Record Information
Version3.6
Creation Date2005-11-16 15:48:42 UTC
Update Date2013-02-09 00:10:31 UTC
HMDB IDHMDB01423
Secondary Accession NumbersNone
Metabolite Identification
Common NameCoenzyme A
DescriptionCoenzyme A (CoA, CoASH, or HSCoA) is a coenzyme, notable for its role in the synthesis and oxidization of fatty acids, and the oxidation of pyruvate in the citric acid cycle. It is adapted from beta-mercaptoethylamine, panthothenate and adenosine triphosphate. Coenzyme A is synthesized in a five-step process from pantothenate and cysteine. In the first step Pantothenate (vitamin B5) is phosphorylated to 4'-phosphopantothenate by the enzyme pantothenate kinase (PanK; CoaA; CoaX)In the second step, a cysteine is added to 4'-phosphopantothenate by the enzyme phosphopantothenoylcysteine synthetase (PPC-DC; CoaB) to form 4'-phospho-N-pantothenoylcysteine (PPC). In the third step, PPC is decarboxylated to 4'-phosphopantetheine by phosphopantothenoylcysteine decarboxylase (CoaC). In the fourth step, 4'-phosphopantetheine is adenylylated to form dephospho-CoA by the enzyme phosphopantetheine adenylyl transferase (CoaD)Finally, dephospho-CoA is phosphorylated using ATP to coenzyme A by the enzyme dephosphocoenzyme A kinase (CoaE). Since coenzyme A is, in chemical terms, a thiol, it can react with carboxylic acids to form thioesters, thus functioning as an acyl group carrier. CoA assists in transferring fatty acids from the cytoplasm to mitochondria. A molecule of coenzyme A carrying an acetyl group is also referred to as acetyl-CoA. When it is not attached to an acyl group, it is usually referred to as 'CoASH' or 'HSCoA'. Coenzyme A is also the source of the phosphopantetheine group that is added as a prosthetic group to proteins such as acyl carrier protein and formyltetrahydrofolate dehydrogenase Acetyl-CoA is an important molecule itself. It is the precursor to HMG CoA, which is a vital component in cholesterol and ketone synthesis. Furthermore, it contributes an acetyl group to choline to produce acetylcholine, in a reaction catalysed by choline acetyltransferase. Its main task is conveying the carbon atoms within the acetyl group to the citric acid cycle to be oxidized for energy production. -- Wikipedia.
Structure
Thumb
Synonyms
  1. Acetoacetyl coenzyme A sodium salt
  2. CoA
  3. CoA hydrate
  4. CoA-SH
  5. CoASH
  6. Coenzyme A
  7. Coenzyme A hydrate
  8. Coenzyme A-SH
  9. Coenzyme ASH
  10. Coenzymes A
  11. Depot-Zeel
  12. Propionyl CoA
  13. Propionyl Coenzyme A
  14. S-Propanoate
  15. S-Propanoate CoA
  16. S-Propanoate Coenzyme A
  17. S-Propanoic acid
  18. S-Propionate CoA
  19. S-Propionate Coenzyme A
  20. Zeel
  21. [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl 3-hydroxy-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)-2,2-dimethyl-4-oxobutyl dihydrogen diphosphate
Chemical FormulaC21H36N7O16P3S
Average Molecular Weight767.534
Monoisotopic Molecular Weight767.115208365
IUPAC Name{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[3-hydroxy-2,2-dimethyl-3-({2-[(2-sulfanylethyl)carbamoyl]ethyl}carbamoyl)propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acid
Traditional IUPAC Name[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[({hydroxy[hydroxy(3-hydroxy-2,2-dimethyl-3-({2-[(2-sulfanylethyl)carbamoyl]ethyl}carbamoyl)propoxy)phosphoryl]oxyphosphoryl}oxy)methyl]oxolan-3-yl]oxyphosphonic acid
CAS Registry Number85-61-0
SMILES
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS
InChI Identifier
InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/t11-,14-,15-,16?,20-/m1/s1
InChI KeyRGJOEKWQDUBAIZ-DRCCLKDXSA-N
Chemical Taxonomy
KingdomOrganic Compounds
Super ClassNucleosides, Nucleotides, and Analogues
ClassPurine Nucleotides
Sub ClassPurine Ribonucleotides
Other Descriptors
  • Aromatic Heteropolycyclic Compounds
Substituents
  • 1 Phosphoribosyl Imidazole
  • Alkylthiol
  • Aminopyrimidine
  • Carboxamide Group
  • Glycosyl Compound
  • Imidazole
  • Imidazopyrimidine
  • Monosaccharide Phosphate
  • N Glycosyl Compound
  • Organic Hypophosphite
  • Organic Phosphite
  • Organic Pyrophosphate
  • Oxolane
  • Pentose Monosaccharide
  • Phosphoric Acid Ester
  • Purine
  • Purine Ribonucleoside 3',5' Bisphosphate
  • Pyrimidine
  • Saccharide
  • Secondary Alcohol
  • Secondary Carboxylic Acid Amide
  • Thiol (Sulfanyl Compound)
Direct ParentCoenzyme A and Derivatives
Ontology
StatusExpected and Not Quantified
Origin
  • Endogenous
Biofunction
  • Component of Alanine and aspartate metabolism
  • Component of Aminosugars metabolism
  • Component of Arginine and proline metabolism
  • Component of Bile acid biosynthesis
  • Component of Butanoate metabolism
  • Component of C5-Branched dibasic acid metabolism
  • Component of Fatty acid metabolism
  • Component of Glutamate metabolism
  • Component of Glycerolipid metabolism
  • Component of Glycerophospholipid metabolism
  • Component of Glycine, serine and threonine metabolism
  • Component of Glycosphingolipid metabolism
  • Component of Glyoxylate and dicarboxylate metabolism
  • Component of Inositol metabolism
  • Component of Propanoate metabolism
  • Component of Pyruvate metabolism
  • Component of Tryptophan metabolism
ApplicationNot Available
Cellular locations
  • Mitochondria
  • Nucleus
  • Lysosome
  • Endoplasmic reticulum
  • Golgi apparatus
  • Peroxisome
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
water solubility4.64 g/LALOGPS
logP-0.61ALOGPS
logP-6.8ChemAxon
logS-2.2ALOGPS
pKa (strongest acidic)0.83ChemAxon
pKa (strongest basic)4.95ChemAxon
physiological charge-4ChemAxon
hydrogen acceptor count16ChemAxon
hydrogen donor count10ChemAxon
polar surface area346.56ChemAxon
rotatable bond count18ChemAxon
refractivity162.74ChemAxon
polarizability66.81ChemAxon
Spectra
Spectra
Biological Properties
Cellular Locations
  • Mitochondria
  • Nucleus
  • Lysosome
  • Endoplasmic reticulum
  • Golgi apparatus
  • Peroxisome
Biofluid LocationsNot Available
Tissue Location
  • Adipose Tissue
  • Fibroblasts
  • Skeletal Muscle
Pathways
NameSMPDB LinkKEGG Link
Amino Sugar MetabolismSMP00045map00520
Beta Oxidation of Very Long Chain Fatty AcidsSMP00052map01040
Beta-Alanine MetabolismSMP00007map00410
Bile Acid BiosynthesisSMP00035map00120
Butyrate MetabolismSMP00073map00650
Citric Acid CycleSMP00057map00020
Ethanol DegradationSMP00449Not Available
Fatty acid MetabolismSMP00051map00071
Glycine and Serine MetabolismSMP00004map00260
Ketone Body MetabolismSMP00071map00072
Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty AcidsSMP00482Not Available
Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty AcidsSMP00481Not Available
Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty AcidsSMP00480Not Available
Oxidation of Branched Chain Fatty AcidsSMP00030Not Available
Pantothenate and CoA BiosynthesisSMP00027map00770
Phenylacetate MetabolismSMP00126map00360
Plasmalogen SynthesisSMP00479Not Available
Threonine and 2-Oxobutanoate DegradationSMP00452Not Available
Transfer of Acetyl Groups into MitochondriaSMP00466Not Available
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB022614
KNApSAcK IDNot Available
Chemspider ID6557
KEGG Compound IDC00010
BioCyc IDCO-A
BiGG ID33502
Wikipedia LinkCoenzyme A
NuGOwiki LinkHMDB01423
Metagene LinkHMDB01423
METLIN ID6235
PubChem Compound6816
PDB ID1A59
ChEBI ID1146900
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Wendel U, Zass R, Leupold D: Contribution of odd-numbered fatty acid oxidation to propionate production in neonates with methylmalonic and propionic acidaemias. Eur J Pediatr. 1993 Dec;152(12):1021-3. Pubmed: 8131803
  2. Bergstrom T, Greter J, Levin AH, Steen G, Tryding N, Wass U: Propionyl-CoA carboxylase deficiency: case report, effect of low-protein diet and identification of 3-oxo-2-methylvaleric acid 3-hydroxy-2-methylvaleric acid, and maleic acid in urine. Scand J Clin Lab Invest. 1981 Apr;41(2):117-26. Pubmed: 7313494
  3. Roe CR, Sweetman L, Roe DS, David F, Brunengraber H: Treatment of cardiomyopathy and rhabdomyolysis in long-chain fat oxidation disorders using an anaplerotic odd-chain triglyceride. J Clin Invest. 2002 Jul;110(2):259-69. Pubmed: 12122118
  4. Yano S, Li L, Le TP, Moseley K, Guedalia A, Lee J, Gonzalez I, Boles RG: Infantile mitochondrial DNA depletion syndrome associated with methylmalonic aciduria and 3-methylcrotonyl-CoA and propionyl-CoA carboxylase deficiencies in two unrelated patients: a new phenotype of mtDNA depletion syndrome. J Inherit Metab Dis. 2003;26(5):481-8. Pubmed: 14518828
  5. Kretschmer RE, Bachmann C: Methylcitric acid determination in amniotic fluid by electron-impact mass fragmentography. J Clin Chem Clin Biochem. 1988 May;26(5):345-8. Pubmed: 3404093
  6. Osmundsen H, Bremer J, Pedersen JI: Metabolic aspects of peroxisomal beta-oxidation. Biochim Biophys Acta. 1991 Sep 11;1085(2):141-58. Pubmed: 1892883
  7. Reihner E, Angelin B, Rudling M, Ewerth S, Bjorkhem I, Einarsson K: Regulation of hepatic cholesterol metabolism in humans: stimulatory effects of cholestyramine on HMG-CoA reductase activity and low density lipoprotein receptor expression in gallstone patients. J Lipid Res. 1990 Dec;31(12):2219-26. Pubmed: 2090716
  8. Salen G, Batta AK, Tint GS, Shefer S: Comparative effects of lovastatin and chenodeoxycholic acid on plasma cholestanol levels and abnormal bile acid metabolism in cerebrotendinous xanthomatosis. Metabolism. 1994 Aug;43(8):1018-22. Pubmed: 8052141
  9. Lehnert W, Junker A: [2-Methyl-3-oxovaleric acid: a characteristic metabolite in propionic acidemia] Clin Chim Acta. 1980 May 21;104(1):47-51. Pubmed: 7389125

Only showing the first 50 proteins. There are 186 proteins in total.

Enzymes

Gene Name:
ACLY
Uniprot ID:
P53396
Reactions
ADP + Phosphoric acid + Acetyl-CoA + Oxalacetic acid unknown Adenosine triphosphate + Citric acid + Coenzyme Adetails
Adenosine triphosphate + Citric acid + Coenzyme A unknown ADP + Phosphoric acid + Acetyl-CoA + Oxalacetic aciddetails
Gene Name:
EP300
Uniprot ID:
Q09472
Reactions
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone]details
Gene Name:
ACAT2
Uniprot ID:
Q9BWD1
Reactions
Acetyl-CoA unknown Coenzyme A + Acetoacetyl-CoAdetails
Acetyl-CoA + Butyryl-CoA unknown Coenzyme A + 3-Oxohexanoyl-CoAdetails
Gene Name:
CREBBP
Uniprot ID:
Q92793
Reactions
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone]details
Gene Name:
SAT2
Uniprot ID:
Q96F10
Reactions
Acetyl-CoA + an alkane-alpha,omega-diamine unknown Coenzyme A + an N-acetyldiaminedetails
Acetyl-CoA + Putrescine unknown Coenzyme A + N-Acetylputrescinedetails
Gene Name:
ALAS2
Uniprot ID:
P22557
Reactions
Succinyl-CoA + Glycine unknown 5-Aminolevulinic acid + Coenzyme A + CO(2)details
Succinyl-CoA + Glycine unknown 5-Aminolevulinic acid + Coenzyme A + Carbon dioxidedetails
Gene Name:
NAT1
Uniprot ID:
P18440
Reactions
Acetyl-CoA + an arylamine unknown Coenzyme A + an N-acetylarylaminedetails
2,4-Diamino-6-nitrotoluene + Acetyl-CoA unknown 4-Acetamido-2-amino-6-nitrotoluene + Coenzyme Adetails
Acetyl-CoA + Isoniazid unknown Coenzyme A + Acetylisoniaziddetails
Acetyl-CoA + Acetylhydrazine unknown Coenzyme A + N,N'-Diacetylhydrazinedetails
Gene Name:
NAT2
Uniprot ID:
P11245
Reactions
Acetyl-CoA + an arylamine unknown Coenzyme A + an N-acetylarylaminedetails
2,4-Diamino-6-nitrotoluene + Acetyl-CoA unknown 4-Acetamido-2-amino-6-nitrotoluene + Coenzyme Adetails
Acetyl-CoA + Isoniazid unknown Coenzyme A + Acetylisoniaziddetails
Acetyl-CoA + Acetylhydrazine unknown Coenzyme A + N,N'-Diacetylhydrazinedetails
Gene Name:
ALAS1
Uniprot ID:
P13196
Reactions
Succinyl-CoA + Glycine unknown 5-Aminolevulinic acid + Coenzyme A + CO(2)details
Succinyl-CoA + Glycine unknown 5-Aminolevulinic acid + Coenzyme A + Carbon dioxidedetails
Gene Name:
GTF3C4
Uniprot ID:
Q9UKN8
Reactions
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone]details
Gene Name:
ACOT12
Uniprot ID:
Q8WYK0
Reactions
Acetyl-CoA + Water unknown Coenzyme A + Acetic aciddetails
Gene Name:
CHAT
Uniprot ID:
P28329
Reactions
Acetyl-CoA + Choline unknown Coenzyme A + Acetylcholine details
Gene Name:
NCOA3
Uniprot ID:
Q9Y6Q9
Reactions
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone]details
Gene Name:
KAT2B
Uniprot ID:
Q92831
Reactions
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone]details
Gene Name:
CRAT
Uniprot ID:
P43155
Reactions
Acetyl-CoA + L-Carnitine unknown Coenzyme A + L-Acetylcarnitinedetails
Gene Name:
SAT1
Uniprot ID:
P21673
Reactions
Acetyl-CoA + an alkane-alpha,omega-diamine unknown Coenzyme A + an N-acetyldiaminedetails
Acetyl-CoA + Putrescine unknown Coenzyme A + N-Acetylputrescinedetails
Gene Name:
AANAT
Uniprot ID:
Q16613
Reactions
Acetyl-CoA + a 2-arylethylamine unknown Coenzyme A + an N-acetyl-2-arylethylaminedetails
Acetyl-CoA + Serotonin unknown Coenzyme A + N-Acetylserotonindetails
Gene Name:
ACAA2
Uniprot ID:
P42765
Reactions
Acyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-oxoacyl-CoAdetails
Acyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxoacyl-CoAdetails
Succinyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxoadipyl-CoAdetails
Propionyl-CoA + Acetyl-CoA unknown Coenzyme A + 2-Methylacetoacetyl-CoAdetails
Acetyl-CoA + Butyryl-CoA unknown Coenzyme A + 3-Oxohexanoyl-CoAdetails
Octanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxodecanoyl-CoAdetails
Lauroyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxotetradecanoyl-CoAdetails
Tetradecanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxohexadecanoyl-CoAdetails
Propionyl-CoA + Chenodeoxycholoyl-CoA unknown Coenzyme A + 3a,7a-Dihydroxy-5b-cholestanoyl-CoAdetails
Decanoyl-CoA (n-C10:0CoA) + Acetyl-CoA unknown Coenzyme A + 3-Oxododecanoyl-CoAdetails
Hexanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxooctanoyl-CoAdetails
Gene Name:
CDY1
Uniprot ID:
Q9Y6F8
Reactions
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone]details
Gene Name:
FASN
Uniprot ID:
P49327
Reactions
Acetyl-CoA + [acyl-carrier-protein] unknown Coenzyme A + acetyl-[acyl-carrier-protein]details
Malonyl-CoA + [acyl-carrier-protein] unknown Coenzyme A + malonyl-[acyl-carrier-protein]details
Acetyl-CoA + Acyl-carrier protein unknown Coenzyme A + Acetyl-[acyl-carrier protein]details
Malonyl-CoA + Acyl-carrier protein unknown Coenzyme A + Malonyl-[acyl-carrier protein]details
Gene Name:
KAT5
Uniprot ID:
Q92993
Reactions
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone]details
Gene Name:
ACSS2
Uniprot ID:
Q9NR19
Reactions
Adenosine triphosphate + Acetic acid + Coenzyme A unknown Adenosine monophosphate + Pyrophosphate + Acetyl-CoAdetails
Acetyl adenylate + Coenzyme A unknown Adenosine monophosphate + Acetyl-CoAdetails
Propinol adenylate + Coenzyme A unknown Adenosine monophosphate + Propionyl-CoAdetails
Gene Name:
ACAT1
Uniprot ID:
P24752
Reactions
Acetyl-CoA unknown Coenzyme A + Acetoacetyl-CoAdetails
Acetyl-CoA + Butyryl-CoA unknown Coenzyme A + 3-Oxohexanoyl-CoAdetails
Gene Name:
NCOA1
Uniprot ID:
Q15788
Reactions
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone]details
Gene Name:
HMGCS2
Uniprot ID:
P54868
Reactions
Acetyl-CoA + Water + Acetoacetyl-CoA unknown 3-Hydroxy-3-methylglutaryl-CoA + Coenzyme Adetails
3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A unknown Acetyl-CoA + Water + Acetoacetyl-CoAdetails
Gene Name:
ACSS1
Uniprot ID:
Q9NUB1
Reactions
Adenosine triphosphate + Acetic acid + Coenzyme A unknown Adenosine monophosphate + Pyrophosphate + Acetyl-CoAdetails
Acetyl adenylate + Coenzyme A unknown Adenosine monophosphate + Acetyl-CoAdetails
Propinol adenylate + Coenzyme A unknown Adenosine monophosphate + Propionyl-CoAdetails
Gene Name:
CS
Uniprot ID:
O75390
Reactions
Acetyl-CoA + Water + Oxalacetic acid unknown Citric acid + Coenzyme Adetails
Citric acid + Coenzyme A unknown Acetyl-CoA + Water + Oxalacetic aciddetails
Gene Name:
CDY2A
Uniprot ID:
Q9Y6F7
Reactions
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone]details
Gene Name:
ACAA1
Uniprot ID:
P09110
Reactions
Acyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-oxoacyl-CoAdetails
Succinyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxoadipyl-CoAdetails
Propionyl-CoA + Acetyl-CoA unknown Coenzyme A + 2-Methylacetoacetyl-CoAdetails
Acetyl-CoA + Butyryl-CoA unknown Coenzyme A + 3-Oxohexanoyl-CoAdetails
Octanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxodecanoyl-CoAdetails
Lauroyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxotetradecanoyl-CoAdetails
Tetradecanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxohexadecanoyl-CoAdetails
Propionyl-CoA + Chenodeoxycholoyl-CoA unknown Coenzyme A + 3a,7a-Dihydroxy-5b-cholestanoyl-CoAdetails
Decanoyl-CoA (n-C10:0CoA) + Acetyl-CoA unknown Coenzyme A + 3-Oxododecanoyl-CoAdetails
Hexanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxooctanoyl-CoAdetails
OPC6-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxo-OPC8-CoAdetails
OPC4-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxo-OPC6-CoAdetails
(+)-7-Isojasmonic acid CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxo-OPC4-CoAdetails
Cervonyl coenzyme A + Acetyl-CoA unknown Coenzyme A + (6Z,9Z,12Z,15Z,18Z,21Z)-3-Oxotetracosahexa-6,9,12,15,18,21-enoyl-CoAdetails
Docosa-4,7,10,13,16-pentaenoyl CoA + Acetyl-CoA unknown Coenzyme A + (6Z,9Z,12Z,15Z,18Z)-3-Oxotetracosapenta-6,9,12,15,18-enoyl-CoAdetails
Gene Name:
HADHB
Uniprot ID:
P55084
Reactions
Acyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-oxoacyl-CoAdetails
Acyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxoacyl-CoAdetails
Succinyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxoadipyl-CoAdetails
Propionyl-CoA + Acetyl-CoA unknown Coenzyme A + 2-Methylacetoacetyl-CoAdetails
Acetyl-CoA + Butyryl-CoA unknown Coenzyme A + 3-Oxohexanoyl-CoAdetails
Octanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxodecanoyl-CoAdetails
Lauroyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxotetradecanoyl-CoAdetails
Tetradecanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxohexadecanoyl-CoAdetails
Propionyl-CoA + Chenodeoxycholoyl-CoA unknown Coenzyme A + 3a,7a-Dihydroxy-5b-cholestanoyl-CoAdetails
Decanoyl-CoA (n-C10:0CoA) + Acetyl-CoA unknown Coenzyme A + 3-Oxododecanoyl-CoAdetails
Hexanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxooctanoyl-CoAdetails
Gene Name:
GCAT
Uniprot ID:
O75600
Reactions
Acetyl-CoA + Glycine unknown Coenzyme A + L-2-Amino-3-oxobutanoic aciddetails
Acetyl-CoA + Glycine unknown Coenzyme A + L-2-Amino-3-oxobutanoic aciddetails
Gene Name:
ALDH6A1
Uniprot ID:
Q02252
Reactions
2-Methyl-3-oxopropanoic acid + Coenzyme A + Water + NAD unknown Propionyl-CoA + Carbonic acid + NADHdetails
Malonic semialdehyde + Coenzyme A + NAD(P)(+) unknown Acetyl-CoA + CO(2) + NAD(P)Hdetails
Malonic semialdehyde + Coenzyme A + NAD unknown Acetyl-CoA + Carbon dioxide + NADH + Hydrogen Iondetails
Malonic semialdehyde + Coenzyme A + NADP unknown Acetyl-CoA + Carbon dioxide + NADPH + Hydrogen Iondetails
Malonic semialdehyde + Coenzyme A + NADP unknown Malonyl-CoA + NADPH + Hydrogen Iondetails
(S)-Methylmalonic acid semialdehyde + Coenzyme A + NAD unknown Propionyl-CoA + Carbon dioxide + NADH + Hydrogen Iondetails
(S)-Methylmalonic acid semialdehyde + Coenzyme A + NAD unknown Methylmalonyl-CoA + NADH + Hydrogen Iondetails
Gene Name:
GNPNAT1
Uniprot ID:
Q96EK6
Reactions
Acetyl-CoA + Glucosamine 6-phosphate unknown Coenzyme A + N-Acetyl-D-Glucosamine 6-Phosphatedetails
Gene Name:
HMGCS1
Uniprot ID:
Q01581
Reactions
Acetyl-CoA + Water + Acetoacetyl-CoA unknown 3-Hydroxy-3-methylglutaryl-CoA + Coenzyme Adetails
3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A unknown Acetyl-CoA + Water + Acetoacetyl-CoAdetails
Gene Name:
DLAT
Uniprot ID:
P10515
Reactions
Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine unknown Coenzyme A + enzyme N(6)-(S-acetyldihydrolipoyl)lysinedetails
Acetyl-CoA + Enzyme N6-(dihydrolipoyl)lysine unknown Coenzyme A + [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysinedetails
Gene Name:
DGAT1
Uniprot ID:
O75907
Reactions
Acyl-CoA + 1,2-diacylglycerol unknown Coenzyme A + triacylglyceroldetails
Acyl-CoA + Vitamin A unknown Coenzyme A + Retinyl esterdetails
Triacylglycerol + Coenzyme A unknown 1,2-Diacyl-sn-glycerol + Acyl-CoAdetails
Acyl-CoA + Vitamin A unknown Coenzyme A + Retinyl esterdetails
hexadecanoyl-CoA + Vitamin A unknown Coenzyme A + Retinyl palmitatedetails
hexadecanoyl-CoA + 11-cis-Retinol unknown Coenzyme A + 11-cis-Retinyl palmitatedetails
Gene Name:
CROT
Uniprot ID:
Q9UKG9
Reactions
Octanoyl-CoA + L-Carnitine unknown Coenzyme A + L-Octanoylcarnitinedetails
Gene Name:
CPT1B
Uniprot ID:
Q92523
Reactions
hexadecanoyl-CoA + L-Carnitine unknown Coenzyme A + L-Palmitoylcarnitinedetails
Gene Name:
CPT1A
Uniprot ID:
P50416
Reactions
hexadecanoyl-CoA + L-Carnitine unknown Coenzyme A + L-Palmitoylcarnitinedetails
Gene Name:
CPT2
Uniprot ID:
P23786
Reactions
hexadecanoyl-CoA + L-Carnitine unknown Coenzyme A + L-Palmitoylcarnitinedetails
Gene Name:
CPT1C
Uniprot ID:
Q8TCG5
Reactions
hexadecanoyl-CoA + L-Carnitine unknown Coenzyme A + L-Palmitoylcarnitinedetails
Gene Name:
MCAT
Uniprot ID:
Q8IVS2
Reactions
Malonyl-CoA + [acyl-carrier-protein] unknown Coenzyme A + malonyl-[acyl-carrier-protein]details
Malonyl-CoA + Acyl-carrier protein unknown Coenzyme A + Malonyl-[acyl-carrier protein]details
Gene Name:
OGDH
Uniprot ID:
Q02218
Reactions
Oxoadipic acid + Coenzyme A + NAD unknown Glutaryl-CoA + Carbon dioxide + NADH + Hydrogen Iondetails
Gene Name:
SCP2
Uniprot ID:
P22307
Reactions
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoyl-CoA + Propionyl-CoA unknown Coenzyme A + 3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholestanoyl-CoAdetails
Propionyl-CoA + Choloyl-CoA unknown Coenzyme A + 3a,7a,12a-Trihydroxy-5b-24-oxocholestanoyl-CoAdetails
Propionyl-CoA + Chenodeoxycholoyl-CoA unknown Coenzyme A + 3a,7a-Dihydroxy-5b-24-oxocholestanoyl-CoAdetails
Gene Name:
SOAT2
Uniprot ID:
O75908
Reactions
Acyl-CoA + Cholesterol unknown Coenzyme A + cholesterol esterdetails
Gene Name:
SOAT1
Uniprot ID:
P35610
Reactions
Acyl-CoA + Cholesterol unknown Coenzyme A + cholesterol esterdetails

Only showing the first 50 proteins. There are 186 proteins in total.