| Identification |
|---|
| HMDB Protein ID
| HMDBP07724 |
| Secondary Accession Numbers
| |
| Name
| Guanylyl cyclase-activating protein 3 |
| Synonyms
|
- GCAP 3
- Guanylate cyclase activator 1C
|
| Gene Name
| GUCA1C |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)- sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3q13.1 |
| SNPs
| GUCA1C |
| Gene Sequence
|
>630 bp
ATGGGGAATGGCAAATCTATAGCTGGTGATCAGAAAGCAGTTCCTACACAAGAGACCCAT
GTGTGGTACAGAACATTTATGATGGAATATCCATCCGGCCTGCAAACACTACATGAATTT
AAGACACTTTTGGGTCTGCAAGGTCTGAATCAGAAGGCCAATAAACATATTGATCAAGTT
TATAATACCTTTGACACGAACAAGGATGGATTTGTTGACTTTTTGGAGTTTATTGCTGCT
GTAAATCTAATCATGCAAGAAAAAATGGAGCAAAAATTAAAATGGTATTTTAAGCTGTAT
GATGCTGATGGAAATGGTTCTATTGACAAAAATGAACTACTGGACATGTTCATGGCGGTA
CAAGCCCTCAATGGCCAGCAAACTCTGAGTCCTGAAGAATTCATCAACTTGGTGTTCCAT
AAGATCGATATAAACAATGATGGGGAATTGACTTTAGAAGAATTTATCAATGGCATGGCA
AAAGATCAGGATCTCCTGGAGATTGTTTACAAGAGCTTCGACTTCTCCAATGTGCTGAGA
GTAATCTGTAATGGGAAGCAGCCAGACATGGAGACAGACTCCTCCAAATCTCCTGACAAG
GCTGGTCTAGGGAAGGTGAAAATGAAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 209 |
| Molecular Weight
| 23822.0 |
| Theoretical pI
| 4.71 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Guanylyl cyclase-activating protein 3
MGNGKSIAGDQKAVPTQETHVWYRTFMMEYPSGLQTLHEFKTLLGLQGLNQKANKHIDQV
YNTFDTNKDGFVDFLEFIAAVNLIMQEKMEQKLKWYFKLYDADGNGSIDKNELLDMFMAV
QALNGQQTLSPEEFINLVFHKIDINNDGELTLEEFINGMAKDQDLLEIVYKSFDFSNVLR
VICNGKQPDMETDSSKSPDKAGLGKVKMK
|
| External Links |
|---|
| GenBank ID Protein
| 4406344 |
| UniProtKB/Swiss-Prot ID
| O95843 |
| UniProtKB/Swiss-Prot Entry Name
| GUC1C_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF110001 |
| GeneCard ID
| GUCA1C |
| GenAtlas ID
| GUCA1C |
| HGNC ID
| HGNC:4680 |
| References |
|---|
| General References
| - Haeseleer F, Sokal I, Li N, Pettenati M, Rao N, Bronson D, Wechter R, Baehr W, Palczewski K: Molecular characterization of a third member of the guanylyl cyclase-activating protein subfamily. J Biol Chem. 1999 Mar 5;274(10):6526-35. [PubMed:10037746 ]
- Stephen R, Palczewski K, Sousa MC: The crystal structure of GCAP3 suggests molecular mechanism of GCAP-linked cone dystrophies. J Mol Biol. 2006 Jun 2;359(2):266-75. Epub 2006 Apr 3. [PubMed:16626734 ]
|
