| Identification |
|---|
| HMDB Protein ID
| HMDBP14475 |
| Secondary Accession Numbers
| None |
| Name
| Runt-related transcription factor 3 |
| Synonyms
|
- Acute myeloid leukemia 2 protein
- Core-binding factor subunit alpha-3
- Oncogene AML-2
- Polyomavirus enhancer-binding protein 2 alpha C subunit
- SL3-3 enhancer factor 1 alpha C subunit
- SL3/AKV core-binding factor alpha C subunit
- CBF-alpha-3
- PEA2-alpha C
- PEBP2-alpha C
|
| Gene Name
| RUNX3 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (By similarity). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation (PubMed:18258917). CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (PubMed:23481257). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| negative regulation of cell cycle |
| positive regulation of CD8-positive, alpha-beta T cell differentiation |
| chondrocyte differentiation |
| negative regulation of CD4-positive, alpha-beta T cell differentiation |
| positive regulation of extrinsic apoptotic signaling pathway |
| negative regulation of epithelial cell proliferation |
| neuron projection development |
| hemopoiesis |
| regulation of cell differentiation |
| regulation of transcription from RNA polymerase II promoter |
| cell maturation |
| positive regulation of transcription, DNA-dependent |
| axon guidance |
| negative regulation of transcription from RNA polymerase II promoter |
| positive regulation of transcription from RNA polymerase II promoter |
| protein phosphorylation |
| ossification |
| hair follicle morphogenesis |
| response to transforming growth factor beta |
| neuron differentiation |
| Cellular Component |
| cytosol |
| core-binding factor complex |
| cytoplasm |
| nucleolus |
| nucleus |
| nucleoplasm |
| chromatin |
| intracellular membrane-bounded organelle |
| Molecular Function |
| RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| histone deacetylase binding |
| ATP binding |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding |
| sequence-specific double-stranded DNA binding |
| DNA binding |
| SMAD binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 43517.2 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q64131 |
| UniProtKB/Swiss-Prot Entry Name
| RUNX3_MOUSE |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP: Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol. 2009 May 5;7(5):e1000112. doi: 10.1371/journal.pbio.1000112. Epub 2009 May 26. [PubMed:19468303 ]
- Yarmus M, Woolf E, Bernstein Y, Fainaru O, Negreanu V, Levanon D, Groner Y: Groucho/transducin-like Enhancer-of-split (TLE)-dependent and -independent transcriptional regulation by Runx3. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7384-9. doi: 10.1073/pnas.0602470103. Epub 2006 May 1. [PubMed:16651517 ]
- Wijmenga C, Speck NA, Dracopoli NC, Hofker MH, Liu P, Collins FS: Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35-pter. Genomics. 1995 Apr 10;26(3):611-4. doi: 10.1016/0888-7543(95)80185-o. [PubMed:7607690 ]
- Calabi F, Rhodes M, Williamson P, Boyd Y: Identification and chromosomal mapping of a third mouse runt-like locus. Genomics. 1995 Apr 10;26(3):607-10. doi: 10.1016/0888-7543(95)80184-n. [PubMed:7607689 ]
- Bangsow C, Rubins N, Glusman G, Bernstein Y, Negreanu V, Goldenberg D, Lotem J, Ben-Asher E, Lancet D, Levanon D, Groner Y: The RUNX3 gene--sequence, structure and regulated expression. Gene. 2001 Nov 28;279(2):221-32. doi: 10.1016/s0378-1119(01)00760-0. [PubMed:11733147 ]
- Setoguchi R, Tachibana M, Naoe Y, Muroi S, Akiyama K, Tezuka C, Okuda T, Taniuchi I: Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development. Science. 2008 Feb 8;319(5864):822-5. doi: 10.1126/science.1151844. [PubMed:18258917 ]
- Lazarevic V, Chen X, Shim JH, Hwang ES, Jang E, Bolm AN, Oukka M, Kuchroo VK, Glimcher LH: T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORgammat. Nat Immunol. 2011 Jan;12(1):96-104. doi: 10.1038/ni.1969. Epub 2010 Dec 12. [PubMed:21151104 ]
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