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Human Metabolome Database Version 2.5

 

Showing metabocard for Dimethylbenzimidazole (HMDB03701)

Legend: metabolite field enzyme field

Version 2.5
Creation Date 2006-08-13 04:39:40
Update Date 2009-05-25 15:17:35
Accession Number HMDB03701
Secondary Accession Numbers Not Available
Common Name Dimethylbenzimidazole
Description Dimethylbenzimidazole is an intermediate in Riboflavin metabolism. Dimethylbenzimidazole is the second to last step for the synthesis of alpha-Ribazole. It is converted from Riboflavin then it is converted to N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole via the enzyme nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21).
Synonyms
  1. 5,6-Dimethylbenzimidazole
  2. 5,6-dimethyl-1H-Benzimidazole
  3. Dimedazole
  4. Dimezol (VAN)
  5. Dimesol
  6. DimezolDimedazol
Chemical IUPAC Name 5,6-dimethyl-1H-benzoimidazole
Chemical Formula C9H10N2
Chemical Structure Structure
Chemical Taxonomy
Kingdom
  • Organic
Super Class
—
Class
—
Sub Class
—
Family
  • Microbial Metabolite
Species
  • aromatic compound
  • heterocyclic compound
Biofunction
—
Application
—
Source
  • Endogenous
Average Molecular Weight 146.189
Monoisotopic Molecular Weight 146.084396
Isomeric SMILES CC1=CC2=C(C=C1C)N=CN2
Canonical SMILES CC1=CC2=C(C=C1C)N=CN2
KEGG Compound ID C03114 Link Image
BioCyc ID Not Available
BiGG ID Not Available
Wikipedia Link Not Available
NuGOwiki Link HMDB03701 Link Image
Metagene Link HMDB03701 Link Image
METLIN ID Not Available
PubChem Compound 675 Link Image
PubChem Substance 836758 Link Image
ChEBI ID 15890 Link Image
CAS Registry Number 582-60-5
InChI Identifier InChI=1/C9H10N2/c1-6-3-8-9(4-7(6)2)11-5-10-8/h3-5H,1-2H3,(H,10,11)
Synthesis Reference Not Available
Melting Point (Experimental) 205.5 oC
Experimental Water Solubility Not Available Source: PhysProp
Predicted Water Solubility 776 mg/L at 25 oC [MEYLAN,WM et al. (1996)] Calculated using ALOGPS
Physiological Charge 0
State Solid
Experimental LogP/Hydrophobicity 1.854 Source: PhysProp
Predicted LogP/Hydrophobicity 1.88 [Predicted by ALOGPS] Calculated using ALOGPS
Material Safety Data Sheet (MSDS)
MOL File Show Link Image
SDF File Show Link Image
PDB File Show Link Image
2D Structure
3D Structure
Experimental PDB ID Not Available
Experimental 1H NMR Spectrum Not Available
Experimental 13C NMR Spectrum Not Available
Experimental 13C HSQC Spectrum Not Available
Predicted 1H NMR Spectrum Not Available
Not Available
Predicted 13C NMR Spectrum Not Available
Not Available
Mass Spectrum Not Available
Simplified TOCSY Spectrum Not Available
BMRB Spectrum Not Available
Cellular Location Not Available
Biofluid Location
  • Prostate Tissue
Tissue Location Not Available
Concentrations (Normal) Not Available
Concentrations (Abnormal)
Biofluid Prostate Tissue
Value 0.5 (0.0-1.0) umol/gr tissue
Age Adult:>18 yrs old
Sex Both
Condition Prostate cancer
Comments Estimated concentration
References
  • Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. [PubMed Link Image]
Associated Disorders
Condition References
Prostate cancer
  • Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. [PubMed Link Image]
OMIM ID
Pathways
Name SMPDB Link KEGG Link
Riboflavin Metabolism SMP00070 Link Image map00740 Link Image
General References Not Available
Metabolic Enzymes
  1. Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
  2. Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
  3. Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
  4. Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
  5. Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
  6. Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
  7. Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
  8. Inner membrane protein ycfZ
  9. Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Enzyme 1 [top]
Enzyme 1 ID 16319
Enzyme 1 Name Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Enzyme 1 Synonyms
  1. NN:DBI PRT
  2. N(1)-alpha-phosphoribosyltransferase
Enzyme 1 Gene Name cobT
Enzyme 1 Protein Sequence >Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 
MKTFQITRPDETIREALTDKINNLTKPKGSLGTLEELALQIGLIQQTLTPELRHPQNIIF
AADHGIVDEGVSLSPKEITWQQISNFLHGGAGVNFLCRQHGFELKIVDAGVDYDLPYEKG
IINMKVRKSSRNYLYEAAMTEEEMNLCIERGAEVVRQCHAEGCNVLSLGEMGIGNTSSSS
MWMTCFTHIPLELCVGAGSGLDNAGVRHKYNVLQQALDHYQGDGSAHDLIRYFGGLEMVM
AIGAMLQAAELKMIILVDGFIMTNCILAASQLYPEVLHYAIFGHQGDEAGHKLVLDAMGA
KPLLNLGLRLGEGTGAICSYPIIDSAVRMINEMDNFAHAAITKYF
Enzyme 1 Number of Residues 345
Enzyme 1 Molecular Weight 37873.3
Enzyme 1 Theoretical pI 5.35
Enzyme 1 GO Classification
Function
  • catalytic activity
  • nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
  • transferase activity
  • transferase activity, transferring glycosyl groups
  • transferase activity, transferring pentosyl groups
Process
  • cellular nitrogen compound metabolic process
  • cobalamin biosynthetic process
  • metabolic process
  • nitrogen compound metabolic process
  • nucleobase, nucleoside and nucleotide metabolic process
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
  • nucleoside biosynthetic process
  • nucleoside metabolic process
  • porphyrin biosynthetic process
  • porphyrin metabolic process
  • tetrapyrrole metabolic process
Component
—
Enzyme 1 General Function Involved in nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Enzyme 1 Specific Function Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)
Enzyme 1 Pathways Not Available
Enzyme 1 Reactions
  • beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate [RN:R04148]
Enzyme 1 Pfam Domain Function
Enzyme 1 Signals
  • None
Enzyme 1 Transmembrane Regions
  • None
Enzyme 1 Essentiality Not Available
Enzyme 1 GenBank ID Protein 60493433 Link Image
Enzyme 1 UniProtKB/Swiss-Prot ID Q5LCE6 Link Image
Enzyme 1 UniProtKB/Swiss-Prot Entry Name COBT_BACFN Link Image
Enzyme 1 PDB ID Not Available
Enzyme 1 Cellular Location Not Available
Enzyme 1 Gene Sequence >1038 bp 
ATGAAAACATTTCAAATCACCAGACCGGACGAAACCATCCGGGAAGCACTGACCGATAAA
ATAAATAATCTGACCAAGCCCAAAGGCTCTCTGGGAACACTTGAAGAACTGGCCTTGCAG
ATCGGGCTTATCCAGCAAACACTTACTCCCGAGCTGAGACATCCTCAAAATATCATATTC
GCAGCCGATCATGGCATTGTCGACGAGGGAGTCAGCCTCTCTCCCAAAGAGATCACCTGG
CAACAAATCAGCAATTTTCTTCACGGAGGGGCAGGTGTCAACTTCCTTTGCCGCCAGCAC
GGATTCGAGTTGAAGATTGTAGATGCCGGAGTGGATTACGACCTCCCATACGAGAAAGGA
ATCATCAACATGAAGGTACGCAAAAGCTCGCGTAACTATCTGTACGAGGCAGCCATGACA
GAAGAAGAAATGAATTTGTGCATCGAGCGCGGAGCGGAAGTAGTCCGTCAGTGTCATGCC
GAAGGGTGCAATGTGCTTTCTTTGGGCGAAATGGGTATCGGCAACACTTCTTCGTCTTCC
ATGTGGATGACATGCTTCACCCATATTCCTCTCGAACTGTGTGTCGGAGCAGGCAGCGGA
CTCGACAATGCAGGCGTCCGTCATAAATATAATGTATTGCAGCAGGCACTGGACCATTAT
CAGGGAGACGGAAGCGCACACGACCTGATCCGCTATTTCGGCGGACTGGAAATGGTAATG
GCAATAGGCGCCATGCTTCAGGCAGCCGAGTTAAAGATGATTATCCTGGTAGACGGATTC
ATCATGACAAACTGCATCCTTGCAGCCTCCCAACTTTACCCTGAGGTATTGCATTATGCC
ATCTTCGGTCATCAGGGAGATGAAGCCGGACATAAGCTGGTACTCGATGCCATGGGAGCC
AAGCCATTACTGAATCTGGGTTTACGTCTCGGAGAAGGAACCGGAGCCATCTGCTCCTAT
CCTATCATTGACTCTGCCGTACGGATGATCAACGAGATGGACAACTTTGCACATGCAGCC
ATCACCAAATATTTCTAA
Enzyme 1 GenBank Gene ID CR626927 Link Image
Enzyme 1 GeneCard ID cobT Link Image
Enzyme 1 GenAtlas ID Not Available
Enzyme 1 HGNC ID Not Available
Enzyme 1 Chromosome Location Not Available
Enzyme 1 Locus BF2519
Enzyme 1 SNPs SNPJam Report Link Image
Enzyme 1 General References
  1. Cerdeno-Tarraga AM, Patrick S, Crossman LC, Blakely G, Abratt V, Lennard N, Poxton I, Duerden B, Harris B, Quail MA, Barron A, Clark L, Corton C, Doggett J, Holden MT, Larke N, Line A, Lord A, Norbertczak H, Ormond D, Price C, Rabbinowitsch E, Woodward J, Barrell B, Parkhill J: Extensive DNA inversions in the B. fragilis genome control variable gene expression. Science. 2005 Mar 4;307(5714):1463-5. [PubMed Link Image]
Enzyme 1 Metabolite References Not Available
Enzyme 2 [top]
Enzyme 2 ID 16320
Enzyme 2 Name Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Enzyme 2 Synonyms
  1. NN:DBI PRT
  2. N(1)-alpha-phosphoribosyltransferase
Enzyme 2 Gene Name cobT
Enzyme 2 Protein Sequence >Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 
MKTFQITRPDETIREALTDKINNLTKPKGSLGTLEELALQIGLIQQTLTPELRHPQNIIF
AADHGIVDEGVSLSPKEITWQQISNFLHGGAGVNFLCRQHGFELKIVDAGVDYDLPYEKG
IINMKVRKSSRNYLYEAAMTEEEMNLCIERGAEVVRQCHAEGCNVLSLGEMGIGNTSSSS
MWMTCFTHIPLELCVGAGSGLDNAGVHHKYNVLQQALDHYQGDGSAHDLIRYFGGLEMVM
AIGAMLQAAELKMIILVDGFIMTNCILAASQLYPEVLHYAIFGHQGDEAGHKLVLDAMGA
KPLLNLGLRLGEGTGAICSYPIIDSAIRMINEMDNFAHAAITKYF
Enzyme 2 Number of Residues 345
Enzyme 2 Molecular Weight 37868.3
Enzyme 2 Theoretical pI 5.33
Enzyme 2 GO Classification
Function
  • catalytic activity
  • nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
  • transferase activity
  • transferase activity, transferring glycosyl groups
  • transferase activity, transferring pentosyl groups
Process
  • cellular nitrogen compound metabolic process
  • cobalamin biosynthetic process
  • metabolic process
  • nitrogen compound metabolic process
  • nucleobase, nucleoside and nucleotide metabolic process
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
  • nucleoside biosynthetic process
  • nucleoside metabolic process
  • porphyrin biosynthetic process
  • porphyrin metabolic process
  • tetrapyrrole metabolic process
Component
—
Enzyme 2 General Function Involved in nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Enzyme 2 Specific Function Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)
Enzyme 2 Pathways Not Available
Enzyme 2 Reactions
  • beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate [RN:R04148]
Enzyme 2 Pfam Domain Function
Enzyme 2 Signals
  • None
Enzyme 2 Transmembrane Regions
  • None
Enzyme 2 Essentiality Not Available
Enzyme 2 GenBank ID Protein 52215598 Link Image
Enzyme 2 UniProtKB/Swiss-Prot ID Q64TE4 Link Image
Enzyme 2 UniProtKB/Swiss-Prot Entry Name COBT_BACFR Link Image
Enzyme 2 PDB ID Not Available
Enzyme 2 Cellular Location Not Available
Enzyme 2 Gene Sequence >1038 bp 
ATGTTTCCTTATTTTCTTATATATTTTTTCTTACTAATCTTTTGCTCTTTAGGAAGTGTC
ACTAAAAATCGATTTTTTCTAATTTGTGTATTTATTCTTTTTTCCATTTTCTCTGGGTTT
AGGTATTATGTAGGAGTAGATTATGTTAATTATGTGAAAATATATAATCTTGAAGAAGGA
TATGGAAGTCGAGAATTAGGATTTAACTTGATTCTAGATTTTTTGCGATACATCGGGGCT
AGCTATCAATTCATGTTTTTTATAATGGCTGTTGTCATGCAAATACTGGTATATAATATT
ATTAAACGATATAATTACAGTGTTTGGATTTCAGTTTTTATTTATTATTGTATCTCTCCG
TTTTATATTGCAACCTTTAATGGGATGAGGCAATACTTAGCAATCGCTGTTTTTATTGTT
GCATTAAAGTATATTGAACAAAAAAAAATATTTAAGTATATCGTTTCTCTTTTGTTGGGA
GGATTCTTCTTTCATGAATCGATTTTAGTTTTTATTCCTTTATATTATATATTAAATAAG
ACTATATCTATAAAAAGCAAATTACTTGCGTTTTTGTTGACTATTGTGGGTAGCTTGGCT
ATAGATAAACTTATTTCCTATACTCCATATATTGTGTATTTGACAAGAGATCGAGAAACT
CATATAAGCTCATTCACTTATATTTTTGCGGGCATTTCAATCTTATTCATCATTTTTTGG
AATAAGCTTAATTCTTTTAAAAGTAAGCTTATAATGGAGAATATGAATCTTTTTTGTTTT
TTGTCATTATTAGTAGTGTTACTTCAATCTAATGGAGTACTTATTCAAATGACTCTCCGA
ATGAATAGTTATTTCTTCTTTGTGTATATCATATTGGTTCCAGCCGTTATATCATCTATA
AAGAATGTCCATATGCGTATTGGTATGTATTTCAGCCTTCATTTAGTGCTGTTATTATAC
CTTGTCCGTACCATTTGTTTTAATGGGCATTTGTATGATTTGGTTCCTTATTCTATGAAT
TTCAACTTATTTAAATAA
Enzyme 2 GenBank Gene ID AP006841 Link Image
Enzyme 2 GeneCard ID cobT Link Image
Enzyme 2 GenAtlas ID Not Available
Enzyme 2 HGNC ID Not Available
Enzyme 2 Chromosome Location Not Available
Enzyme 2 Locus BF2486
Enzyme 2 SNPs SNPJam Report Link Image
Enzyme 2 General References
  1. Kuwahara T, Yamashita A, Hirakawa H, Nakayama H, Toh H, Okada N, Kuhara S, Hattori M, Hayashi T, Ohnishi Y: Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation. Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14919-24. Epub 2004 Oct 4. [PubMed Link Image]
Enzyme 2 Metabolite References Not Available
Enzyme 3 [top]
Enzyme 3 ID 16321
Enzyme 3 Name Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Enzyme 3 Synonyms
  1. NN:DBI PRT
  2. N(1)-alpha-phosphoribosyltransferase
Enzyme 3 Gene Name cobT
Enzyme 3 Protein Sequence >Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 
MSLLESISKNIYSLDNSSIEKTKQRLDRLIHPTGSLGKIEDICMQLAGIFGNENFDTSKK
VIIAFAGDHGVYEEGVAPDPQNITKLQFPNFSKGLCGVGVISKFVGADVVAVDVGINCDE
KLDGVLDYKIRKGTSNMAKGPAMSKQEAIRCLEIGIEIAEQCIEKDYKVIGIGEMGIANT
TPSTAIISVISGCDPLEVTGIGAGLKKERLKHKAEVIRKAIEINNPNPTDGVDILSKVGG
FEIGSMAGVILGCSANRIPVVIDGFISYAAALIAYKINPKTREYMIASHLSAESGTKRAL
DILKLDPLLNMDMRLGEGSGAALAFDIIEASNYTYKNMATFDEIDMGR
Enzyme 3 Number of Residues 348
Enzyme 3 Molecular Weight 37353.7
Enzyme 3 Theoretical pI 5.14
Enzyme 3 GO Classification
Function
  • catalytic activity
  • nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
  • transferase activity
  • transferase activity, transferring glycosyl groups
  • transferase activity, transferring pentosyl groups
Process
  • cellular nitrogen compound metabolic process
  • cobalamin biosynthetic process
  • metabolic process
  • nitrogen compound metabolic process
  • nucleobase, nucleoside and nucleotide metabolic process
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
  • nucleoside biosynthetic process
  • nucleoside metabolic process
  • porphyrin biosynthetic process
  • porphyrin metabolic process
  • tetrapyrrole metabolic process
Component
—
Enzyme 3 General Function Involved in nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Enzyme 3 Specific Function Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)
Enzyme 3 Pathways Not Available
Enzyme 3 Reactions
  • beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate [RN:R04148]
Enzyme 3 Pfam Domain Function
Enzyme 3 Signals
  • None
Enzyme 3 Transmembrane Regions
  • None
Enzyme 3 Essentiality Not Available
Enzyme 3 GenBank ID Protein 115249041 Link Image
Enzyme 3 UniProtKB/Swiss-Prot ID Q180T6 Link Image
Enzyme 3 UniProtKB/Swiss-Prot Entry Name COBT_CLOD6 Link Image
Enzyme 3 PDB ID Not Available
Enzyme 3 Cellular Location Not Available
Enzyme 3 Gene Sequence >1047 bp 
ATGGTGGCAAATAAAATAAAAGCCACACCAGCAGCTAGAAGTCAGGCAAGAAAAGACAAT
ATAAAATTAGATAGGCTGATTGGAAGTGGAGAAAATGGAAGGATTCATTTAGTAGATGTG
TTAAATTATTTAAAAGATAATAAAGCAAATACTACTCCTTTAGCTAGAAGAATAGCAGAA
GATTTAAATATAGATTTAGAAACTATTGTAGGTACTGGATATAATGGAAAGATAAGAAAG
TGTGATGTGGAAAAATTAACTGCAAAAGAAACTATTGTATCAACTAATACATCTAAATCT
AGTGAGAAAAAAGAGCTGAAAATTGAAAATGAAAATTCAAGCATGTTTAACACAGTAGAA
GGAATATTTGAAAAGCCAAATCCAATGAGAGCTACTGTAGCAAAACGAATGTCAGAAAGT
TATTTTAGTGCTCCTGTATTTACATTCAATATAGAAGTAGATGCTACAGAATTGAAGGTA
CTTAGAGCAAAGTTAATCGACACAGTAAAAGAATCAACTGGAGTAAAATTAACTATGACA
GATTTAATAGTAATGGCAGTATCTAAAATACTTCCAAATCATCAAGCCTTAAATTCAGCA
TGGACAGATGAGGGTATATTTAGATATAAAGATGTAAATATAGCTATTGCAGTTGGTTTA
GATGAAGGCTTATATGTTCCGGTAGTAAAAAATGCAAACAAAAAGTCTTTAAAAGAAATA
GCAAAAGAAAGCAAAGAACTTGCGGAAAAAGTAAAGACAGGGAAACTTATGCCAGCAGAC
CAAGAAGGTAATACATTTACAATAAGTAATGTTGGAATGTATGGTATAACTACATTTACA
CCTATAATAAATATGCCTTCAAGTGCAATCTTAGGGGTAGGTGCTACACAAGATAAGTTT
GTTCCAGTAAATGGAGAGGCTAAAATAAAACCTATAATGAACTTATCATTAACATCAGAC
CATAGAGTAATAGATGGAACAGTAGCTGCAAAATTCTTAAAAGATTTAAAAGAATTGTTA
GAAAATCCTTTATCAATGCTTGTATAG
Enzyme 3 GenBank Gene ID AM180355 Link Image
Enzyme 3 GeneCard ID cobT Link Image
Enzyme 3 GenAtlas ID Not Available
Enzyme 3 HGNC ID Not Available
Enzyme 3 Chromosome Location Not Available
Enzyme 3 Locus CD3439
Enzyme 3 SNPs SNPJam Report Link Image
Enzyme 3 General References
  1. Sebaihia M, Wren BW, Mullany P, Fairweather NF, Minton N, Stabler R, Thomson NR, Roberts AP, Cerdeno-Tarraga AM, Wang H, Holden MT, Wright A, Churcher C, Quail MA, Baker S, Bason N, Brooks K, Chillingworth T, Cronin A, Davis P, Dowd L, Fraser A, Feltwell T, Hance Z, Holroyd S, Jagels K, Moule S, Mungall K, Price C, Rabbinowitsch E, Sharp S, Simmonds M, Stevens K, Unwin L, Whithead S, Dupuy B, Dougan G, Barrell B, Parkhill J: The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome. Nat Genet. 2006 Jul;38(7):779-86. Epub 2006 Jun 25. [PubMed Link Image]
Enzyme 3 Metabolite References Not Available
Enzyme 4 [top]
Enzyme 4 ID 16322
Enzyme 4 Name Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Enzyme 4 Synonyms
  1. NN:DBI PRT
  2. N(1)-alpha-phosphoribosyltransferase
Enzyme 4 Gene Name cobT
Enzyme 4 Protein Sequence >Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 
MLNEVLKGIEGLDNDMIVKAKNRVDSLAKPLGSLGKLEDIAIRLSGITGNMFNNIDKKCV
IIMSSDNGVEEEGVASAPQCVTLLQTKNFIKGTTGVATLAKANGTDLMVFDVGINSDEVV
EGVINRKISKGTKNIYKEPAMTYEEAKKSLEIGIEAVKIAKEKGYKILGVGEMGIGNTTT
SAAVLKALIGCETSQVVGKGGGINNDSFEKKKRIVEEVVKKHNINFDDSIDIISKVGGYD
IGAMTGVFLGAAFYRIPVVIDGFISVVTALLANRLNPLVKEFCFTSHKSQEIGYELAIKE
LGLDPMLDLNMRLGEGSGCPIAFSVIDFATAMMNNMATFEEGNIDNSYLEDVKDEECYIV
L
Enzyme 4 Number of Residues 361
Enzyme 4 Molecular Weight 38886.6
Enzyme 4 Theoretical pI 4.68
Enzyme 4 GO Classification
Function
  • catalytic activity
  • nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
  • transferase activity
  • transferase activity, transferring glycosyl groups
  • transferase activity, transferring pentosyl groups
Process
  • cellular nitrogen compound metabolic process
  • cobalamin biosynthetic process
  • metabolic process
  • nitrogen compound metabolic process
  • nucleobase, nucleoside and nucleotide metabolic process
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
  • nucleoside biosynthetic process
  • nucleoside metabolic process
  • porphyrin biosynthetic process
  • porphyrin metabolic process
  • tetrapyrrole metabolic process
Component
—
Enzyme 4 General Function Involved in nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Enzyme 4 Specific Function Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)
Enzyme 4 Pathways Not Available
Enzyme 4 Reactions
  • beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate [RN:R04148]
Enzyme 4 Pfam Domain Function
Enzyme 4 Signals
  • None
Enzyme 4 Transmembrane Regions
  • None
Enzyme 4 Essentiality Not Available
Enzyme 4 GenBank ID Protein 18143661 Link Image
Enzyme 4 UniProtKB/Swiss-Prot ID Q8XLK7 Link Image
Enzyme 4 UniProtKB/Swiss-Prot Entry Name COBT_CLOPE Link Image
Enzyme 4 PDB ID Not Available
Enzyme 4 Cellular Location Not Available
Enzyme 4 Gene Sequence >1086 bp 
ATGTATATAAAAAGTTTGCAATTAATTAATTATAGAAATTATGAAAATTTATCAATTAAG
CTTTGTCCTAATGTAAATGTCTTTATAGGTGATAATGCACAAGGTAAAACCAATGTAATA
GAAGCTATATATTATTGTGGATTTGCTAAGTCACACAGAACTAATAGAGACAAGGAGCTA
ATAGAGTGGAATAAGGACAGAGCTTTTATAAGGTTAGATGTTCATAAGGATAGATTAGAC
AAAATCATAGATGTGAATATTTTAAAAGACGGAAAAAAAGCTATTAGCATAAATTCAATA
AAGATAAGTAAAATTGGAGAATTAATTGGAACATTTAACGTAGTTATGTTCTCTCCAGAA
GATTTAAAAATAGTAAAAGAATCTCCTGGAATAAGAAGAAGATTTATTGATATGGAACTT
AGCCAATTAAACAAAAGGTATTATCATAATTTAGTTCAATATAATAAAGTATTACATGAA
AGAAATTTAGTTTTAAAGAATAAAAATATAAATGAGGAAATGTTAGACATATATGATATA
CAATTGGCTCAATATGGAGAGAATATTATAAAGACTAGATTAAAATATATAGAACAGTTA
AACAAATATTCTAAAGAAATTCATAAAGAGATAACTTCAGGAAAAGAAGAAATTGAATTT
AAATATATTTCCACTGTAAAAGATTTAGATAATATTAAAGATTCTATGATAAAACTATTA
GAACAAAATAGAAAAAAGGATATAGATAAAAGAGCTACATCTATAGGTCCACATAGAGAT
GATTTTAATATATATTTAAATAATATAGATGCAAAGATTTATGGTTCACAAGGTCAGCAA
AGAACTAGTGTATTAACAATAAAATTTGCATCTTTAAAAATAATAAAAGAAATAACAGGT
GAATATCCTGTGTTATTATTAGATGATGTATTGTCAGAATTAGACTTTAATAGAAAAAGA
TATGTTTTAACATCAATAAAAAATATACAAACAGTAATAACATGTACGGGAATAGAAGAT
CTAACCAGTTATTTAGATGAAAACTCAAAAGTATTTAGAGTTATAAATGGACGTATTCAA
TGTTAA
Enzyme 4 GenBank Gene ID BA000016 Link Image
Enzyme 4 GeneCard ID cobT Link Image
Enzyme 4 GenAtlas ID Not Available
Enzyme 4 HGNC ID Not Available
Enzyme 4 Chromosome Location Not Available
Enzyme 4 Locus CPE1034
Enzyme 4 SNPs SNPJam Report Link Image
Enzyme 4 General References
  1. Shimizu T, Ohtani K, Hirakawa H, Ohshima K, Yamashita A, Shiba T, Ogasawara N, Hattori M, Kuhara S, Hayashi H: Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater. Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):996-1001. Epub 2002 Jan 15. [PubMed Link Image]
Enzyme 4 Metabolite References Not Available
Enzyme 5 [top]
Enzyme 5 ID 16323
Enzyme 5 Name Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Enzyme 5 Synonyms
  1. NN:DBI PRT
  2. N(1)-alpha-phosphoribosyltransferase
Enzyme 5 Gene Name cobT
Enzyme 5 Protein Sequence >Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 
MLNEVLKGIEGLDNDMILKAKNRVDSLAKPLGSLGKLEDIAIRLSGITGNMFNNIDKKCV
IIMSSDNGVEEEGVASAPQCVTLLQTKNFIKGTTGVATLAKSNGTDLMVFDVGINSDEVV
EGVINRKISKGTKNIYKEPAMTYEEAKKSLEIGIEAVKIAKEKGYKILGVGEMGIGNTTT
SAAVLKALIGCETSQVVGKGGGINNASFEKKKRIVEEVVKKHNINFDDPIDIISKVGGYD
IGAMTGVFLGAAFYRIPVVIDGFISVVAALLANRLNPLVKEFCFTSHKSQEIGYELAIKE
LGLDPMLDLNMRLGEGSGCPIAFSVIDFATAMMNNMATFEEGNIDNSYLEDVKDEECYIV
L
Enzyme 5 Number of Residues 361
Enzyme 5 Molecular Weight 38852.6
Enzyme 5 Theoretical pI 4.74
Enzyme 5 GO Classification
Function
  • catalytic activity
  • nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
  • transferase activity
  • transferase activity, transferring glycosyl groups
  • transferase activity, transferring pentosyl groups
Process
  • cellular nitrogen compound metabolic process
  • cobalamin biosynthetic process
  • metabolic process
  • nitrogen compound metabolic process
  • nucleobase, nucleoside and nucleotide metabolic process
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
  • nucleoside biosynthetic process
  • nucleoside metabolic process
  • porphyrin biosynthetic process
  • porphyrin metabolic process
  • tetrapyrrole metabolic process
Component
—
Enzyme 5 General Function Involved in nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Enzyme 5 Specific Function Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)
Enzyme 5 Pathways Not Available
Enzyme 5 Reactions
  • beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate [RN:R04148]
Enzyme 5 Pfam Domain Function
Enzyme 5 Signals
  • None
Enzyme 5 Transmembrane Regions
  • None
Enzyme 5 Essentiality Not Available
Enzyme 5 GenBank ID Protein 110675709 Link Image
Enzyme 5 UniProtKB/Swiss-Prot ID Q0TRK5 Link Image
Enzyme 5 UniProtKB/Swiss-Prot Entry Name COBT_CLOP1 Link Image
Enzyme 5 PDB ID Not Available
Enzyme 5 Cellular Location Not Available
Enzyme 5 Gene Sequence >1086 bp 
ATGTATATAAAAAGTTTGCAATTAATTAATTATAGAAATTATGAAAATTTATCAATTAAG
CTTTGTCCTAATGTAAATGTCTTTATAGGTGATAATGCACAAGGTAAAACCAATGTAATA
GAAGCTATATATTATTGTGGATTTGCTAAGTCACACAGAACTAATAGAGACAAGGAGCTA
ATAGAGTGGAATAAGGACAGAGCTTTTATAAGGTTAGATGTTCATAAGGATAGATTAGAC
AAAATCATAGATGTGAATATTTTAAAAGACGGAAAAAAAGCTATTAGCATAAATTCAATA
AAGATAAGTAAAATTGGAGAATTAATTGGAACATTTAACGTAGTTATGTTCTCTCCAGAA
GATTTAAAAATAGTAAAAGAATCTCCTGGAATAAGAAGAAGATTTATTGATATGGAACTT
AGCCAATTAAACAAAAGGTATTATCATAATTTAGTTCAATATAATAAAGTCTTACATGAA
AGAAATTTAGTTTTAAAGAATAAAAATATAAATGAGGAAATGTTAGACATATATGATATA
CAATTGGCTCAATATGGAGAGAATATTATAAAGACTAGATTAAAATATATAGAACAGTTA
AACAAATATTCTAAAGAAATTCATAAAGAGATAACTTCAGGAAAAGAAGAAATTGAATTT
AAATATATTTCCACTGTAAAAGATTTAGATAATATTAAAGATTCTATGATAAAACTATTA
GAACAAAATAGAAAAAAGGATATAGATAAAAGAGCTACATCTATAGGTCCACATAGAGAT
GATTTTAATATATATTTAAATAATATAGATGCAAAGATTTATGGTTCACAAGGTCAGCAA
AGAACTAGTGTATTAACAATAAAATTTGCATCTTTAAAAATAATAAAAGAAATAACAGGT
GAATATCCTGTGTTATTATTAGATGATGTATTGTCAGAATTAGACTTTAATAGAAAAAGA
TATGTTTTAACATCAATAAAAAATATACAAACAGTAATAACATGTACGGGAATAGAAGAT
CTAACCAGTTATTTAGATGAAAACTCAAAAGTATTTAGAGTTATAAATGGACGTATTCAA
TGTTAA
Enzyme 5 GenBank Gene ID CP000246 Link Image
Enzyme 5 GeneCard ID cobT Link Image
Enzyme 5 GenAtlas ID Not Available
Enzyme 5 HGNC ID Not Available
Enzyme 5 Chromosome Location Not Available
Enzyme 5 Locus CPF_1289
Enzyme 5 SNPs SNPJam Report Link Image
Enzyme 5 General References
  1. Myers GS, Rasko DA, Cheung JK, Ravel J, Seshadri R, DeBoy RT, Ren Q, Varga J, Awad MM, Brinkac LM, Daugherty SC, Haft DH, Dodson RJ, Madupu R, Nelson WC, Rosovitz MJ, Sullivan SA, Khouri H, Dimitrov GI, Watkins KL, Mulligan S, Benton J, Radune D, Fisher DJ, Atkins HS, Hiscox T, Jost BH, Billington SJ, Songer JG, McClane BA, Titball RW, Rood JI, Melville SB, Paulsen IT: Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens. Genome Res. 2006 Aug;16(8):1031-40. Epub 2006 Jul 6. [PubMed Link Image]
Enzyme 5 Metabolite References Not Available
Enzyme 6 [top]
Enzyme 6 ID 16324
Enzyme 6 Name Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Enzyme 6 Synonyms
  1. NN:DBI PRT
  2. N(1)-alpha-phosphoribosyltransferase
Enzyme 6 Gene Name cobT
Enzyme 6 Protein Sequence >Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 
MLNEVLKGIQGLDNDMILKAKNRVDSLAKPLGSLGKLEDIAIRLSGITGNMFNNIDKKCV
IIMSSDNGVEEEGVASAPQCLTLLQTKNFIKGINGVGTLAKTNGTDLIVFDVGINSDEVI
EGVIDRKISKGTKNIYKEPAMTYEEAKKSLEIGIEAVKIAKEKGYKILGVGEMGIGNTTT
SAAVLKALIGCETSKVVGKGGGINNASFEKKKIIVEEVVKKHNIDFDDPIDIISKVGGYD
IGAMAGVFLGAAFYRIPVVIDGFISVVAALLANRLNPLVKEFCFTSHKSQEIGYDLAIKE
LGLDPILDLNMRLGEGSGCPIAFSVINFAISMMNNMATFEEVNIDNSYLEDVKDKECYVV
L
Enzyme 6 Number of Residues 361
Enzyme 6 Molecular Weight 38837.8
Enzyme 6 Theoretical pI 4.86
Enzyme 6 GO Classification
Function
  • catalytic activity
  • nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
  • transferase activity
  • transferase activity, transferring glycosyl groups
  • transferase activity, transferring pentosyl groups
Process
  • cellular nitrogen compound metabolic process
  • cobalamin biosynthetic process
  • metabolic process
  • nitrogen compound metabolic process
  • nucleobase, nucleoside and nucleotide metabolic process
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
  • nucleoside biosynthetic process
  • nucleoside metabolic process
  • porphyrin biosynthetic process
  • porphyrin metabolic process
  • tetrapyrrole metabolic process
Component
—
Enzyme 6 General Function Involved in nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Enzyme 6 Specific Function Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)
Enzyme 6 Pathways Not Available
Enzyme 6 Reactions
  • beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate [RN:R04148]
Enzyme 6 Pfam Domain Function
Enzyme 6 Signals
  • None
Enzyme 6 Transmembrane Regions
  • None
Enzyme 6 Essentiality Not Available
Enzyme 6 GenBank ID Protein 110682820 Link Image
Enzyme 6 UniProtKB/Swiss-Prot ID Q0STX7 Link Image
Enzyme 6 UniProtKB/Swiss-Prot Entry Name Q0STX7_CLOPS Link Image
Enzyme 6 PDB ID Not Available
Enzyme 6 Cellular Location Not Available
Enzyme 6 Gene Sequence >1086 bp 
ATGTATATAAAAAGTTTGCAATTAATTAATTATAGAAATTATGAAAATTTATCAATTAAG
CTTTGTCCTAATGTAAATGTCTTTATAGGTGATAATGCACAAGGTAAAACCAATGTAATA
GAAGCTATATATTATTGTGGATTTGCTAAGTCACACAGAACTAATAGAGACAAGGAGCTA
ATAGAGTGGAATAAGGACAGAGCTTTTATAAGGTTAGATGTTCATAAGGATAGATTAGAC
AAAATCATAGATGTGAATATTTTAAAAGACGGAAAAAAAGCTATTAGCATAAATTCAATA
AAGATAAGCAAAATTGGAGAATTAATTGGAACATTTAACGTAGTTATGTTCTCTCCAGAA
GATTTAAAAATAGTAAAAGAATCTCCTGGAATAAGAAGAAGATTTATTGATATGGAACTT
AGCCAATTAAACAAAAGGTATTATCATAATTTAGTTCAATATAATAAAGTCTTACATGAA
AGAAATTTAGTTTTAAAGAATAAAAATATAAATGAGGAAATGTTAGACATATATGATATA
CAATTGGCTCAATATGGAGAGAATATTATAAAGACTAGATTAAAATATATAGAACAGTTA
AACAAATATTCTAAAGAAATTCATAAAGAGATAACTTCAGGAAAAGAAGAAATTGAATTT
AAATATATTTCCACTGTAAAAGATTTAGATAATATTAAAGATTCTATGATAAAACTATTA
GAACAAAATAGAAAAAAGGATATAGATAAAAGAGCTACATCTATAGGTCCACATAGAGAT
GATTTTAATATATATTTAAATAATATAGATGCAAAGATTTATGGTTCACAAGGTCAGCAA
AGAACTAGTGTATTAACAATAAAATTTGCATCTTTAAAAATAATAAAAGAAATAACAGGT
GAATATCCTGTGTTATTATTAGATGATGTATTGTCAGAATTAGACTTTAATAGAAAAAGA
TATGTTTTAACATCAATAAAAAATATACAAACAGTAATAACATGTACGGGAATAGAAGAT
CTAACCAGTTATTTAGATGAAAACTCAAAAGTATTTAGAGTTATAAATGGACGTATTCAA
TGTTAA
Enzyme 6 GenBank Gene ID CP000312 Link Image
Enzyme 6 GeneCard ID cobT Link Image
Enzyme 6 GenAtlas ID Not Available
Enzyme 6 HGNC ID Not Available
Enzyme 6 Chromosome Location Not Available
Enzyme 6 Locus CPR_1108
Enzyme 6 SNPs SNPJam Report Link Image
Enzyme 6 General References
  1. Myers GS, Rasko DA, Cheung JK, Ravel J, Seshadri R, DeBoy RT, Ren Q, Varga J, Awad MM, Brinkac LM, Daugherty SC, Haft DH, Dodson RJ, Madupu R, Nelson WC, Rosovitz MJ, Sullivan SA, Khouri H, Dimitrov GI, Watkins KL, Mulligan S, Benton J, Radune D, Fisher DJ, Atkins HS, Hiscox T, Jost BH, Billington SJ, Songer JG, McClane BA, Titball RW, Rood JI, Melville SB, Paulsen IT: Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens. Genome Res. 2006 Aug;16(8):1031-40. Epub 2006 Jul 6. [PubMed Link Image]
Enzyme 6 Metabolite References Not Available
Enzyme 7 [top]
Enzyme 7 ID 16325
Enzyme 7 Name Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Enzyme 7 Synonyms
  1. NN:DBI PRT
  2. N(1)-alpha-phosphoribosyltransferase
Enzyme 7 Gene Name cobT
Enzyme 7 Protein Sequence >Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 
MQILADLLNTIPAIDSTAMSRAQRHIDGLLKPVGSLGKLEVLAIQLAGMPGLNGIPHVGK
KAVLVMCADHGVWEEGVAISPKEVTAIQAENMTRGTTGVCVLAEQAGANVHVIDVGIDTA
EPIPGLINMRVARGSGNIASAPAMSRRQAEKLLLDVICYTQELAKNGVTLFGVGELGMAN
TTPAAAIVSTITGRDPEEVVGIGANLPTDKLANKIDVVRRAITLNQPNPQDGVDVLAKVG
GFDLVGIAGVMLGAASCGLPVLLDGFLSYAAALAACQMSPAIKPYLIPSHLSAEKGARIA
LSHLGLEPYLNMEMRLGEGSGAALAMPIIEAACAIYNNMGELAASNIVLPGNTTSDLNS
Enzyme 7 Number of Residues 359
Enzyme 7 Molecular Weight 36986.6
Enzyme 7 Theoretical pI 5.00
Enzyme 7 GO Classification
Function
  • catalytic activity
  • nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
  • transferase activity
  • transferase activity, transferring glycosyl groups
  • transferase activity, transferring pentosyl groups
Process
  • cellular nitrogen compound metabolic process
  • cobalamin biosynthetic process
  • metabolic process
  • nitrogen compound metabolic process
  • nucleobase, nucleoside and nucleotide metabolic process
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
  • nucleoside biosynthetic process
  • nucleoside metabolic process
  • porphyrin biosynthetic process
  • porphyrin metabolic process
  • tetrapyrrole metabolic process
Component
—
Enzyme 7 General Function Involved in nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Enzyme 7 Specific Function Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)
Enzyme 7 Pathways Not Available
Enzyme 7 Reactions
  • beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate [RN:R04148]
Enzyme 7 Pfam Domain Function
Enzyme 7 Signals
  • None
Enzyme 7 Transmembrane Regions
  • None
Enzyme 7 Essentiality Not Available
Enzyme 7 GenBank ID Protein 1736652 Link Image
Enzyme 7 UniProtKB/Swiss-Prot ID P36562 Link Image
Enzyme 7 UniProtKB/Swiss-Prot Entry Name COBT_ECOLI Link Image
Enzyme 7 PDB ID Not Available
Enzyme 7 Cellular Location Not Available
Enzyme 7 Gene Sequence >1080 bp 
ATGCAAATACTTGCCGATTTACTGAATACGATCCCAGCCATCGATTCTACCGCTATGTCG
CGTGCACAACGGCATATTGACGGGTTACTCAAACCTGTTGGTAGCCTGGGAAAGCTGGAG
GTGCTTGCCATACAACTGGCAGGAATGCCGGGGTTGAATGGCATACCGCATGTGGGCAAA
AAAGCGGTACTGGTTATGTGTGCCGATCACGGCGTCTGGGAGGAAGGGGTCGCTATTTCT
CCAAAAGAAGTGACAGCCATACAGGCTGAAAATATGACCCGTGGAACAACCGGCGTGTGT
GTGCTGGCAGAACAAGCGGGCGCTAACGTCCACGTAATTGATGTTGGTATTGATACTGCT
GAGCCTATCCCCGGGCTTATCAACATGCGTGTCGCACGAGGTAGCGGCAATATTGCTTCA
GCTCCGGCAATGAGTCGCCGTCAGGCTGAAAAGTTGCTTTTGGACGTCATATGTTATACG
CAGGAGCTGGCAAAAAACGGTGTCACGCTGTTTGGTGTAGGTGAACTGGGGATGGCAAAC
ACGACACCGGCAGCAGCAATAGTCAGCACAATCACTGGCCGGGATCCTGAAGAAGTGGTT
GGGATTGGCGCAAACCTGCCGACAGATAAACTGGCTAATAAAATTGATGTTGTGCGTCGG
GCGATTACGTTGAATCAACCAAATCCTCAGGATGGTGTTGATGTCCTGGCAAAAGTGGGT
GGATTTGATTTGGTCGGAATAGCTGGAGTGATGTTAGGTGCTGCTTCCTGCGGTTTACCC
GTGTTGCTGGATGGATTTCTTTCTTATGCTGCTGCGCTCGCAGCCTGCCAGATGTCTCCT
GCGATCAAACCGTATCTCATTCCTTCTCACCTGTCGGCAGAAAAAGGCGCGCGTATAGCG
CTCTCGCATTTGGGGCTGGAGCCTTATCTCAATATGGAGATGCGTTTAGGTGAGGGGAGT
GGCGCAGCTCTGGCGATGCCCATCATCGAAGCTGCCTGTGCGATATACAACAACATGGGC
GAACTTGCTGCCAGTAATATTGTTCTACCGGGGAATACGACTTCTGATTTGAACAGTTAA
Enzyme 7 GenBank Gene ID AP009048 Link Image
Enzyme 7 GeneCard ID cobT Link Image
Enzyme 7 GenAtlas ID Not Available
Enzyme 7 HGNC ID Not Available
Enzyme 7 Chromosome Location Not Available
Enzyme 7 Locus b1991
Enzyme 7 SNPs SNPJam Report Link Image
Enzyme 7 General References
  1. Lawrence JG, Roth JR: The cobalamin (coenzyme B12) biosynthetic genes of Escherichia coli. J Bacteriol. 1995 Nov;177(22):6371-80. [PubMed Link Image]
  2. Itoh T, Aiba H, Baba T, Hayashi K, Inada T, Isono K, Kasai H, Kimura S, Kitakawa M, Kitagawa M, Makino K, Miki T, Mizobuchi K, Mori H, Mori T, Motomura K, Nakade S, Nakamura Y, Nashimoto H, Nishio Y, Oshima T, Saito N, Sampei G, Seki Y, Horiuchi T, et al.: A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map. DNA Res. 1996 Dec 31;3(6):379-92. [PubMed Link Image]
  3. Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-74. [PubMed Link Image]
  4. Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [PubMed Link Image]
Enzyme 7 Metabolite References Not Available
Enzyme 8 [top]
Enzyme 8 ID 16326
Enzyme 8 Name Inner membrane protein ycfZ
Enzyme 8 Synonyms Not Available
Enzyme 8 Gene Name ycfZ
Enzyme 8 Protein Sequence >Inner membrane protein ycfZ 
MKKFIILLSLLILLPLTAASKPLIPIMKTLFTDVTGTVPDAEEIAHKAELFRQQTGIAPF
IVVLPDINNEASLRQNGKAMLAHASSSLSDVKGSVLLLFTTREPRLIMITNGQVESGLDD
KHLGLLIENHTLAYLNADLWYQGINNALAVLQAQILKQSTPPLTYYPHPGQQHENAPPGS
TNTLGFIAWAATFILFSRIFYYTTRFIYALKFAVAMTIANMGYQALCLYIDNSFAITRIS
PLWAGLIGVCTFIAALLLTSKR
Enzyme 8 Number of Residues 262
Enzyme 8 Molecular Weight 28864.5
Enzyme 8 Theoretical pI 8.98
Enzyme 8 GO Classification Not Available
Enzyme 8 General Function Not Available
Enzyme 8 Specific Function Not Available
Enzyme 8 Pathways Not Available
Enzyme 8 Reactions Not Available
Enzyme 8 Pfam Domain Function Not Available
Enzyme 8 Signals
  • None
Enzyme 8 Transmembrane Regions
  • 5-27 183-202 207-229 239-258
Enzyme 8 Essentiality Not Available
Enzyme 8 GenBank ID Protein 85674370 Link Image
Enzyme 8 UniProtKB/Swiss-Prot ID P75961 Link Image
Enzyme 8 UniProtKB/Swiss-Prot Entry Name YCFZ_ECOLI Link Image
Enzyme 8 PDB ID Not Available
Enzyme 8 Cellular Location Not Available
Enzyme 8 Gene Sequence >789 bp 
GTGATTGATAAATCCGCCTTTGTGCATCCAACCGCCATTGTGGAAGAGGGCGCGTCAATT
GGCGCGAACGCACACATTGGTCCTTTTTGTATCGTTGGACCCCATGTCGAAATTGGTGAG
GGTACCGTACTGAAATCTCACGTTGTCGTGAATGGTCATACTAAAATTGGCCGCGATAAT
GAGATTTATCAGTTCGCCTCCATCGGCGAAGTTAACCAGGATCTGAAATATGCTGGCGAA
CCGACCCGTGTGGAAATCGGCGATCGTAACCGCATTCGCGAAAGCGTCACCATTCATCGT
GGCACAGTCCAGGGCGGTGGATTGACGAAGGTGGGCAGCGACAACTTACTGATGATCAAC
GCGCACATTGCGCACGATTGTACGGTAGGTAACCGCTGTATTCTCGCCAACAACGCAACG
CTGGCGGGTCACGTATCGGTTGACGACTTCGCGATCATCGGCGGCATGACCGCAGTCCAT
CAGTTCTGCATCATTGGTGCGCACGTGATGGTTGGCGGCTGCTCCGGTGTGGCGCAGGAC
GTCCCTCCTTATGTCATTGCGCAGGGTAACCACGCAACGCCGTTCGGTGTCAATATCGAA
GGGCTGAAGCGCCGCGGATTCAGCCGTGAGGCGATTACCGCTATCCGCAATGCGTATAAG
CTGATTTATCGTAGCGGTAAAACGCTCGATGAAGTGAAACCGGAAATTGCTGAACTGGCG
GAAACATATCCGGAAGTGAAAGCCTTTACCGATTTCTTTGCACGCTCAACGCGCGGTCTG
ATTCGTTAA
Enzyme 8 GenBank Gene ID AP009048 Link Image
Enzyme 8 GeneCard ID ycfZ Link Image
Enzyme 8 GenAtlas ID Not Available
Enzyme 8 HGNC ID Not Available
Enzyme 8 Chromosome Location Not Available
Enzyme 8 Locus b1121
Enzyme 8 SNPs SNPJam Report Link Image
Enzyme 8 General References
  1. Oshima T, Aiba H, Baba T, Fujita K, Hayashi K, Honjo A, Ikemoto K, Inada T, Itoh T, Kajihara M, Kanai K, Kashimoto K, Kimura S, Kitagawa M, Makino K, Masuda S, Miki T, Mizobuchi K, Mori H, Motomura K, Nakamura Y, Nashimoto H, Nishio Y, Saito N, Horiuchi T, et al.: A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map. DNA Res. 1996 Jun 30;3(3):137-55. [PubMed Link Image]
  2. Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-74. [PubMed Link Image]
  3. Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [PubMed Link Image]
  4. Daley DO, Rapp M, Granseth E, Melen K, Drew D, von Heijne G: Global topology analysis of the Escherichia coli inner membrane proteome. Science. 2005 May 27;308(5726):1321-3. [PubMed Link Image]
Enzyme 8 Metabolite References Not Available
Enzyme 9 [top]
Enzyme 9 ID 16834
Enzyme 9 Name Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Enzyme 9 Synonyms
  1. NN:DBI PRT
  2. N(1)-alpha-phosphoribosyltransferase
Enzyme 9 Gene Name cobT
Enzyme 9 Protein Sequence >Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 
MQILADLLNTIPAIDSTAMSRAQRHIDGLLKPVGSLGKLEVLAIQLAGMPGLNGIPHVGK
KAVLVMCADHGVWEEGVAISPKEVTAIQAENMTRGTTGVCVLAEQAGANVHVIDVGIDTA
EPIPGLINMRVARGSGNIASAPAMSRRQAEKLLLDVICYTQELAKNGVTLFGVGELGMAN
TTPAAAIVSTITGRDPEEVVGIGANLPTDKLANKIDVVRRAITLNQPNPQDGVDVLAKVG
GFDLVGIAGVMLGAASCGLPVLLDGFLSYAAALAACQMSPAIKPYLIPSHLSAEKGARIA
LSHLGLEPYLNMEMRLGEGSGAALAMPIIEAACAIYNNMGELAASNIVLPGNTTSDLNS
Enzyme 9 Number of Residues 359
Enzyme 9 Molecular Weight 36986.6
Enzyme 9 Theoretical pI 5.00
Enzyme 9 GO Classification
Function
  • catalytic activity
  • nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
  • transferase activity
  • transferase activity, transferring glycosyl groups
  • transferase activity, transferring pentosyl groups
Process
  • cellular nitrogen compound metabolic process
  • cobalamin biosynthetic process
  • metabolic process
  • nitrogen compound metabolic process
  • nucleobase, nucleoside and nucleotide metabolic process
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
  • nucleoside biosynthetic process
  • nucleoside metabolic process
  • porphyrin biosynthetic process
  • porphyrin metabolic process
  • tetrapyrrole metabolic process
Component
—
Enzyme 9 General Function Involved in nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Enzyme 9 Specific Function Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)
Enzyme 9 Pathways Not Available
Enzyme 9 Reactions
  • beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate [RN:R04148]
Enzyme 9 Pfam Domain Function
Enzyme 9 Signals
  • None
Enzyme 9 Transmembrane Regions
  • None
Enzyme 9 Essentiality Not Available
Enzyme 9 GenBank ID Protein 169889458 Link Image
Enzyme 9 UniProtKB/Swiss-Prot ID B1X6S9 Link Image
Enzyme 9 UniProtKB/Swiss-Prot Entry Name COBT_ECODH Link Image
Enzyme 9 PDB ID Not Available
Enzyme 9 Cellular Location Not Available
Enzyme 9 Gene Sequence >1080 bp 
ATGCAAATACTTGCCGATTTACTGAATACGATCCCAGCCATCGATTCTACCGCTATGTCG
CGTGCACAACGGCATATTGACGGGTTACTCAAACCTGTTGGTAGCCTGGGAAAGCTGGAG
GTGCTTGCCATACAACTGGCAGGAATGCCGGGGTTGAATGGCATACCGCATGTGGGCAAA
AAAGCGGTACTGGTTATGTGTGCCGATCACGGCGTCTGGGAGGAAGGGGTCGCTATTTCT
CCAAAAGAAGTGACAGCCATACAGGCTGAAAATATGACCCGTGGAACAACCGGCGTGTGT
GTGCTGGCAGAACAAGCGGGCGCTAACGTCCACGTAATTGATGTTGGTATTGATACTGCT
GAGCCTATCCCCGGGCTTATCAACATGCGTGTCGCACGAGGTAGCGGCAATATTGCTTCA
GCTCCGGCAATGAGTCGCCGTCAGGCTGAAAAGTTGCTTTTGGACGTCATATGTTATACG
CAGGAGCTGGCAAAAAACGGTGTCACGCTGTTTGGTGTAGGTGAACTGGGGATGGCAAAC
ACGACACCGGCAGCAGCAATAGTCAGCACAATCACTGGCCGGGATCCTGAAGAAGTGGTT
GGGATTGGCGCAAACCTGCCGACAGATAAACTGGCTAATAAAATTGATGTTGTGCGTCGG
GCGATTACGTTGAATCAACCAAATCCTCAGGATGGTGTTGATGTCCTGGCAAAAGTGGGT
GGATTTGATTTGGTCGGAATAGCTGGAGTGATGTTAGGTGCTGCTTCCTGCGGTTTACCC
GTGTTGCTGGATGGATTTCTTTCTTATGCTGCTGCGCTCGCAGCCTGCCAGATGTCTCCT
GCGATCAAACCGTATCTCATTCCTTCTCACCTGTCGGCAGAAAAAGGCGCGCGTATAGCG
CTCTCGCATTTGGGGCTGGAGCCTTATCTCAATATGGAGATGCGTTTAGGTGAGGGGAGT
GGCGCAGCTCTGGCGATGCCCATCATCGAAGCTGCCTGTGCGATATACAACAACATGGGC
GAACTTGCTGCCAGTAATATTGTTCTACCGGGGAATACGACTTCTGATTTGAACAGTTAA
Enzyme 9 GenBank Gene ID CP000948 Link Image
Enzyme 9 GeneCard ID cobT Link Image
Enzyme 9 GenAtlas ID Not Available
Enzyme 9 HGNC ID Not Available
Enzyme 9 Chromosome Location Not Available
Enzyme 9 Locus ECDH10B_2135
Enzyme 9 SNPs SNPJam Report Link Image
Enzyme 9 General References
  1. Durfee T, Nelson R, Baldwin S, Plunkett G 3rd, Burland V, Mau B, Petrosino JF, Qin X, Muzny DM, Ayele M, Gibbs RA, Csorgo B, Posfai G, Weinstock GM, Blattner FR: The complete genome sequence of Escherichia coli DH10B: insights into the biology of a laboratory workhorse. J Bacteriol. 2008 Apr;190(7):2597-606. Epub 2008 Feb 1. [PubMed Link Image]
Enzyme 9 Metabolite References Not Available