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Human Metabolome Database Version 3.5

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Showing metabocard for NADH (HMDB01487)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-05-15 14:41:54 -0600
HMDB ID HMDB01487
Secondary Accession Numbers None
Metabolite Identification
Common Name NADH
Description NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). It forms NADP with the addition of a phosphate group to the 2' position of the adenosyl nucleotide through an ester linkage.(Dorland, 27th ed).
Structure Thumb
Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. 1,4-Dihydronicotinamide adenine dinucleotide
  2. b-DPNH
  3. b-NADH
  4. beta-DPNH
  5. beta-NADH
  6. Dihydrocodehydrogenase I
  7. Dihydrocozymase
  8. Dihydronicotinamide adenine dinucleotide
  9. Dihydronicotinamide mononucleotide
  10. DPNH
  11. ENADA
  12. NADH
  13. NADH2
  14. Reduced codehydrogenase I
  15. Reduced diphosphopyridine nucleotide
  16. Reduced nicotinamide adenine diphosphate
  17. Reduced nicotinamide-adenine dinucleotide
Chemical Formula C21H29N7O14P2
Average Molecular Weight 665.441
Monoisotopic Molecular Weight 665.124771695
IUPAC Name {[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}[({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphinic acid
Traditional IUPAC Name [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy({[(2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy)phosphinic acid
CAS Registry Number 58-68-4
SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
InChI Identifier InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
InChI Key BOPGDPNILDQYTO-NNYOXOHSSA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Nucleosides, Nucleotides, and Analogues
Class Purine Nucleotides
Sub Class Purine Ribonucleotides
Other Descriptors
  • Aromatic Heteropolycyclic Compounds
Substituents
  • 1,2 Diol
  • 1 Phosphoribosyl Imidazole
  • Aminopyrimidine
  • Carboxamide Group
  • Dihydropyridine
  • Disaccharide Phosphate
  • Enamine
  • Glycosyl Compound
  • Hemiaminal
  • Hydropyridine
  • Imidazole
  • Imidazopyrimidine
  • N Glycosyl Compound
  • Nicotinamide Nucleotide
  • Organic Hypophosphite
  • Organic Phosphite
  • Organic Pyrophosphate
  • Oxolane
  • Pentose Disaccharide
  • Phosphoric Acid Ester
  • Primary Carboxylic Acid Amide
  • Purine
  • Pyrimidine
  • Saccharide
  • Secondary Alcohol
Direct Parent Purine Ribonucleoside Diphosphates
Ontology
Status Detected and Quantified
Origin
  • Endogenous
Biofunction
  • Component of Aminosugars metabolism
  • Component of Arginine and proline metabolism
  • Component of Ascorbate and aldarate metabolism
  • Component of Bile acid biosynthesis
  • Component of Butanoate metabolism
  • Component of Cysteine metabolism
  • Component of Fatty acid metabolism
  • Component of Fructose and mannose metabolism
  • Component of Glutamate metabolism
  • Component of Glycerolipid metabolism
  • Component of Glycerophospholipid metabolism
  • Component of Glycine, serine and threonine metabolism
  • Component of Glyoxylate and dicarboxylate metabolism
  • Component of Histidine metabolism
  • Component of Inositol metabolism
  • Component of Methane metabolism
  • Component of Nicotinate and nicotinamide metabolism
  • Component of Nucleotide sugars metabolism
  • Component of Propanoate metabolism
  • Component of Purine metabolism
  • Component of Pyruvate metabolism
  • Component of Retinol metabolism
  • Component of Starch and sucrose metabolism
  • Component of Tryptophan metabolism
  • Component of Tyrosine metabolism
  • Component of Ubiquinone biosynthesis
  • Component of beta-Alanine metabolism
Application Not Available
Cellular locations
  • Mitochondria
  • Endoplasmic reticulum
  • Peroxisome
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point 140.0 - 142.0 °C Not Available
Boiling Point Not Available Not Available
Water Solubility Not Available Not Available
LogP Not Available Not Available
Predicted Properties
Property Value Source
Water Solubility 2.95 g/L ALOGPS
LogP -1.45 ALOGPS
LogP -6.7 ChemAxon
LogS -2.35 ALOGPS
pKa (strongest acidic) -7 ChemAxon
pKa (strongest basic) 5 ChemAxon
Hydrogen Acceptor Count 16 ChemAxon
Hydrogen Donor Count 8 ChemAxon
Polar Surface Area 317.62 A2 ChemAxon
Rotatable Bond Count 11 ChemAxon
Refractivity 143 ChemAxon
Polarizability 57.65 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge -2 ChemAxon
Spectra
Not Available
Biological Properties
Cellular Locations
  • Mitochondria
  • Endoplasmic reticulum
  • Peroxisome
Biofluid Locations
  • Blood
Tissue Location
  • Muscle
  • Bladder
  • Fibroblasts
  • Brain
  • Platelet
Pathways
Name SMPDB Link KEGG Link
Histidine Metabolism SMP00044 map00340 Link_out
Malate-Aspartate Shuttle SMP00129 Not Available
Glycerolipid Metabolism SMP00039 map00561 Link_out
Ammonia Recycling SMP00009 map00910 Link_out
Glycolysis SMP00040 map00010 Link_out
Citric Acid Cycle SMP00057 map00020 Link_out
Gluconeogenesis SMP00128 map00010 Link_out
Glycerol Phosphate Shuttle SMP00124 Not Available
Glucose-Alanine Cycle SMP00127 Not Available
Mitochondrial Electron Transport Chain SMP00355 map00190 Link_out
Ketone Body Metabolism SMP00071 map00072 Link_out
Threonine and 2-Oxobutanoate Degradation SMP00452 Not Available
Ethanol Degradation SMP00449 Not Available
Carnitine Synthesis SMP00465 Not Available
Transfer of Acetyl Groups into Mitochondria SMP00466 Not Available
Plasmalogen Synthesis SMP00479 Not Available
Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids SMP00480 Not Available
Glycine and Serine Metabolism SMP00004 map00260 Link_out
Folate Metabolism SMP00053 map00670 Link_out
Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids SMP00481 Not Available
Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids SMP00482 Not Available
Normal Concentrations
Biofluid Status Value Age Sex Condition Comments
Blood Detected and Quantified
Article_icon
22.0 (14.0-40.0) uM Adult (>18 years old) Both Normal Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease References None
Associated OMIM IDs None
DrugBank ID Not Available
Phenol Explorer Compound ID Not Available
Phenol Explorer Metabolite ID Not Available
FoodDB ID FDB022649
KNApSAcK ID Not Available
Chemspider ID 903 Link_out
KEGG Compound ID C00004 Link_out
BioCyc ID NADH Link_out
BiGG ID 33484 Link_out
Wikipedia Link NADH Link_out
NuGOwiki Link HMDB01487 Link_out
Metagene Link HMDB01487 Link_out
METLIN ID 3687 Link_out
PubChem Compound 928 Link_out
PDB ID Not Available
ChEBI ID 16908 Link_out
References
Synthesis Reference Marek, Miroslav; Vrbova, Eva; Horakova, Irena; Musil, Petr; Kefurt, Karel. NADH manufacture with immobilized Candida formate dehydrogenase. Czech. (1992), 4 pp.
Material Safety Data Sheet (MSDS) Download (PDF)
General References
  1. Yamamoto T, Moriwaki Y, Takahashi S, Suda M, Higashino K: Ethanol as a xanthine dehydrogenase inhibitor. Metabolism. 1995 Jun;44(6):779-85. Pubmed: 7783663 Link_out
  2. Nadlinger K, Westerthaler W, Storga-Tomic D, Birkmayer JG: Extracellular metabolisation of NADH by blood cells correlates with intracellular ATP levels. Biochim Biophys Acta. 2002 Nov 14;1573(2):177-82. Pubmed: 12399028 Link_out
  3. Saada A, Bar-Meir M, Belaiche C, Miller C, Elpeleg O: Evaluation of enzymatic assays and compounds affecting ATP production in mitochondrial respiratory chain complex I deficiency. Anal Biochem. 2004 Dec 1;335(1):66-72. Pubmed: 15519572 Link_out
  4. Heiman-Patterson TD, Argov Z, Chavin JM, Kalman B, Alder H, DiMauro S, Bank W, Tahmoush AJ: Biochemical and genetic studies in a family with mitochondrial myopathy. Muscle Nerve. 1997 Oct;20(10):1219-24. Pubmed: 9324076 Link_out
  5. Mintun MA, Vlassenko AG, Rundle MM, Raichle ME: Increased lactate/pyruvate ratio augments blood flow in physiologically activated human brain. Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):659-64. Epub 2004 Jan 2. Pubmed: 14704276 Link_out
  6. Yeo SF, Zhang Y, Schafer D, Campbell S, Wong B: A rapid, automated enzymatic fluorometric assay for determination of D-arabinitol in serum. J Clin Microbiol. 2000 Apr;38(4):1439-43. Pubmed: 10747122 Link_out
  7. Uppal A, Ghosh N, Datta A, Gupta PK: Fluorimetric estimation of the concentration of NADH from human blood samples. Biotechnol Appl Biochem. 2005 Feb;41(Pt 1):43-7. Pubmed: 15035655 Link_out
  8. Yamamoto T, Moriwaki Y, Takahashi S, Suda M, Higashino K: Xylitol-induced increase in the concentration of oxypurines and its mechanism. Int J Clin Pharmacol Ther. 1995 Jun;33(6):360-5. Pubmed: 7582389 Link_out
  9. Helge JW, Fraser AM, Kriketos AD, Jenkins AB, Calvert GD, Ayre KJ, Storlien LH: Interrelationships between muscle fibre type, substrate oxidation and body fat. Int J Obes Relat Metab Disord. 1999 Sep;23(9):986-91. Pubmed: 10490806 Link_out
  10. Fulco M, Schiltz RL, Iezzi S, King MT, Zhao P, Kashiwaya Y, Hoffman E, Veech RL, Sartorelli V: Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol Cell. 2003 Jul;12(1):51-62. Pubmed: 12887892 Link_out
  11. Krotz F, Sohn HY, Gloe T, Zahler S, Riexinger T, Schiele TM, Becker BF, Theisen K, Klauss V, Pohl U: NAD(P)H oxidase-dependent platelet superoxide anion release increases platelet recruitment. Blood. 2002 Aug 1;100(3):917-24. Pubmed: 12130503 Link_out
  12. Li D, Gan Y, Wientjes MG, Badalament RA, Au JL: Distribution of DT-diaphorase and reduced nicotinamide adenine dinucleotide phosphate: cytochrome p450 oxidoreductase in bladder tissues and tumors. J Urol. 2001 Dec;166(6):2500-5. Pubmed: 11696818 Link_out
  13. Desir G, Bratusch-Marrain P, DeFronzo RA: Effect of hyperketonemia on renal ammonia excretion in man. Metabolism. 1986 Aug;35(8):736-43. Pubmed: 3736414 Link_out
  14. Odland LM, Heigenhauser GJ, Spriet LL: Effects of high fat provision on muscle PDH activation and malonyl-CoA content in moderate exercise. J Appl Physiol. 2000 Dec;89(6):2352-8. Pubmed: 11090589 Link_out
  15. Rani K, Garg P, Pundir CS: Measurement of bile acid in serum and bile with arylamine-glass-bound 3alpha-hydroxysteroid dehydrogenase and diaphorase. Anal Biochem. 2004 Sep 1;332(1):32-7. Pubmed: 15301946 Link_out
  16. Nomura H, Koike F, Tsuruta Y, Iwaki A, Iwaki T: Autopsy case of autosomal recessive hereditary spastic paraplegia with reference to the muscular pathology. Neuropathology. 2001 Sep;21(3):212-7. Pubmed: 11666018 Link_out
  17. Orallo F, Alvarez E, Camina M, Leiro JM, Gomez E, Fernandez P: The possible implication of trans-Resveratrol in the cardioprotective effects of long-term moderate wine consumption. Mol Pharmacol. 2002 Feb;61(2):294-302. Pubmed: 11809853 Link_out
  18. Jawed S, Stevens CR, Harrison R, Blake DR: Elevated circulating plasma NADH oxidising activity of xanthine oxidoreductase in plasma. Biochem Soc Trans. 1997 Aug;25(3):531S. Pubmed: 9388747 Link_out
  19. Harbord MG, Hwang PA, Robinson BH, Becker LE, Hunjan A, Murphy EG: Infant-onset progressive myoclonus epilepsy. J Child Neurol. 1991 Apr;6(2):134-42. Pubmed: 1904460 Link_out
  20. Mayevsky A, Meilin S, Manor T, Ornstein E, Zarchin N, Sonn J: Multiparametric monitoring of brain oxygen balance under experimental and clinical conditions. Neurol Res. 1998;20 Suppl 1:S76-80. Pubmed: 9584930 Link_out
Enzymes
Name: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Reactions:
  • pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2 [RN:R01699]
Gene Name: PDHB
Uniprot ID: P11177 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Reactions:
  • pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2 [RN:R01699]
Gene Name: PDHA1
Uniprot ID: P08559 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
Reactions:
  • pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2 [RN:R01699]
Gene Name: PDHA2
Uniprot ID: P29803 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
Reactions:
  • 2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH [RN:R00922]
Gene Name: ALDH6A1
Uniprot ID: Q02252 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Dihydrolipoyl dehydrogenase, mitochondrial
Reactions:
  • protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+ [RN:R08550]
Gene Name: DLD
Uniprot ID: P09622 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Reactions:
  • acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine [RN:R02569]
Gene Name: DLAT
Uniprot ID: P10515 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Aldo-keto reductase family 1 member C4
Reactions:
  • chlordecone alcohol + NADP+ = chlordecone + NADPH + H+ [RN:R03716]
Gene Name: AKR1C4
Uniprot ID: P17516 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 15-hydroxyprostaglandin dehydrogenase [NAD+]
Reactions:
  • (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ = (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ [RN:R02580]
Gene Name: HPGD
Uniprot ID: P15428 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Tyrosinase
Reactions:
  • L-tyrosine + L-dopa + O2 = L-dopa + dopaquinone + H2O [RN:R02078]
Gene Name: TYR
Uniprot ID: P14679 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Aldose reductase
Reactions:
  • alditol + NAD(P)+ = aldose + NAD(P)H + H+ [RN:R02819 R02820]
Gene Name: AKR1B1
Uniprot ID: P15121 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Short-chain specific acyl-CoA dehydrogenase, mitochondrial
Reactions:
  • butanoyl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor [RN:R01178]
Gene Name: ACADS
Uniprot ID: P16219 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
Reactions:
  • --- []
Gene Name: NDUFB10
Uniprot ID: O96000 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: NADH-ubiquinone oxidoreductase chain 1
Reactions:
  • NADH + H+ + ubiquinone = NAD+ + ubiquinol [RN:R02163]
Gene Name: MT-ND1
Uniprot ID: P03886 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
Reactions:
  • --- []
Gene Name: NDUFB1
Uniprot ID: O75438 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Reactions:
  • a dinucleotide + H2O = 2 mononucleotides [RN:R00056]
Gene Name: ENPP1
Uniprot ID: P22413 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
Reactions:
  • NADH + H+ + acceptor = NAD+ + reduced acceptor [RN:R00281]
Gene Name: NDUFS2
Uniprot ID: O75306 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
Reactions:
  • --- []
Gene Name: NDUFA12
Uniprot ID: Q9UI09 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: NADH-cytochrome b5 reductase 3
Reactions:
  • NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5 [RN:R00100]
Gene Name: CYB5R3
Uniprot ID: P00387 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
Reactions:
  • --- []
Gene Name: NDUFA1
Uniprot ID: O15239 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2
Reactions:
    Gene Name: NDUFA4L2
    Uniprot ID: Q9NRX3 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
    Reactions:
    • --- []
    Gene Name: NDUFA3
    Uniprot ID: O95167 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
    Reactions:
    • --- []
    Gene Name: NDUFA8
    Uniprot ID: P51970 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4
    Reactions:
    • --- []
    Gene Name: NDUFA4
    Uniprot ID: O00483 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH-ubiquinone oxidoreductase chain 4L
    Reactions:
    • NADH + H+ + ubiquinone = NAD+ + ubiquinol [RN:R02163]
    Gene Name: MT-ND4L
    Uniprot ID: P03901 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
    Reactions:
    • --- []
    Gene Name: NDUFA11
    Uniprot ID: Q86Y39 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Lathosterol oxidase
    Reactions:
    • 5alpha-cholest-7-en-3beta-ol + NAD(P)H + H+ + O2 = cholesta-5,7-dien-3beta-ol + NAD(P)+ + 2 H2O [RN:R03310 R07215]
    Gene Name: SC5DL
    Uniprot ID: O75845 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
    Reactions:
    • --- []
    Gene Name: NDUFB2
    Uniprot ID: O95178 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
    Reactions:
    • --- []
    Gene Name: NDUFS4
    Uniprot ID: O43181 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH-ubiquinone oxidoreductase chain 5
    Reactions:
    • NADH + H+ + ubiquinone = NAD+ + ubiquinol [RN:R02163]
    Gene Name: MT-ND5
    Uniprot ID: P03915 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
    Reactions:
    • NADH + H+ + acceptor = NAD+ + reduced acceptor [RN:R00281]
    Gene Name: NDUFS3
    Uniprot ID: O75489 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
    Reactions:
    • --- []
    Gene Name: NDUFS5
    Uniprot ID: O43920 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
    Reactions:
    • NADH + H+ + acceptor = NAD+ + reduced acceptor [RN:R00281]
    Gene Name: NDUFV2
    Uniprot ID: P19404 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
    Reactions:
    • --- []
    Gene Name: NDUFA10
    Uniprot ID: O95299 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
    Reactions:
    • --- []
    Gene Name: NDUFA6
    Uniprot ID: P56556 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
    Reactions:
    • --- []
    Gene Name: NDUFV3
    Uniprot ID: P56181 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
    Reactions:
    • --- []
    Gene Name: NDUFB4
    Uniprot ID: O95168 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
    Reactions:
    • NADH + H+ + acceptor = NAD+ + reduced acceptor [RN:R00281]
    Gene Name: NDUFS8
    Uniprot ID: O00217 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH-ubiquinone oxidoreductase chain 2
    Reactions:
    • NADH + H+ + ubiquinone = NAD+ + ubiquinol [RN:R02163]
    Gene Name: MT-ND2
    Uniprot ID: P03891 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
    Reactions:
    • (S)-1-pyrroline-5-carboxylate + NAD(P)+ + 2 H2O = L-glutamate + NAD(P)H + H+ [RN:R00707 R00708]
    Gene Name: ALDH4A1
    Uniprot ID: P30038 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
    Reactions:
    • --- []
    Gene Name: NDUFA7
    Uniprot ID: O95182 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
    Reactions:
    • --- []
    Gene Name: NDUFA2
    Uniprot ID: O43678 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
    Reactions:
    • NADH + H+ + acceptor = NAD+ + reduced acceptor [RN:R00281]
    Gene Name: NDUFS1
    Uniprot ID: P28331 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
    Reactions:
    • --- []
    Gene Name: NDUFB5
    Uniprot ID: O43674 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
    Reactions:
    • --- []
    Gene Name: NDUFC1
    Uniprot ID: O43677 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] 1 subunit C2
    Reactions:
    • --- []
    Gene Name: NDUFC2
    Uniprot ID: O95298 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
    Reactions:
    • --- []
    Gene Name: NDUFB3
    Uniprot ID: O43676 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
    Reactions:
    • --- []
    Gene Name: NDUFB7
    Uniprot ID: P17568 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Acyl carrier protein, mitochondrial
    Reactions:
    • --- []
    Gene Name: NDUFAB1
    Uniprot ID: O14561 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
    Reactions:
    • --- []
    Gene Name: NDUFA5
    Uniprot ID: Q16718 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
    Reactions:
    • --- []
    Gene Name: NDUFA9
    Uniprot ID: Q16795 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH-ubiquinone oxidoreductase chain 4
    Reactions:
    • NADH + H+ + ubiquinone = NAD+ + ubiquinol [RN:R02163]
    Gene Name: MT-ND4
    Uniprot ID: P03905 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
    Reactions:
    • NADH + H+ + acceptor = NAD+ + reduced acceptor [RN:R00281]
    Gene Name: NDUFS7
    Uniprot ID: O75251 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Xanthine dehydrogenase/oxidase
    Reactions:
    • xanthine + H2O + O2 = urate + H2O2 [RN:R02107]
    Gene Name: XDH
    Uniprot ID: P47989 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH-ubiquinone oxidoreductase chain 3
    Reactions:
    • NADH + H+ + ubiquinone = NAD+ + ubiquinol [RN:R02163]
    Gene Name: MT-ND3
    Uniprot ID: P03897 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
    Reactions:
    • NADH + H+ + acceptor = NAD+ + reduced acceptor [RN:R00281]
    Gene Name: NDUFV1
    Uniprot ID: P49821 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
    Reactions:
    • --- []
    Gene Name: NDUFB9
    Uniprot ID: Q9Y6M9 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Methylenetetrahydrofolate reductase
    Reactions:
    • 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+ [RN:R01224 R07168]
    Gene Name: MTHFR
    Uniprot ID: P42898 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH-ubiquinone oxidoreductase chain 6
    Reactions:
    • NADH + H+ + ubiquinone = NAD+ + ubiquinol [RN:R02163]
    Gene Name: MT-ND6
    Uniprot ID: P03923 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
    Reactions:
    • --- []
    Gene Name: NDUFA13
    Uniprot ID: Q9P0J0 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
    Reactions:
    • --- []
    Gene Name: NDUFS6
    Uniprot ID: O75380 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
    Reactions:
    • a dinucleotide + H2O = 2 mononucleotides [RN:R00056]
    Gene Name: ENPP3
    Uniprot ID: O14638 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
    Reactions:
    • --- []
    Gene Name: NDUFB6
    Uniprot ID: O95139 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Glutathione reductase, mitochondrial
    Reactions:
    • 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+ [RN:R00115]
    Gene Name: GSR
    Uniprot ID: P00390 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Retinal dehydrogenase 1
    Reactions:
    • retinal + NAD+ + H2O = retinoate + NADH + 2 H+ [RN:R02123]
    Gene Name: ALDH1A1
    Uniprot ID: P00352 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
    Reactions:
    • --- []
    Gene Name: NDUFB8
    Uniprot ID: O95169 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Retinal dehydrogenase 2
    Reactions:
    • retinal + NAD+ + H2O = retinoate + NADH + 2 H+ [RN:R02123]
    Gene Name: ALDH1A2
    Uniprot ID: O94788 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Succinate-semialdehyde dehydrogenase, mitochondrial
    Reactions:
    • succinate semialdehyde + NAD+ + H2O = succinate + NADH + 2 H+ [RN:R00713]
    Gene Name: ALDH5A1
    Uniprot ID: P51649 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: C-4 methylsterol oxidase
    Reactions:
    • (1) (1a) 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + NAD(P)H + H+ + O2 = 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NAD(P)+ + H2O [RN:R04501 R05736]
    • (2) (1b) 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NAD(P)H + H+ + O2 = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + NAD(P)+ + 2 H2O [RN:R05733 R05737]
    • (3) (1c) 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + NAD(P)H + H+ + O2 = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NAD(P)+ + H2O [RN:R05734 R05738]
    Gene Name: SC4MOL
    Uniprot ID: Q15800 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
    Reactions:
    • 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NAD(P)+ = 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NAD(P)H [RN:R04483 R07149]
    Gene Name: NSDHL
    Uniprot ID: Q15738 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: 4-trimethylaminobutyraldehyde dehydrogenase
    Reactions:
    • 4-trimethylammoniobutanal + NAD+ + H2O = 4-trimethylammoniobutanoate + NADH + 2 H+ [RN:R03283]
    Gene Name: ALDH9A1
    Uniprot ID: P49189 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Alpha-aminoadipic semialdehyde dehydrogenase
    Reactions:
    • L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + H+ [RN:R03102 R03103]
    Gene Name: ALDH7A1
    Uniprot ID: P49419 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Aldehyde dehydrogenase family 1 member A3
    Reactions:
    • an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+ [RN:R00538 R00634]
    Gene Name: ALDH1A3
    Uniprot ID: P47895 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Aldehyde dehydrogenase, mitochondrial
    Reactions:
    • an aldehyde + NAD+ + H2O = an acid + NADH + H+ [RN:R00538]
    Gene Name: ALDH2
    Uniprot ID: P05091 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Fatty aldehyde dehydrogenase
    Reactions:
    • an aldehyde + NAD+ + H2O = an acid + NADH + H+ [RN:R00538]
    Gene Name: ALDH3A2
    Uniprot ID: P51648 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Aldehyde dehydrogenase X, mitochondrial
    Reactions:
    • an aldehyde + NAD+ + H2O = an acid + NADH + H+ [RN:R00538]
    Gene Name: ALDH1B1
    Uniprot ID: P30837 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Reactions:
    • L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H + H+ [RN:R01248 R01251]
    Gene Name: PYCR1
    Uniprot ID: P32322 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Pyrroline-5-carboxylate reductase 2
    Reactions:
    • L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H + H+ [RN:R01248 R01251]
    Gene Name: PYCR2
    Uniprot ID: Q96C36 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: GDH/6PGL endoplasmic bifunctional protein
    Reactions:
    • 6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate [RN:R02035]
    Gene Name: H6PD
    Uniprot ID: O95479 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Nicotinamide mononucleotide adenylyltransferase 1
    Reactions:
    • ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+ [RN:R03005]
    Gene Name: NMNAT1
    Uniprot ID: Q9HAN9 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Nicotinamide mononucleotide adenylyltransferase 3
    Reactions:
    • ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+ [RN:R03005]
    Gene Name: NMNAT3
    Uniprot ID: Q96T66 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Nicotinamide mononucleotide adenylyltransferase 2
    Reactions:
    • ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+ [RN:R03005]
    Gene Name: NMNAT2
    Uniprot ID: Q9BZQ4 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Aldo-keto reductase family 1 member C3
    Reactions:
    • trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ [RN:R00814]
    Gene Name: AKR1C3
    Uniprot ID: P42330 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: 3-hydroxyacyl-CoA dehydrogenase type-2
    Reactions:
    • (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD+ = 2-methylacetoacetyl-CoA + NADH + H+ [RN:R04203]
    Gene Name: HSD17B10
    Uniprot ID: Q99714 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Peroxisomal bifunctional enzyme
    Reactions:
    • (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA [RN:R04100]
    Gene Name: EHHADH
    Uniprot ID: Q08426 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
    Reactions:
    • (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+ [RN:R01778]
    Gene Name: HADH
    Uniprot ID: Q16836 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: GDP-mannose 4,6 dehydratase
    Reactions:
    • GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H2O [RN:R00888]
    Gene Name: GMDS
    Uniprot ID: O60547 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Aldo-keto reductase family 1 member C1
    Reactions:
    • trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ [RN:R00814]
    Gene Name: AKR1C1
    Uniprot ID: Q04828 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Aldo-keto reductase family 1 member C2
    Reactions:
    • trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ [RN:R00814]
    Gene Name: AKR1C2
    Uniprot ID: P52895 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Trifunctional enzyme subunit alpha, mitochondrial
    Reactions:
    • (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O [RN:R02685 R07314]
    Gene Name: HADHA
    Uniprot ID: P40939 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Glyoxylate reductase/hydroxypyruvate reductase
    Reactions:
    • D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H + H+ [RN:R01388 R01392]
    Gene Name: GRHPR
    Uniprot ID: Q9UBQ7 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
    Reactions:
    • 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+ [RN:R02047]
    Gene Name: HIBADH
    Uniprot ID: P31937 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Cytochrome P450 4A11
    Reactions:
    • octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O [RN:R02879]
    Gene Name: CYP4A11
    Uniprot ID: Q02928 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: 2-oxoglutarate dehydrogenase, mitochondrial
    Reactions:
    • 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 [RN:R01700]
    Gene Name: OGDH
    Uniprot ID: Q02218 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Estradiol 17-beta-dehydrogenase 2
    Reactions:
    • testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+ [RN:R01836]
    Gene Name: HSD17B2
    Uniprot ID: P37059 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Estradiol 17-beta-dehydrogenase 8
    Reactions:
    • testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+ [RN:R01836]
    Gene Name: HSD17B8
    Uniprot ID: Q92506 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Peroxisomal multifunctional enzyme type 2
    Reactions:
    • (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O [RN:R04813]
    Gene Name: HSD17B4
    Uniprot ID: P51659 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: 11-cis retinol dehydrogenase
    Reactions:
    • retinol + NAD+ = retinal + NADH + H+ [RN:R02124]
    Gene Name: RDH5
    Uniprot ID: Q92781 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Sorbitol dehydrogenase
    Reactions:
    • L-iditol + NAD+ = L-sorbose + NADH + H+ [RN:R07145]
    Gene Name: SORD
    Uniprot ID: Q00796 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Alcohol dehydrogenase [NADP+]
    Reactions:
    • an alcohol + NADP+ = an aldehyde + NADPH + H+ [RN:R07328]
    Gene Name: AKR1A1
    Uniprot ID: P14550 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Alcohol dehydrogenase 4
    Reactions:
    • an alcohol + NAD+ = an aldehyde or ketone + NADH + H+ [RN:R07326 R07327]
    Gene Name: ADH4
    Uniprot ID: P08319 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: D-beta-hydroxybutyrate dehydrogenase, mitochondrial
    Reactions:
    • (R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH + H+ [RN:R01361]
    Gene Name: BDH1
    Uniprot ID: Q02338 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Aldehyde dehydrogenase family 3 member B2
    Reactions:
    • an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+ [RN:R00538 R00634]
    Gene Name: ALDH3B2
    Uniprot ID: P48448 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Aldehyde dehydrogenase family 3 member B1
    Reactions:
    • an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+ [RN:R00538 R00634]
    Gene Name: ALDH3B1
    Uniprot ID: P43353 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: 7-dehydrocholesterol reductase
    Reactions:
    • cholesterol + NADP+ = cholesta-5,7-dien-3beta-ol + NADPH + H+ [RN:R01456]
    Gene Name: DHCR7
    Uniprot ID: Q9UBM7 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Glutamate dehydrogenase 2, mitochondrial
    Reactions:
    • L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+ [RN:R00243 R00248]
    Gene Name: GLUD2
    Uniprot ID: P49448 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Aminomethyltransferase, mitochondrial
    Reactions:
    • [protein]-S8-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3 [RN:R04125]
    Gene Name: AMT
    Uniprot ID: P48728 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
    Reactions:
    • D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+ [RN:R01061]
    Gene Name: GAPDHS
    Uniprot ID: O14556 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Glutamate dehydrogenase 1, mitochondrial
    Reactions:
    • L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+ [RN:R00243 R00248]
    Gene Name: GLUD1
    Uniprot ID: P00367 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Glyceraldehyde-3-phosphate dehydrogenase
    Reactions:
    • D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+ [RN:R01061]
    Gene Name: GAPDH
    Uniprot ID: P04406 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Biliverdin reductase A
    Reactions:
    • bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+ [RN:R02391 R02393]
    Gene Name: BLVRA
    Uniprot ID: P53004 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Flavin reductase
    Reactions:
    • reduced riboflavin + NADP+ = riboflavin + NADPH + H+ [RN:R05707]
    Gene Name: BLVRB
    Uniprot ID: P30043 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Adenylate cyclase type 7
    Reactions:
    • ATP = 3',5'-cyclic AMP + diphosphate [RN:R00089]
    Gene Name: ADCY7
    Uniprot ID: P51828 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Adenylate cyclase type 4
    Reactions:
    • ATP = 3',5'-cyclic AMP + diphosphate [RN:R00089]
    Gene Name: ADCY4
    Uniprot ID: Q8NFM4 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Adenylate cyclase type 6
    Reactions:
    • ATP = 3',5'-cyclic AMP + diphosphate [RN:R00089]
    Gene Name: ADCY6
    Uniprot ID: O43306 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Adenylate cyclase type 5
    Reactions:
    • ATP = 3',5'-cyclic AMP + diphosphate [RN:R00089]
    Gene Name: ADCY5
    Uniprot ID: O95622 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Adenylate cyclase type 8
    Reactions:
    • ATP = 3',5'-cyclic AMP + diphosphate [RN:R00089]
    Gene Name: ADCY8
    Uniprot ID: P40145 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Adenylate cyclase type 9
    Reactions:
    • ATP = 3',5'-cyclic AMP + diphosphate [RN:R00089]
    Gene Name: ADCY9
    Uniprot ID: O60503 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Adenylate cyclase type 3
    Reactions:
    • ATP = 3',5'-cyclic AMP + diphosphate [RN:R00089]
    Gene Name: ADCY3
    Uniprot ID: O60266 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Adenylate cyclase type 1
    Reactions:
    • ATP = 3',5'-cyclic AMP + diphosphate [RN:R00089]
    Gene Name: ADCY1
    Uniprot ID: Q08828 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Corticosteroid 11-beta-dehydrogenase isozyme 2
    Reactions:
    • --- []
    Gene Name: HSD11B2
    Uniprot ID: P80365 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Corticosteroid 11-beta-dehydrogenase isozyme 1
    Reactions:
    • an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+ [RN:R03203]
    Gene Name: HSD11B1
    Uniprot ID: P28845 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Alcohol dehydrogenase class-3
    Reactions:
    • S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+ [RN:R06983 R07140]
    Gene Name: ADH5
    Uniprot ID: P11766 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Alcohol dehydrogenase 1B
    Reactions:
    • an alcohol + NAD+ = an aldehyde or ketone + NADH + H+ [RN:R07326 R07327]
    Gene Name: ADH1B
    Uniprot ID: P00325 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Alcohol dehydrogenase class 4 mu/sigma chain
    Reactions:
    • an alcohol + NAD+ = an aldehyde or ketone + NADH + H+ [RN:R07326 R07327]
    Gene Name: ADH7
    Uniprot ID: P40394 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Alcohol dehydrogenase 1A
    Reactions:
    • an alcohol + NAD+ = an aldehyde or ketone + NADH + H+ [RN:R07326 R07327]
    Gene Name: ADH1A
    Uniprot ID: P07327 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Alcohol dehydrogenase 6
    Reactions:
    • an alcohol + NAD+ = an aldehyde or ketone + NADH + H+ [RN:R07326 R07327]
    Gene Name: ADH6
    Uniprot ID: P28332 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Alcohol dehydrogenase 1C
    Reactions:
    • an alcohol + NAD+ = an aldehyde or ketone + NADH + H+ [RN:R07326 R07327]
    Gene Name: ADH1C
    Uniprot ID: P00326 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic
    Reactions:
    • sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+ [RN:R00842]
    Gene Name: GPD1
    Uniprot ID: P21695 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Testosterone 17-beta-dehydrogenase 3
    Reactions:
    • testosterone + NADP+ = androst-4-ene-3,17-dione + NADPH + H+ [RN:R01838]
    Gene Name: HSD17B3
    Uniprot ID: P37058 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Estradiol 17-beta-dehydrogenase 1
    Reactions:
    • estradiol-17beta + NAD(P)+ = estrone + NAD(P)H + H+ [RN:R02352 R02353]
    Gene Name: HSD17B1
    Uniprot ID: P14061 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: 3-keto-steroid reductase
    Reactions:
    • 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP+ = 4alpha-methyl-5alpha-cholest-7-en-3-one + NADPH + H+ [RN:R05691]
    Gene Name: HSD17B7
    Uniprot ID: P56937 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Alpha-aminoadipic semialdehyde synthase, mitochondrial
    Reactions:
    • N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+ [RN:R02313]
    Gene Name: AASS
    Uniprot ID: Q9UDR5 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADP-dependent malic enzyme
    Reactions:
    • (S)-malate + NADP+ = pyruvate + CO2 + NADPH [RN:R00216]
    Gene Name: ME1
    Uniprot ID: P48163 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Malate dehydrogenase, mitochondrial
    Reactions:
    • (S)-malate + NAD+ = oxaloacetate + NADH + H+ [RN:R00342]
    Gene Name: MDH2
    Uniprot ID: P40926 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NADP-dependent malic enzyme, mitochondrial
    Reactions:
    • (S)-malate + NADP+ = pyruvate + CO2 + NADPH [RN:R00216]
    Gene Name: ME3
    Uniprot ID: Q16798 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Malate dehydrogenase, cytoplasmic
    Reactions:
    • (S)-malate + NAD+ = oxaloacetate + NADH + H+ [RN:R00342]
    Gene Name: MDH1
    Uniprot ID: P40925 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NAD-dependent malic enzyme, mitochondrial
    Reactions:
    • (S)-malate + NAD+ = pyruvate + CO2 + NADH [RN:R00214]
    Gene Name: ME2
    Uniprot ID: P23368 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Inosine-5'-monophosphate dehydrogenase 2
    Reactions:
    • inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+ [RN:R01130]
    Gene Name: IMPDH2
    Uniprot ID: P12268 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Inosine-5'-monophosphate dehydrogenase 1
    Reactions:
    • inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+ [RN:R01130]
    Gene Name: IMPDH1
    Uniprot ID: P20839 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: L-lactate dehydrogenase A-like 6A
    Reactions:
    • (S)-lactate + NAD+ = pyruvate + NADH + H+ [RN:R00703]
    Gene Name: LDHAL6A
    Uniprot ID: Q6ZMR3 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
    Reactions:
    • isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH [RN:R00709]
    Gene Name: IDH3B
    Uniprot ID: O43837 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
    Reactions:
    • isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH [RN:R00709]
    Gene Name: IDH3A
    Uniprot ID: P50213 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
    Reactions:
    • isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH [RN:R00709]
    Gene Name: IDH3G
    Uniprot ID: P51553 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Tankyrase-2
    Reactions:
    • NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+ [RN:R04176]
    Gene Name: TNKS2
    Uniprot ID: Q9H2K2 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: dTDP-D-glucose 4,6-dehydratase
    Reactions:
    • dTDP-glucose = dTDP-4-dehydro-6-deoxy-D-glucose + H2O [RN:R06513]
    Gene Name: TGDS
    Uniprot ID: O95455 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: NAD-dependent deacetylase sirtuin-6
    Reactions:
      Gene Name: SIRT6
      Uniprot ID: Q8N6T7 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: UDP-glucose 4-epimerase
      Reactions:
      • UDP-glucose = UDP-galactose [RN:R00291]
      Gene Name: GALE
      Uniprot ID: Q14376 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Poly [ADP-ribose] polymerase 3
      Reactions:
      • NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+ [RN:R04176]
      Gene Name: PARP3
      Uniprot ID: Q9Y6F1 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Ecto-ADP-ribosyltransferase 3
      Reactions:
      • NAD+ + protein L-arginine = nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine [RN:R00555]
      Gene Name: ART3
      Uniprot ID: Q13508 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: UDP-glucose 6-dehydrogenase
      Reactions:
      • UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH + 2 H+ [RN:R00286]
      Gene Name: UGDH
      Uniprot ID: O60701 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Ecto-ADP-ribosyltransferase 5
      Reactions:
      • NAD+ + protein L-arginine = nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine [RN:R00555]
      Gene Name: ART5
      Uniprot ID: Q96L15 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
      Reactions:
      • NAD+ + protein L-arginine = nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine [RN:R00555]
      Gene Name: ART1
      Uniprot ID: P52961 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: NAD(P) transhydrogenase, mitochondrial
      Reactions:
      • NADPH + NAD+ = NADP+ + NADH [RN:R00112]
      Gene Name: NNT
      Uniprot ID: Q13423 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Tankyrase-1
      Reactions:
      • NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+ [RN:R04176]
      Gene Name: TNKS
      Uniprot ID: O95271 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Poly [ADP-ribose] polymerase 1
      Reactions:
      • NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+ [RN:R04176]
      Gene Name: PARP1
      Uniprot ID: P09874 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Urocanate hydratase
      Reactions:
      • 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O [RN:R02914]
      Gene Name: UROC1
      Uniprot ID: Q96N76 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: ADP-ribosyl cyclase 2
      Reactions:
      • NAD+ + H2O = ADP-ribose + nicotinamide [RN:R00102]
      Gene Name: BST1
      Uniprot ID: Q10588 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Poly [ADP-ribose] polymerase 2
      Reactions:
      • NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+ [RN:R04176]
      Gene Name: PARP2
      Uniprot ID: Q9UGN5 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: NAD kinase
      Reactions:
      • ATP + NAD+ = ADP + NADP+ [RN:R00104]
      Gene Name: NADK
      Uniprot ID: O95544 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: ADP-ribosyl cyclase 1
      Reactions:
      • NAD+ + H2O = ADP-ribose + nicotinamide [RN:R00102]
      Gene Name: CD38
      Uniprot ID: P28907 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Ecto-ADP-ribosyltransferase 4
      Reactions:
      • NAD+ + protein L-arginine = nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine [RN:R00555]
      Gene Name: ART4
      Uniprot ID: Q93070 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
      Reactions:
      • 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate [RN:R01655]
      Gene Name: MTHFD2
      Uniprot ID: P13995 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Adenylate cyclase type 2
      Reactions:
      • ATP = 3',5'-cyclic AMP + diphosphate [RN:R00089]
      Gene Name: ADCY2
      Uniprot ID: Q08462 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: D-3-phosphoglycerate dehydrogenase
      Reactions:
      • (1) 3-phospho-D-glycerate + NAD+ = 3-phosphonooxypyruvate + NADH + H+ [RN:R01513]
      • (2) 2-hydroxyglutarate + NAD+ = 2-oxoglutarate + NADH + H+ [RN:R08198]
      Gene Name: PHGDH
      Uniprot ID: O43175 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: C-1-tetrahydrofolate synthase, cytoplasmic
      Reactions:
      • ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate [RN:R00943]
      Gene Name: MTHFD1
      Uniprot ID: P11586 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Poly [ADP-ribose] polymerase 4
      Reactions:
      • NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+ [RN:R04176]
      Gene Name: PARP4
      Uniprot ID: Q9UKK3 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
      Reactions:
        Gene Name: NDUFB11
        Uniprot ID: Q9NX14 Link_out
        Protein Sequence: FASTA
        Gene Sequence: FASTA
        Name: NAD(P)H dehydrogenase [quinone] 1
        Reactions:
        • NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone [RN:R07358 R07359]
        Gene Name: NQO1
        Uniprot ID: P15559 Link_out
        Protein Sequence: FASTA
        Gene Sequence: FASTA
        Name: Proline dehydrogenase, mitochondrial
        Reactions:
        • L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor [RN:R01253]
        Gene Name: PRODH
        Uniprot ID: O43272 Link_out
        Protein Sequence: FASTA
        Gene Sequence: FASTA
        Name: Dehydrogenase/reductase SDR family member 9
        Reactions:
          Gene Name: DHRS9
          Uniprot ID: Q9BPW9 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: 17-beta-hydroxysteroid dehydrogenase type 6
          Reactions:
          • retinol + NAD+ = retinal + NADH + H+ [RN:R02124]
          Gene Name: HSD17B6
          Uniprot ID: O14756 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: UDP-glucuronic acid decarboxylase 1
          Reactions:
          • UDP-D-glucuronate = UDP-D-xylose + CO2 [RN:R01384]
          Gene Name: UXS1
          Uniprot ID: Q8NBZ7 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Glutamine-dependent NAD(+) synthetase
          Reactions:
          • ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate [RN:R00257]
          Gene Name: NADSYN1
          Uniprot ID: Q6IA69 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
          Reactions:
          • a 3-oxo-Delta5-steroid = a 3-oxo-Delta4-steroid [RN:R02644]
          Gene Name: HSD3B2
          Uniprot ID: P26439 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: 3 beta-hydroxysteroid dehydrogenase type 7
          Reactions:
          • cholest-5-ene-3beta,7alpha-diol + NAD+ = 7alpha-hydroxycholest-4-en-3-one + NADH + H+ [RN:R04263]
          Gene Name: HSD3B7
          Uniprot ID: Q9H2F3 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Inositol-3-phosphate synthase 1
          Reactions:
          • D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate [RN:R07324]
          Gene Name: ISYNA1
          Uniprot ID: Q9NPH2 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: 3-hydroxybutyrate dehydrogenase type 2
          Reactions:
          • (R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH + H+ [RN:R01361]
          Gene Name: BDH2
          Uniprot ID: Q9BUT1 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Glycerol-3-phosphate dehydrogenase 1-like protein
          Reactions:
          • sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+ [RN:R00842]
          Gene Name: GPD1L
          Uniprot ID: Q8N335 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2
          Reactions:
          • 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate [RN:R01655]
          Gene Name: MTHFD2L
          Uniprot ID: Q9H903 Link_out
          Protein Sequence: FASTA
          Name: NADH-cytochrome b5 reductase 1
          Reactions:
          • NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5 [RN:R00100]
          Gene Name: CYB5R1
          Uniprot ID: Q9UHQ9 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: NADH-cytochrome b5 reductase 2
          Reactions:
          • NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5 [RN:R00100]
          Gene Name: CYB5R2
          Uniprot ID: Q6BCY4 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome b5 reductase 4
          Reactions:
          • NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5 [RN:R00100]
          Gene Name: CYB5R4
          Uniprot ID: Q7L1T6 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: NADH-cytochrome b5 reductase-like
          Reactions:
          • NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5 [RN:R00100]
          Gene Name: CYB5RL
          Uniprot ID: Q6IPT4 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Probable saccharopine dehydrogenase
          Reactions:
          • N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+ [RN:R02313]
          Gene Name: SCCPDH
          Uniprot ID: Q8NBX0 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 4A22
          Reactions:
          • octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O [RN:R02879]
          Gene Name: CYP4A22
          Uniprot ID: Q5TCH4 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Dihydrofolate reductase
          Reactions:
            Gene Name: DYR
            Uniprot ID: B0YJ76 Link_out
            Protein Sequence: FASTA
            Gene Sequence: FASTA
            Name: Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
            Reactions:
              Gene Name: MTHFD2
              Uniprot ID: Q7Z650 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: Acyl-CoA synthetase family member 4
              Reactions:
                Gene Name: AASDH
                Uniprot ID: Q4L235 Link_out
                Protein Sequence: FASTA
                Gene Sequence: FASTA
                Name: Aminoadipate-semialdehyde synthase
                Reactions:
                  Gene Name: AASS
                  Uniprot ID: A4D0W4 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Peroxisomal NADH pyrophosphatase NUDT12
                  Reactions:
                  • NAD+ + H2O = AMP + NMN [RN:R00103]
                  Gene Name: NUDT12
                  Uniprot ID: Q9BQG2 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Inosine-5'-monophosphate dehydrogenase
                  Reactions:
                  • inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+ [RN:R01130]
                  Gene Name: IMPDH1
                  Uniprot ID: A4D0Z6 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Cytochrome b5 type B
                  Reactions:
                    Gene Name: CYB5B
                    Uniprot ID: O43169 Link_out
                    Protein Sequence: FASTA
                    Gene Sequence: FASTA
                    Name: Peroxisomal coenzyme A diphosphatase NUDT7
                    Reactions:
                      Gene Name: NUDT7
                      Uniprot ID: P0C024 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: NAD-dependent deacetylase sirtuin-1
                      Reactions:
                        Gene Name: SIRT1
                        Uniprot ID: Q96EB6 Link_out
                        Protein Sequence: FASTA
                        Gene Sequence: FASTA
                        Name: Complex I intermediate-associated protein 30, mitochondrial
                        Reactions:
                          Gene Name: NDUFAF1
                          Uniprot ID: Q9Y375 Link_out
                          Protein Sequence: FASTA
                          Gene Sequence: FASTA
                          Name: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
                          Reactions:
                            Gene Name: ECSIT
                            Uniprot ID: Q9BQ95 Link_out
                            Protein Sequence: FASTA
                            Gene Sequence: FASTA
                            Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4
                            Reactions:
                              Gene Name: NDUFAF4
                              Uniprot ID: Q9P032 Link_out
                              Protein Sequence: FASTA
                              Gene Sequence: FASTA
                              Name: Mimitin, mitochondrial
                              Reactions:
                                Gene Name: NDUFAF2
                                Uniprot ID: Q8N183 Link_out
                                Protein Sequence: FASTA
                                Gene Sequence: FASTA
                                Name: MOSC domain-containing protein 2, mitochondrial
                                Reactions:
                                  Gene Name: MOSC2
                                  Uniprot ID: Q969Z3 Link_out
                                  Protein Sequence: FASTA
                                  Gene Sequence: FASTA
                                  Name: 2-oxoglutarate dehydrogenase-like, mitochondrial
                                  Reactions:
                                    Gene Name: OGDHL
                                    Uniprot ID: Q9ULD0 Link_out
                                    Protein Sequence: FASTA
                                    Gene Sequence: FASTA
                                    Name: NADH dehydrogenase (Ubiquinone) 1 beta subcomplex, 2, 8kDa
                                    Reactions:
                                      Gene Name: NDUFB2
                                      Uniprot ID: A4D1T5 Link_out
                                      Protein Sequence: FASTA
                                      Gene Sequence: FASTA
                                      Name: L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
                                      Reactions:
                                        Gene Name: AASDHPPT
                                        Uniprot ID: Q9NRN7 Link_out
                                        Protein Sequence: FASTA
                                        Gene Sequence: FASTA