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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2021-09-23 20:57:15 UTC
Update Date2021-09-23 20:57:15 UTC
HMDB IDHMDB0302823
Secondary Accession NumbersNone
Metabolite Identification
Common Name1-Rhamnono-1,4-lactone
Description1-rhamnono-1,4-lactone is a member of the class of compounds known as gamma butyrolactones. Gamma butyrolactones are compounds containing a gamma butyrolactone moiety, which consists of an aliphatic five-member ring with four carbon atoms, one oxygen atom, and bears a ketone group on the carbon adjacent to the oxygen atom. 1-rhamnono-1,4-lactone is soluble (in water) and a very weakly acidic compound (based on its pKa). 1-rhamnono-1,4-lactone can be found in rice, which makes 1-rhamnono-1,4-lactone a potential biomarker for the consumption of this food product.
Structure
Thumb
SynonymsNot Available
Chemical FormulaC6H10O5
Average Molecular Weight162.1406
Monoisotopic Molecular Weight162.05282343
IUPAC Name3,4-dihydroxy-5-(1-hydroxyethyl)oxolan-2-one
Traditional Name3,4-dihydroxy-5-(1-hydroxyethyl)oxolan-2-one
CAS Registry NumberNot Available
SMILES
CC(O)C1OC(=O)C(O)C1O
InChI Identifier
InChI=1S/C6H10O5/c1-2(7)5-3(8)4(9)6(10)11-5/h2-5,7-9H,1H3
InChI KeyVASLEPDZAKCNJX-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as gamma butyrolactones. Gamma butyrolactones are compounds containing a gamma butyrolactone moiety, which consists of an aliphatic five-member ring with four carbon atoms, one oxygen atom, and bears a ketone group on the carbon adjacent to the oxygen atom.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassLactones
Sub ClassGamma butyrolactones
Direct ParentGamma butyrolactones
Alternative Parents
Substituents
  • Gamma butyrolactone
  • Tetrahydrofuran
  • Secondary alcohol
  • Carboxylic acid ester
  • Oxacycle
  • Monocarboxylic acid or derivatives
  • Carboxylic acid derivative
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
ProcessNot Available
RoleNot Available
Physical Properties
StateNot Available
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
logP-1.6ALOGPS
logP-1.7ChemAxon
logS0.59ALOGPS
pKa (Strongest Acidic)11.63ChemAxon
pKa (Strongest Basic)-3.1ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area86.99 ŲChemAxon
Rotatable Bond Count1ChemAxon
Refractivity33.24 m³·mol⁻¹ChemAxon
Polarizability14.67 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
AllCCS[M+H]+136.96732859911
AllCCS[M+H-H2O]+132.61132859911
AllCCS[M+Na]+142.19832859911
AllCCS[M+NH4]+141.02732859911
AllCCS[M-H]-128.46632859911
AllCCS[M+Na-2H]-129.80532859911
AllCCS[M+HCOO]-131.33832859911
DeepCCS[M+H]+136.58330932474
DeepCCS[M-H]-133.96630932474
DeepCCS[M-2H]-170.22130932474
DeepCCS[M+Na]+145.34630932474

Predicted Kovats Retention Indices

Not Available
Spectra

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Rhamnono-1,4-lactone 10V, Positive-QTOFsplash10-03dj-2900000000-c68a3835d672d17d35492016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Rhamnono-1,4-lactone 20V, Positive-QTOFsplash10-01ot-3900000000-e063575f8f51152f4b412016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Rhamnono-1,4-lactone 40V, Positive-QTOFsplash10-052f-9100000000-bab6ce75ad44527e538f2016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Rhamnono-1,4-lactone 10V, Negative-QTOFsplash10-03di-2900000000-f3e2b5fe85a1098fd6232016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Rhamnono-1,4-lactone 20V, Negative-QTOFsplash10-03dl-2900000000-e7f6a79be8c85975d9cc2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Rhamnono-1,4-lactone 40V, Negative-QTOFsplash10-0a4i-9100000000-eecab364a4d0c38af6122016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Rhamnono-1,4-lactone 10V, Positive-QTOFsplash10-0002-1900000000-5b7d387819d5468afa8d2021-10-21Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Rhamnono-1,4-lactone 20V, Positive-QTOFsplash10-054k-9300000000-78af2abf088e47abf5302021-10-21Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Rhamnono-1,4-lactone 40V, Positive-QTOFsplash10-0a4m-9000000000-5cc6d6671344ad20759c2021-10-21Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Rhamnono-1,4-lactone 10V, Negative-QTOFsplash10-03xr-3900000000-7a583cafda1c490504aa2021-10-21Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Rhamnono-1,4-lactone 20V, Negative-QTOFsplash10-0005-9000000000-53834ef5de1c8023d8fe2021-10-21Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Rhamnono-1,4-lactone 40V, Negative-QTOFsplash10-0006-9000000000-9c94c3454b1a295645482021-10-21Wishart LabView Spectrum
Biological Properties
Cellular LocationsNot Available
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB006380
KNApSAcK IDNot Available
Chemspider ID212003
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound242516
PDB IDNot Available
ChEBI IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available