Human Metabolome Database: Showing Protein Relaxin receptor 2 (HMDBP08172)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP08172

Secondary Accession Numbers

13883

Name

Relaxin receptor 2

Synonyms

G-protein coupled receptor 106
G-protein coupled receptor affecting testicular descent
Leucine-rich repeat-containing G-protein coupled receptor 8
Relaxin family peptide receptor 2

Gene Name

RXFP2

Protein Type

Unknown

Biological Properties

General Function

Involved in G-protein coupled receptor protein signaling pathway

Specific Function

Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3)

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
membrane
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
binding
receptor activity
transmembrane receptor activity
protein binding
molecular transducer activity
signal transducer activity
g-protein coupled receptor activity
Process
biological regulation
regulation of biological process
regulation of cellular process
signal transduction
signaling
signaling pathway
cell surface receptor linked signaling pathway
g-protein coupled receptor protein signaling pathway

Cellular Location

Cell membrane
Multi-pass membrane protein

Gene Properties

Chromosome Location

Chromosome:1

Locus

13q13.1

SNPs

RXFP2

Gene Sequence

>2265 bp
ATGATTGTTTTTCTGGTTTTTAAACATCTCTTCAGCCTCAGATTGATTACAATGTTCTTT
CTACTTCATTTCATCGTTCTGATCAATGTCAAAGATTTTGCACTGACTCAAGGTAGCATG
ATCACTCCTTCATGCCAAAAAGGATATTTTCCCTGTGGGAATCTTACCAAGTGCTTACCC
CGAGCTTTTCACTGTGATGGCAAGGATGACTGTGGGAACGGGGCGGACGAAGAGAACTGT
GGTGACACTAGTGGATGGGCGACCATATTTGGCACAGTGCATGGAAATGCTAACAGCGTG
GCCTTAACACAGGAGTGCTTTCTAAAACAGTATCCACAATGCTGTGACTGCAAAGAAACT
GAATTGGAATGTGTAAATGGTGACTTAAAGTCTGTGCCGATGATTTCTAACAATGTGACA
TTACTGTCTCTTAAGAAAAACAAAATCCACAGTCTTCCAGATAAAGTTTTCATCAAATAC
ACAAAACTTAAAAAGATATTTCTTCAGCATAATTGCATTAGACACATATCCAGGAAAGCA
TTTTTTGGATTATGTAATCTGCAAATATTATATCTCAACCACAACTGCATCACAACCCTC
AGACCTGGAATATTCAAAGACTTACATCAGCTAACTTGGCTAATTCTAGATGACAATCCA
ATAACCAGAATTTCACAGCGCTTGTTTACGGGATTAAATTCCTTGTTTTTCCTGTCTATG
GTTAATAACTACTTAGAAGCTCTTCCCAAGCAGATGTGTGCCCAAATGCCTCAACTCAAC
TGGGTGGATTTGGAAGGCAATAGAATAAAGTATCTCACAAATTCTACGTTTCTGTCGTGC
GATTCGCTCACAGTGCTGTTTCTGCCTAGAAATCAAATTGGTTTTGTTCCAGAGAAGACA
TTTTCTTCATTAAAAAATTTAGGAGAACTGGATCTGTCTAGCAATACGATAACGGAGCTA
TCACCTCACCTTTTTAAAGACTTGAAGCTTCTACAAAAGCTGAACCTGTCATCCAATCCT
CTTATGTATCTTCACAAGAACCAGTTTGAAAGTCTTAAACAACTTCAGTCTCTAGACCTG
GAAAGGATAGAGATTCCAAATATAAACACACGAATGTTTCAACCCATGAAGAATCTTTCT
CACATTTATTTCAAAAACTTTCGATACTGCTCCTATGCTCCCCATGTCCGAATATGTATG
CCCTTGACGGACGGCATTTCTTCATTTGAGGACCTCTTGGCTAACAATATCCTCAGAATA
TTTGTCTGGGTTATAGCTTTCATTACCTGCTTTGGAAATCTTTTTGTCATTGGCATGAGA
TCTTTCATTAAAGCTGAAAATACAACTCACGCTATGTCCATCAAAATCCTTTGTTGTGCT
GATTGCCTGATGGGTGTTTACTTGTTCTTTGTTGGCATTTTCGATATAAAATACCGAGGG
CAGTATCAGAAGTATGCCTTGCTGTGGATGGAGAGCGTGCAGTGCCGCCTCATGGGGTTC
CTGGCCATGCTGTCCACCGAAGTCTCTGTTCTGCTACTGACCTACTTGACTTTGGAGAAG
TTCCTGGTCATTGTCTTCCCCTTCAGTAACATTCGACCTGGAAAACGGCAGACCTCAGTC
ATCCTCATTTGCATCTGGATGGCGGGATTTTTAATAGCTGTAATTCCATTTTGGAATAAG
GATTATTTTGGAAACTTTTATGGGAAAAATGGAGTATGTTTCCCACTTTATTATGACCAA
ACAGAAGATATTGGAAGCAAAGGGTATTCTCTTGGAATTTTCCTAGGTGTGAACTTGCTG
GCTTTTCTCATCATTGTGTTTTCCTATATTACTATGTTCTGTTCCATTCAAAAAACCGCC
TTGCAGACCACAGAAGTAAGGAATTGTTTTGGAAGAGAGGTGGCTGTTGCAAATCGTTTC
TTTTTTATAGTGTTCTCTGATGCCATCTGCTGGATTCCTGTATTTGTAGTTAAAATCCTT
TCCCTCTTCCGGGTGGAAATACCAGACACAATGACTTCCTGGATAGTGATTTTTTTCCTT
CCAGTTAACAGTGCTTTGAATCCAATCCTCTATACTCTCACAACCAACTTTTTTAAGGAC
AAGTTGAAACAGCTGCTGCACAAACATCAGAGGAAATCAATTTTCAAAATTAAAAAAAAA
AGTTTATCTACATCCATTGTGTGGATAGAGGACTCCTCTTCCCTGAAACTTGGGGTTTTG
AACAAAATAACACTTGGAGACAGTATAATGAAACCAGTTTCCTAG

Protein Properties

Number of Residues

754

Molecular Weight

86452.3

Theoretical pI

8.92

Pfam Domain Function

7tm_1 (PF00001 )
Ldl_recept_a (PF00057 )
LRR_1 (PF00560 )

Signals

None

Transmembrane Regions

417-437
456-476
496-518
538-558
593-613
640-660
671-691

Protein Sequence

>Relaxin receptor 2
MIVFLVFKHLFSLRLITMFFLLHFIVLINVKDFALTQGSMITPSCQKGYFPCGNLTKCLP
RAFHCDGKDDCGNGADEENCGDTSGWATIFGTVHGNANSVALTQECFLKQYPQCCDCKET
ELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKA
FFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSM
VNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKT
FSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDL
ERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRI
FVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRG
QYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRPGKRQTSV
ILICIWMAGFLIAVIPFWNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLL
AFLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKIL
SLFRVEIPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKLKQLLHKHQRKSIFKIKKK
SLSTSIVWIEDSSSLKLGVLNKITLGDSIMKPVS

External Links

GenBank ID Protein

18702460

UniProtKB/Swiss-Prot ID

Q8WXD0

UniProtKB/Swiss-Prot Entry Name

RXFP2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Dunham A, Matthews LH, Burton J, Ashurst JL, Howe KL, Ashcroft KJ, Beare DM, Burford DC, Hunt SE, Griffiths-Jones S, Jones MC, Keenan SJ, Oliver K, Scott CE, Ainscough R, Almeida JP, Ambrose KD, Andrews DT, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Bannerjee R, Barlow KF, Bates K, Beasley H, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burrill W, Carder C, Carter NP, Chapman JC, Clamp ME, Clark SY, Clarke G, Clee CM, Clegg SC, Cobley V, Collins JE, Corby N, Coville GJ, Deloukas P, Dhami P, Dunham I, Dunn M, Earthrowl ME, Ellington AG, Faulkner L, Frankish AG, Frankland J, French L, Garner P, Garnett J, Gilbert JG, Gilson CJ, Ghori J, Grafham DV, Gribble SM, Griffiths C, Hall RE, Hammond S, Harley JL, Hart EA, Heath PD, Howden PJ, Huckle EJ, Hunt PJ, Hunt AR, Johnson C, Johnson D, Kay M, Kimberley AM, King A, Laird GK, Langford CJ, Lawlor S, Leongamornlert DA, Lloyd DM, Lloyd C, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, McLaren SJ, McMurray A, Milne S, Moore MJ, Nickerson T, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter KM, Rice CM, Searle S, Sehra HK, Shownkeen R, Skuce CD, Smith M, Steward CA, Sycamore N, Tester J, Thomas DW, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Wilming L, Wray PW, Wright MW, Young L, Coulson A, Durbin R, Hubbard T, Sulston JE, Beck S, Bentley DR, Rogers J, Ross MT: The DNA sequence and analysis of human chromosome 13. Nature. 2004 Apr 1;428(6982):522-8. [PubMed:15057823 ]
Hsu SY, Nakabayashi K, Nishi S, Kumagai J, Kudo M, Sherwood OD, Hsueh AJ: Activation of orphan receptors by the hormone relaxin. Science. 2002 Jan 25;295(5555):671-4. [PubMed:11809971 ]
Gorlov IP, Kamat A, Bogatcheva NV, Jones E, Lamb DJ, Truong A, Bishop CE, McElreavey K, Agoulnik AI: Mutations of the GREAT gene cause cryptorchidism. Hum Mol Genet. 2002 Sep 15;11(19):2309-18. [PubMed:12217959 ]