGGAAGCAAATATTAGACTCCCCATGCAGACATCCAACATTTGT
GACACAAGCATGTCTGTTGGTACTGTTGGTGGCCAGGGAATCAAAACACAGCAAAGTTTT
GAGATGGTCAAAGGAGGCTACACTTTGGATTCCAACAAAGGAGGTGGACATCAGACCTTG
GAGTCCGTCAAGGGAGTGGGGCAGGGAGATACTGGCAGATATGCGTACACGGACTGGCAG
AGTTTCACCCAACCTCGGCTTGGCGAAAAGGTGTATTTGTGTGGACAAGATGAGGAGCAT
AAACATTGTGAAGACTACGTTTGTTCGTATAACTATGAAGGCAAAGGTTCTCTGGCCGGC
TCAGTAGGTTGCTGCAGCGATCGGCAGGAAGAAGAGGGACTGGAGTTTCTAGATCACCTG
GAACCCAAATTTAGGACATTAGCAAAGACATGCATCAAGAAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 894 |
| Molecular Weight
| 99986.1 |
| Theoretical pI
| 5.08 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Desmocollin-1
MALASAAPGSIFCKQLLFSLLVLTLLCDACQKVYLRVPSHLQAETLVGKVNLEECLKSAS
LIRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSARENKSPK
KRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKE
PFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAP
YFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDT
GVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYV
TEVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVK
PLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQS
QDGFPAGQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFV
KNNQYNISVVAVDAVGRSCTGTLVVHLDDYNDHAPQIDKEVTICQNNEDFAVLKPVDPDG
PENGPPFQFFLDNSASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRHGLVATHML
TVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFCVTAKRTV
KKCFPEDIAQQNLIVSNTEGPGEEVTEANIRLPMQTSNICDTSMSVGTVGGQGIKTQQSF
EMVKGGYTLDSNKGGGHQTLESVKGVGQGDTGRYAYTDWQSFTQPRLGEKVYLCGQDEEH
KHCEDYVCSYNYEGKGSLAGSVGCCSDRQEEEGLEFLDHLEPKFRTLAKTCIKK
|
| External Links |
|---|
| GenBank ID Protein
| 10801202 |
| UniProtKB/Swiss-Prot ID
| Q08554 |
| UniProtKB/Swiss-Prot Entry Name
| DSC1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF293358 |
| GeneCard ID
| DSC1 |
| GenAtlas ID
| DSC1 |
| HGNC ID
| HGNC:3035 |
| References |
|---|
| General References
| - Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. J Proteome Res. 2007 Nov;6(11):4150-62. Epub 2007 Oct 9. [PubMed:17924679 ]
- Giorgianni F, Zhao Y, Desiderio DM, Beranova-Giorgianni S: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line. Electrophoresis. 2007 Jun;28(12):2027-34. [PubMed:17487921 ]
- Theis DG, Koch PJ, Franke WW: Differential synthesis of type 1 and type 2 desmocollin mRNAs in human stratified epithelia. Int J Dev Biol. 1993 Mar;37(1):101-10. [PubMed:8507556 ]
- King IA, Arnemann J, Spurr NK, Buxton RS: Cloning of the cDNA (DSC1) coding for human type 1 desmocollin and its assignment to chromosome 18. Genomics. 1993 Nov;18(2):185-94. [PubMed:8288219 ]
- Whittock NV, Hunt DM, Rickman L, Malhi S, Vogazianou AP, Dawson LF, Eady RA, Buxton RS, McGrath JA: Genomic organization and amplification of the human desmosomal cadherin genes DSC1 and DSC3, encoding desmocollin types 1 and 3. Biochem Biophys Res Commun. 2000 Sep 24;276(2):454-60. [PubMed:11027496 ]
- King IA, Magee AI, Rees DA, Buxton RS: Keratinization is associated with the expression of a new protein related to the desmosomal cadherins DGII/III. FEBS Lett. 1991 Jul 29;286(1-2):9-12. [PubMed:1713860 ]
|
