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Identification
HMDB Protein ID HMDBP01071
Secondary Accession Numbers
  • 6360
Name Inorganic pyrophosphatase
Synonyms
  1. PPase
  2. Pyrophosphate phospho-hydrolase
Gene Name PPA1
Protein Type Unknown
Biological Properties
General Function Involved in magnesium ion binding
Specific Function Not Available
Pathways
  • Oxidative phosphorylation
Reactions
Pyrophosphate + Water → Phosphate details
GO Classification
Biological Process
diphosphate metabolic process
tRNA aminoacylation for protein translation
phosphate-containing compound metabolic process
Cellular Component
cytosol
Component
cell part
intracellular part
cytoplasm
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
hydrolase activity
magnesium ion binding
inorganic diphosphatase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
Molecular Function
magnesium ion binding
inorganic diphosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
Cellular Location
  1. Cytoplasm
Gene Properties
Chromosome Location 10
Locus 10q11.1-q24
SNPs PPA1
Gene Sequence
>870 bp
ATGAGCGGCTTCAGCACCGAGGAGCGCGCCGCGCCCTTCTCCCTGGAGTACCGAGTCTTC
CTCAAAAATGAGAAAGGACAATATATATCTCCATTTCATGATATTCCAATTTATGCAGAT
AAGGATGTGTTTCACATGGTAGTTGAAGTACCACGCTGGTCTAATGCAAAAATGGAGATT
GCTACAAAGGACCCTTTAAACCCTATTAAACAAGATGTGAAAAAAGGAAAACTTCGCTAT
GTTGCGAATTTGTTCCCGTATAAAGGATATATCTGGAACTATGGTGCCATCCCTCAGACT
TGGGAAGACCCAGGGCACAATGATAAACATACTGGCTGTTGTGGTGACAATGACCCAATT
GATGTGTGTGAAATTGGAAGCAAGGTATGTGCAAGAGGTGAAATAATTGGCGTGAAAGTT
CTAGGCATATTGGCTATGATTGACGAAGGGGAAACCGACTGGAAAGTCATTGCCATTAAT
GTGGATGATCCTGATGCAGCCAATTATAATGATATCAATGATGTCAAACGGCTGAAACCT
GGCTACTTAGAAGCTACTGTGGACTGGTTTAGAAGGTATAAGGTTCCTGATGGAAAACCA
GAAAATGAGTTTGCGTTTAATGCAGAATTTAAAGATAAGGACTTTGCCATTGATATTATT
AAAAGCACTCATGACCATTGGAAAGCATTAGTGACTAAGAAAACGAATGGAAAAGGAATC
AGTTGCATGAATACAACTTTGTCTGAGAGCCCCTTCAAGTGTGATCCTGATGCTGCCAGA
GCCATTGTGGATGCTTTACCACCACCCTGTGAATCTGCCTGCACAGTACCAACAGACGTG
GATAAGTGGTTCCATCACCAGAAAAACTAA
Protein Properties
Number of Residues 289
Molecular Weight 32659.77
Theoretical pI 5.858
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Inorganic pyrophosphatase
MSGFSTEERAAPFSLEYRVFLKNEKGQYISPFHDIPIYADKDVFHMVVEVPRWSNAKMEI
ATKDPLNPIKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHNDKHTGCCGDNDPI
DVCEIGSKVCARGEIIGVKVLGILAMIDEGETDWKVIAINVDDPDAANYNDINDVKRLKP
GYLEATVDWFRRYKVPDGKPENEFAFNAEFKDKDFAIDIIKSTHDHWKALVTKKTNGKGI
SCMNTTLSESPFKCDPDAARAIVDALPPPCESACTVPTDVDKWFHHQKN
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q15181
UniProtKB/Swiss-Prot Entry Name IPYR_HUMAN
PDB IDs Not Available
GenBank Gene ID AF154065
GeneCard ID PPA1
GenAtlas ID PPA1
HGNC ID HGNC:9226
References
General References
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