Showing metabocard for Uridine triphosphate (HMDB00285)

General function:

Involved in hydrolase activity

Specific function:

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.

Gene Name:

ENTPD1

Uniprot ID:

P49961

Molecular weight:

58706.0

Reactions

General function:

Involved in calcium ion binding

Specific function:

Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.

Gene Name:

CANT1

Uniprot ID:

Q8WVQ1

Molecular weight:

44839.24

General function:

Involved in hydrolase activity

Specific function:

Has a threefold preference for the hydrolysis of ATP over ADP.

Gene Name:

ENTPD3

Uniprot ID:

O75355

Molecular weight:

59104.76

Reactions

General function:

Involved in ATP binding

Specific function:

Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.

Gene Name:

UCK1

Uniprot ID:

Q9HA47

Molecular weight:

22760.43

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity).

Gene Name:

NME4

Uniprot ID:

O00746

Molecular weight:

20658.45

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.

Gene Name:

NME1

Uniprot ID:

P15531

Molecular weight:

17148.635

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

Gene Name:

NME7

Uniprot ID:

Q9Y5B8

Molecular weight:

42491.365

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.

Gene Name:

NME2

Uniprot ID:

P22392

Molecular weight:

30136.92

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.

Gene Name:

NME3

Uniprot ID:

Q13232

Molecular weight:

19014.85

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.

Gene Name:

NME6

Uniprot ID:

O75414

Molecular weight:

22002.965

Reactions

General function:

Involved in hydrolase activity

Specific function:

Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Gene Name:

ITPA

Uniprot ID:

Q9BY32

Molecular weight:

16833.23

Reactions

General function:

Involved in ATP binding

Specific function:

Not Available

Gene Name:

AK3

Uniprot ID:

Q9UIJ7

Molecular weight:

21013.93

Reactions

General function:

Involved in hydrolase activity

Specific function:

Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.

Gene Name:

NUDT2

Uniprot ID:

P50583

Molecular weight:

16829.09

Reactions

General function:

Involved in CTP synthase activity

Specific function:

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

Gene Name:

CTPS1

Uniprot ID:

P17812

Molecular weight:

66689.9

Reactions

General function:

Involved in 6-phosphofructokinase activity

Specific function:

Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP.

Gene Name:

PFKP

Uniprot ID:

Q01813

Molecular weight:

85595.405

Reactions

General function:

Involved in DNA binding

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Gene Name:

POLR3D

Uniprot ID:

P05423

Molecular weight:

Not Available

Reactions

General function:

Involved in DNA-directed RNA polymerase activity

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).

Gene Name:

POLR2B

Uniprot ID:

P30876

Molecular weight:

133895.435

Reactions

General function:

Involved in DNA binding

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Acts as a RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome.

Gene Name:

POLR2A

Uniprot ID:

P24928

Molecular weight:

217204.265

Reactions

General function:

Involved in DNA binding

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates.

Gene Name:

POLRMT

Uniprot ID:

O00411

Molecular weight:

138619.335

General function:

Involved in DNA-directed RNA polymerase activity

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).

Gene Name:

POLR1B

Uniprot ID:

Q9H9Y6

Molecular weight:

121987.24

Reactions

General function:

Involved in DNA-directed RNA polymerase activity

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Gene Name:

POLR3G

Uniprot ID:

O15318

Molecular weight:

Not Available

Reactions

General function:

Involved in DNA-directed RNA polymerase activity

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Gene Name:

POLR3B

Uniprot ID:

Q9NW08

Molecular weight:

121119.23

Reactions

General function:

Involved in DNA binding

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (By similarity).

Gene Name:

POLR1E

Uniprot ID:

Q9GZS1

Molecular weight:

47259.7

Reactions

General function:

Involved in 6-phosphofructokinase activity

Specific function:

Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP.

Gene Name:

PFKL

Uniprot ID:

P17858

Molecular weight:

85017.825

Reactions

General function:

Involved in DNA-directed RNA polymerase activity

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Gene Name:

POLR3H

Uniprot ID:

Q9Y535

Molecular weight:

Not Available

Reactions

General function:

Involved in DNA binding

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Gene Name:

POLR3K

Uniprot ID:

Q9Y2Y1

Molecular weight:

Not Available

Reactions

General function:

Involved in 6-phosphofructokinase activity

Specific function:

Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP.

Gene Name:

PFKM

Uniprot ID:

P08237

Molecular weight:

85181.925

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

Gene Name:

PKM

Uniprot ID:

P14618

Molecular weight:

65930.14

General function:

Involved in magnesium ion binding

Specific function:

Plays a key role in glycolysis (By similarity).

Gene Name:

PKLR

Uniprot ID:

P30613

Molecular weight:

61829.575

General function:

Involved in nucleotidyltransferase activity

Specific function:

Plays a central role as a glucosyl donor in cellular metabolic pathways.

Gene Name:

UGP2

Uniprot ID:

Q16851

Molecular weight:

55676.36

Reactions

General function:

Involved in nucleotidyltransferase activity

Specific function:

Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.

Gene Name:

UAP1

Uniprot ID:

Q16222

Molecular weight:

57027.91

Reactions

General function:

Involved in ATP binding

Specific function:

Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.

Gene Name:

UCK2

Uniprot ID:

Q9BZX2

Molecular weight:

29298.92

Reactions

General function:

Involved in hydrolase activity

Specific function:

This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).

Gene Name:

CAD

Uniprot ID:

P27708

Molecular weight:

242981.73

General function:

Involved in CTP synthase activity

Specific function:

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.

Gene Name:

CTPS2

Uniprot ID:

Q9NRF8

Molecular weight:

65677.005

Reactions

General function:

Involved in ATP binding

Specific function:

May contribute to UTP accumulation needed for blast transformation and proliferation.

Gene Name:

UCKL1

Uniprot ID:

Q9NWZ5

Molecular weight:

59465.77

Reactions

General function:

Involved in hydrolase activity

Specific function:

Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP.

Gene Name:

ENTPD8

Uniprot ID:

Q5MY95

Molecular weight:

53903.14

Reactions

General function:

Involved in DNA binding

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Gene Name:

POLR3A

Uniprot ID:

O14802

Molecular weight:

155640.155

Reactions

General function:

Involved in DNA binding

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).

Gene Name:

POLR1A

Uniprot ID:

O95602

Molecular weight:

194809.645

Reactions

General function:

Involved in nucleic acid binding

Specific function:

Not Available

Gene Name:

ZNRD1

Uniprot ID:

Q2L6J2

Molecular weight:

13903.6

General function:

Involved in DNA-directed RNA polymerase activity

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.

Gene Name:

POLR1D

Uniprot ID:

Q9Y2S0

Molecular weight:

11018.355

Reactions

General function:

Involved in DNA-directed RNA polymerase activity

Specific function:

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

Gene Name:

DKFZp686D10173

Uniprot ID:

Q7Z3R8

Molecular weight:

127818.1

General function:

Transcription

Specific function:

Not Available

Gene Name:

POLR3GL

Uniprot ID:

Q9BT43

Molecular weight:

Not Available

Reactions

General function:

Involved in DNA binding

Specific function:

Not Available

Gene Name:

POLR1C

Uniprot ID:

Q96HT3

Molecular weight:

38461.5

General function:

Not Available

Specific function:

Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity).

Gene Name:

NME5

Uniprot ID:

P56597

Molecular weight:

Not Available

Reactions

General function:

Not Available

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.

Gene Name:

ZNRD1

Uniprot ID:

Q9P1U0

Molecular weight:

Not Available

Reactions

General function:

Not Available

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.

Gene Name:

TWISTNB

Uniprot ID:

Q3B726

Molecular weight:

37432.025

Reactions

General function:

Not Available

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity).

Gene Name:

POLR2E

Uniprot ID:

P19388

Molecular weight:

24611.175

Reactions

General function:

Not Available

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and togther with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).

Gene Name:

POLR2F

Uniprot ID:

P61218

Molecular weight:

14477.92

Reactions

General function:

Not Available

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

Gene Name:

POLR2H

Uniprot ID:

P52434

Molecular weight:

17143.115

Reactions

General function:

Not Available

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.

Gene Name:

POLR2K

Uniprot ID:

P53803

Molecular weight:

7004.145

Reactions