Hmdb loader
Identification
HMDB Protein ID HMDBP08225
Secondary Accession Numbers
  • 13937
Name Solute carrier family 12 member 8
Synonyms
  1. Cation-chloride cotransporter 9
Gene Name SLC12A8
Protein Type Unknown
Biological Properties
General Function Involved in transport
Specific Function Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
Process
establishment of localization
transport
transmembrane transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein (Potential)
Gene Properties
Chromosome Location Chromosome:3
Locus 3q21.2
SNPs SLC12A8
Gene Sequence
>2145 bp
ATGACCCAGATGTCCCAGGTGCAGGAGCTCTTCCATGAGGCAGCCCAGCAGGATGCCCTG
GCCCAGCCCCAGCCCTGGTGGAAGACCCAGCTGTTCATGTGGGAGCCTGTGCTGTTTGGG
ACCTGGGATGGTGTGTTCACATCCTGCATGATCAACATCTTTGGGGTTGTGCTCTTCCTG
AGGACTGGCTGGCTGGTGGGAAACACAGGAGTGCTCCTGGGCATGTTCCTGGTGTCCTTC
GTCATCCTGGTGGCCCTCGTCACGGTGCTGTCTGGCATTGGCGTCGGGGAGCGCAGCAGC
ATCGGCAGCGGTGGCGTCTACTCCATGATCTCCTCGGTCCTGGGTGGGCAGACGGGAGGC
ACCATCGGGCTGCTCTATGTGTTTGGACAGTGTGTTGCAGGTGCCATGTATATCACCGGC
TTTGCTGAATCCATCTCGGATTTGCTGGGCCTCGGGAATATCTGGGCTGTGCGAGGAATT
TCAGTTGCGGTGCTTCTGGCCTTGCTGGGCATTAACCTCGCAGGTGTCAAATGGATAATC
CGCCTCCAGCTGCTGTTGCTGTTCCTGCTGGCCGTGTCCACACTGGACTTTGTGGTGGGT
TCTTTCACCCACCTGGACCCAGAACATGGTTTCATTGGATATTCACCCGAACTGCTACAG
AACAACACGCTGCCCGATTACAGCCCGGGGGAATCTTTTTTCACTGTCTTTGGGGTTTTC
TTCCCAGCGGCTACAGGAGTCATGGCCGGCTTCAACATGGGGGGCGACCTCAGGGAGCCT
GCCGCCAGCATTCCCCTGGGCTCCCTGGCAGCTGTTGGCATCTCGTGGTTTCTGTACATC
GTCTTCGTCTTCCTCCTGGGCGCCATCTGCACTCGAGAGGCCCTTCGCTATGACTTCCTG
ATAGCGGAAAAGGTATCCCTCATGGGCTTCCTGTTCCTTTTGGGCTTATACATCTCGTCC
CTGGCTTCCTGCATGGGAGGACTTTATGGAGCTCCCCGCATCCTGCAGTGCATTGCCCAG
GAGAAAGTGATCCCTGCACTTGCCTGTCTGGGACAAGGGAAGGGGCCAAACAAAACACCC
GTGGCTGCCATCTGCCTGACCAGCTTGGTGACCATGGCCTTTGTTTTTGTGGGTCAAGTG
AACGTTCTGGCCCCCATCGTCACCATCAACTTCATGCTGACATACGTTGCAGTGGACTAC
TCTTACTTCTCCCTGTCCATGTGTTCCTGCAGCCTGACCCCGGTGCCTGAGCCGGTGCTC
AGGGAGGGCGCAGAAGGCCTCCACTGCTCTGAGCACCTGCTCTTAGAGAAAGCTCCCAGT
TACGGCTCTGAGGGACCTGCCCAAAGAGTCTTGGAGGGCACGCTACTGGAATTCACCAAG
GACATGGATCAGCTCCTCCAGCTAACCAGGAAGCTTGAGAGTAGCCAGCCCAGGCAAGGA
GAGGGTAACAGGACCCCAGAAAGTCAGAAGAGGAAAAGCAAGAAGGCCACCAAGCAGACC
CTACAAGATAGCTTCCTCTTGGACCTCAAATCCCCTCCTTCTTTCCCTGTCGAGATCTCT
GACAGGTTGCCCGCTGCCTCCTGGGAGGGGCAGGAGTCCTGCTGGAACAAGCAGACTTCC
AAGAGCGAAGGGACTCAGCCTGAGGGAACATATGGAGAGCAACTTGTTCCTGAGCTGTGC
AACCAATCAGAGTCCAGTGGAGAAGATTTCTTCCTGAAGTCCAGGCTCCAAGAACAAGAT
GTCTGGAGAAGATCCACTTCTTTCTATACCCACATGTGCAACCCCTGGGTCTCCCTGTTG
GGGGCTGTTGGGTCCCTTCTCATCATGTTTGTGATACAGTGGGTGTATACCCTGGTTAAC
ATGGGTGTTGCTGCCATCGTGTATTTCTACATTGGCCGGGCCAGTCCAGGGCTTCACCTT
GGATCAGCCTCCAACTTCAGCTTTTTCCGGTGGATGAGGTCTCTCTTGCTCCCCTCCTGC
AGGAGCTTGCGGTCCCCTCAGGAGCAGATCATCTTGGCGCCGTCCCTGGCTAAGGTTGAC
ATGGAGATGACTCAGCTCACCCAGGAGAATGCAGACTTCGCCACTCGGGATCGCTACCAC
CACTCCTCCCTCGTGAACCGGGAGCAGCTGATGCCTCACTACTAG
Protein Properties
Number of Residues 714
Molecular Weight 78222.1
Theoretical pI 5.5
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 37-60
  • 72-93
  • 99-116
  • 123-142
  • 154-173
  • 185-205
  • 233-254
  • 266-289
  • 309-331
  • 360-377
  • 383-403
  • 593-616
  • 622-643
Protein Sequence
>Solute carrier family 12 member 8
MTQMSQVQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFL
RTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGG
TIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISVAVLLALLGINLAGVKWII
RLQLLLLFLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVF
FPAATGVMAGFNMGGDLREPAASIPPGSLAAVGISWFLYIIFVFLLGAICTREALRYDFL
IAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTP
VAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVL
REGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQG
EGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTS
KSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLL
GAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSC
RSLRSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY
GenBank ID Protein 306774092
UniProtKB/Swiss-Prot ID A0AV02
UniProtKB/Swiss-Prot Entry Name S12A8_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001195483.1
GeneCard ID SLC12A8
GenAtlas ID SLC12A8
HGNC ID HGNC:15595
References
General References
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