Hmdb loader
Identification
HMDB Protein ID HMDBP01204
Secondary Accession Numbers
  • 6500
Name Dual specificity testis-specific protein kinase 2
Synonyms
  1. Testicular protein kinase 2
Gene Name TESK2
Protein Type Unknown
Biological Properties
General Function Involved in protein kinase activity
Specific Function Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis
Pathways Not Available
Reactions Not Available
GO Classification
Function
protein tyrosine kinase activity
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location
  1. Nucleus
Gene Properties
Chromosome Location Chromosome:1
Locus 1p32
SNPs TESK2
Gene Sequence
>1716 bp
ATGGATCGGAGCAAACGGAATTCAATTGCAGGATTTCCTCCACGTGTGGAGCGTCTTGAA
GAGTTTGAAGGAGGTGGTGGAGGAGAAGGAAATGTGAGCCAGGTGGGAAGAGTTTGGCCA
TCTTCGTATCGAGCTCTTATAAGTGCCTTTTCCAGACTGACGCGTTTGGATGATTTCACC
TGTGAAAAAATAGGGTCTGGCTTCTTTTCTGAAGTGTTCAAGGTACGACACCGAGCTTCT
GGTCAGGTGATGGCTCTTAAGATGAACACATTGAGCAGTAACCGGGCAAACATGCTGAAA
GAAGTACAGCTCATGAATAGACTCTCCCATCCCAACATCCTTAGGTTCATGGGTGTATGT
GTTCATCAAGGACAATTGCATGCACTTACAGAGTATATCAACTCCGGGAACCTGGAACAG
TTGCTAGACAGTAACCTGCATTTGCCTTGGACTGTGAGGGTAAAACTGGCCTATGACATA
GCAGTGGGCCTCAGCTACCTTCACTTCAAAGGCATTTTTCATCGGGACCTCACATCTAAG
AACTGCCTGATAAAGAGGGATGAGAATGGTTACTCTGCAGTGGTAGCTGACTTTGGCCTG
GCTGAGAAGATCCCCGATGTCAGCATGGGGAGTGAGAAGCTGGCCGTGGTGGGTTCCCCA
TTCTGGATGGCACCTGAGGTTCTCCGAGATGAGCCCTATAATGAAAAGGCAGATGTGTTC
TCTTATGGTATCATCCTCTGCGAGATCATCGCCCGCATCCAGGCCGATCCGGACTATCTT
CCCCGCACAGAGAATTTCGGGCTGGACTATGATGCTTTCCAGCACATGGTGGGAGACTGT
CCCCCAGATTTTCTGCAACTTACTTTCAACTGCTGTAACATGGATCCCAAACTGCGCCCA
TCTTTTGTGGAGATTGGGAAGACCCTGGAGGAAATTCTGAGCCGCCTACAGGAAGAAGAG
CAGGAGAGGGATAGGAAGCTGCAGCCCACAGCCAGGGGACTCTTGGAGAAAGCACCTGGG
GTGAAGCGACTAAGCTCACTGGATGACAAGATCCCCCACAAGTCACCATGCCCAAGACGT
ACCATCTGGCTGTCTCGAAGCCAGTCAGATATCTTTTCCCGTAAGCCCCCACGTACAGTG
AGTGTCTTGGACCCATACTACCGGCCACGAGATGGTGCTGCCCGCACCCCCAAAGTCAAC
CCTTTTAGTGCTCGCCAGGACCTCATGGGGGGCAAGATCAAGTTTTTTGACCTGCCCAGC
AAGTCTGTCATCTCTCTGGTATTTGACCTGGATGCACCAGGGCCCGGAACTATGCCCCTG
GCTGACTGGCAGGAGCCCCTGGCCCCACCTATTCGCCGGTGGCGTTCCTTGCCTGGTTCG
CCTGAGTTCTTGCATCAAGAGGCTTGTCCATTTGTGGGCCGGGAAGAATCGCTATCTGAT
GGGCCCCCACCACGCCTAAGTAGTCTCAAGTACAGAGTTAAAGAGATCCCACCATTCCGG
GCATCTGCCCTACCAGCTGCTCAAGCCCATGAGGCTATGGACTGCTCCATTCTCCAGGAA
GAAAATGGTTTTGGGTCCAGGCCCCAGGGGACCAGTCCATGCCCTGCGGGTGCTTCTGAG
GAGATGGAGGTAGAAGAAAGGCCAGCAGGCTCAACTCCAGCCACCTTCTCCACCTCAGGC
ATAGGCCTGCAAACCCAGGGAAAGCAGGATGGGTGA
Protein Properties
Number of Residues 571
Molecular Weight 63638.8
Theoretical pI 7.06
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Dual specificity testis-specific protein kinase 2
MDRSKRNSIAGFPPRVERLEEFEGGGGGEGNVSQVGRVWPSSYRALISAFSRLTRLDDFT
CEKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVC
VHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSK
NCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVF
SYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVGDCPPDFLQLTFNCCNMDPKLRP
SFVEIGKTLEEILSRLQEEEQERDRKLQPTARGLLEKAPGVKRLSSLDDKIPHKSPCPRR
TIWLSRSQSDIFSRKPPRTVSVLDPYYRPRDGAARTPKVNPFSARQDLMGGKIKFFDLPS
KSVISLVFDLDAPGPGTMPLADWQEPLAPPIRRWRSLPGSPEFLHQEACPFVGREESLSD
GPPPRLSSLKYRVKEIPPFRASALPAAQAHEAMDCSILQEENGFGSRPQGTSPCPAGASE
EMEVEERPAGSTPATFSTSGIGLQTQGKQDG
GenBank ID Protein 15207801
UniProtKB/Swiss-Prot ID Q96S53
UniProtKB/Swiss-Prot Entry Name TESK2_HUMAN
PDB IDs Not Available
GenBank Gene ID AB057597
GeneCard ID TESK2
GenAtlas ID TESK2
HGNC ID HGNC:11732
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
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  3. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [PubMed:17344846 ]
  4. Rosok O, Pedeutour F, Ree AH, Aasheim HC: Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis. Genomics. 1999 Oct 1;61(1):44-54. [PubMed:10512679 ]
  5. Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K: Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells. J Biol Chem. 2001 Aug 17;276(33):31449-58. Epub 2001 Jun 19. [PubMed:11418599 ]