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Identification
HMDB Protein ID HMDBP02816
Secondary Accession Numbers
  • 8322
Name Dual specificity protein phosphatase 2
Synonyms
  1. Dual specificity protein phosphatase PAC-1
Gene Name DUSP2
Protein Type Enzyme
Biological Properties
General Function Involved in phosphatase activity
Specific Function Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
Pathways
  • MAPK signaling pathway
Reactions
Protein tyrosine phosphate + Water → protein tyrosine + Phosphate details
A phosphoprotein + Water → a protein + Phosphate details
GO Classification
Biological Process
regulation of apoptotic process
endoderm formation
Cellular Component
nucleoplasm
Function
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
map kinase tyrosine/serine/threonine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
Molecular Function
MAP kinase tyrosine/serine/threonine phosphatase activity
protein tyrosine/threonine phosphatase activity
protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
Cellular Location
  1. Nucleus
Gene Properties
Chromosome Location 2
Locus 2q11
SNPs DUSP2
Gene Sequence
>945 bp
ATGGGGCTGGAGGCGGCGCGCGAGCTGGAGTGCGCGGCGCTGGGCACGCTGCTGCGGGAT
CCGCGGGAGGCGGAACGCACGCTGCTGCTGGACTGCCGCCCCTTCCTGGCCTTCTGCCGG
CGCCACGTGCGCGCCGCGCGGCCAGTGCCTTGGAACGCGCTGCTGCGGCGCCGCGCGCGC
GGCCCTCCTGCCGCCGTTCTCGCCTGCCTGCTGCCCGACCGCGCGCTGCGGACGCGCCTG
GTCCGCGGGGAGCTGGCGCGGGCCGTGGTGCTGGACGAGGGCAGTGCCTCGGTGGCGGAG
CTCCGGCCCGACAGCCCGGCTCATGTGCTGCTGGCCGCGCTGCTGCACGAGACCCGCGCG
GGGCCCACTGCCGTGTACTTCCTGCGAGGAGGCTTCGACGGCTTCCAGGGCTGCTGTCCC
GATCTGTGCTCTGAGGCCCCCGCCCCTGCGCTGCCGCCAACAGGGGACAAAACCAGCCGC
TCCGACTCCAGGGCTCCTGTCTACGACCAGGGTGGCCCTGTGGAGATCTTGCCCTACCTG
TTCCTGGGCAGCTGCAGTCACTCGTCAGACCTGCAGGGGCTGCAGGCCTGTGGCATCACA
GCCGTCCTCAACGTGTCCGCCAGCTGCCCCAACCACTTTGAGGGCCTTTTCCGCTACAAG
AGTATCCCTGTGGAGGACAACCAGATGGTGGAGATCAGTGCCTGGTTCCAGGAGGCCATA
GGCTTCATTGACTGGGTGAAGAACAGCGGAGGCCGGGTGCTGGTGCACTGCCAGGCGGGT
ATCTCGCGCTCTGCCACCATCTGTCTGGCATACCTCATGCAGAGTCGCCGTGTGCGGCTG
GACGAGGCCTTTGACTTCGTTAAGCAGCGCCGGGGGGTCATCTCCCCCAACTTCAGTTTC
ATGGGGCAGCTGCTGCAGTTTGAGACCCAGGTGCTGTGTCACTGA
Protein Properties
Number of Residues 314
Molecular Weight 34399.195
Theoretical pI 7.924
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Dual specificity protein phosphatase 2
MGLEAARELECAALGTLLRDPREAERTLLLDCRPFLAFCRRHVRAARPVPWNALLRRRAR
GPPAAVLACLLPDRALRTRLVRGELARAVVLDEGSASVAELRPDSPAHVLLAALLHETRA
GPTAVYFLRGGFDGFQGCCPDLCSEAPAPALPPTGDKTSRSDSRAPVYDQGGPVEILPYL
FLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAI
GFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSF
MGQLLQFETQVLCH
GenBank ID Protein 62988835
UniProtKB/Swiss-Prot ID Q05923
UniProtKB/Swiss-Prot Entry Name DUS2_HUMAN
PDB IDs
GenBank Gene ID AC012307
GeneCard ID DUSP2
GenAtlas ID DUSP2
HGNC ID HGNC:3068
References
General References
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  3. Rohan PJ, Davis P, Moskaluk CA, Kearns M, Krutzsch H, Siebenlist U, Kelly K: PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. Science. 1993 Mar 19;259(5102):1763-6. [PubMed:7681221 ]
  4. Yi H, Morton CC, Weremowicz S, McBride OW, Kelly K: Genomic organization and chromosomal localization of the DUSP2 gene, encoding a MAP kinase phosphatase, to human 2p11.2-q11. Genomics. 1995 Jul 1;28(1):92-6. [PubMed:7590752 ]
  5. Farooq A, Plotnikova O, Chaturvedi G, Yan S, Zeng L, Zhang Q, Zhou MM: Solution structure of the MAPK phosphatase PAC-1 catalytic domain. Insights into substrate-induced enzymatic activation of MKP. Structure. 2003 Feb;11(2):155-64. [PubMed:12575935 ]