| Identification |
|---|
| HMDB Protein ID
| HMDBP07927 |
| Secondary Accession Numbers
| |
| Name
| Protocadherin gamma-B6 |
| Synonyms
|
- PCDH-gamma-B6
|
| Gene Name
| PCDHGB6 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| membrane |
| cell part |
| plasma membrane |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q31 |
| SNPs
| PCDHGB6 |
| Gene Sequence
|
>2793 bp
ATGGGAGGGAGCTGCGCGCAGAGGCGCCGGGCCGGCCCGCGGCAGGTGCTATTTCCTTTG
CTGCTGCCTTTGTTCTACCCCACCCTGAGTGAGCCGATCCGCTACTCGATTCCGGAGGAG
CTGGCCAAGGGCTCGGTGGTGGGGAACCTCGCTAAGGATCTAGGGCTCAGTGTCCTGGAT
GTGTCGGCTCGCAAGCTGCGAGTGAGCGCGGAGAAGCTGCACTTCAGCGTAGACGCGGAG
AGCGGGGACTTACTTGTGAAGAACCGAATAGACCGTGAGCAAATATGCAAAGAGAGAAGA
AGATGTGAGTTGCAATTGGAAGCTGTGGTGGAAAATCCTTTAAATATTTTTCATGTCATT
GTGGTGATTGAGGATGTTAATGACCACGCCCCTCAATTTGATAAAAAGGAAATACATTTA
GAAATTTTCGAATCTGCATCCGCTGGTACACGACTATCGCTTGACCCTGCCACGGATCCT
GATATAAACATAAACTCAATTAAAGATTATAAGATAAACTCTAATCCTTATTTTTCATTA
ATGGTTAGAGTTAATTCCGATGGTGGCAAATACCCAGAGTTATCTCTGGAGAAACTCCTA
GACCGGGAAGAACAGAGATCTCATAGCTTGATATTGACTGCCTTGGACGGAGGGGACCCA
CCAAGAAGTGCCACCGCTCACATAGAAATTTCTGTCAAGGATACCAATGATAACCCCCCG
GTTTTCAGCAGAGACGAATATAGAATTAGTCTTAGTGAAAATCTGCCCCCTGGGTCCCCT
GTGTTGCAAGTGACAGCCACTGACCAGGATGAGGGGGTCAATGCTGAGATAAACTACTAC
TTCCGAAGCACTGCCCAGAGCACAAAACATATGTTCTCATTGGATGAGAAAACAGGTATG
ATTAAGAATAACCAGTCATTTGATTTTGAAGATGTAGAAAGGTACACCATGGAAGTGGAA
GCGAAGGACGGAGGTGGTCTCTCTACCCAGTGTAAAGTAATCATAGAAATCCTTGATGAA
AACGACAACAGCCCAGAAATAATCATCACTTCTCTCTCTGATCAGATTTTGGAGAATTCA
CCTCCAGGAATGGTTGTTGCCCTCTTCAAAACACGGGATCTGGATTTCGGAGGAAATGGA
GAAGTCAGGTGTAATATAGAAACAGACATTCCATTCAAGATTTATTCTTCTTCCAATAAC
TACTACAAACTGGTGACAGATGGAGCCCTGGACCGAGAGCAGACACCAGAATACAATGTC
ACCATCGTAGCCACTGACAGGGGCAAGCCGCCTCTTTCTTCCAGTAGAAGCATCACCTTG
TATGTCGCTGACATCAACGACAACGCCCCAGTTTTCGACCAGACGTCCTACGTGGTCCAC
GTGGCCGAGAACAACCCGCCAGGAGCCTCCATTGCGCAAGTGAGCGCCTCTGACCCGGAT
TTGGGGCTCAATGGCCACATCTCCTACTCTATAGTGGCGAGTGACCTAGAGCCCCTGGCG
GTGTCGTCATACGTGTCAGTGAGCGCGCAGAGCGGGGTGGTGTTCGCGCAGCGCGCCTTT
GATCACGAGCAGCTGCGCGCCTTCGCGCTCACGCTGCAGGCCCGCGACCACGGCTCGCCC
ACGCTCAGCGCCAACGTGAGCCTGCGCGTGTTGGTGGGAGACCGCAATGACAACGCACCG
CGGGTGCTGTACCCAGCTCTGGGTCCTGACGGCTCCGCGTTCTTCGATATGGTACCTCGC
TCTGCAGAGCCCGGCTACCTAGTGACTAAGGTGGTAGCGGTGGACGCCGACTCGGGACAC
AACGCCTGGCTGTCCTACCACGTGCTGCAGGCCAGTGAGCCCGGACTCTTCAGCCTGGGG
CTGCGCACTGGGGAGGTGCGCACGGCTCGAGCCTTAGGCGACAGGGACGCAGCCCGCCAG
CGCCTGCTGGTCGCTGTGCGTGACGGTGGACAGCCGCCACTCTCTGCCACCGCCACGCTT
CATCTGGTCTTCGCAGACAACTTGCAAGAGATACTGCCAGACCTCAGCGACCGCCCTGTA
CTCTCTGACCCCCAGGCTGAACTGCAGTTTTACCTGGTGGTGGCCTTGGCCTTAATCTCA
GTGCTCTTCCTCCTCGCCGTGATTCTGGCCATTGCCTTGCGCCTGCGACGCTCTCTCAGC
CCTGCTACTTGGGACTGCTTCCATCCTGGTCTCTGTGTCAAGTCTGGACCTGTAGTTCCC
CCCAACTACAGTGAGGGGACTTTGCCTTATTCTTATAATCTGTGCATTGCACATACGGGT
ACAAAAGAGTTTAATTTCCTAAAATGCAGTGTGCCCCTACATTCCAATGAAGACATGGTT
TGCAGTGTTTCTCCTGGAGCCTTAATTCCACCTCATGGTGGGGAGGATTTGACTTCACAT
CCTGAGACTCTGACTTCGCAAGCCCCGCCCAACACGGACTGGCGTTTCTCTCAGGCCCAG
AGACCCGGCACCAGCGGCTCCCAAAATGGCGATGACACCGGCACCTGGCCCAACAACCAG
TTTGACACAGAGATGCTGCAAGCCATGATCTTGGCGTCCGCCAGTGAAGCTGCTGATGGG
AGCTCCACCCTGGGAGGGGGTGCCGGCACCATGGGATTGAGCGCCCGCTACGGACCCCAG
TTCACCCTGCAGCACGTGCCCGACTACCGCCAGAATGTCTACATCCCAGGCAGCAATGCC
ACACTGACCAACGCAGCTGGCAAGCGGGATGGCAAGGCCCCAGCAGGTGGCAATGGCAAC
AAGAAGAAGTCGGGCAAGAAGGAGAAGAAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 930 |
| Molecular Weight
| 101042.4 |
| Theoretical pI
| 4.89 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protocadherin gamma-B6
MGGSCAQRRRAGPRQVLFPLLLPLFYPTLSEPIRYSIPEELAKGSVVGNLAKDLGLSVLD
VSARKLRVSAEKLHFSVDAESGDLLVKNRIDREQICKERRRCELQLEAVVENPLNIFHVI
VVIEDVNDHAPQFDKKEIHLEIFESASAGTRLSLDPATDPDININSIKDYKINSNPYFSL
MVRVNSDGGKYPELSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEISVKDTNDNPP
VFSRDEYRISLSENLPPGSPVLQVTATDQDEGVNAEINYYFRSTAQSTKHMFSLDEKTGM
IKNNQSFDFEDVERYTMEVEAKDGGGLSTQCKVIIEILDENDNSPEIIITSLSDQILENS
PPGMVVALFKTRDLDFGGNGEVRCNIETDIPFKIYSSSNNYYKLVTDGALDREQTPEYNV
TIVATDRGKPPLSSSRSITLYVADINDNAPVFDQTSYVVHVAENNPPGASIAQVSASDPD
LGLNGHISYSIVASDLEPLAVSSYVSVSAQSGVVFAQRAFDHEQLRAFALTLQARDHGSP
TLSANVSLRVLVGDRNDNAPRVLYPALGPDGSAFFDMVPRSAEPGYLVTKVVAVDADSGH
NAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATATL
HLVFADNLQEILPDLSDRPVLSDPQAELQFYLVVALALISVLFLLAVILAIALRLRRSLS
PATWDCFHPGLCVKSGPVVPPNYSEGTLPYSYNLCIAHTGTKEFNFLKCSVPLHSNEDMV
CSVSPGALIPPHGGEDLTSHPETLTSQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQ
FDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNA
TLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
|
| External Links |
|---|
| GenBank ID Protein
| 5456973 |
| UniProtKB/Swiss-Prot ID
| Q9Y5F9 |
| UniProtKB/Swiss-Prot Entry Name
| PCDGI_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF152335 |
| GeneCard ID
| PCDHGB6 |
| GenAtlas ID
| PCDHGB6 |
| HGNC ID
| HGNC:8713 |
| References |
|---|
| General References
| - Wu Q, Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90. [PubMed:10380929 ]
|
