Hmdb loader
Identification
HMDB Protein ID HMDBP10929
Secondary Accession Numbers
  • 17231
Name Solute carrier family 22 member 15
Synonyms
  1. Flipt 1
  2. Fly-like putative transporter 1
Gene Name SLC22A15
Protein Type Unknown
Biological Properties
General Function Involved in transporter activity
Specific Function Probably transports organic cations. Appears not to be the agmatine transporter
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
transporter activity
Process
establishment of localization
transport
transmembrane transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein (Potential)
Gene Properties
Chromosome Location Chromosome:1
Locus 1p13.1
SNPs SLC22A15
Gene Sequence
>1644 bp
ATGGAGGTGGAGGAGGCGTTCCAGGCGGTGGGGGAGATGGGCATCTACCAGATGTACTTG
TGCTTCCTGCTGGCCGTGCTGCTGCAGCTCTACGTGGCCACGGAGGCCATCCTCATTGCA
CTGGTTGGGGCCACGCCATCCTACCACTGGGACCTGGCAGAGCTCCTGCCAAATCAGAGC
CACGGTAACCAGTCAGCTGGTGAAGACCAGGCCTTTGGGGACTGGCTCCTGACAGCCAAC
GGCAGTGAGATCCATAAGCACGTGCATTTCAGCAGCAGCTTCACCTCCATCGCCTCGGAG
TGGTTTTTAATTGCCAACAGATCCTACAAAGTCAGTGCAGCAAGCTCTTTTTTCTTCAGT
GGTGTATTTGTTGGAGTTATCTCTTTTGGTCAGCTTTCAGATCGCTTCGGAAGGAAAAAA
GTCTATCTCACAGGTTTTGCTCTTGACATCTTATTTGCAATTGCAAATGGATTTTCCCCC
TCATATGAGTTCTTTGCAGTAACTCGCTTCCTGGTGGGCATGATGAATGGAGGGATGTCG
CTGGTGGCCTTTGTCTTGCTTAATGAATGTGTGGGCACCGCCTACTGGGCACTTGCAGGA
TCGATTGGCGGCCTGTTCTTTGCAGTTGGCATTGCCCAATATGCCCTGTTAGGATACTTC
ATCCGCTCCTGGAGGACCCTAGCCATTCTGGTTAACCTGCAGGGAACGGTGGTCTTTCTC
TTATCTTTATTCATTCCTGAATCACCTCGTTGGTTATACTCCCAGGGTCGACTGAGTGAG
GCTGAAGAGGCGCTGTACCTCATTGCCAAGAGGAACCGCAAACTCAAGTGCACGTTCTCA
CTAACACACCCAGCCAACAGGAGCTGCAGGGAGACTGGAAGTTTCCTGGATCTCTTTCGT
TACCGGGTCCTGTTAGGACACACTTTGATCCTGATGTTCATCTGGTTTGTGTGCAGCTTG
GTGTATTATGGCCTAACTCTGAGTGCGGGTGATCTAGGTGGAAGTATTTATGCCAACCTG
GCCCTGTCTGGCCTCATAGAGATTCCATCTTACCCTCTCTGTATCTACTTGATTAACCAA
AAATGGTTTGGTCGGAAGCGAACATTATCAGCATTTCTGTGCCTAGGAGGACTGGCTTGT
CTTATTGTAATGTTTCTTCCAGAAAAGAAAGACACAGGTGTGTTTGCAGTGGTGAACAGC
CATTCCTTGTCCTTGCTGGGGAAGCTGACCATCAGTGCTGCCTTTAACATTGTTTATATC
TACACCTCTGAGCTTTACCCTACAGTCATCAGGAATGTTGGGCTTGGAACTTGTTCCATG
TTCTCCCGAGTTGGTGGGATTATTGCTCCCTTCATCCCCTCACTGAAATATGTGCAATGG
TCTTTACCATTCATTGTCTTCGGAGCCACGGGTCTGACCTCCGGCCTCCTGAGTTTGTTA
TTGCCGGAGACCCTTAACAGTCCGCTGCTAGAAACATTCTCCGACCTTCAGGTGTATTCG
TATCGCAGGCTGGGAGAAGAAGCATTATCTTTACAGGCTTTGGACCCCCAACAGTGTGTG
GACAAGGAGAGCTCTTTAGGGAGTGAGAGTGAGGAAGAGGAAGAATTTTATGATGCAGAT
GAAGAGACTCAGATGATCAAGTGA
Protein Properties
Number of Residues 547
Molecular Weight 60539.5
Theoretical pI 5.29
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 22-42
  • 111-131
  • 141-161
  • 165-187
  • 201-221
  • 226-246
  • 303-323
  • 338-358
  • 368-388
  • 401-420
  • 433-453
  • 462-482
Protein Sequence
>Solute carrier family 22 member 15
MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYHWDLAELLPNQS
HGNQSAGEDQAFGDWLLTANGSEIHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFS
GVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMS
LVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFL
LSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLKCTFSLTHPANRSCRETGSFLDLFR
YRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQ
KWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYI
YTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLL
LPETLNSPLLETFSDLQVYSYRRLGEEALSLQALDPQQCVDKESSLGSESEEEEEFYDAD
EETQMIK
GenBank ID Protein 166197673
UniProtKB/Swiss-Prot ID Q8IZD6
UniProtKB/Swiss-Prot Entry Name S22AF_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_018420.2
GeneCard ID SLC22A15
GenAtlas ID SLC22A15
HGNC ID HGNC:20301
References
General References
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  3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  4. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [PubMed:12975309 ]
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