| Identification |
|---|
| HMDB Protein ID
| HMDBP12622 |
| Secondary Accession Numbers
| None |
| Name
| 16S rRNA (adenine(1408)-N(1))-methyltransferase |
| Synonyms
|
- 16S rRNA m1A1408 methyltransferase
- Kanamycin-apramycin resistance methylase
|
| Gene Name
| KAMB |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Specifically methylates the N(1) position of adenine 1408 in 16S rRNA. Confers resistance to various aminoglycosides, including kanamycin, neomycin and apramycin. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| response to antibiotic |
| Molecular Function |
| tRNA (guanine-N7-)-methyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 23663.79 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P25920 |
| UniProtKB/Swiss-Prot Entry Name
| KAMB_STRSD |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Holmes DJ, Drocourt D, Tiraby G, Cundliffe E: Cloning of an aminoglycoside-resistance-encoding gene, kamC, from Saccharopolyspora hirsuta: comparison with kamB from Streptomyces tenebrarius. Gene. 1991 Jun 15;102(1):19-26. doi: 10.1016/0378-1119(91)90532-g. [PubMed:1840536 ]
- Savic M, Lovric J, Tomic TI, Vasiljevic B, Conn GL: Determination of the target nucleosides for members of two families of 16S rRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics. Nucleic Acids Res. 2009 Sep;37(16):5420-31. doi: 10.1093/nar/gkp575. Epub 2009 Jul 9. [PubMed:19589804 ]
- Zelinskaya N, Rankin CR, Macmaster R, Savic M, Conn GL: Expression, purification and crystallization of adenosine 1408 aminoglycoside-resistance rRNA methyltransferases for structural studies. Protein Expr Purif. 2011 Jan;75(1):89-94. doi: 10.1016/j.pep.2010.07.005. Epub 2010 Jul 25. [PubMed:20667473 ]
- Macmaster R, Zelinskaya N, Savic M, Rankin CR, Conn GL: Structural insights into the function of aminoglycoside-resistance A1408 16S rRNA methyltransferases from antibiotic-producing and human pathogenic bacteria. Nucleic Acids Res. 2010 Nov;38(21):7791-9. doi: 10.1093/nar/gkq627. Epub 2010 Jul 17. [PubMed:20639535 ]
|
