Human Metabolome Database Version 3.5

Showing metabocard for Coenzyme A (HMDB01423)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-02-08 17:10:31 -0700
HMDB ID HMDB01423
Secondary Accession Numbers None
Metabolite Identification
Common Name Coenzyme A
Description Coenzyme A (CoA, CoASH, or HSCoA) is a coenzyme, notable for its role in the synthesis and oxidization of fatty acids, and the oxidation of pyruvate in the citric acid cycle. It is adapted from beta-mercaptoethylamine, panthothenate and adenosine triphosphate. Coenzyme A is synthesized in a five-step process from pantothenate and cysteine. In the first step Pantothenate (vitamin B5) is phosphorylated to 4'-phosphopantothenate by the enzyme pantothenate kinase (PanK; CoaA; CoaX)In the second step, a cysteine is added to 4'-phosphopantothenate by the enzyme phosphopantothenoylcysteine synthetase (PPC-DC; CoaB) to form 4'-phospho-N-pantothenoylcysteine (PPC). In the third step, PPC is decarboxylated to 4'-phosphopantetheine by phosphopantothenoylcysteine decarboxylase (CoaC). In the fourth step, 4'-phosphopantetheine is adenylylated to form dephospho-CoA by the enzyme phosphopantetheine adenylyl transferase (CoaD)Finally, dephospho-CoA is phosphorylated using ATP to coenzyme A by the enzyme dephosphocoenzyme A kinase (CoaE). Since coenzyme A is, in chemical terms, a thiol, it can react with carboxylic acids to form thioesters, thus functioning as an acyl group carrier. CoA assists in transferring fatty acids from the cytoplasm to mitochondria. A molecule of coenzyme A carrying an acetyl group is also referred to as acetyl-CoA. When it is not attached to an acyl group, it is usually referred to as 'CoASH' or 'HSCoA'. Coenzyme A is also the source of the phosphopantetheine group that is added as a prosthetic group to proteins such as acyl carrier protein and formyltetrahydrofolate dehydrogenase Acetyl-CoA is an important molecule itself. It is the precursor to HMG CoA, which is a vital component in cholesterol and ketone synthesis. Furthermore, it contributes an acetyl group to choline to produce acetylcholine, in a reaction catalysed by choline acetyltransferase. Its main task is conveying the carbon atoms within the acetyl group to the citric acid cycle to be oxidized for energy production. -- Wikipedia.
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. Acetoacetyl coenzyme A sodium salt
  2. CoA
  3. CoA hydrate
  4. CoA-SH
  5. CoASH
  6. Coenzyme A
  7. Coenzyme A hydrate
  8. Coenzyme A-SH
  9. Coenzyme ASH
  10. Coenzymes A
  11. Depot-Zeel
  12. Propionyl CoA
  13. Propionyl Coenzyme A
  14. S-Propanoate
  15. S-Propanoate CoA
  16. S-Propanoate Coenzyme A
  17. S-Propanoic acid
  18. S-Propionate CoA
  19. S-Propionate Coenzyme A
  20. Zeel
  21. [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl 3-hydroxy-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)-2,2-dimethyl-4-oxobutyl dihydrogen diphosphate
Chemical Formula C21H36N7O16P3S
Average Molecular Weight 767.534
Monoisotopic Molecular Weight 767.115208365
IUPAC Name {[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[3-hydroxy-2,2-dimethyl-3-({2-[(2-sulfanylethyl)carbamoyl]ethyl}carbamoyl)propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acid
Traditional IUPAC Name [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[({hydroxy[hydroxy(3-hydroxy-2,2-dimethyl-3-({2-[(2-sulfanylethyl)carbamoyl]ethyl}carbamoyl)propoxy)phosphoryl]oxyphosphoryl}oxy)methyl]oxolan-3-yl]oxyphosphonic acid
CAS Registry Number 85-61-0
SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS
InChI Identifier InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/t11-,14-,15-,16?,20-/m1/s1
InChI Key RGJOEKWQDUBAIZ-DRCCLKDXSA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Nucleosides, Nucleotides, and Analogues
Class Purine Nucleotides
Sub Class Purine Ribonucleotides
Other Descriptors
  • Aromatic Heteropolycyclic Compounds
Substituents
  • 1 Phosphoribosyl Imidazole
  • Alkylthiol
  • Aminopyrimidine
  • Carboxamide Group
  • Glycosyl Compound
  • Imidazole
  • Imidazopyrimidine
  • Monosaccharide Phosphate
  • N Glycosyl Compound
  • Organic Hypophosphite
  • Organic Phosphite
  • Organic Pyrophosphate
  • Oxolane
  • Pentose Monosaccharide
  • Phosphoric Acid Ester
  • Purine
  • Purine Ribonucleoside 3',5' Bisphosphate
  • Pyrimidine
  • Saccharide
  • Secondary Alcohol
  • Secondary Carboxylic Acid Amide
  • Thiol (Sulfanyl Compound)
Direct Parent Coenzyme A and Derivatives
Ontology
Status Expected and Not Quantified
Origin
  • Endogenous
Biofunction
  • Component of Alanine and aspartate metabolism
  • Component of Aminosugars metabolism
  • Component of Arginine and proline metabolism
  • Component of Bile acid biosynthesis
  • Component of Butanoate metabolism
  • Component of C5-Branched dibasic acid metabolism
  • Component of Fatty acid metabolism
  • Component of Glutamate metabolism
  • Component of Glycerolipid metabolism
  • Component of Glycerophospholipid metabolism
  • Component of Glycine, serine and threonine metabolism
  • Component of Glycosphingolipid metabolism
  • Component of Glyoxylate and dicarboxylate metabolism
  • Component of Inositol metabolism
  • Component of Propanoate metabolism
  • Component of Pyruvate metabolism
  • Component of Tryptophan metabolism
Application Not Available
Cellular locations
  • Mitochondria
  • Nucleus
  • Lysosome
  • Endoplasmic reticulum
  • Golgi apparatus
  • Peroxisome
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point Not Available Not Available
Boiling Point Not Available Not Available
Water Solubility Not Available Not Available
LogP Not Available Not Available
Predicted Properties
Property Value Source
Water Solubility 4.64 g/L ALOGPS
LogP -0.61 ALOGPS
LogP -6.8 ChemAxon
LogS -2.22 ALOGPS
pKa (strongest acidic) 0.83 ChemAxon
pKa (strongest basic) 4.95 ChemAxon
Hydrogen Acceptor Count 16 ChemAxon
Hydrogen Donor Count 10 ChemAxon
Polar Surface Area 346.56 A2 ChemAxon
Rotatable Bond Count 18 ChemAxon
Refractivity 162.74 ChemAxon
Polarizability 66.81 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge -4 ChemAxon
Spectra
1H NMR Spectrum
MS/MS Spectrum Quattro_QQQ 10
MS/MS Spectrum Quattro_QQQ 25
MS/MS Spectrum Quattro_QQQ 40
[1H,13C] 2D NMR Spectrum
Biological Properties
Cellular Locations
  • Mitochondria
  • Nucleus
  • Lysosome
  • Endoplasmic reticulum
  • Golgi apparatus
  • Peroxisome
Biofluid Locations Not Available
Tissue Location
  • Skeletal Muscle
  • Fibroblasts
  • Adipose Tissue
Pathways
Name SMPDB Link KEGG Link
Phenylacetate Metabolism SMP00126 map00360 Link_out
Butyrate Metabolism SMP00073 map00650 Link_out
Fatty acid Metabolism SMP00051 map00071 Link_out
Citric Acid Cycle SMP00057 map00020 Link_out
Bile Acid Biosynthesis SMP00035 map00120 Link_out
Pantothenate and CoA Biosynthesis SMP00027 map00770 Link_out
Ketone Body Metabolism SMP00071 map00072 Link_out
Beta-Alanine Metabolism SMP00007 map00410 Link_out
Beta Oxidation of Very Long Chain Fatty Acids SMP00052 map01040 Link_out
Oxidation of Branched Chain Fatty Acids SMP00030 Not Available
Threonine and 2-Oxobutanoate Degradation SMP00452 Not Available
Ethanol Degradation SMP00449 Not Available
Transfer of Acetyl Groups into Mitochondria SMP00466 Not Available
Plasmalogen Synthesis SMP00479 Not Available
Amino Sugar Metabolism SMP00045 map00520 Link_out
Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids SMP00480 Not Available
Glycine and Serine Metabolism SMP00004 map00260 Link_out
Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids SMP00481 Not Available
Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids SMP00482 Not Available
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease References None
Associated OMIM IDs None
DrugBank ID Not Available
DrugBank Metabolite ID Not Available
Phenol Explorer Compound ID Not Available
Phenol Explorer Metabolite ID Not Available
FoodDB ID FDB022614
KNApSAcK ID Not Available
Chemspider ID 6557 Link_out
KEGG Compound ID C00010 Link_out
BioCyc ID CO-A Link_out
BiGG ID 33502 Link_out
Wikipedia Link Coenzyme A Link_out
NuGOwiki Link HMDB01423 Link_out
Metagene Link HMDB01423 Link_out
METLIN ID 6235 Link_out
PubChem Compound 6816 Link_out
PDB ID 1A59 Link_out
ChEBI ID 1146900 Link_out
References
Synthesis Reference Not Available
Material Safety Data Sheet (MSDS) Download (PDF)
General References
  1. Yano S, Li L, Le TP, Moseley K, Guedalia A, Lee J, Gonzalez I, Boles RG: Infantile mitochondrial DNA depletion syndrome associated with methylmalonic aciduria and 3-methylcrotonyl-CoA and propionyl-CoA carboxylase deficiencies in two unrelated patients: a new phenotype of mtDNA depletion syndrome. J Inherit Metab Dis. 2003;26(5):481-8. Pubmed: 14518828 Link_out
  2. Roe CR, Sweetman L, Roe DS, David F, Brunengraber H: Treatment of cardiomyopathy and rhabdomyolysis in long-chain fat oxidation disorders using an anaplerotic odd-chain triglyceride. J Clin Invest. 2002 Jul;110(2):259-69. Pubmed: 12122118 Link_out
  3. Kretschmer RE, Bachmann C: Methylcitric acid determination in amniotic fluid by electron-impact mass fragmentography. J Clin Chem Clin Biochem. 1988 May;26(5):345-8. Pubmed: 3404093 Link_out
  4. Osmundsen H, Bremer J, Pedersen JI: Metabolic aspects of peroxisomal beta-oxidation. Biochim Biophys Acta. 1991 Sep 11;1085(2):141-58. Pubmed: 1892883 Link_out
  5. Reihner E, Angelin B, Rudling M, Ewerth S, Bjorkhem I, Einarsson K: Regulation of hepatic cholesterol metabolism in humans: stimulatory effects of cholestyramine on HMG-CoA reductase activity and low density lipoprotein receptor expression in gallstone patients. J Lipid Res. 1990 Dec;31(12):2219-26. Pubmed: 2090716 Link_out
  6. Bergstrom T, Greter J, Levin AH, Steen G, Tryding N, Wass U: Propionyl-CoA carboxylase deficiency: case report, effect of low-protein diet and identification of 3-oxo-2-methylvaleric acid 3-hydroxy-2-methylvaleric acid, and maleic acid in urine. Scand J Clin Lab Invest. 1981 Apr;41(2):117-26. Pubmed: 7313494 Link_out
  7. Salen G, Batta AK, Tint GS, Shefer S: Comparative effects of lovastatin and chenodeoxycholic acid on plasma cholestanol levels and abnormal bile acid metabolism in cerebrotendinous xanthomatosis. Metabolism. 1994 Aug;43(8):1018-22. Pubmed: 8052141 Link_out
  8. Lehnert W, Junker A: [2-Methyl-3-oxovaleric acid: a characteristic metabolite in propionic acidemia] Clin Chim Acta. 1980 May 21;104(1):47-51. Pubmed: 7389125 Link_out
  9. Wendel U, Zass R, Leupold D: Contribution of odd-numbered fatty acid oxidation to propionate production in neonates with methylmalonic and propionic acidaemias. Eur J Pediatr. 1993 Dec;152(12):1021-3. Pubmed: 8131803 Link_out

Enzymes

Show all enzymes and transporters Important Only showing the first 50 enzymes. There are 186 enzymes in total.

Name: ATP-citrate synthase
Reactions:
ADP + Phosphoric acid + Acetyl-CoA + Oxalacetic acid unknown Adenosine triphosphate + Citric acid + Coenzyme A details
Adenosine triphosphate + Citric acid + Coenzyme A unknown ADP + Phosphoric acid + Acetyl-CoA + Oxalacetic acid details
Gene Name: ACLY
Uniprot ID: P53396 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Histone acetyltransferase p300
Reactions:
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone] details
Gene Name: EP300
Uniprot ID: Q09472 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Reactions: Not Available
Gene Name: PDHB
Uniprot ID: P11177 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acetyl-CoA acetyltransferase, cytosolic
Reactions:
Acetyl-CoA unknown Coenzyme A + Acetoacetyl-CoA details
Acetyl-CoA + Butyryl-CoA unknown Coenzyme A + 3-Oxohexanoyl-CoA details
Gene Name: ACAT2
Uniprot ID: Q9BWD1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: CREB-binding protein
Reactions:
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone] details
Gene Name: CREBBP
Uniprot ID: Q92793 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Diamine acetyltransferase 2
Reactions:
Acetyl-CoA + an alkane-alpha,omega-diamine unknown Coenzyme A + an N-acetyldiamine details
Acetyl-CoA + Putrescine unknown Coenzyme A + N-Acetylputrescine details
Gene Name: SAT2
Uniprot ID: Q96F10 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 5-aminolevulinate synthase, erythroid-specific, mitochondrial
Reactions:
Succinyl-CoA + Glycine unknown 5-Aminolevulinic acid + Coenzyme A + CO(2) details
Succinyl-CoA + Glycine unknown 5-Aminolevulinic acid + Coenzyme A + Carbon dioxide details
Gene Name: ALAS2
Uniprot ID: P22557 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Arylamine N-acetyltransferase 1
Reactions:
Acetyl-CoA + an arylamine unknown Coenzyme A + an N-acetylarylamine details
2,4-Diamino-6-nitrotoluene + Acetyl-CoA unknown 4-Acetamido-2-amino-6-nitrotoluene + Coenzyme A details
Acetyl-CoA + Isoniazid unknown Coenzyme A + Acetylisoniazid details
Acetyl-CoA + Acetylhydrazine unknown Coenzyme A + N,N'-Diacetylhydrazine details
Gene Name: NAT1
Uniprot ID: P18440 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Arylamine N-acetyltransferase 2
Reactions:
Acetyl-CoA + an arylamine unknown Coenzyme A + an N-acetylarylamine details
2,4-Diamino-6-nitrotoluene + Acetyl-CoA unknown 4-Acetamido-2-amino-6-nitrotoluene + Coenzyme A details
Acetyl-CoA + Isoniazid unknown Coenzyme A + Acetylisoniazid details
Acetyl-CoA + Acetylhydrazine unknown Coenzyme A + N,N'-Diacetylhydrazine details
Gene Name: NAT2
Uniprot ID: P11245 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 5-aminolevulinate synthase, nonspecific, mitochondrial
Reactions:
Succinyl-CoA + Glycine unknown 5-Aminolevulinic acid + Coenzyme A + CO(2) details
Succinyl-CoA + Glycine unknown 5-Aminolevulinic acid + Coenzyme A + Carbon dioxide details
Gene Name: ALAS1
Uniprot ID: P13196 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: General transcription factor 3C polypeptide 4
Reactions:
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone] details
Gene Name: GTF3C4
Uniprot ID: Q9UKN8 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acyl-coenzyme A thioesterase 12
Reactions:
Acetyl-CoA + Water unknown Coenzyme A + Acetic acid details
Gene Name: ACOT12
Uniprot ID: Q8WYK0 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Choline O-acetyltransferase
Reactions:
Acetyl-CoA + Choline unknown Coenzyme A + Acetylcholine details
Gene Name: CHAT
Uniprot ID: P28329 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Nuclear receptor coactivator 3
Reactions:
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone] details
Gene Name: NCOA3
Uniprot ID: Q9Y6Q9 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Histone acetyltransferase KAT2B
Reactions:
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone] details
Gene Name: KAT2B
Uniprot ID: Q92831 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Carnitine O-acetyltransferase
Reactions:
Acetyl-CoA + L-Carnitine unknown Coenzyme A + L-Acetylcarnitine details
Gene Name: CRAT
Uniprot ID: P43155 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Diamine acetyltransferase 1
Reactions:
Acetyl-CoA + an alkane-alpha,omega-diamine unknown Coenzyme A + an N-acetyldiamine details
Acetyl-CoA + Putrescine unknown Coenzyme A + N-Acetylputrescine details
Gene Name: SAT1
Uniprot ID: P21673 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Serotonin N-acetyltransferase
Reactions:
Acetyl-CoA + a 2-arylethylamine unknown Coenzyme A + an N-acetyl-2-arylethylamine details
Acetyl-CoA + Serotonin unknown Coenzyme A + N-Acetylserotonin details
Gene Name: AANAT
Uniprot ID: Q16613 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 3-ketoacyl-CoA thiolase, mitochondrial
Reactions:
Acyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-oxoacyl-CoA details
Acyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxoacyl-CoA details
Succinyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxoadipyl-CoA details
Propionyl-CoA + Acetyl-CoA unknown Coenzyme A + 2-Methylacetoacetyl-CoA details
Acetyl-CoA + Butyryl-CoA unknown Coenzyme A + 3-Oxohexanoyl-CoA details
Octanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxodecanoyl-CoA details
Lauroyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxotetradecanoyl-CoA details
Tetradecanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxohexadecanoyl-CoA details
Propionyl-CoA + Chenodeoxycholoyl-CoA unknown Coenzyme A + 3a,7a-Dihydroxy-5b-cholestanoyl-CoA details
Decanoyl-CoA (n-C10:0CoA) + Acetyl-CoA unknown Coenzyme A + 3-Oxododecanoyl-CoA details
Hexanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxooctanoyl-CoA details
Gene Name: ACAA2
Uniprot ID: P42765 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Testis-specific chromodomain protein Y 1
Reactions:
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone] details
Gene Name: CDY1
Uniprot ID: Q9Y6F8 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Fatty acid synthase
Reactions:
Acetyl-CoA + [acyl-carrier-protein] unknown Coenzyme A + acetyl-[acyl-carrier-protein] details
Malonyl-CoA + [acyl-carrier-protein] unknown Coenzyme A + malonyl-[acyl-carrier-protein] details
Acetyl-CoA + Acyl-carrier protein unknown Coenzyme A + Acetyl-[acyl-carrier protein] details
Malonyl-CoA + Acyl-carrier protein unknown Coenzyme A + Malonyl-[acyl-carrier protein] details
Gene Name: FASN
Uniprot ID: P49327 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Histone acetyltransferase KAT5
Reactions:
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone] details
Gene Name: KAT5
Uniprot ID: Q92993 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acetyl-coenzyme A synthetase, cytoplasmic
Reactions:
Adenosine triphosphate + Acetic acid + Coenzyme A unknown Adenosine monophosphate + Pyrophosphate + Acetyl-CoA details
Acetyl adenylate + Coenzyme A unknown Adenosine monophosphate + Acetyl-CoA details
Propinol adenylate + Coenzyme A unknown Adenosine monophosphate + Propionyl-CoA details
Gene Name: ACSS2
Uniprot ID: Q9NR19 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acetyl-CoA acetyltransferase, mitochondrial
Reactions:
Acetyl-CoA unknown Coenzyme A + Acetoacetyl-CoA details
Acetyl-CoA + Butyryl-CoA unknown Coenzyme A + 3-Oxohexanoyl-CoA details
Gene Name: ACAT1
Uniprot ID: P24752 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Nuclear receptor coactivator 1
Reactions:
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone] details
Gene Name: NCOA1
Uniprot ID: Q15788 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Hydroxymethylglutaryl-CoA synthase, mitochondrial
Reactions:
Acetyl-CoA + Water + Acetoacetyl-CoA unknown 3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A details
3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A unknown Acetyl-CoA + Water + Acetoacetyl-CoA details
Gene Name: HMGCS2
Uniprot ID: P54868 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acetyl-coenzyme A synthetase 2-like, mitochondrial
Reactions:
Adenosine triphosphate + Acetic acid + Coenzyme A unknown Adenosine monophosphate + Pyrophosphate + Acetyl-CoA details
Acetyl adenylate + Coenzyme A unknown Adenosine monophosphate + Acetyl-CoA details
Propinol adenylate + Coenzyme A unknown Adenosine monophosphate + Propionyl-CoA details
Gene Name: ACSS1
Uniprot ID: Q9NUB1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Citrate synthase, mitochondrial
Reactions:
Acetyl-CoA + Water + Oxalacetic acid unknown Citric acid + Coenzyme A details
Citric acid + Coenzyme A unknown Acetyl-CoA + Water + Oxalacetic acid details
Gene Name: CS
Uniprot ID: O75390 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Testis-specific chromodomain protein Y 2
Reactions:
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone] details
Gene Name: CDY2A
Uniprot ID: Q9Y6F7 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 3-ketoacyl-CoA thiolase, peroxisomal
Reactions:
Acyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-oxoacyl-CoA details
Succinyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxoadipyl-CoA details
Propionyl-CoA + Acetyl-CoA unknown Coenzyme A + 2-Methylacetoacetyl-CoA details
Acetyl-CoA + Butyryl-CoA unknown Coenzyme A + 3-Oxohexanoyl-CoA details
Octanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxodecanoyl-CoA details
Lauroyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxotetradecanoyl-CoA details
Tetradecanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxohexadecanoyl-CoA details
Propionyl-CoA + Chenodeoxycholoyl-CoA unknown Coenzyme A + 3a,7a-Dihydroxy-5b-cholestanoyl-CoA details
Decanoyl-CoA (n-C10:0CoA) + Acetyl-CoA unknown Coenzyme A + 3-Oxododecanoyl-CoA details
Hexanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxooctanoyl-CoA details
OPC6-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxo-OPC8-CoA details
OPC4-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxo-OPC6-CoA details
(+)-7-Isojasmonic acid CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxo-OPC4-CoA details
Cervonyl coenzyme A + Acetyl-CoA unknown Coenzyme A + (6Z,9Z,12Z,15Z,18Z,21Z)-3-Oxotetracosahexa-6,9,12,15,18,21-enoyl-CoA details
Docosa-4,7,10,13,16-pentaenoyl CoA + Acetyl-CoA unknown Coenzyme A + (6Z,9Z,12Z,15Z,18Z)-3-Oxotetracosapenta-6,9,12,15,18-enoyl-CoA details
Gene Name: ACAA1
Uniprot ID: P09110 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Reactions: Not Available
Gene Name: PDHA1
Uniprot ID: P08559 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Trifunctional enzyme subunit beta, mitochondrial
Reactions:
Acyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-oxoacyl-CoA details
Acyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxoacyl-CoA details
Succinyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxoadipyl-CoA details
Propionyl-CoA + Acetyl-CoA unknown Coenzyme A + 2-Methylacetoacetyl-CoA details
Acetyl-CoA + Butyryl-CoA unknown Coenzyme A + 3-Oxohexanoyl-CoA details
Octanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxodecanoyl-CoA details
Lauroyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxotetradecanoyl-CoA details
Tetradecanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxohexadecanoyl-CoA details
Propionyl-CoA + Chenodeoxycholoyl-CoA unknown Coenzyme A + 3a,7a-Dihydroxy-5b-cholestanoyl-CoA details
Decanoyl-CoA (n-C10:0CoA) + Acetyl-CoA unknown Coenzyme A + 3-Oxododecanoyl-CoA details
Hexanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxooctanoyl-CoA details
Gene Name: HADHB
Uniprot ID: P55084 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
Reactions:
Acetyl-CoA + Glycine unknown Coenzyme A + L-2-Amino-3-oxobutanoic acid details
Acetyl-CoA + Glycine unknown Coenzyme A + L-2-Amino-3-oxobutanoic acid details
Gene Name: GCAT
Uniprot ID: O75600 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
Reactions: Not Available
Gene Name: PDHA2
Uniprot ID: P29803 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
Reactions:
2-Methyl-3-oxopropanoic acid + Coenzyme A + Water + NAD unknown Propionyl-CoA + Carbonic acid + NADH details
Malonic semialdehyde + Coenzyme A + NAD(P)(+) unknown Acetyl-CoA + CO(2) + NAD(P)H details
Malonic semialdehyde + Coenzyme A + NAD unknown Acetyl-CoA + Carbon dioxide + NADH + Hydrogen Ion details
Malonic semialdehyde + Coenzyme A + NADP unknown Acetyl-CoA + Carbon dioxide + NADPH + Hydrogen Ion details
Malonic semialdehyde + Coenzyme A + NADP unknown Malonyl-CoA + NADPH + Hydrogen Ion details
(S)-Methylmalonic acid semialdehyde + Coenzyme A + NAD unknown Propionyl-CoA + Carbon dioxide + NADH + Hydrogen Ion details
(S)-Methylmalonic acid semialdehyde + Coenzyme A + NAD unknown Methylmalonyl-CoA + NADH + Hydrogen Ion details
Gene Name: ALDH6A1
Uniprot ID: Q02252 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glucosamine 6-phosphate N-acetyltransferase
Reactions:
Acetyl-CoA + Glucosamine 6-phosphate unknown Coenzyme A + N-Acetyl-D-Glucosamine 6-Phosphate details
Gene Name: GNPNAT1
Uniprot ID: Q96EK6 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Reactions:
Acetyl-CoA + Water + Acetoacetyl-CoA unknown 3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A details
3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A unknown Acetyl-CoA + Water + Acetoacetyl-CoA details
Gene Name: HMGCS1
Uniprot ID: Q01581 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Dihydrolipoyl dehydrogenase, mitochondrial
Reactions: Not Available
Gene Name: DLD
Uniprot ID: P09622 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Reactions:
Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine unknown Coenzyme A + enzyme N(6)-(S-acetyldihydrolipoyl)lysine details
Acetyl-CoA + Enzyme N6-(dihydrolipoyl)lysine unknown Coenzyme A + [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine details
Gene Name: DLAT
Uniprot ID: P10515 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Diacylglycerol O-acyltransferase 1
Reactions:
Acyl-CoA + 1,2-diacylglycerol unknown Coenzyme A + triacylglycerol details
Acyl-CoA + Vitamin A unknown Coenzyme A + Retinyl ester details
Triacylglycerol + Coenzyme A unknown 1,2-Diacyl-sn-glycerol + Acyl-CoA details
Acyl-CoA + Vitamin A unknown Coenzyme A + Retinyl ester details
hexadecanoyl-CoA + Vitamin A unknown Coenzyme A + Retinyl palmitate details
hexadecanoyl-CoA + 11-cis-Retinol unknown Coenzyme A + 11-cis-Retinyl palmitate details
Gene Name: DGAT1
Uniprot ID: O75907 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Peroxisomal carnitine O-octanoyltransferase
Reactions:
Octanoyl-CoA + L-Carnitine unknown Coenzyme A + L-Octanoylcarnitine details
Gene Name: CROT
Uniprot ID: Q9UKG9 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Carnitine O-palmitoyltransferase 1, muscle isoform
Reactions:
hexadecanoyl-CoA + L-Carnitine unknown Coenzyme A + L-Palmitoylcarnitine details
Gene Name: CPT1B
Uniprot ID: Q92523 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Carnitine O-palmitoyltransferase 1, liver isoform
Reactions:
hexadecanoyl-CoA + L-Carnitine unknown Coenzyme A + L-Palmitoylcarnitine details
Gene Name: CPT1A
Uniprot ID: P50416 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Carnitine O-palmitoyltransferase 2, mitochondrial
Reactions:
hexadecanoyl-CoA + L-Carnitine unknown Coenzyme A + L-Palmitoylcarnitine details
Gene Name: CPT2
Uniprot ID: P23786 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Carnitine O-palmitoyltransferase 1, brain isoform
Reactions:
hexadecanoyl-CoA + L-Carnitine unknown Coenzyme A + L-Palmitoylcarnitine details
Gene Name: CPT1C
Uniprot ID: Q8TCG5 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Malonyl-CoA-acyl carrier protein transacylase, mitochondrial
Reactions:
Malonyl-CoA + [acyl-carrier-protein] unknown Coenzyme A + malonyl-[acyl-carrier-protein] details
Malonyl-CoA + Acyl-carrier protein unknown Coenzyme A + Malonyl-[acyl-carrier protein] details
Gene Name: MCAT
Uniprot ID: Q8IVS2 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 2-oxoglutarate dehydrogenase, mitochondrial
Reactions:
Oxoadipic acid + Coenzyme A + NAD unknown Glutaryl-CoA + Carbon dioxide + NADH + Hydrogen Ion details
Gene Name: OGDH
Uniprot ID: Q02218 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Non-specific lipid-transfer protein
Reactions:
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoyl-CoA + Propionyl-CoA unknown Coenzyme A + 3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholestanoyl-CoA details
Propionyl-CoA + Choloyl-CoA unknown Coenzyme A + 3a,7a,12a-Trihydroxy-5b-24-oxocholestanoyl-CoA details
Propionyl-CoA + Chenodeoxycholoyl-CoA unknown Coenzyme A + 3a,7a-Dihydroxy-5b-24-oxocholestanoyl-CoA details
Gene Name: SCP2
Uniprot ID: P22307 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sterol O-acyltransferase 2
Reactions:
Acyl-CoA + Cholesterol unknown Coenzyme A + cholesterol ester details
Gene Name: SOAT2
Uniprot ID: O75908 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sterol O-acyltransferase 1
Reactions:
Acyl-CoA + Cholesterol unknown Coenzyme A + cholesterol ester details
Gene Name: SOAT1
Uniprot ID: P35610 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA