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Record Information
Version3.6
Creation Date2006-07-16 11:50:55 UTC
Update Date2016-02-11 01:05:38 UTC
HMDB IDHMDB02386
Secondary Accession NumbersNone
Metabolite Identification
Common NameBoron
DescriptionBoron may be an essential nutrient for animals and humans. Physiologically, this metal/element exists as an ion in the body. Dietary boron influences the activity of many metabolic enzymes, as well as the metabolism of steroid hormones and several micronutrients, including calcium, magnesium, and vitamin D. Boron may also play a role in improving arthritis, plasma lipid profiles, and brain function.
Structure
Thumb
Synonyms
ValueSource
b(3+)ChEBI
Boron, ion(3+)ChEBI
BHMDB
Boron metallicHMDB
Trona elemental boronHMDB
Chemical FormulaB
Average Molecular Weight10.811
Monoisotopic Molecular Weight11.009305466
IUPAC Nameboron(3+) ion
Traditional Nameboron(3+) ion
CAS Registry Number7440-42-8
SMILES
[B+3]
InChI Identifier
InChI=1S/B/q+3
InChI KeyInChIKey=FRWDHMWMHYXNLW-UHFFFAOYSA-N
Chemical Taxonomy
DescriptionThis compound belongs to the class of inorganic compounds known as homogeneous metalloid compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a metalloid atom.
KingdomInorganic compounds
Super ClassHomogeneous metal compounds
ClassHomogeneous metalloid compounds
Sub ClassNot Available
Direct ParentHomogeneous metalloid compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous metalloid
  • Acyclic compound
Molecular FrameworkAcyclic compounds
External Descriptors
Ontology
StatusDetected and Quantified
Origin
  • Drug
  • Food
  • Plant
Biofunction
  • Essential minerals
ApplicationNot Available
Cellular locationsNot Available
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point2076 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP0.33ChemAxon
Physiological Charge3ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
SpectraNot Available
Biological Properties
Cellular LocationsNot Available
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Saliva
  • Urine
Tissue Location
  • Bone
  • Kidney
PathwaysNot Available
Normal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified23.0 (0.0 - 116.0) uMChildren (1-13 years old)BothNormal
    • Geigy Scientific ...
details
Cerebrospinal Fluid (CSF)Detected and Quantified3587 +/- 1093 uMAdult (>18 years old)Not SpecifiedNormal details
SalivaDetected and Quantified1623.87 +/- 494.41 uMAdult (>18 years old)BothNormal
    • Zerihun T. Dame, ...
details
UrineDetected and Quantified161.14(39.58-543.63) umol/mmol creatinineAdult (>18 years old)Both
Normal
details
UrineDetected and Quantified5.92 +/- 0.0 umol/mmol creatinineAdult (>18 years old)BothNormal
    • Geigy Scientific ...
details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB003575
KNApSAcK IDNot Available
Chemspider ID4574026
KEGG Compound IDC06266
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkBoron
NuGOwiki LinkHMDB02386
Metagene LinkHMDB02386
METLIN IDNot Available
PubChem CompoundNot Available
PDB IDNot Available
ChEBI ID30168
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Hunt CD, Butte NF, Johnson LK: Boron concentrations in milk from mothers of exclusively breast-fed healthy full-term infants are stable during the first four months of lactation. J Nutr. 2005 Oct;135(10):2383-6. [16177200 ]
  2. Devirian TA, Volpe SL: The physiological effects of dietary boron. Crit Rev Food Sci Nutr. 2003;43(2):219-31. [12705642 ]
  3. Nielsen FH, Penland JG: Boron deprivation alters rat behaviour and brain mineral composition differently when fish oil instead of safflower oil is the diet fat source. Nutr Neurosci. 2006 Feb-Apr;9(1-2):105-12. [16910176 ]

Enzymes

General function:
Involved in anion transport
Specific function:
Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (By similarity). Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter.
Gene Name:
SLC4A11
Uniprot ID:
Q8NBS3
Molecular weight:
98180.24