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Identification
HMDB Protein ID HMDBP03128
Secondary Accession Numbers
  • 8673
Name Sodium-coupled neutral amino acid transporter 4
Synonyms
  1. Amino acid transporter A3
  2. Na(+)-coupled neutral amino acid transporter 4
  3. Solute carrier family 38 member 4
  4. System A amino acid transporter 3
  5. System N amino acid transporter 3
Gene Name SLC38A4
Protein Type Unknown
Biological Properties
General Function Amino acid transport and metabolism
Specific Function Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5
Pathways
  • Amiloride Action Pathway
  • Bendroflumethiazide Action Pathway
  • Blue diaper syndrome
  • Bumetanide Action Pathway
  • Chlorothiazide Action Pathway
  • Chlorthalidone Action Pathway
  • Cyclothiazide Action Pathway
  • Cystinuria
  • Eplerenone Action Pathway
  • Ethacrynic Acid Action Pathway
  • Furosemide Action Pathway
  • Glucose Transporter Defect (SGLT2)
  • Glucose-Alanine Cycle
  • Hartnup Disorder
  • Hydrochlorothiazide Action Pathway
  • Hydroflumethiazide Action Pathway
  • Iminoglycinuria
  • Indapamide Action Pathway
  • Kidney Function
  • Lysinuric Protein Intolerance
  • Lysinuric protein intolerance (LPI)
  • Methyclothiazide Action Pathway
  • Metolazone Action Pathway
  • Polythiazide Action Pathway
  • Quinethazone Action Pathway
  • Spironolactone Action Pathway
  • Torsemide Action Pathway
  • Triamterene Action Pathway
  • Trichlormethiazide Action Pathway
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location Chromosome:1
Locus 12q13
SNPs SLC38A4
Gene Sequence
>1644 bp
ATGGATCCCATGGAACTGAGAAATGTCAACATCGAACCAGATGATGAGAGCAGCAGTGGA
GAAAGTGCTCCAGATAGCTACATCGGGATAGGAAATTCAGAAAAGGCAGCAATGAGCAGT
CAATTTGCTAATGAAGACACTGAAAGTCAGAAATTCCTGACAAATGGATTTTTGGGGAAA
AAGAAGCTGGCAGATTATGCTGATGAACACCATCCCGGAACCACTTCCTTTGGAATGTCT
TCATTTAACCTGAGTAATGCCATCATGGGCAGTGGGATCCTGGGCTTGTCCTATGCCATG
GCCAACACAGGGATCATACTTTTTATAATCATGCTGCTTGCTGTGGCAATATTATCACTG
TATTCAGTTCACCTTTTATTAAAAACAGCCAAGGAAGGAGGGTCTTTGATTTATGAAAAA
TTAGGAGAAAAGGCATTTGGATGGCCGGGAAAAATTGGAGCTTTTGTTTCCATTACAATG
CAGAACATTGGAGCAATGTCAAGCTACCTCTTTATCATTAAATATGAACTACCTGAAGTA
ATCAGAGCATTCATGGGACTTGAAGAAAATACTGGAGAATGGTACCTCAATGGCAACTAC
CTCATCATATTTGTGTCTGTTGGAATTATTCTTCCACTTTCGCTCCTTAAAAATTTAGGT
TATCTTGGCTATACCAGTGGATTTTCTCTTACCTGCATGGTGTTTTTTGTTAGTGTGGTG
ATTTACAAGAAATTCCAAATACCCTGCCCTCTACCTGTTTTGGATCACAGTGTTGGAAAT
CTGTCATTCAACAACACGCTTCCAATGCATGTGGTAATGTTACCCAACAACTCTGAGAGT
TCTGATGTGAACTTCATGATGGATTACACCCACCGCAATCCTGCAGGGCTGGATGAGAAC
CAGGCCAAGGGCTCTCTTCATGACAGTGGAGTAGAATATGAAGCTCATAGTGATGACAAG
TGTGAACCCAAATACTTTGTATTCAACTCCCGGACGGCCTATGCAATTCCTATCCTAGTA
TTTGCTTTTGTATGCCACCCTGAGGTCCTTCCCATCTACAGTGAACTTAAAGATCGGTCC
CGGAGAAAAATGCAAACGGTGTCAAATATTTCCATCACGGGGATGCTTGTCATGTACCTG
CTTGCCGCCCTCTTTGGTTACCTAACCTTCTATGGAGAAGTTGAAGATGAATTACTTCAT
GCCTACAGCAAAGTGTATACATTAGACATCCCTCTTCTCATGGTTCGCCTGGCAGTCCTT
GTGGCAGTAACACTAACTGTGCCCATTGTCCTCTTCCCAATTCGTACATCAGTGATCACA
CTGTTATTTCCCAAACGACCCTTCAGCTGGATACGACATTTCCTGATTGCAGCTGTGCTT
ATTGCACTTAATAATGTTCTGGTCATCCTTGTGCCAACTATAAAATACATCTTCGGATTC
ATAGGGGCTTCTTCTGCCACTATGCTGATTTTTATTCTTCCAGCAGTTTTTTATCTTAAA
CTTGTCAAGAAAGAAACTTTTAGGTCACCCCAAAAGGTCGGGGCTTTAATTTTCCTTGTG
GTTGGAATATTCTTCATGATTGGAAGCATGGCACTCATTATAATTGACTGGATTTATGAT
CCTCCAAATTCCAAGCATCACTAA
Protein Properties
Number of Residues 547
Molecular Weight 60763.6
Theoretical pI 6.45
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 81-101
  • 105-125
  • 152-172
  • 196-216
  • 221-241
  • 333-353
  • 370-390
  • 412-432
  • 454-474
  • 477-497
  • 515-535
Protein Sequence
>Sodium-coupled neutral amino acid transporter 4
MDPMELRNVNIEPDDESSSGESAPDSYIGIGNSEKAAMSSQFANEDTESQKFLTNGFLGK
KKLADYADEHHPGTTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSL
YSVHLLLKTAKEGGSLIYEKLGEKAFGWPGKIGAFVSITMQNIGAMSSYLFIIKYELPEV
IRAFMGLEENTGEWYLNGNYLIIFVSVGIILPLSLLKNLGYLGYTSGFSLTCMVFFVSVV
IYKKFQIPCPLPVLDHSVGNLSFNNTLPMHVVMLPNNSESSDVNFMMDYTHRNPAGLDEN
QAKGSLHDSGVEYEAHSDDKCEPKYFVFNSRTAYAIPILVFAFVCHPEVLPIYSELKDRS
RRKMQTVSNISITGMLVMYLLAALFGYLTFYGEVEDELLHAYSKVYTLDIPLLMVRLAVL
VAVTLTVPIVLFPIRTSVITLLFPKRPFSWIRHFLIAAVLIALNNVLVILVPTIKYIFGF
IGASSATMLIFILPAVFYLKLVKKETFRSPQKVGALIFLVVGIFFMIGSMALIIIDWIYD
PPNSKHH
GenBank ID Protein 18369789
UniProtKB/Swiss-Prot ID Q969I6
UniProtKB/Swiss-Prot Entry Name S38A4_HUMAN
PDB IDs Not Available
GenBank Gene ID AB055003
GeneCard ID SLC38A4
GenAtlas ID SLC38A4
HGNC ID HGNC:14679
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Hatanaka T, Huang W, Ling R, Prasad PD, Sugawara M, Leibach FH, Ganapathy V: Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A. Biochim Biophys Acta. 2001 Feb 9;1510(1-2):10-7. [PubMed:11342143 ]
  4. Gu S, Adan-Rice D, Leach RJ, Jiang JX: A novel human amino acid transporter, hNAT3: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization. Genomics. 2001 Jun 15;74(3):262-72. [PubMed:11414754 ]
  5. Mackenzie B, Erickson JD: Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family. Pflugers Arch. 2004 Feb;447(5):784-95. Epub 2003 Jul 4. [PubMed:12845534 ]
  6. Desforges M, Lacey HA, Glazier JD, Greenwood SL, Mynett KJ, Speake PF, Sibley CP: SNAT4 isoform of system A amino acid transporter is expressed in human placenta. Am J Physiol Cell Physiol. 2006 Jan;290(1):C305-12. Epub 2005 Sep 7. [PubMed:16148032 ]