Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP07740
Secondary Accession Numbers
  • 13449
Name Immunoglobulin superfamily member 5
Synonyms
  1. IgSF5
  2. JAM-4
  3. Junctional adhesion molecule 4
Gene Name IGSF5
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia- spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells- Sertoli cells
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Cell membrane
  2. Single-pass membrane protein
  3. Cell junction
  4. tight junction
Gene Properties
Chromosome Location Chromosome:2
Locus 21q22.2
SNPs IGSF5
Gene Sequence
>1224 bp
ATGGGTCAGAAGGAAAGGAGCACAGCAGATACTCTGCCGGATCTGGAGGAATGGAAGTCA
GCGGCGGGTCTGCGATGGTGGCAAACAGCAGTGGTGGACGGTTCTGGGTCTGGTAATGAA
GTCATAGAAGGCCCCCAGAATGCAACAGTCCTGAAGGGCTCCCAGGCTCGCTTCAACTGC
ACCGTCTCCCAGGGCTGGAAGCTCATCATGTGGGCTCTCAGTGACATGGTGGTGCTAAGC
GTCAGGCCCATGGAGCCCATCATCACCAATGACCGCTTCACCTCTCAGAGGTACGACCAG
GGCGGGAACTTCACCTCGGAGATGATCATCCACAATGTGGAGCCCAGTGATTCGGGGAAC
ATCAGATGCAGCCTCCAGAACAGTCGCCTGCATGGATCTGCTTACCTTACCGTCCAAGTT
ATGGGAGAGCTGTTCATTCCCAGTGTTAATCTTGTAGTCGCTGAGAATGAACCTTGTGAA
GTTACTTGTCTACCCTCACACTGGACCCGGCTCCCGGATATTTCCTGGGAGCTCGGTCTC
CTGGTCAGCCATTCAAGCTATTATTTTGTTCCGGAGCCCAGCGACCTTCAAAGTGCAGTG
AGCATCCTGGCTCTGACCCCACAGAGCAATGGGACTTTGACTTGCGTGGCTACCTGGAAG
AGCCTGAAGGCCCGCAAGTCTGCAACTGTAAATCTCACTGTGATTCGGTGTCCCCAAGAC
ACTGGAGGTGGTATTAATATTCCAGGTGTATTATCAAGTTTACCGAGTTTAGGTTTTTCA
TTGCCTACTTGGGGCAAAGTTGGACTTGGACTAGCAGGCACCATGCTTCTGACGCCGACG
TGTACTCTTACAATACGCTGCTGCTGCTGCCGCCGTCGTTGTTGTGGCTGCAACTGCTGC
TGCCGTTGTTGTTTCTGCTGTAGAAGAAAAAGAGGATTTCGTATTCAATTTCAAAAGAAA
TCTGAAAAAGAGAAGACAAACAAAGAAACTGAGACAGAAAGTGGAAATGAAAACTCCGGC
TACAATTCAGATGAACAAAAGACCACAGAAACCGCTTCTCTCCCTCCCAAATCCTGTGAA
TCCAGTGATCCTGAACAAAGAAACAGTAGCTGTGGCCCTCCTCACCAGCGGGCTGATCAA
CGTCCACCCAGGCCAGCAAGTCATCCACAGGCTTCTTTTAATCTGGCCAGTCCTGAGAAG
GTCAGTAATACAACTGTAGTATAG
Protein Properties
Number of Residues 407
Molecular Weight 44592.2
Theoretical pI 7.83
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 267-285
Protein Sequence
>Immunoglobulin superfamily member 5
MGQKERSTADTLPDLEEWKSAAGLRWWQTAVVDGSGSGNEVIEGPQNARVLKGSQARFNC
TVSQGWKLIMWALSDMVVLSVRPMEPIITNDRFTSQRYDQGGNFTSEMIIHNVEPSDSGN
IRCSLQNSRLHGSAYLTVQVMGELFIPSVNLVVAENEPCEVTCLPSHWTRLPDISWELGL
LVSHSSYYFVPEPSDLQSAVSILALTPQSNGTLTCVATWKSLKARKSATVNLTVIRCPQD
TGGGINIPGVLSSLPSLGFSLPTWGKVGLGLAGTMLLTPTCTLTIRCCCCRRRCCGCNCC
CRCCFCCRRKRGFRIQFQKKSEKEKTNKETETESGNENSGYNSDEQKTTDTASLPPKSCE
SSDPEQRNSSCGPPHQRADQRPPRPASHPQASFNLASPEKVSNTTVV
GenBank ID Protein 193787359
UniProtKB/Swiss-Prot ID Q9NSI5
UniProtKB/Swiss-Prot Entry Name IGSF5_HUMAN
PDB IDs Not Available
GenBank Gene ID AK092516
GeneCard ID IGSF5
GenAtlas ID IGSF5
HGNC ID HGNC:5952
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML: The DNA sequence of human chromosome 21. Nature. 2000 May 18;405(6784):311-9. [PubMed:10830953 ]