Hmdb loader
Identification
HMDB Protein ID HMDBP07510
Secondary Accession Numbers
  • 13218
Name Cadherin-18
Synonyms
  1. Cadherin-14
Gene Name CDH18
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Cell membrane
  2. Single-pass type I membrane protein
Gene Properties
Chromosome Location Chromosome:5
Locus 5p14.3
SNPs CDH18
Gene Sequence
>2373 bp
ATGAAAATTACTAGCACATCTTGCATCTGTCCAGTCCTAGTGTGTCTCTGTTTTGTGCAG
AGGTGTTATGGAACTGCTCACCACAGCTCCATCAAGGTGATGAGAAACCAAACCAAACAC
ATTGAAGGTGAAACCGAAGTCCATCATCGTCCCAAAAGGGGATGGGTATGGAATCAGTTC
TTTGTTTTAGAAGAACATATGGGACCAGATCCTCAGTATGTTGGAAAGCTGCACTCCAAT
TCTGACAAAGGTGATGGATCTGTCAAGTACATCCTTACTGGAGAGGGTGCTGGGACTATA
TTTATCATTGACGATACCACGGGTGATATCCACTCAACAAAAAGCCTAGACAGAGAGCAG
AAGACCCACTATGTGCTTCATGCTCAAGCTATTGATAGACGTACAAACAAACCTCTTGAG
CCTGAATCCGAGTTCATCATCAAAGTGCAAGACATCAATGACAACGCTCCAAAATTCACA
GATGGACCATACATTGTTACTGTGCCTGAAATGTCAGATATGGGTACCTCTGTTCTACAG
GTGACAGCTACTGATGCAGATGACCCTACCTATGGAAACAGCGCTCGGGTGGTTTACAGC
ATTCTCCAGGGACAACCCTACTTCTCCGTCGACCCTAAAACAGGAGTTATTAGAACGGCC
TTACATAACATGGACAGAGAAGCCAGAGAACATTACTCCGTAGTCATTCAAGCCAAAGAC
ATGGCTGGGCAAGTTGGAGGGCTTTCAGGATCTACAACAGTCAACATCACCTTAACCGAT
GTCAATGACAACCCACCACGCTTTCCTCAAAAACACTATCAGCTATATGTTCCTGAGTCA
GCTCAAGTTGGTTCAGCTGTTGGGAAAATCAAGGCAAATGATGCTGACACTGGCTCAAAT
GCTGACATGACCTACTCCATCATAAATGGTGATGGCATGGGAATATTCTCAATCTCCACT
GACAAAGAGACCAGAGAAGGAATCCTTTCTTTAAAGAAGCCACTGAACTATGAGAAAAAG
AAGTCATATACCCTCAACATAGAAGGAGCAAATACACATCTTGATTTTCGCTTTTCTCAC
TTGGGTCCTTTTAAAGATGCTACTATGCTGAAGATCATTGTTGGGGATGTAGATGAACCA
CCACTATTTTCCATGCCTTCCTACCTCATGGAAGTCTACGAAAATGCCAAGATTGGGACC
GTCGTTGGTACAGTTTTGGCACAAGATCCTGACAGTACTAACAGCTTAGTAAGATACTTC
ATCAACTACAATGTTGAAGACGACAGATTTTTCAACATTGATGCCAATACTGGGACCATT
AGGACTACAAAGGTTCTCGACAGAGAAGAAACTCCATGGTACAACATCACAGTCACTGCT
TCAGAAATTGATAATCCTGATTTGCTGAGCCATGTCACAGTGGGTATTAGAGTTCTGGAT
GTCAATGACAATCCACCCGAACTTGCCAGGGAATATGATATTATTGTATGTGAAAATTCT
AAGCCTGGCCAGGTTATTCATACCATCAGTGCCACTGATAAAGATGATTTTGCCAATGGA
CCAAGGTTTAACTTCTTTCTTGATGAACGCCTGCCTGTAAATCCAAACTTCACTCTGAAG
GACAATGAAGATAACACAGCCAGCATTCTGACAAGGCGGAGGAGATTTAGTCGAACTGTT
CAGGATGTGTATTATCTGCCCATTATGATCTCTGATGGTGGAATCCCCTCTCTCAGCAGC
AGCAGCACCCTCACCATCAGGGTTTGTGCATGCGAGAGAGATGGGCGTGTGCGGACCTGC
CATGCAGAAGCCTTCCTGTCCTCGGCTGGTTTGAGTACAGGAGCCTTAATCGCTATTCTT
CTCTGTGTTCTCATTCTCCTGGCAATTGTGGTACTTTTTATCACCCTGAGGCGCAGCAAA
AAAGAGCCCTTGATCATTTCAGAAGAGGATGTACGGGAGAACGTGGTCACCTATGATGAT
GAAGGAGGCGGAGAGGAAGACACAGAGGCCTTTGACATCACAGCCTTGAGGAATCCTTCT
GCTGCTGAGGAGCTCAAGTACCGGAGGGATATCAGACCTGAAGTGAAGCTCACTCCCAGA
CACCAGACATCATCCACCCTGGAAAGCATAGATGTTCAGGAATTTATTAAGCAAAGACTG
GCAGAAGCAGACCTAGACCCTAGCGTTCCCCCTTATGACTCTCTTCAGACTTATGCCTAT
GAGGGTCAGAGATCAGAAGCTGGGTCTATCAGCTCGCTGGATTCAGCAACGACACAATCA
GACCAGGATTATCACTACCTTGGAGACTGGGGACCCGAGTTTAAAAAGTTAGCTGAACTC
TATGGAGAAATAGAATCTGAAAGAACAACTTAG
Protein Properties
Number of Residues 790
Molecular Weight 88071.9
Theoretical pI 4.76
Pfam Domain Function
Signals
  • 1-24
Transmembrane Regions
  • 609-636
Protein Sequence
>Cadherin-18
MKITSTSCICPVLVCLCFVQRCYGTAHHSSIKVMRNQTKHIEGETEVHHRPKRGWVWNQF
FVLEEHMGPDPQYVGKLHSNSDKGDGSVKYILTGEGAGTIFIIDDTTGDIHSTKSLDREQ
KTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVTVPEMSDMGTSVLQ
VTATDADDPTYGNSARVVYSILQGQPYFSVDPKTGVIRTALHNMDREAREHYSVVIQAKD
MAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPESAQVGSAVGKIKANDADTGSN
ADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSYTLNIEGANTHLDFRFSH
LGPFKDATMLKIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPDSTNSLVRYF
INYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTASEIDNPDLLSHVTVGIRVLD
VNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFNFFLDERLPVNPNFTLK
DNEDNTASILTRRRRFSRTVQDVYYLPIMISDGGIPSLSSSSTLTIRVCACERDGRVRTC
HAEAFLSSAGLSTGALIAILLCVLILLAIVVLFITLRRSKKEPLIISEEDVRENVVTYDD
EGGGEEDTEAFDITALRNPSAAEELKYRRDIRPEVKLTPRHQTSSTLESIDVQEFIKQRL
AEADLDPSVPPYDSLQTYAYEGQRSEAGSISSLDSATTQSDQDYHYLGDWGPEFKKLAEL
YGEIESERTT
GenBank ID Protein 158260117
UniProtKB/Swiss-Prot ID Q13634
UniProtKB/Swiss-Prot Entry Name CAD18_HUMAN
PDB IDs Not Available
GenBank Gene ID AK289547
GeneCard ID CDH18
GenAtlas ID CDH18
HGNC ID HGNC:1757
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Shibata T, Shimoyama Y, Gotoh M, Hirohashi S: Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning. J Biol Chem. 1997 Feb 21;272(8):5236-40. [PubMed:9030594 ]