Showing Protein Centrin-2 (HMDBP07583)

• 13291

1. Caltractin isoform 1

1. Cytoplasm
2. cytoskeleton
3. centrosome
4. centriole

>519 bp
ATGGCCTCCAACTTTAAGAAGGCAAACATGGCATCAAGTTCTCAGCGAAAAAGAATGAGC
CCTAAGCCTGAGCTTACTGAAGAGCAAAAGCAGGAGATCCGGGAAGCTTTTGATCTTTTC
GATGCGGATGGAACTGGCACCATAGATGTTAAAGAACTGAAGGTGGCAATGAGGGCCCTG
GGCTTTGAACCCAAGAAAGAAGAAATTAAGAAAATGATAAGTGAAATTGATAAGGAAGGG
ACAGGAAAAATGAACTTTGGTGACTTTTTAACTGTGATGACCCAGAAAATGTCTGAGAAA
GATACTAAAGAAGAAATCCTGAAAGCTTTCAAGCTCTTTGATGATGATGAAACTGGGAAG
ATTTCGTTCAAAAATCTGAAACGCGTGGCCAAGGAGTTGGGTGAGAACCTGACTGATGAG
GAGCTGCAGGAAATGATTGATGAAGCTGATCGAGATGGAGATGGAGAGGTCAGTGAGCAA
GAGTTCCTGCGCATCATGAAAAAGACCAGCCTCTATTAA

• efhand (PF00036 )

• None

• None

>Centrin-2
MASNFKKANMASSSQRKRMSPKPELTEEQKQEIREAFDLFDADGTGTIDVKELKVAMRAL
GFEPKKEEIKKMISEIDKEGTGKMNFGDFLTVMTQKMSEKDTKEEILKAFKLFDDDETGK
ISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVSEQEFLRIMKKTSLY

• 1M39

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3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
4. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [PubMed:17081983 ]
5. Molina H, Horn DM, Tang N, Mathivanan S, Pandey A: Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2199-204. Epub 2007 Feb 7. [PubMed:17287340 ]
6. Mallon AM, Platzer M, Bate R, Gloeckner G, Botcherby MR, Nordsiek G, Strivens MA, Kioschis P, Dangel A, Cunningham D, Straw RN, Weston P, Gilbert M, Fernando S, Goodall K, Hunter G, Greystrong JS, Clarke D, Kimberley C, Goerdes M, Blechschmidt K, Rump A, Hinzmann B, Mundy CR, Miller W, Poustka A, Herman GE, Rhodes M, Denny P, Rosenthal A, Brown SD: Comparative genome sequence analysis of the Bpa/Str region in mouse and Man. Genome Res. 2000 Jun;10(6):758-75. [PubMed:10854409 ]
7. Tsang WY, Spektor A, Luciano DJ, Indjeian VB, Chen Z, Salisbury JL, Sanchez I, Dynlacht BD: CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. Mol Biol Cell. 2006 Aug;17(8):3423-34. Epub 2006 Jun 7. [PubMed:16760425 ]
8. Lee VD, Huang B: Molecular cloning and centrosomal localization of human caltractin. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11039-43. [PubMed:8248209 ]
9. Salisbury JL, Suino KM, Busby R, Springett M: Centrin-2 is required for centriole duplication in mammalian cells. Curr Biol. 2002 Aug 6;12(15):1287-92. [PubMed:12176356 ]
10. Martinez-Sanz J, Yang A, Blouquit Y, Duchambon P, Assairi L, Craescu CT: Binding of human centrin 2 to the centrosomal protein hSfi1. FEBS J. 2006 Oct;273(19):4504-15. Epub 2006 Sep 5. [PubMed:16956364 ]
11. Matei E, Miron S, Blouquit Y, Duchambon P, Durussel I, Cox JA, Craescu CT: C-terminal half of human centrin 2 behaves like a regulatory EF-hand domain. Biochemistry. 2003 Feb 18;42(6):1439-50. [PubMed:12578356 ]
12. Yang A, Miron S, Duchambon P, Assairi L, Blouquit Y, Craescu CT: The N-terminal domain of human centrin 2 has a closed structure, binds calcium with a very low affinity, and plays a role in the protein self-assembly. Biochemistry. 2006 Jan 24;45(3):880-9. [PubMed:16411764 ]
13. Yang A, Miron S, Mouawad L, Duchambon P, Blouquit Y, Craescu CT: Flexibility and plasticity of human centrin 2 binding to the xeroderma pigmentosum group C protein (XPC) from nuclear excision repair. Biochemistry. 2006 Mar 21;45(11):3653-63. [PubMed:16533048 ]
14. Thompson JR, Ryan ZC, Salisbury JL, Kumar R: The structure of the human centrin 2-xeroderma pigmentosum group C protein complex. J Biol Chem. 2006 Jul 7;281(27):18746-52. Epub 2006 Apr 20. [PubMed:16627479 ]