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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2009-07-25 00:03:28 UTC
Update Date2022-03-07 02:51:27 UTC
HMDB IDHMDB0012587
Secondary Accession Numbers
  • HMDB12587
Metabolite Identification
Common Name15-Epi-lipoxin A4
Description15-Epi-lipoxin A4 is a lipoxin derivative. Lipoxins (LXs) and aspirin-triggered Lipoxin (ATL) are trihydroxytetraene-containing eicosanoids generated from arachidonic acid that are distinct in structure, formation, and function from the many other proinflammatory lipid-derived mediators. These endogenous eicosanoids have now emerged as founding members of the first class of lipid/chemical mediators involved in the resolution of the inflammatory response. Lipoxin A4 (LXA4), ATL, and their metabolic stable analogs elicit cellular responses and regulate leukocyte trafficking in vivo by activating the specific receptor, ALX. Many of the eicosanoids derived from arachidonic acid (AA2), including prostaglandins (PGs) and leukotrienes (LTs), play important roles as local mediators exerting a wide range of actions relevant in immune hypersensitivity and inflammation. However, recent observations indicate that other agents derived from the lipoxygenase (LO) pathways are formed and play a key role in initiating the resolution of acute inflammation. This phenomenon is an active process that is governed by specific lipid mediators and involves a series of well-orchestrated temporal events. Thus, potent locally released mediators serve as checkpoint controllers of inflammation. In addition to the well-appreciated ability of aspirin to inhibit PGs, aspirin also acetylates cyclooxygenase (COX)-2, triggering the formation of a 15-epimeric form of lipoxins, termed aspirin-triggered LXA4 (ATL). These eicosanoids (i.e., LXA4 and ATL) with a unique trihydroxytetraene structure function as 'stop signals' in inflammation and actively participate in dampening host responses to bring the inflammation to a close, namely, resolution. LXA4 and ATL elicit the multicellular responses via a specific G protein-coupled receptor (GPCR) termed ALX that has been identified in human. (PMID: 16968948 , 11478982 ).
Structure
Data?1582753066
Synonyms
ValueSource
15-Epi-lxa(,4)HMDB
5(S),6(R),15(R)-Trihydroxy-7,9,13-trans-11-cis eicosatetraenoateHMDB
5(S),6(R),15(R)-Trihydroxy-7,9,13-trans-11-cis eicosatetraenoic acidHMDB
5(S),6(R),15(R)-Trihydroxy-7,9,13-trans-11-cis eicosatetraenoic acid anionHMDB
5(S),6(R),15(R)-Trihydroxy-7E,9E,11Z,13E-eicosatetraenoateHMDB
5(S),6(R),15(R)-Trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acidHMDB
5(S),6(R),15(R)-Trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid anionHMDB
15-Epi-lxa4MeSH, HMDB
5,6,15-TriHETEMeSH, HMDB
5,6,15-Trihydroxy-7,9,11,13-eicosatetraenoic acidMeSH, HMDB
5,6,15-Tri-heteMeSH, HMDB
LXA4MeSH, HMDB
Lipoxin a4MeSH, HMDB
(5R,6R,7E,9E,11Z,15R)-5,6,15-Trihydroxyicosa-7,9,11,13-tetraenoateGenerator
Chemical FormulaC20H32O5
Average Molecular Weight352.4651
Monoisotopic Molecular Weight352.224974134
IUPAC Name(5R,6R,7E,9E,11Z,13E,15R)-5,6,15-trihydroxyicosa-7,9,11,13-tetraenoic acid
Traditional Name(5R,6R,7E,9E,11Z,13E,15R)-5,6,15-trihydroxyicosa-7,9,11,13-tetraenoic acid
CAS Registry NumberNot Available
SMILES
CCCCC[C@@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@H](O)CCCC(O)=O
InChI Identifier
InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18-,19-/m1/s1
InChI KeyIXAQOQZEOGMIQS-BZIKWXEGSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as lipoxins. These are eicosanoids with a trihydroxyicosatetraenoic acid skeleton (a c20-fatty acid, with the chain bearing three hydroxyl groups and four double bonds). Lipoxins have four double bonds, which are all conjugated. In some cases a hydroxyl group is substituted by a C=O group.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassFatty Acyls
Sub ClassEicosanoids
Direct ParentLipoxins
Alternative Parents
Substituents
  • Lipoxin
  • Long-chain fatty acid
  • Hydroxy fatty acid
  • Fatty acid
  • Unsaturated fatty acid
  • Secondary alcohol
  • Carboxylic acid derivative
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Polyol
  • Organic oxide
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Carbonyl group
  • Organooxygen compound
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External DescriptorsNot Available
Ontology
Physiological effectNot Available
Disposition
Process
Role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.044 g/LALOGPS
logP4.61ALOGPS
logP3.05ChemAxon
logS-3.9ALOGPS
pKa (Strongest Acidic)4.48ChemAxon
pKa (Strongest Basic)-1.6ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area97.99 ŲChemAxon
Rotatable Bond Count14ChemAxon
Refractivity104.35 m³·mol⁻¹ChemAxon
Polarizability41.17 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+193.45131661259
DarkChem[M-H]-192.67531661259
DeepCCS[M+H]+201.35830932474
DeepCCS[M-H]-199.030932474
DeepCCS[M-2H]-232.95430932474
DeepCCS[M+Na]+208.18230932474
AllCCS[M+H]+194.532859911
AllCCS[M+H-H2O]+191.832859911
AllCCS[M+NH4]+197.132859911
AllCCS[M+Na]+197.832859911
AllCCS[M-H]-189.732859911
AllCCS[M+Na-2H]-191.632859911
AllCCS[M+HCOO]-193.732859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
15-Epi-lipoxin A4CCCCC[C@@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@H](O)CCCC(O)=O4963.4Standard polar33892256
15-Epi-lipoxin A4CCCCC[C@@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@H](O)CCCC(O)=O2873.2Standard non polar33892256
15-Epi-lipoxin A4CCCCC[C@@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@H](O)CCCC(O)=O3099.1Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
15-Epi-lipoxin A4,1TMS,isomer #1CCCCC[C@H](/C=C/C=C\C=C\C=C\[C@@H](O)[C@H](O)CCCC(=O)O)O[Si](C)(C)C3198.8Semi standard non polar33892256
15-Epi-lipoxin A4,1TMS,isomer #2CCCCC[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O[Si](C)(C)C)[C@H](O)CCCC(=O)O3157.1Semi standard non polar33892256
15-Epi-lipoxin A4,1TMS,isomer #3CCCCC[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](CCCC(=O)O)O[Si](C)(C)C3154.4Semi standard non polar33892256
15-Epi-lipoxin A4,1TMS,isomer #4CCCCC[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@H](O)CCCC(=O)O[Si](C)(C)C3112.7Semi standard non polar33892256
15-Epi-lipoxin A4,2TMS,isomer #1CCCCC[C@H](/C=C/C=C\C=C\C=C\[C@@H](O[Si](C)(C)C)[C@H](O)CCCC(=O)O)O[Si](C)(C)C3188.5Semi standard non polar33892256
15-Epi-lipoxin A4,2TMS,isomer #2CCCCC[C@H](/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](CCCC(=O)O)O[Si](C)(C)C)O[Si](C)(C)C3182.2Semi standard non polar33892256
15-Epi-lipoxin A4,2TMS,isomer #3CCCCC[C@H](/C=C/C=C\C=C\C=C\[C@@H](O)[C@H](O)CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C3156.1Semi standard non polar33892256
15-Epi-lipoxin A4,2TMS,isomer #4CCCCC[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O[Si](C)(C)C)[C@@H](CCCC(=O)O)O[Si](C)(C)C3175.2Semi standard non polar33892256
15-Epi-lipoxin A4,2TMS,isomer #5CCCCC[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O[Si](C)(C)C)[C@H](O)CCCC(=O)O[Si](C)(C)C3109.6Semi standard non polar33892256
15-Epi-lipoxin A4,2TMS,isomer #6CCCCC[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C3105.1Semi standard non polar33892256
15-Epi-lipoxin A4,3TMS,isomer #1CCCCC[C@H](/C=C/C=C\C=C\C=C\[C@@H](O[Si](C)(C)C)[C@@H](CCCC(=O)O)O[Si](C)(C)C)O[Si](C)(C)C3187.2Semi standard non polar33892256
15-Epi-lipoxin A4,3TMS,isomer #2CCCCC[C@H](/C=C/C=C\C=C\C=C\[C@@H](O[Si](C)(C)C)[C@H](O)CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C3143.5Semi standard non polar33892256
15-Epi-lipoxin A4,3TMS,isomer #3CCCCC[C@H](/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C3130.5Semi standard non polar33892256
15-Epi-lipoxin A4,3TMS,isomer #4CCCCC[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O[Si](C)(C)C)[C@@H](CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C3127.3Semi standard non polar33892256
15-Epi-lipoxin A4,4TMS,isomer #1CCCCC[C@H](/C=C/C=C\C=C\C=C\[C@@H](O[Si](C)(C)C)[C@@H](CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C3155.9Semi standard non polar33892256
15-Epi-lipoxin A4,1TBDMS,isomer #1CCCCC[C@H](/C=C/C=C\C=C\C=C\[C@@H](O)[C@H](O)CCCC(=O)O)O[Si](C)(C)C(C)(C)C3450.6Semi standard non polar33892256
15-Epi-lipoxin A4,1TBDMS,isomer #2CCCCC[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O)CCCC(=O)O3413.6Semi standard non polar33892256
15-Epi-lipoxin A4,1TBDMS,isomer #3CCCCC[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](CCCC(=O)O)O[Si](C)(C)C(C)(C)C3408.0Semi standard non polar33892256
15-Epi-lipoxin A4,1TBDMS,isomer #4CCCCC[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@H](O)CCCC(=O)O[Si](C)(C)C(C)(C)C3377.5Semi standard non polar33892256
15-Epi-lipoxin A4,2TBDMS,isomer #1CCCCC[C@H](/C=C/C=C\C=C\C=C\[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O)CCCC(=O)O)O[Si](C)(C)C(C)(C)C3676.6Semi standard non polar33892256
15-Epi-lipoxin A4,2TBDMS,isomer #2CCCCC[C@H](/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](CCCC(=O)O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3675.1Semi standard non polar33892256
15-Epi-lipoxin A4,2TBDMS,isomer #3CCCCC[C@H](/C=C/C=C\C=C\C=C\[C@@H](O)[C@H](O)CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3667.6Semi standard non polar33892256
15-Epi-lipoxin A4,2TBDMS,isomer #4CCCCC[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H](CCCC(=O)O)O[Si](C)(C)C(C)(C)C3671.2Semi standard non polar33892256
15-Epi-lipoxin A4,2TBDMS,isomer #5CCCCC[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O)CCCC(=O)O[Si](C)(C)C(C)(C)C3619.3Semi standard non polar33892256
15-Epi-lipoxin A4,2TBDMS,isomer #6CCCCC[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3616.4Semi standard non polar33892256
15-Epi-lipoxin A4,3TBDMS,isomer #1CCCCC[C@H](/C=C/C=C\C=C\C=C\[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H](CCCC(=O)O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3954.0Semi standard non polar33892256
15-Epi-lipoxin A4,3TBDMS,isomer #2CCCCC[C@H](/C=C/C=C\C=C\C=C\[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O)CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3914.5Semi standard non polar33892256
15-Epi-lipoxin A4,3TBDMS,isomer #3CCCCC[C@H](/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3913.7Semi standard non polar33892256
15-Epi-lipoxin A4,3TBDMS,isomer #4CCCCC[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H](CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3903.6Semi standard non polar33892256
15-Epi-lipoxin A4,4TBDMS,isomer #1CCCCC[C@H](/C=C/C=C\C=C\C=C\[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H](CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C4175.2Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - 15-Epi-lipoxin A4 GC-MS (Non-derivatized) - 70eV, Positivesplash10-02ti-3942000000-539dee31c556f111beef2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 15-Epi-lipoxin A4 GC-MS (4 TMS) - 70eV, Positivesplash10-004i-9023156000-8244ac03abe716c2ce532017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 15-Epi-lipoxin A4 GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 15-Epi-lipoxin A4 GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Epi-lipoxin A4 10V, Positive-QTOFsplash10-00kr-0019000000-19caadde5e524b5ae2502017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Epi-lipoxin A4 20V, Positive-QTOFsplash10-00kr-9466000000-dc971dc55975b569912b2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Epi-lipoxin A4 40V, Positive-QTOFsplash10-000f-9430000000-bc82bb195c4947fa53cf2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Epi-lipoxin A4 10V, Negative-QTOFsplash10-0udi-0009000000-009f9c82d818546c61022017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Epi-lipoxin A4 20V, Negative-QTOFsplash10-0kai-4379000000-52c1e5333adc5555ffef2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Epi-lipoxin A4 40V, Negative-QTOFsplash10-0a4i-9340000000-ca0cb5410468b7dee5f82017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Epi-lipoxin A4 10V, Negative-QTOFsplash10-0ue9-0009000000-cb99b6286e5f411abaa32021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Epi-lipoxin A4 20V, Negative-QTOFsplash10-0gc0-4459000000-b29437cc7614015ca29b2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Epi-lipoxin A4 40V, Negative-QTOFsplash10-014j-9320000000-477457ab7d09daaade6b2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Epi-lipoxin A4 10V, Positive-QTOFsplash10-014r-0119000000-a8a3218eed37097e38da2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Epi-lipoxin A4 20V, Positive-QTOFsplash10-00kr-1936000000-0ece3e36fd898b1f90972021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Epi-lipoxin A4 40V, Positive-QTOFsplash10-059f-9600000000-18d8014a43feca3a38b62021-09-23Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB029135
KNApSAcK IDNot Available
Chemspider ID30776639
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound52224362
PDB IDNot Available
ChEBI IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. McMahon B, Mitchell S, Brady HR, Godson C: Lipoxins: revelations on resolution. Trends Pharmacol Sci. 2001 Aug;22(8):391-5. [PubMed:11478982 ]
  2. Chiang N, Serhan CN, Dahlen SE, Drazen JM, Hay DW, Rovati GE, Shimizu T, Yokomizo T, Brink C: The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo. Pharmacol Rev. 2006 Sep;58(3):463-87. [PubMed:16968948 ]
  3. Simons K, Toomre D: Lipid rafts and signal transduction. Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9. [PubMed:11413487 ]
  4. Watson AD: Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Lipidomics: a global approach to lipid analysis in biological systems. J Lipid Res. 2006 Oct;47(10):2101-11. Epub 2006 Aug 10. [PubMed:16902246 ]
  5. Sethi JK, Vidal-Puig AJ: Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res. 2007 Jun;48(6):1253-62. Epub 2007 Mar 20. [PubMed:17374880 ]
  6. Lingwood D, Simons K: Lipid rafts as a membrane-organizing principle. Science. 2010 Jan 1;327(5961):46-50. doi: 10.1126/science.1174621. [PubMed:20044567 ]
  7. Gunstone, Frank D., John L. Harwood, and Albert J. Dijkstra (2007). The lipid handbook with CD-ROM. CRC Press.