Hmdb loader
Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2021-09-14 14:57:15 UTC
HMDB IDHMDB0000845
Secondary Accession Numbers
  • HMDB0000838
  • HMDB00838
  • HMDB00845
Metabolite Identification
Common NameNeopterin
DescriptionNeopterin, also known as monapterin, belongs to the class of organic compounds known as biopterins and derivatives. These are coenzymes containing a 2-amino-pteridine-4-one derivative and are mainly synthesized in several parts of the body, including the pineal gland. Neopterin is a solid that is soluble in water. Neopterin is a catabolic product of guanosine triphosphate (GTP). In humans, it is involved in pterine biosynthesis and it also serves as a precursor in the biosynthesis of biopterin, which is an essential cofactor in neurotransmitter synthesis. Neopterin has been identified as a uremic toxin according to the European Uremic Toxin Working Group (PMID: 22626821 ). Most uremic toxins are metabolic waste products and are normally excreted in the urine or feces. Uremic toxins can cause kidney, liver and heart damage. They can also cause changes in mental status, such as confusion, reduced awareness, agitation, psychosis, seizures, and coma. Uremic toxins such as neopterin are actively transported into the kidneys via organic ion transporters (especially OAT3). Elevated levels of neopterin result from immune system activation, including from malignant cancer, allograft rejection, viral infection, and autoimmune disorders (PMID: 19500901 ). Measurement of neopterin concentration allows estimation of the extent of oxidative stress elicited by the immune system. Neopterin concentrations usually correlate with the extent and activity of a given disease, and are also used to monitor the course of the disease. Elevated neopterin concentrations are among the best predictors of adverse outcome in patients with HIV infection, in cardiovascular disease, and in various types of cancer.
Structure
Data?1582752159
Synonyms
ValueSource
6-(D-erythro-1,2,3-Trihydroxypropyl)pterinHMDB
6-D-erythro-NeopterinHMDB
D-erythro-NeopterinHMDB
D-NeopterinHMDB
NeopterineHMDB
[S-(R*,s*)]-2-amino-6-(1,2,3-trihydroxypropyl)-1H-pteridin-4-ONHMDB
[S-(R*,s*)]-2-amino-6-(1,2,3-trihydroxypropyl)-1H-pteridin-4-oneHMDB
[S-(R*,s*)]-2-amino-6-(1,2,3-trihydroxypropyl)-1H-pteridine-4-oneHMDB
MonapterinMeSH, HMDB
Neopterin, (r*, r*)-isomerMeSH, HMDB
UmanopterinMeSH, HMDB
Neopterin, (erythro-D)-isomerMeSH, HMDB
2-amino-6-(1,2,3-Trihydroxypropyl)-4(3H)-pteridinoneMeSH, HMDB
Neopterin, (erythro-L)-isomerMeSH, HMDB
Neopterin, (threo-D)-isomerMeSH, HMDB
Neopterin, (threo-L)-isomerMeSH, HMDB
Chemical FormulaC9H11N5O4
Average Molecular Weight253.2147
Monoisotopic Molecular Weight253.081103865
IUPAC Name2-amino-6-(1,2,3-trihydroxypropyl)-3,4-dihydropteridin-4-one
Traditional Name2-amino-6-(1,2,3-trihydroxypropyl)-3H-pteridin-4-one
CAS Registry Number2009-64-5
SMILES
NC1=NC2=C(N=C(C=N2)C(O)C(O)CO)C(=O)N1
InChI Identifier
InChI=1S/C9H11N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h1,4,6,15-17H,2H2,(H3,10,11,13,14,18)
InChI KeyBMQYVXCPAOLZOK-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as biopterins and derivatives. These are coenzymes containing a 2-amino-pteridine-4-one derivative. They are mainly synthesized in several parts of the body, including the pineal gland.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPteridines and derivatives
Sub ClassPterins and derivatives
Direct ParentBiopterins and derivatives
Alternative Parents
Substituents
  • Biopterin
  • Aminopyrimidine
  • Pyrimidone
  • Pyrazine
  • Pyrimidine
  • Heteroaromatic compound
  • Vinylogous amide
  • Secondary alcohol
  • Polyol
  • Azacycle
  • Hydrocarbon derivative
  • Organic oxide
  • Organopnictogen compound
  • Primary amine
  • Primary alcohol
  • Alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Organic oxygen compound
  • Organic nitrogen compound
  • Amine
  • Aromatic alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Ontology
Physiological effectNot Available
Disposition
Biological locationSource
Process
Role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M-H]-Not Available150.307http://allccs.zhulab.cn/database/detail?ID=AllCCS00000332
[M+H]+Not Available157.304http://allccs.zhulab.cn/database/detail?ID=AllCCS00000332
Predicted Molecular Properties
PropertyValueSource
Water Solubility6.26 g/LALOGPS
logP-1.8ALOGPS
logP-2.8ChemAxon
logS-1.6ALOGPS
pKa (Strongest Acidic)9.99ChemAxon
pKa (Strongest Basic)-2.2ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area153.95 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity60.11 m³·mol⁻¹ChemAxon
Polarizability23.36 ųChemAxon
Number of Rings2ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+159.39431661259
DarkChem[M-H]-156.17631661259
AllCCS[M+H]+156.19632859911
AllCCS[M-H]-154.80232859911
DeepCCS[M+H]+154.13130932474
DeepCCS[M-H]-151.77330932474
DeepCCS[M-2H]-184.71530932474
DeepCCS[M+Na]+160.22430932474
AllCCS[M+H]+156.232859911
AllCCS[M+H-H2O]+152.532859911
AllCCS[M+NH4]+159.632859911
AllCCS[M+Na]+160.632859911
AllCCS[M-H]-154.832859911
AllCCS[M+Na-2H]-154.632859911
AllCCS[M+HCOO]-154.532859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
NeopterinNC1=NC2=C(N=C(C=N2)C(O)C(O)CO)C(=O)N13502.9Standard polar33892256
NeopterinNC1=NC2=C(N=C(C=N2)C(O)C(O)CO)C(=O)N12337.6Standard non polar33892256
NeopterinNC1=NC2=C(N=C(C=N2)C(O)C(O)CO)C(=O)N12989.9Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Neopterin,1TMS,isomer #1C[Si](C)(C)OC(C1=CN=C2N=C(N)[NH]C(=O)C2=N1)C(O)CO2689.3Semi standard non polar33892256
Neopterin,1TMS,isomer #2C[Si](C)(C)OC(CO)C(O)C1=CN=C2N=C(N)[NH]C(=O)C2=N12699.0Semi standard non polar33892256
Neopterin,1TMS,isomer #3C[Si](C)(C)OCC(O)C(O)C1=CN=C2N=C(N)[NH]C(=O)C2=N12684.1Semi standard non polar33892256
Neopterin,1TMS,isomer #4C[Si](C)(C)NC1=NC2=NC=C(C(O)C(O)CO)N=C2C(=O)[NH]12773.8Semi standard non polar33892256
Neopterin,1TMS,isomer #5C[Si](C)(C)N1C(N)=NC2=NC=C(C(O)C(O)CO)N=C2C1=O2728.9Semi standard non polar33892256
Neopterin,2TMS,isomer #1C[Si](C)(C)OC(CO)C(O[Si](C)(C)C)C1=CN=C2N=C(N)[NH]C(=O)C2=N12538.4Semi standard non polar33892256
Neopterin,2TMS,isomer #10C[Si](C)(C)N(C1=NC2=NC=C(C(O)C(O)CO)N=C2C(=O)[NH]1)[Si](C)(C)C2657.6Semi standard non polar33892256
Neopterin,2TMS,isomer #11C[Si](C)(C)NC1=NC2=NC=C(C(O)C(O)CO)N=C2C(=O)N1[Si](C)(C)C2705.1Semi standard non polar33892256
Neopterin,2TMS,isomer #2C[Si](C)(C)OCC(O)C(O[Si](C)(C)C)C1=CN=C2N=C(N)[NH]C(=O)C2=N12594.7Semi standard non polar33892256
Neopterin,2TMS,isomer #3C[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C)C(O)CO)N=C2C(=O)[NH]12561.2Semi standard non polar33892256
Neopterin,2TMS,isomer #4C[Si](C)(C)OC(C1=CN=C2N=C(N)N([Si](C)(C)C)C(=O)C2=N1)C(O)CO2579.3Semi standard non polar33892256
Neopterin,2TMS,isomer #5C[Si](C)(C)OCC(O[Si](C)(C)C)C(O)C1=CN=C2N=C(N)[NH]C(=O)C2=N12565.1Semi standard non polar33892256
Neopterin,2TMS,isomer #6C[Si](C)(C)NC1=NC2=NC=C(C(O)C(CO)O[Si](C)(C)C)N=C2C(=O)[NH]12562.9Semi standard non polar33892256
Neopterin,2TMS,isomer #7C[Si](C)(C)OC(CO)C(O)C1=CN=C2N=C(N)N([Si](C)(C)C)C(=O)C2=N12592.4Semi standard non polar33892256
Neopterin,2TMS,isomer #8C[Si](C)(C)NC1=NC2=NC=C(C(O)C(O)CO[Si](C)(C)C)N=C2C(=O)[NH]12601.3Semi standard non polar33892256
Neopterin,2TMS,isomer #9C[Si](C)(C)OCC(O)C(O)C1=CN=C2N=C(N)N([Si](C)(C)C)C(=O)C2=N12613.0Semi standard non polar33892256
Neopterin,3TMS,isomer #1C[Si](C)(C)OCC(O[Si](C)(C)C)C(O[Si](C)(C)C)C1=CN=C2N=C(N)[NH]C(=O)C2=N12503.4Semi standard non polar33892256
Neopterin,3TMS,isomer #10C[Si](C)(C)OC(CO)C(O)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)[NH]C(=O)C2=N12505.6Semi standard non polar33892256
Neopterin,3TMS,isomer #11C[Si](C)(C)NC1=NC2=NC=C(C(O)C(CO)O[Si](C)(C)C)N=C2C(=O)N1[Si](C)(C)C2540.1Semi standard non polar33892256
Neopterin,3TMS,isomer #12C[Si](C)(C)OCC(O)C(O)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)[NH]C(=O)C2=N12533.3Semi standard non polar33892256
Neopterin,3TMS,isomer #13C[Si](C)(C)NC1=NC2=NC=C(C(O)C(O)CO[Si](C)(C)C)N=C2C(=O)N1[Si](C)(C)C2547.2Semi standard non polar33892256
Neopterin,3TMS,isomer #14C[Si](C)(C)N(C1=NC2=NC=C(C(O)C(O)CO)N=C2C(=O)N1[Si](C)(C)C)[Si](C)(C)C2658.0Semi standard non polar33892256
Neopterin,3TMS,isomer #2C[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C)C(CO)O[Si](C)(C)C)N=C2C(=O)[NH]12459.0Semi standard non polar33892256
Neopterin,3TMS,isomer #3C[Si](C)(C)OC(CO)C(O[Si](C)(C)C)C1=CN=C2N=C(N)N([Si](C)(C)C)C(=O)C2=N12524.3Semi standard non polar33892256
Neopterin,3TMS,isomer #4C[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C)C(O)CO[Si](C)(C)C)N=C2C(=O)[NH]12485.1Semi standard non polar33892256
Neopterin,3TMS,isomer #5C[Si](C)(C)OCC(O)C(O[Si](C)(C)C)C1=CN=C2N=C(N)N([Si](C)(C)C)C(=O)C2=N12548.0Semi standard non polar33892256
Neopterin,3TMS,isomer #6C[Si](C)(C)OC(C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)[NH]C(=O)C2=N1)C(O)CO2463.3Semi standard non polar33892256
Neopterin,3TMS,isomer #7C[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C)C(O)CO)N=C2C(=O)N1[Si](C)(C)C2529.9Semi standard non polar33892256
Neopterin,3TMS,isomer #8C[Si](C)(C)NC1=NC2=NC=C(C(O)C(CO[Si](C)(C)C)O[Si](C)(C)C)N=C2C(=O)[NH]12471.7Semi standard non polar33892256
Neopterin,3TMS,isomer #9C[Si](C)(C)OCC(O[Si](C)(C)C)C(O)C1=CN=C2N=C(N)N([Si](C)(C)C)C(=O)C2=N12501.2Semi standard non polar33892256
Neopterin,4TMS,isomer #1C[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C)C(CO[Si](C)(C)C)O[Si](C)(C)C)N=C2C(=O)[NH]12472.3Semi standard non polar33892256
Neopterin,4TMS,isomer #1C[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C)C(CO[Si](C)(C)C)O[Si](C)(C)C)N=C2C(=O)[NH]12577.6Standard non polar33892256
Neopterin,4TMS,isomer #1C[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C)C(CO[Si](C)(C)C)O[Si](C)(C)C)N=C2C(=O)[NH]13666.9Standard polar33892256
Neopterin,4TMS,isomer #10C[Si](C)(C)OC(CO)C(O)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)C(=O)C2=N12573.8Semi standard non polar33892256
Neopterin,4TMS,isomer #10C[Si](C)(C)OC(CO)C(O)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)C(=O)C2=N12781.2Standard non polar33892256
Neopterin,4TMS,isomer #10C[Si](C)(C)OC(CO)C(O)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)C(=O)C2=N13575.4Standard polar33892256
Neopterin,4TMS,isomer #11C[Si](C)(C)OCC(O)C(O)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)C(=O)C2=N12579.1Semi standard non polar33892256
Neopterin,4TMS,isomer #11C[Si](C)(C)OCC(O)C(O)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)C(=O)C2=N12828.7Standard non polar33892256
Neopterin,4TMS,isomer #11C[Si](C)(C)OCC(O)C(O)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)C(=O)C2=N13584.5Standard polar33892256
Neopterin,4TMS,isomer #2C[Si](C)(C)OCC(O[Si](C)(C)C)C(O[Si](C)(C)C)C1=CN=C2N=C(N)N([Si](C)(C)C)C(=O)C2=N12517.0Semi standard non polar33892256
Neopterin,4TMS,isomer #2C[Si](C)(C)OCC(O[Si](C)(C)C)C(O[Si](C)(C)C)C1=CN=C2N=C(N)N([Si](C)(C)C)C(=O)C2=N12542.7Standard non polar33892256
Neopterin,4TMS,isomer #2C[Si](C)(C)OCC(O[Si](C)(C)C)C(O[Si](C)(C)C)C1=CN=C2N=C(N)N([Si](C)(C)C)C(=O)C2=N13824.7Standard polar33892256
Neopterin,4TMS,isomer #3C[Si](C)(C)OC(CO)C(O[Si](C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)[NH]C(=O)C2=N12492.7Semi standard non polar33892256
Neopterin,4TMS,isomer #3C[Si](C)(C)OC(CO)C(O[Si](C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)[NH]C(=O)C2=N12730.6Standard non polar33892256
Neopterin,4TMS,isomer #3C[Si](C)(C)OC(CO)C(O[Si](C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)[NH]C(=O)C2=N13551.6Standard polar33892256
Neopterin,4TMS,isomer #4C[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C)C(CO)O[Si](C)(C)C)N=C2C(=O)N1[Si](C)(C)C2541.5Semi standard non polar33892256
Neopterin,4TMS,isomer #4C[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C)C(CO)O[Si](C)(C)C)N=C2C(=O)N1[Si](C)(C)C2626.5Standard non polar33892256
Neopterin,4TMS,isomer #4C[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C)C(CO)O[Si](C)(C)C)N=C2C(=O)N1[Si](C)(C)C3635.5Standard polar33892256
Neopterin,4TMS,isomer #5C[Si](C)(C)OCC(O)C(O[Si](C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)[NH]C(=O)C2=N12498.0Semi standard non polar33892256
Neopterin,4TMS,isomer #5C[Si](C)(C)OCC(O)C(O[Si](C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)[NH]C(=O)C2=N12742.3Standard non polar33892256
Neopterin,4TMS,isomer #5C[Si](C)(C)OCC(O)C(O[Si](C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)[NH]C(=O)C2=N13539.5Standard polar33892256
Neopterin,4TMS,isomer #6C[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C)C(O)CO[Si](C)(C)C)N=C2C(=O)N1[Si](C)(C)C2539.7Semi standard non polar33892256
Neopterin,4TMS,isomer #6C[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C)C(O)CO[Si](C)(C)C)N=C2C(=O)N1[Si](C)(C)C2621.8Standard non polar33892256
Neopterin,4TMS,isomer #6C[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C)C(O)CO[Si](C)(C)C)N=C2C(=O)N1[Si](C)(C)C3625.6Standard polar33892256
Neopterin,4TMS,isomer #7C[Si](C)(C)OC(C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)C(=O)C2=N1)C(O)CO2572.6Semi standard non polar33892256
Neopterin,4TMS,isomer #7C[Si](C)(C)OC(C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)C(=O)C2=N1)C(O)CO2782.3Standard non polar33892256
Neopterin,4TMS,isomer #7C[Si](C)(C)OC(C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)C(=O)C2=N1)C(O)CO3578.3Standard polar33892256
Neopterin,4TMS,isomer #8C[Si](C)(C)OCC(O[Si](C)(C)C)C(O)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)[NH]C(=O)C2=N12481.2Semi standard non polar33892256
Neopterin,4TMS,isomer #8C[Si](C)(C)OCC(O[Si](C)(C)C)C(O)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)[NH]C(=O)C2=N12752.3Standard non polar33892256
Neopterin,4TMS,isomer #8C[Si](C)(C)OCC(O[Si](C)(C)C)C(O)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)[NH]C(=O)C2=N13555.3Standard polar33892256
Neopterin,4TMS,isomer #9C[Si](C)(C)NC1=NC2=NC=C(C(O)C(CO[Si](C)(C)C)O[Si](C)(C)C)N=C2C(=O)N1[Si](C)(C)C2515.5Semi standard non polar33892256
Neopterin,4TMS,isomer #9C[Si](C)(C)NC1=NC2=NC=C(C(O)C(CO[Si](C)(C)C)O[Si](C)(C)C)N=C2C(=O)N1[Si](C)(C)C2641.4Standard non polar33892256
Neopterin,4TMS,isomer #9C[Si](C)(C)NC1=NC2=NC=C(C(O)C(CO[Si](C)(C)C)O[Si](C)(C)C)N=C2C(=O)N1[Si](C)(C)C3646.7Standard polar33892256
Neopterin,5TMS,isomer #1C[Si](C)(C)OCC(O[Si](C)(C)C)C(O[Si](C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)[NH]C(=O)C2=N12534.3Semi standard non polar33892256
Neopterin,5TMS,isomer #1C[Si](C)(C)OCC(O[Si](C)(C)C)C(O[Si](C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)[NH]C(=O)C2=N12709.4Standard non polar33892256
Neopterin,5TMS,isomer #1C[Si](C)(C)OCC(O[Si](C)(C)C)C(O[Si](C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)[NH]C(=O)C2=N13336.3Standard polar33892256
Neopterin,5TMS,isomer #2C[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C)C(CO[Si](C)(C)C)O[Si](C)(C)C)N=C2C(=O)N1[Si](C)(C)C2561.4Semi standard non polar33892256
Neopterin,5TMS,isomer #2C[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C)C(CO[Si](C)(C)C)O[Si](C)(C)C)N=C2C(=O)N1[Si](C)(C)C2624.6Standard non polar33892256
Neopterin,5TMS,isomer #2C[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C)C(CO[Si](C)(C)C)O[Si](C)(C)C)N=C2C(=O)N1[Si](C)(C)C3405.9Standard polar33892256
Neopterin,5TMS,isomer #3C[Si](C)(C)OC(CO)C(O[Si](C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)C(=O)C2=N12609.2Semi standard non polar33892256
Neopterin,5TMS,isomer #3C[Si](C)(C)OC(CO)C(O[Si](C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)C(=O)C2=N12782.4Standard non polar33892256
Neopterin,5TMS,isomer #3C[Si](C)(C)OC(CO)C(O[Si](C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)C(=O)C2=N13321.9Standard polar33892256
Neopterin,5TMS,isomer #4C[Si](C)(C)OCC(O)C(O[Si](C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)C(=O)C2=N12606.7Semi standard non polar33892256
Neopterin,5TMS,isomer #4C[Si](C)(C)OCC(O)C(O[Si](C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)C(=O)C2=N12780.0Standard non polar33892256
Neopterin,5TMS,isomer #4C[Si](C)(C)OCC(O)C(O[Si](C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)C(=O)C2=N13305.5Standard polar33892256
Neopterin,5TMS,isomer #5C[Si](C)(C)OCC(O[Si](C)(C)C)C(O)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)C(=O)C2=N12575.5Semi standard non polar33892256
Neopterin,5TMS,isomer #5C[Si](C)(C)OCC(O[Si](C)(C)C)C(O)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)C(=O)C2=N12802.2Standard non polar33892256
Neopterin,5TMS,isomer #5C[Si](C)(C)OCC(O[Si](C)(C)C)C(O)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)C(=O)C2=N13324.4Standard polar33892256
Neopterin,6TMS,isomer #1C[Si](C)(C)OCC(O[Si](C)(C)C)C(O[Si](C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)C(=O)C2=N12634.2Semi standard non polar33892256
Neopterin,6TMS,isomer #1C[Si](C)(C)OCC(O[Si](C)(C)C)C(O[Si](C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)C(=O)C2=N12773.3Standard non polar33892256
Neopterin,6TMS,isomer #1C[Si](C)(C)OCC(O[Si](C)(C)C)C(O[Si](C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)C(=O)C2=N13130.0Standard polar33892256
Neopterin,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(C1=CN=C2N=C(N)[NH]C(=O)C2=N1)C(O)CO2920.4Semi standard non polar33892256
Neopterin,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC(CO)C(O)C1=CN=C2N=C(N)[NH]C(=O)C2=N12893.8Semi standard non polar33892256
Neopterin,1TBDMS,isomer #3CC(C)(C)[Si](C)(C)OCC(O)C(O)C1=CN=C2N=C(N)[NH]C(=O)C2=N12904.8Semi standard non polar33892256
Neopterin,1TBDMS,isomer #4CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O)C(O)CO)N=C2C(=O)[NH]12940.8Semi standard non polar33892256
Neopterin,1TBDMS,isomer #5CC(C)(C)[Si](C)(C)N1C(N)=NC2=NC=C(C(O)C(O)CO)N=C2C1=O2933.7Semi standard non polar33892256
Neopterin,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(CO)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N)[NH]C(=O)C2=N12951.6Semi standard non polar33892256
Neopterin,2TBDMS,isomer #10CC(C)(C)[Si](C)(C)N(C1=NC2=NC=C(C(O)C(O)CO)N=C2C(=O)[NH]1)[Si](C)(C)C(C)(C)C2991.3Semi standard non polar33892256
Neopterin,2TBDMS,isomer #11CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O)C(O)CO)N=C2C(=O)N1[Si](C)(C)C(C)(C)C3071.5Semi standard non polar33892256
Neopterin,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)OCC(O)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N)[NH]C(=O)C2=N13011.0Semi standard non polar33892256
Neopterin,2TBDMS,isomer #3CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C(C)(C)C)C(O)CO)N=C2C(=O)[NH]12932.3Semi standard non polar33892256
Neopterin,2TBDMS,isomer #4CC(C)(C)[Si](C)(C)OC(C1=CN=C2N=C(N)N([Si](C)(C)C(C)(C)C)C(=O)C2=N1)C(O)CO3027.1Semi standard non polar33892256
Neopterin,2TBDMS,isomer #5CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)C(O)C1=CN=C2N=C(N)[NH]C(=O)C2=N12990.0Semi standard non polar33892256
Neopterin,2TBDMS,isomer #6CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O)C(CO)O[Si](C)(C)C(C)(C)C)N=C2C(=O)[NH]12914.5Semi standard non polar33892256
Neopterin,2TBDMS,isomer #7CC(C)(C)[Si](C)(C)OC(CO)C(O)C1=CN=C2N=C(N)N([Si](C)(C)C(C)(C)C)C(=O)C2=N12996.0Semi standard non polar33892256
Neopterin,2TBDMS,isomer #8CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O)C(O)CO[Si](C)(C)C(C)(C)C)N=C2C(=O)[NH]12947.2Semi standard non polar33892256
Neopterin,2TBDMS,isomer #9CC(C)(C)[Si](C)(C)OCC(O)C(O)C1=CN=C2N=C(N)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13043.9Semi standard non polar33892256
Neopterin,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N)[NH]C(=O)C2=N13084.3Semi standard non polar33892256
Neopterin,3TBDMS,isomer #10CC(C)(C)[Si](C)(C)OC(CO)C(O)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[NH]C(=O)C2=N13042.1Semi standard non polar33892256
Neopterin,3TBDMS,isomer #11CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O)C(CO)O[Si](C)(C)C(C)(C)C)N=C2C(=O)N1[Si](C)(C)C(C)(C)C3133.0Semi standard non polar33892256
Neopterin,3TBDMS,isomer #12CC(C)(C)[Si](C)(C)OCC(O)C(O)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[NH]C(=O)C2=N13059.4Semi standard non polar33892256
Neopterin,3TBDMS,isomer #13CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O)C(O)CO[Si](C)(C)C(C)(C)C)N=C2C(=O)N1[Si](C)(C)C(C)(C)C3168.0Semi standard non polar33892256
Neopterin,3TBDMS,isomer #14CC(C)(C)[Si](C)(C)N(C1=NC2=NC=C(C(O)C(O)CO)N=C2C(=O)N1[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C3224.1Semi standard non polar33892256
Neopterin,3TBDMS,isomer #2CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C(C)(C)C)C(CO)O[Si](C)(C)C(C)(C)C)N=C2C(=O)[NH]13019.3Semi standard non polar33892256
Neopterin,3TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(CO)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13135.1Semi standard non polar33892256
Neopterin,3TBDMS,isomer #4CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C(C)(C)C)C(O)CO[Si](C)(C)C(C)(C)C)N=C2C(=O)[NH]13057.8Semi standard non polar33892256
Neopterin,3TBDMS,isomer #5CC(C)(C)[Si](C)(C)OCC(O)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13183.4Semi standard non polar33892256
Neopterin,3TBDMS,isomer #6CC(C)(C)[Si](C)(C)OC(C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[NH]C(=O)C2=N1)C(O)CO3050.1Semi standard non polar33892256
Neopterin,3TBDMS,isomer #7CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C(C)(C)C)C(O)CO)N=C2C(=O)N1[Si](C)(C)C(C)(C)C3142.9Semi standard non polar33892256
Neopterin,3TBDMS,isomer #8CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O)C(CO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)N=C2C(=O)[NH]13044.3Semi standard non polar33892256
Neopterin,3TBDMS,isomer #9CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)C(O)C1=CN=C2N=C(N)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13156.2Semi standard non polar33892256
Neopterin,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C(C)(C)C)C(CO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)N=C2C(=O)[NH]13216.9Semi standard non polar33892256
Neopterin,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C(C)(C)C)C(CO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)N=C2C(=O)[NH]13390.3Standard non polar33892256
Neopterin,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C(C)(C)C)C(CO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)N=C2C(=O)[NH]13841.0Standard polar33892256
Neopterin,4TBDMS,isomer #10CC(C)(C)[Si](C)(C)OC(CO)C(O)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13308.3Semi standard non polar33892256
Neopterin,4TBDMS,isomer #10CC(C)(C)[Si](C)(C)OC(CO)C(O)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13486.8Standard non polar33892256
Neopterin,4TBDMS,isomer #10CC(C)(C)[Si](C)(C)OC(CO)C(O)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13703.6Standard polar33892256
Neopterin,4TBDMS,isomer #11CC(C)(C)[Si](C)(C)OCC(O)C(O)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13323.8Semi standard non polar33892256
Neopterin,4TBDMS,isomer #11CC(C)(C)[Si](C)(C)OCC(O)C(O)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13494.3Standard non polar33892256
Neopterin,4TBDMS,isomer #11CC(C)(C)[Si](C)(C)OCC(O)C(O)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13714.6Standard polar33892256
Neopterin,4TBDMS,isomer #2CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13324.5Semi standard non polar33892256
Neopterin,4TBDMS,isomer #2CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13338.0Standard non polar33892256
Neopterin,4TBDMS,isomer #2CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13937.5Standard polar33892256
Neopterin,4TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(CO)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[NH]C(=O)C2=N13193.2Semi standard non polar33892256
Neopterin,4TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(CO)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[NH]C(=O)C2=N13468.9Standard non polar33892256
Neopterin,4TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(CO)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[NH]C(=O)C2=N13710.3Standard polar33892256
Neopterin,4TBDMS,isomer #4CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C(C)(C)C)C(CO)O[Si](C)(C)C(C)(C)C)N=C2C(=O)N1[Si](C)(C)C(C)(C)C3305.3Semi standard non polar33892256
Neopterin,4TBDMS,isomer #4CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C(C)(C)C)C(CO)O[Si](C)(C)C(C)(C)C)N=C2C(=O)N1[Si](C)(C)C(C)(C)C3403.6Standard non polar33892256
Neopterin,4TBDMS,isomer #4CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C(C)(C)C)C(CO)O[Si](C)(C)C(C)(C)C)N=C2C(=O)N1[Si](C)(C)C(C)(C)C3759.9Standard polar33892256
Neopterin,4TBDMS,isomer #5CC(C)(C)[Si](C)(C)OCC(O)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[NH]C(=O)C2=N13212.2Semi standard non polar33892256
Neopterin,4TBDMS,isomer #5CC(C)(C)[Si](C)(C)OCC(O)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[NH]C(=O)C2=N13470.8Standard non polar33892256
Neopterin,4TBDMS,isomer #5CC(C)(C)[Si](C)(C)OCC(O)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[NH]C(=O)C2=N13708.4Standard polar33892256
Neopterin,4TBDMS,isomer #6CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C(C)(C)C)C(O)CO[Si](C)(C)C(C)(C)C)N=C2C(=O)N1[Si](C)(C)C(C)(C)C3337.0Semi standard non polar33892256
Neopterin,4TBDMS,isomer #6CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C(C)(C)C)C(O)CO[Si](C)(C)C(C)(C)C)N=C2C(=O)N1[Si](C)(C)C(C)(C)C3401.3Standard non polar33892256
Neopterin,4TBDMS,isomer #6CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C(C)(C)C)C(O)CO[Si](C)(C)C(C)(C)C)N=C2C(=O)N1[Si](C)(C)C(C)(C)C3758.0Standard polar33892256
Neopterin,4TBDMS,isomer #7CC(C)(C)[Si](C)(C)OC(C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C(=O)C2=N1)C(O)CO3337.7Semi standard non polar33892256
Neopterin,4TBDMS,isomer #7CC(C)(C)[Si](C)(C)OC(C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C(=O)C2=N1)C(O)CO3470.6Standard non polar33892256
Neopterin,4TBDMS,isomer #7CC(C)(C)[Si](C)(C)OC(C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C(=O)C2=N1)C(O)CO3704.4Standard polar33892256
Neopterin,4TBDMS,isomer #8CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)C(O)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[NH]C(=O)C2=N13193.8Semi standard non polar33892256
Neopterin,4TBDMS,isomer #8CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)C(O)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[NH]C(=O)C2=N13468.0Standard non polar33892256
Neopterin,4TBDMS,isomer #8CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)C(O)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[NH]C(=O)C2=N13713.5Standard polar33892256
Neopterin,4TBDMS,isomer #9CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O)C(CO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)N=C2C(=O)N1[Si](C)(C)C(C)(C)C3304.0Semi standard non polar33892256
Neopterin,4TBDMS,isomer #9CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O)C(CO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)N=C2C(=O)N1[Si](C)(C)C(C)(C)C3401.0Standard non polar33892256
Neopterin,4TBDMS,isomer #9CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O)C(CO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)N=C2C(=O)N1[Si](C)(C)C(C)(C)C3768.6Standard polar33892256
Neopterin,5TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[NH]C(=O)C2=N13380.0Semi standard non polar33892256
Neopterin,5TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[NH]C(=O)C2=N13618.2Standard non polar33892256
Neopterin,5TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[NH]C(=O)C2=N13634.3Standard polar33892256
Neopterin,5TBDMS,isomer #2CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C(C)(C)C)C(CO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)N=C2C(=O)N1[Si](C)(C)C(C)(C)C3477.9Semi standard non polar33892256
Neopterin,5TBDMS,isomer #2CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C(C)(C)C)C(CO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)N=C2C(=O)N1[Si](C)(C)C(C)(C)C3568.0Standard non polar33892256
Neopterin,5TBDMS,isomer #2CC(C)(C)[Si](C)(C)NC1=NC2=NC=C(C(O[Si](C)(C)C(C)(C)C)C(CO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)N=C2C(=O)N1[Si](C)(C)C(C)(C)C3702.9Standard polar33892256
Neopterin,5TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(CO)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13495.5Semi standard non polar33892256
Neopterin,5TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(CO)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13652.1Standard non polar33892256
Neopterin,5TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(CO)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13595.9Standard polar33892256
Neopterin,5TBDMS,isomer #4CC(C)(C)[Si](C)(C)OCC(O)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13519.0Semi standard non polar33892256
Neopterin,5TBDMS,isomer #4CC(C)(C)[Si](C)(C)OCC(O)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13655.6Standard non polar33892256
Neopterin,5TBDMS,isomer #4CC(C)(C)[Si](C)(C)OCC(O)C(O[Si](C)(C)C(C)(C)C)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13591.8Standard polar33892256
Neopterin,5TBDMS,isomer #5CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)C(O)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13474.1Semi standard non polar33892256
Neopterin,5TBDMS,isomer #5CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)C(O)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13659.0Standard non polar33892256
Neopterin,5TBDMS,isomer #5CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)C(O)C1=CN=C2N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C(=O)C2=N13608.0Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (Non-derivatized) - 70eV, Positivesplash10-01ox-9720000000-287de905bc263a1d3fef2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (3 TMS) - 70eV, Positivesplash10-0pb9-3393300000-91821528c6f566d171742017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (TMS_1_1) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (TMS_1_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (TMS_1_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (TMS_1_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (TMS_1_5) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (TMS_2_1) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (TMS_2_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (TMS_2_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (TMS_2_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (TMS_2_5) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (TMS_2_6) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (TMS_2_7) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (TMS_2_8) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (TMS_2_9) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (TMS_2_10) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (TMS_2_11) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (TMS_3_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (TMS_3_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (TMS_3_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (TMS_3_5) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Neopterin GC-MS (TMS_3_6) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Neopterin Quattro_QQQ 10V, Positive-QTOF (Annotated)splash10-0udi-0090000000-3a09212908092a492f4d2012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Neopterin Quattro_QQQ 25V, Positive-QTOF (Annotated)splash10-054y-0920000000-6241d1b694e32019a9272012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Neopterin Quattro_QQQ 40V, Positive-QTOF (Annotated)splash10-05mp-4900000000-877883fea7e0d415c8402012-07-24HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Neopterin 10V, Positive-QTOFsplash10-0udi-0090000000-bd6cd1a1bfbd14b712cf2015-04-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Neopterin 20V, Positive-QTOFsplash10-0f79-1190000000-2cfad581ae89edd75d7a2015-04-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Neopterin 40V, Positive-QTOFsplash10-03dm-9610000000-935c14541b2551e1a2ae2015-04-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Neopterin 10V, Negative-QTOFsplash10-0udl-1490000000-873c74c47753e32ed9f42015-04-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Neopterin 20V, Negative-QTOFsplash10-01ox-4950000000-0c17274f2f41e583bbd62015-04-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Neopterin 40V, Negative-QTOFsplash10-052f-9400000000-8ae2879ae5357154c5d12015-04-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Neopterin 10V, Positive-QTOFsplash10-0udr-0190000000-5eeae3db4e4f85b1ce392021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Neopterin 20V, Positive-QTOFsplash10-0o70-0390000000-a441f62b61df43ffd7a62021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Neopterin 40V, Positive-QTOFsplash10-00b9-0910000000-a539711a0c44dc33cde82021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Neopterin 10V, Negative-QTOFsplash10-0006-0910000000-0a62087f9b31592e385c2021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Neopterin 20V, Negative-QTOFsplash10-01ox-0900000000-6854f20331ecc6eb7d8d2021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Neopterin 40V, Negative-QTOFsplash10-0006-6910000000-b1ce97d80b5467300fd92021-09-24Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Experimental 2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental)2012-12-05Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
Biospecimen Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Feces
  • Urine
Tissue Locations
  • Bone Marrow
  • Brain
  • Epidermis
  • Erythrocyte
  • Fibroblasts
  • Kidney
  • Leukocyte
  • Liver
  • Pancreas
  • Spleen
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.0060 +/- 0.0016 uMAdult (>18 years old)BothNormal details
BloodDetected and Quantified0.0150 +/- 0.0041 uMAdult (>18 years old)Not SpecifiedNormal
    • Geigy Scientific ...
details
BloodDetected and Quantified0.005 +/- 0.002 uMAdult (>18 years old)BothNormal details
BloodDetected and Quantified0.0038 +/- 0.0022 uMAdult (>18 years old)BothNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.018 +/- 0.002 uMAdult (>18 years old)Not SpecifiedNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.01 uMAdult (>18 years old)Not SpecifiedNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.0252 +/- 0.002 uMNot SpecifiedNot SpecifiedNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.0110-0.0240 uMAdolescent (13-18 years old)Not SpecifiedNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.002-0.014 uMChildren (1-13 years old)MaleNormal details
FecesDetected but not QuantifiedNot QuantifiedChildren (6 - 18 years old)Not SpecifiedNormal details
UrineDetected and Quantified2.0+/-0.8 umol/mmol creatinineNewborn (0-30 days old)FemaleNormal details
UrineDetected and Quantified0.21 +/- 0.08 umol/mmol creatinineAdult (>18 years old)MaleNormal
    • Geigy Scientific ...
details
UrineDetected and Quantified0.23 +/- 0.08 umol/mmol creatinineAdult (>18 years old)FemaleNormal
    • Geigy Scientific ...
details
UrineDetected and Quantified0.36 +/- 0.07 umol/mmol creatinineChildren (1-13 years old)BothNormal
    • Geigy Scientific ...
details
UrineDetected and Quantified1.4 +/- 0.71 umol/mmol creatinineNewborn (0-30 days old)BothNormal details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.0347 +/- 0.0250 uMChildren (1-13 years old)BothAIDS details
BloodDetected and Quantified0.33 +/- 0.04 uMAdult (>18 years old)Bothuremia details
BloodDetected and Quantified0.0050 +/- 0.0028 uMAdult (>18 years old)BothMultiple sclerosis details
Cerebrospinal Fluid (CSF)Detected and Quantified0.01175 (0.008-0.0155) uMChildren (1-13 years old)Malesepiapterin reductase deficiency details
Cerebrospinal Fluid (CSF)Detected and Quantified0.0091 +/- 0.0074 uMAdult (>18 years old)Not SpecifiedMultiple Sclerosis details
Cerebrospinal Fluid (CSF)Detected and Quantified0.01 +/- 0.001 uMAdult (>18 years old)Not SpecifiedHydrocephalus details
Cerebrospinal Fluid (CSF)Detected and Quantified0.023 +/- 0.01 uMAdult (>18 years old)Not SpecifiedCNS Tumors details
Cerebrospinal Fluid (CSF)Detected and Quantified0.12 +/- 0.083 uMAdult (>18 years old)Not SpecifiedCNS Infections details
Cerebrospinal Fluid (CSF)Detected and Quantified0.009 uMAdolescent (13-18 years old)Not AvailableUrocanase deficiency details
Cerebrospinal Fluid (CSF)Detected and Quantified0.0226 +/- 0.001 uMNot SpecifiedNot Specifiedidiopathic parkinsonisam details
Cerebrospinal Fluid (CSF)Detected and Quantified0.0252 +/- 0.0022 uMNot SpecifiedNot Specifieddopa-nonresponsive dystonia details
FecesDetected but not QuantifiedNot QuantifiedChildren (6 - 18 years old)Not SpecifiedCrohns disease details
FecesDetected but not QuantifiedNot QuantifiedChildren (6 - 18 years old)Not SpecifiedUlcerative colitis details
FecesDetected but not QuantifiedNot QuantifiedChildren (6 - 18 years old)Not SpecifiedUnclassified IBD details
UrineDetected and Quantified22.6 umol/mmol creatinineNewborn (0-30 days old)FemaleHyperphenylalaninemia due to pterin-4a-carbinolamine dehydratase details
Associated Disorders and Diseases
Disease References
AIDS
  1. Ellaurie M, Calvelli T, Rubinstein A: Neopterin concentrations in pediatric human immunodeficiency virus infection as predictor of disease activity. Pediatr Infect Dis J. 1992 Apr;11(4):286-9. [PubMed:1565552 ]
Uremia
  1. Duranton F, Cohen G, De Smet R, Rodriguez M, Jankowski J, Vanholder R, Argiles A: Normal and pathologic concentrations of uremic toxins. J Am Soc Nephrol. 2012 Jul;23(7):1258-70. doi: 10.1681/ASN.2011121175. Epub 2012 May 24. [PubMed:22626821 ]
Multiple sclerosis
  1. Shaw CE, Dunbar PR, Macaulay HA, Neale TJ: Measurement of immune markers in the serum and cerebrospinal fluid of multiple sclerosis patients during clinical remission. J Neurol. 1995 Jan;242(2):53-8. [PubMed:7707089 ]
Hydrocephalus
  1. Heyes MP, Saito K, Milstien S, Schiff SJ: Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children. J Neurol Sci. 1995 Nov;133(1-2):112-8. [PubMed:8583213 ]
CNS tumors
  1. Heyes MP, Saito K, Milstien S, Schiff SJ: Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children. J Neurol Sci. 1995 Nov;133(1-2):112-8. [PubMed:8583213 ]
CNS infections
  1. Heyes MP, Saito K, Milstien S, Schiff SJ: Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children. J Neurol Sci. 1995 Nov;133(1-2):112-8. [PubMed:8583213 ]
Sepiapterin reductase deficiency
  1. Verbeek MM, Willemsen MA, Wevers RA, Lagerwerf AJ, Abeling NG, Blau N, Thony B, Vargiami E, Zafeiriou DI: Two Greek siblings with sepiapterin reductase deficiency. Mol Genet Metab. 2008 Aug;94(4):403-9. doi: 10.1016/j.ymgme.2008.04.003. Epub 2008 May 27. [PubMed:18502672 ]
Parkinson's disease
  1. Furukawa Y, Nishi K, Mizuno Y, Narabayashi H: [Significance of CSF biopterin and neopterin in hereditary progressive dystonia with marked diurnal fluctuation (HPD)--a clue to pathogenesis]. No To Shinkei. 1995 Mar;47(3):261-8. [PubMed:7669428 ]
Urocanase deficiency
  1. Espinos C, Pineda M, Martinez-Rubio D, Lupo V, Ormazabal A, Vilaseca MA, Spaapen LJ, Palau F, Artuch R: Mutations in the urocanase gene UROC1 are associated with urocanic aciduria. J Med Genet. 2009 Jun;46(6):407-11. doi: 10.1136/jmg.2008.060632. Epub 2009 Mar 19. [PubMed:19304569 ]
Crohn's disease
  1. Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V: Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158. [PubMed:27609529 ]
Ulcerative colitis
  1. Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V: Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158. [PubMed:27609529 ]
Pterin-4a carbinolamine dehydratase deficiency
  1. Blaskovics M, Giudici TA: A new variant of biopterin deficiency. N Engl J Med. 1988 Dec 15;319(24):1611-2. doi: 10.1056/NEJM198812153192420. [PubMed:3200274 ]
Associated OMIM IDs
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB112166
KNApSAcK IDC00007312
Chemspider ID4300
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNeopterin
METLIN IDNot Available
PubChem Compound135408877
PDB IDNot Available
ChEBI IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDMDB00000264
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Heyes MP, Saito K, Milstien S, Schiff SJ: Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children. J Neurol Sci. 1995 Nov;133(1-2):112-8. [PubMed:8583213 ]
  2. Azumagawa K, Suzuki S, Tanabe T, Wakamiya E, Kawamura N, Tamai H: Neopterin, biopterin, and nitric oxide concentrations in the cerebrospinal fluid of children with central nervous system infections. Brain Dev. 2003 Apr;25(3):200-2. [PubMed:12689700 ]
  3. Shaw CE, Dunbar PR, Macaulay HA, Neale TJ: Measurement of immune markers in the serum and cerebrospinal fluid of multiple sclerosis patients during clinical remission. J Neurol. 1995 Jan;242(2):53-8. [PubMed:7707089 ]
  4. Gisslen M, Chiodi F, Fuchs D, Norkrans G, Svennerholm B, Wachter H, Hagberg L: Markers of immune stimulation in the cerebrospinal fluid during HIV infection: a longitudinal study. Scand J Infect Dis. 1994;26(5):523-33. [PubMed:7855550 ]
  5. Reibnegger GJ, Bichler AH, Dapunt O, Fuchs DN, Fuith LC, Hausen A, Hetzel HM, Lutz H, Werner ER, Wachter H: Neopterin as a prognostic indicator in patients with carcinoma of the uterine cervix. Cancer Res. 1986 Feb;46(2):950-5. [PubMed:3940654 ]
  6. Niederwieser D, Huber C, Wachter H: [Neopterin, a new biochemical marker for the detection of activated T lymphocytes]. Wien Klin Wochenschr. 1983 Mar 4;95(5):161-4. [PubMed:6602425 ]
  7. Abdulle S, Hagberg L, Svennerholm B, Fuchs D, Gisslen M: Continuing intrathecal immunoactivation despite two years of effective antiretroviral therapy against HIV-1 infection. AIDS. 2002 Nov 8;16(16):2145-9. [PubMed:12409735 ]
  8. Niederwieser A, Curtius HC: Tetrahydrobiopterin biosynthetic pathway and deficiency. Enzyme. 1987;38(1-4):302-11. [PubMed:3326735 ]
  9. Kokcam I, Naziroglu M: Effects of vitamin E supplementation on blood antioxidants levels in patients with Behcet's disease. Clin Biochem. 2002 Nov;35(8):633-9. [PubMed:12498998 ]
  10. Margreiter R, Aichberger C, Konigsrainer A, Reibnegger G, Weiss G, Wachter H: Biliary neopterin for differentiation between liver allograft rejection and viral graft infection. Transpl Int. 1992;5 Suppl 1:S199-200. [PubMed:14621776 ]
  11. Steiner G, Zlabinger G, Karamehic J, Pohanka E, Kovarik J, Woloszczuk W: Interferon-gamma, neopterin, and interleukin-2 receptor levels in the serum of kidney transplant recipients. Transplant Proc. 1990 Aug;22(4):1857-8. [PubMed:2117813 ]
  12. Inci Fisenk B, Us D, Ozcebe OI, Hascelik G: The value of increased neopterin levels in reducing transfusion-transmitted virus infections: detection of a donation from a HBsAg positive chronic carrier by screening of neopterin in Turkish blood donors. Scand J Infect Dis. 2005;37(8):599-604. [PubMed:16099770 ]
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