Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP08246
Secondary Accession Numbers
  • 13958
Name Ecto-NOX disulfide-thiol exchanger 1
Synonyms
  1. Candidate growth-related and time keeping constitutive hydroquinone [NADH] oxidase
  2. Cell proliferation-inducing gene 38 protein
  3. Constitutive Ecto-NOX
  4. Hydroquinone [NADH] oxidase
  5. Protein disulfide-thiol oxidoreductase
  6. cCNOX
  7. cNOX
Gene Name ENOX1
Protein Type Unknown
Biological Properties
General Function Involved in nucleotide binding
Specific Function Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
nucleotide binding
nucleic acid binding
Cellular Location
  1. Cell membrane
  2. Secreted
  3. extracellular space
Gene Properties
Chromosome Location Chromosome:1
Locus 13q14.11
SNPs ENOX1
Gene Sequence
>1932 bp
ATGGTAGATGCAGGTGGAGTTGAGAACATCACCCAGCTTCCCCAGGAGCTTCCTCAGATG
ATGGCTGCAGCAGCCGATGGTTTGGGGAGTATAGCGATAGACACGACCCAGCTCAACATG
TCCGTGACAGATCCCACAGCCTGGGCTACAGCCATGAATAACCTGGGCATGGTTCCCGTA
GGGTTGCCTGGACAGCAGCTCGTGTCTGACTCAATCTGTGTCCCAGGCTTTGATCCAAGC
CTCAACATGATGACTGGAATCACCCCCATTAACCCAATGATACCAGGCCTTGGACTGGTA
CCTCCCCCACCACCAACAGAAGTGGCTGTTGTCAAAGAAATAATCCACTGCAAAAGCTGT
ACTCTTTTTCCTCAAAATCCAAATCTTCCACCTCCTTCCACAAGAGAACGACCTCCTGGG
TGTAAGACCGTGTTTGTCGGAGGATTACCAGAAAATGCTACTGAGGAAATTATTCAAGAA
GTCTTTGAACAGTGCGGTGATATTACAGCAATTCGGAAAAGCAAGAAGAATTTTTGTCAC
ATTCGCTTTGCAGAGGAATTCATGGTTGATAAAGCCATTTACCTTTCTGGTTATAGGATG
CGATTAGGGTCTAGCACCGACAAAAAGGATTCAGGCCGCCTTCATGTGGACTTTGCCCAG
GCCAGGGATGACTTCTATGAGTGGGAATGCAAGCAGAGGATGCGTGCCCGGGAGGAGCGG
CACCGGCGCAAGCTGGAGGAGGACCGGCTCAGGCCCCCATCCCCGCCTGCCATAATGCAC
TACTCGGAGCACGAAGCCGCTCTGCTGGCTGAAAAGCTGAAAGATGATAGCAAGTCTTCA
GAGGCTATCACAGTGCTGCTTTCCTGGATTGAACGAGGGGAAGTGAATCGGCGCTCTGCA
AACCAGTTCTATTCCATGGTGCAGTCGGCCAACAGCCACGTCCGCCGGCTAATGAATGAA
AAAGCCACCCATGAGCAAGAGATGGAGGAAGCCAAGGAGAATTTTAAAAATGCCTTAACT
GGGATTCTCACTCAATTTGAGCAGATTGTGGCCGTTTTCAACGCTTCTACCAGACAAAAA
GCTTGGGACCATTTCTCGAAAGCCCAGCGCAAGAACATAGACATTTGGCGAAAGCATTCT
GAGGAGCTCCGGAATGCTCAAAGTGAGCAGCTCATGGGCATCCGCCGCGAAGAAGAAATG
GAAATGTCTGATGATGAGAACTGTGACAGCCCTACAAAGAAAATGAGAGTCGATGAATCA
GCCCTGGCTGCCCAGGCCTACGCTCTGAAAGAGGAGAATGACAGTCTCCGCTGGCAGCTG
GATGCCTACAGGAATGAGGTGGAGCTGCTGAAACAAGAAAAAGAACAGCTTTTCCGAACA
GAAGAAAACCTCACCAAGGACCAGCAACTGCAGTTTCTGCAGCAAACCATGCAAGGCATG
CAGCAGCAATTGCTAACCATCCAGGAGGAGTTAAACAACAAAAAGTCAGAATTGGAACAA
GCAAAGGAAGAGCAGTCCCATACACAAGCGTTACTAAAAGTCCTGCAGGAACAATTAAAA
GGTACCAAGGAATTGGTCGAGACCAATGGCCACAGCCATGAGGATTCAAATGAAATCAAT
GTGTTGACAGTTGCATTAGTCAACCAAGACCGAGAGAACAATATTGAGAAAAGAAGCCAA
GGCTTAAAATCAGAGAAAGAAGCTCTGCTAATAGGTATCATATCAACGTTTCTTCACGTC
CATCCTTTTGGAGCCAACATAGAATATCTTTGGTCATACATGCAGCAGCTGGACTCCAAG
ATATCTGCAAATGAAATAGAAATGCTTTTGATGAGGCTGCCACGCATGTTCAAACAGGAA
TTCACGGGTGTGGGAGCCACGCTGGAAAAAAGATGGAAGTTGTGTGCCTTTGAAGGAATT
AAAACCACCTAA
Protein Properties
Number of Residues 643
Molecular Weight 73347.8
Theoretical pI 5.25
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Ecto-NOX disulfide-thiol exchanger 1
MVDAGGVENITQLPQELPQMMAAAADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPV
GLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSC
TLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCH
IRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREER
HRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSA
NQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQK
AWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDES
ALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGM
QQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN
VLTVALVNQDRENNIEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSK
ISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKLCAFEGIKTT
GenBank ID Protein 7021942
UniProtKB/Swiss-Prot ID Q8TC92
UniProtKB/Swiss-Prot Entry Name ENOX1_HUMAN
PDB IDs Not Available
GenBank Gene ID AK000956
GeneCard ID ENOX1
GenAtlas ID ENOX1
HGNC ID HGNC:25474
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Dunham A, Matthews LH, Burton J, Ashurst JL, Howe KL, Ashcroft KJ, Beare DM, Burford DC, Hunt SE, Griffiths-Jones S, Jones MC, Keenan SJ, Oliver K, Scott CE, Ainscough R, Almeida JP, Ambrose KD, Andrews DT, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Bannerjee R, Barlow KF, Bates K, Beasley H, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burrill W, Carder C, Carter NP, Chapman JC, Clamp ME, Clark SY, Clarke G, Clee CM, Clegg SC, Cobley V, Collins JE, Corby N, Coville GJ, Deloukas P, Dhami P, Dunham I, Dunn M, Earthrowl ME, Ellington AG, Faulkner L, Frankish AG, Frankland J, French L, Garner P, Garnett J, Gilbert JG, Gilson CJ, Ghori J, Grafham DV, Gribble SM, Griffiths C, Hall RE, Hammond S, Harley JL, Hart EA, Heath PD, Howden PJ, Huckle EJ, Hunt PJ, Hunt AR, Johnson C, Johnson D, Kay M, Kimberley AM, King A, Laird GK, Langford CJ, Lawlor S, Leongamornlert DA, Lloyd DM, Lloyd C, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, McLaren SJ, McMurray A, Milne S, Moore MJ, Nickerson T, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter KM, Rice CM, Searle S, Sehra HK, Shownkeen R, Skuce CD, Smith M, Steward CA, Sycamore N, Tester J, Thomas DW, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Wilming L, Wray PW, Wright MW, Young L, Coulson A, Durbin R, Hubbard T, Sulston JE, Beck S, Bentley DR, Rogers J, Ross MT: The DNA sequence and analysis of human chromosome 13. Nature. 2004 Apr 1;428(6982):522-8. [PubMed:15057823 ]
  4. Sedlak D, Moore DM, Moore DJ: A drug-unresponsive and protease-resistant CNOX protein from human sera. Arch Biochem Biophys. 2001 Feb 1;386(1):106-16. [PubMed:11360993 ]
  5. Wang S, Morre DM, Morre DJ: Sera from cancer patients contain two oscillating ECTO-NOX activities with different period lengths. Cancer Lett. 2003 Feb 20;190(2):135-41. [PubMed:12565167 ]
  6. Jiang Z, Morre DM, Morre DJ: A role for copper in biological time-keeping. J Inorg Biochem. 2006 Dec;100(12):2140-9. Epub 2006 Aug 30. [PubMed:17027975 ]