You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database.
Identification
HMDB Protein ID HMDBP02093
Secondary Accession Numbers
  • 7575
Name Apolipoprotein A-IV precursor
Synonyms
  1. Apo-AIV
  2. ApoA-IV
Gene Name APOA4
Protein Type Transporter
Biological Properties
General Function Replication, recombination and repair
Specific Function May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons
Pathways Not Available
Reactions Not Available
GO Classification
Component
extracellular region
Function
binding
lipid binding
Process
lipoprotein metabolism
transport
physiological process
metabolism
macromolecule metabolism
protein metabolism
cellular protein metabolism
cellular physiological process
lipid transport
Cellular Location
  1. Secreted
Gene Properties
Chromosome Location Chromosome:11
Locus 11q23
SNPs APOA4
Gene Sequence
>1191 bp
ATGTTCCTGAAGGCCGTGGTCCTGACCCTGGCCCTGGTGGCTGTCGCCGGAGCCAGGGCT
GAGGTCAGTGCTGACCAGGTGGCCACAGTGATGTGGGACTACTTCAGCCAGCTGAGCAAC
AATGCCAAGGAGGCCGTGGAACATCTCCAGAAATCTGAACTCACCCAGCAACTCAATGCC
CTCTTCCAGGACAAACTTGGAGAAGTGAACACTTACGCAGGTGACCTGCAGAAGAAGCTG
GTGCCCTTTGCCACCGAGCTGCATGAACGCCTGGCCAAGGACTCGGAGAAACTGAAGGAG
GAGATTGGGAAGGAGCTGGAGGAGCTGAGGGCCCGGCTGCTGCCCCATGCCAATGAGGTG
AGCCAGAAGATCGGGGACAACCTGCGAGAGCTTCAGCAGCGCCTGGAGCCCTACGCGGAC
CAGCTGCGCACCCAGGTCAACACGCAGGCCGAGCAGCTGCGGCGCCAGCTGGACCCCCTA
GCACAGCGCATGGAGAGAGTGCTGCGGGAGAACGCCGACAGCCTGCAGGCCTCGCTGAGG
CCCCACGCCGACGAGCTCAAGGCCAAGATCGACCAGAACGTGGAGGAGCTCAAGGGACGC
CTTACGCCCTACGCTGACGAATTCAAAGTCAAGATTGACCAGACCGTGGAGGAGCTGCGC
CGCAGCCTGGCTCCCTATGCTCAGGACACGCAGGAGAAGCTCAACCACCAGCTTGAGGGC
CTGACCTTCCAGATGAAGAAGAACGCCGAGGAGCTCAAGGCCAGGATCTCGGCCAGTGCC
GAGGAGCTGCGGCAGAGGCTGGCGCCCTTGGCCGAGGACGTGCGTGGCAACCTGAAGGGC
AACACCGAGGGGCTGCAGAAGTCACTGGCAGAGCTGGGTGGGCACCTGGACCAGCAGGTG
GAGGAGTTCCGACGCCGGGTGGAGCCCTACGGGGAAAACTTCAACAAAGCCCTGGTGCAG
CAGATGGAACAGCTCAGGCAGAAACTGGGCCCCCATGCGGGGGACGTGGAAGGCCACTTG
AGCTTCCTGGAGAAGGACCTGAGGGACAAGGTCAACTCCTTCTTCAGCACCTTCAAGGAG
AAAGAGAGCCAGGACAAGACTCTCTCCCTCCCTGAGCTGGAGCAACAGCAGGAACAGCAG
CAGGAGCAGCAGCAGGAGCAGGTGCAGATGCTGGCCCCTTTGGAGAGCTGA
Protein Properties
Number of Residues 396
Molecular Weight 45400.0
Theoretical pI 5.05
Pfam Domain Function
Signals
  • 1-20
Transmembrane Regions Not Available
Protein Sequence
>Apolipoprotein A-IV precursor
MFLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNA
LFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEV
SQKIGDNLRELQQRLEPYADQLRTQVNTQAEQLRRQLTPYAQRMERVLRENADSLQASLR
PHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEG
LTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQV
EEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKE
KESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPLES
GenBank ID Protein 178759
UniProtKB/Swiss-Prot ID P06727
UniProtKB/Swiss-Prot Entry Name APOA4_HUMAN
PDB IDs Not Available
GenBank Gene ID M13654
GeneCard ID APOA4
GenAtlas ID APOA4
HGNC ID HGNC:602
References
General References
  1. Halushka MK, Fan JB, Bentley K, Hsie L, Shen N, Weder A, Cooper R, Lipshutz R, Chakravarti A: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat Genet. 1999 Jul;22(3):239-47. [PubMed:10391210 ]
  2. Karathanasis SK, Yunis I, Zannis VI: Structure, evolution, and tissue-specific synthesis of human apolipoprotein AIV. Biochemistry. 1986 Jul 1;25(13):3962-70. [PubMed:3755616 ]
  3. Karathanasis SK, Oettgen P, Haddad IA, Antonarakis SE: Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4). Proc Natl Acad Sci U S A. 1986 Nov;83(22):8457-61. [PubMed:3095836 ]
  4. Elshourbagy NA, Walker DW, Paik YK, Boguski MS, Freeman M, Gordon JI, Taylor JM: Structure and expression of the human apolipoprotein A-IV gene. J Biol Chem. 1987 Jun 15;262(17):7973-81. [PubMed:3036793 ]
  5. Yang CY, Gu ZW, Chong IS, Xiong WJ, Rosseneu M, Yang HX, Lee BR, Gotto AM Jr, Chan L: The primary structure of human apolipoprotein A-IV. Biochim Biophys Acta. 1989 Apr 3;1002(2):231-7. [PubMed:2930771 ]
  6. Elshourbagy NA, Walker DW, Boguski MS, Gordon JI, Taylor JM: The nucleotide and derived amino acid sequence of human apolipoprotein A-IV mRNA and the close linkage of its gene to the genes of apolipoproteins A-I and C-III. J Biol Chem. 1986 Feb 15;261(5):1998-2002. [PubMed:3080432 ]
  7. Gordon JI, Bisgaier CL, Sims HF, Sachdev OP, Glickman RM, Strauss AW: Biosynthesis of human preapolipoprotein A-IV. J Biol Chem. 1984 Jan 10;259(1):468-74. [PubMed:6706947 ]
  8. Lohse P, Kindt MR, Rader DJ, Brewer HB Jr: Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene. J Biol Chem. 1990 Jun 15;265(17):10061-4. [PubMed:2351649 ]
  9. Lohse P, Kindt MR, Rader DJ, Brewer HB Jr: Human plasma apolipoproteins A-IV-0 and A-IV-3. Molecular basis for two rare variants of apolipoprotein A-IV-1. J Biol Chem. 1990 Jul 25;265(21):12734-9. [PubMed:1973689 ]
  10. Lohse P, Kindt MR, Rader DJ, Brewer HB Jr: Three genetic variants of human plasma apolipoprotein A-IV. apoA-IV-1(Thr347----Ser), apoA-IV-0(Lys167----Glu,Gln360----His), and apoA-IV-3(Glu165----Lys). J Biol Chem. 1991 Jul 25;266(21):13513-8. [PubMed:1677358 ]
  11. von Eckardstein A, Funke H, Schulte M, Erren M, Schulte H, Assmann G: Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A-I-containing lipoproteins in a normal population. Am J Hum Genet. 1992 May;50(5):1115-28. [PubMed:1349197 ]
  12. Tenkanen H, Koskinen P, Metso J, Baumann M, Lukka M, Kauppinen-Makelin R, Kontula K, Taskinen MR, Manttari M, Manninen V, et al.: A novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127. Biochim Biophys Acta. 1992 Jan 16;1138(1):27-33. [PubMed:1737067 ]
  13. Kamboh MI, Williams ER, Law JC, Aston CE, Bunker CH, Ferrell RE, Pollitzer WS: Molecular basis of a unique African variant (A-IV 5) of human apolipoprotein A-IV and its significance in lipid metabolism. Genet Epidemiol. 1992;9(6):379-88. [PubMed:1487136 ]
  14. Menzel HJ, Dieplinger H, Sandholzer C, Karadi I, Utermann G, Csaszar A: Apolipoprotein A-IV polymorphism in the Hungarian population: gene frequencies, effect on lipid levels, and sequence of two new variants. Hum Mutat. 1995;5(1):58-65. [PubMed:7728150 ]
  15. Deeb SS, Nevin DN, Iwasaki L, Brunzell JD: Two novel apolipoprotein A-IV variants in individuals with familial combined hyperlipidemia and diminished levels of lipoprotein lipase activity. Hum Mutat. 1996;8(4):319-25. [PubMed:8956036 ]