Hmdb loader
Identification
HMDB Protein ID HMDBP08261
Secondary Accession Numbers
  • 13973
Name Apoptosis-inducing factor 2
Synonyms
  1. Apoptosis-inducing factor homologous mitochondrion-associated inducer of death
  2. Apoptosis-inducing factor-like mitochondrion-associated inducer of death
  3. p53-responsive gene 3 protein
Gene Name AIFM2
Protein Type Unknown
Biological Properties
General Function Involved in oxidoreductase activity
Specific Function Oxidoreductase, which may play a role in mediating a TP53/p53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
catalytic activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
oxidoreductase activity
fad or fadh2 binding
Process
metabolic process
oxidation reduction
Cellular Location
  1. Cytoplasm
  2. Mitochondrion outer membrane
Gene Properties
Chromosome Location Chromosome:1
Locus 10q22.1
SNPs AIFM2
Gene Sequence
>1122 bp
ATGGGGTCCCAGGTCTCGGTGGAATCGGGAGCTCTGCACGTGGTGATTGTGGGTGGGGGC
TTTGGCGGGATCGCAGCAGCCAGCCAGCTGCAGGCCCTGAACGTCCCCTTCATGCTGGTG
GACATGAAGGACTCCTTCCACCACAATGTGGCTGCTCTCCGAGCCTCCGTGGAGACAGGG
TTCGCCAAAAAGACATTCATTTCTTACTCGGTGACTTTCAAGGACAACTTCCGGCAGGGG
CTAGTAGTGGGGATAGACCTGAAGAACCAGATGGTGCTGCTGCAGGGTGGCGAGGCCCTG
CCCTTCTCTCATCTTATCCTGGCCACGGGCAGCACTGGGCCCTTCCCGGGCAAGTTTAAT
GAGGTTTCCAGCCAGCAGGCCGCTATCCAGGCCTATGAGGACATGGTGAGGCAGGTCCAG
CGCTCACGGTTCATCGTGGTGGTGGGAGGAGGCTCGGCTGGAGTGGAGATGGCAGCAGAG
ATTAAAACAGAATATCCTGAGAAAGAGGTCACTCTCATTCACTCCCAAGTGGCCCTGGCT
GACAAGGAGCTCCTGCCCTCCGTCCGGCAGGAAGTGAAGGAGATCCTCCTCCGGAAGGGC
GTGCAGCTGCTGCTGAGTGAGCGGGTGAGCAATCTGGAGGAGCTGCCTCTCAATGAGTAT
CGAGAGTACATCAAAGTGCAGACGGACAAAGGCACAGAGGTGGCCACCAACCTGGTGATT
CTCTGCACCGGCATCAAGATCAACAGCTCCGCCTACCGCAAAGCATTTGAGAGCAGACTA
GCCAGCAGTGGTGCTCTGAGAGTGAACGAGCACCTCCAGGTGGAGGGCCACAGCAACGTC
TACGCCATTGGTGACTGTGCCGACGTGAGGACGCCCAAGATGGCCTATCTTGCCGGCCTC
CACGCCAACATCGCCGTGGCCAACATCGTCAACTCTGTGAAGCAGCGGCCTCTCCAGGCC
TACAAGCCGGGTGCACTGACGTTCCTCCTGTCCATGGGGAGAAATGACGGTGTGGGCCAA
ATCAGTGGCTTCTATGTGGGCCGGCTCATGGTTCGGCTGACCAAGAGCCGGGACCTGTTC
GTCTCTACGAGCTGGAAAACCATGAGGCAGTCTCCACCTTGA
Protein Properties
Number of Residues 373
Molecular Weight 40526.4
Theoretical pI 9.55
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 7-27
Protein Sequence
>Apoptosis-inducing factor 2
MGSQVSVESGALHVVIVGGGFGGIAAASQLQALNVPFMLVDMKDSFHHNVAALRASVETG
FAKKTFISYSVTFKDNFRQGLVVGIDLKNQMVLLQGGEALPFSHLILATGSTGPFPGKFN
EVSSQQAAIQAYEDMVRQVQRSRFIVVVGGGSAGVEMAAEIKTEYPEKEVTLIHSQVALA
DKELLPSVRQEVKEILLRKGVQLLLSERVSNLEELPLNEYREYIKVQTDKGTEVATNLVI
LCTGIKINSSAYRKAFESRLASSGALRVNEHLQVEGHSNVYAIGDCADVRTPKMAYLAGL
HANIAVANIVNSVKQRPLQAYKPGALTFLLSMGRNDGVGQISGFYVGRLMVRLTKSRDLF
VSTSWKTMRQSPP
GenBank ID Protein 18478646
UniProtKB/Swiss-Prot ID Q9BRQ8
UniProtKB/Swiss-Prot Entry Name AIFM2_HUMAN
PDB IDs Not Available
GenBank Gene ID AF337957
GeneCard ID AIFM2
GenAtlas ID AIFM2
HGNC ID HGNC:21411
References
General References
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