| Record Information |
| Version |
3.5 |
| Creation Date |
2010-07-16 07:49:07 -0600 |
| Update Date |
2013-05-29 13:48:57 -0600 |
| HMDB ID |
HMDB13636 |
| Secondary Accession Numbers |
None |
| Metabolite Identification |
| Common Name |
Pyrroloquinoline quinone |
| Description |
Enzymes containing PQQ are called quinoproteins. PQQ and quinoproteins play a role in the redox metabolism and structural integrity of cells and tissues [PMID:2558842 ]. It was reported that aminoadipate semialdehyde dehydrogenase (AASDH) might also use PQQ as a cofactor, suggesting a possibility that PQQ is a vitamin in mammals. [PMID:12712191 ]. |
| Structure |
Download:
MOL |
SDF |
SMILES |
InChI
Display:
2D Structure |
3D Structure
|
| Synonyms |
- Methoxatin
- PQQ
- Pyrrolo-quinoline quinone
- Pyrroloquinoline-quinone
|
| Chemical Formula |
C14H6N2O8 |
| Average Molecular Weight |
330.206 |
| Monoisotopic Molecular Weight |
330.012415178 |
| IUPAC Name |
4,5-dioxo-1H,4H,5H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid |
| Traditional IUPAC Name |
pyrroloquinoline quinone |
| CAS Registry Number |
72909-34-3 |
| SMILES |
OC(=O)C1=CC2=C(N1)C1=C(N=C(C=C1C(O)=O)C(O)=O)C(=O)C2=O |
| InChI Identifier |
InChI=1S/C14H6N2O8/c17-10-4-2-6(14(23)24)15-8(4)7-3(12(19)20)1-5(13(21)22)16-9(7)11(10)18/h1-2,15H,(H,19,20)(H,21,22)(H,23,24) |
| InChI Key |
MMXZSJMASHPLLR-UHFFFAOYSA-N |
| Chemical Taxonomy |
| Kingdom |
Organic Compounds |
| Super Class |
Amino Acids, Peptides, and Analogues |
| Class |
Amino Acids and Derivatives |
| Sub Class |
Alpha Amino Acids and Derivatives |
| Other Descriptors |
- Aromatic Heteropolycyclic Compounds
- Prosthetic group [Fig](KEGG)
- pyrroloquinoline cofactor(ChEBI)
- quinone(ChEBI)
- tricarboxylic acid(ChEBI)
|
| Substituents |
- Benzoquinone
- Carboxylic Acid
- Ketone
- Pyridine
- Pyridine Carboxylic Acid
- Pyrrole
- Pyrroloquinoline
- Tricarboxylic Acid Derivative
|
| Direct Parent |
Alpha Amino Acids and Derivatives |
| Ontology |
| Status |
Expected and Not Quantified |
| Origin |
|
| Biofunction |
Not Available |
| Application |
Not Available |
| Cellular locations |
Not Available |
| Physical Properties |
| State |
Solid |
| Experimental Properties |
| Property |
Value |
Reference |
| Melting Point |
Not Available |
Not Available |
| Boiling Point |
Not Available |
Not Available |
| Water Solubility |
Not Available |
Not Available |
| LogP |
Not Available |
Not Available |
|
| Predicted Properties |
|
| Spectra |
|
Not Available
|
| Biological Properties |
| Cellular Locations |
Not Available
|
| Biofluid Locations |
Not Available
|
| Tissue Location |
Not Available
|
| Pathways |
Not Available
|
| Normal Concentrations |
|
Not Available |
| Abnormal Concentrations |
|
Not Available |
| Associated Disorders and Diseases |
| Disease References |
None |
| Associated OMIM IDs |
None |
| External Links |
| DrugBank ID |
DB03205  |
| Phenol Explorer Compound ID |
Not Available |
| Phenol Explorer Metabolite ID |
Not Available |
| FoodDB ID |
FDB012848 |
| KNApSAcK ID |
Not Available |
| Chemspider ID |
997  |
| KEGG Compound ID |
C00113  |
| BioCyc ID |
PQQ  |
| BiGG ID |
Not Available |
| Wikipedia Link |
Pyrroloquinoline_quinone  |
| NuGOwiki Link |
HMDB13636  |
| Metagene Link |
HMDB13636  |
| METLIN ID |
Not Available |
| PubChem Compound |
1024  |
| PDB ID |
PQQ  |
| ChEBI ID |
18315  |
| References |
| Synthesis Reference |
Not Available |
| Material Safety Data Sheet (MSDS) |
Not Available
|
| General References |
- Paz MA, Fluckiger R, Torrelio BM, Gallop PM: Methoxatin (PQQ), coenzyme for copper-dependent amine and mixed-function oxidation in mammalian tissues. Connect Tissue Res. 1989;20(1-4):251-7.
Pubmed: 2558842
- Kasahara T, Kato T: Nutritional biochemistry: A new redox-cofactor vitamin for mammals. Nature. 2003 Apr 24;422(6934):832.
Pubmed: 12712191
|