Hmdb loader
Identification
HMDB Protein ID HMDBP08268
Secondary Accession Numbers
  • 13980
Name tRNA-dihydrouridine synthase 4-like
Synonyms
  1. pp35
Gene Name DUS4L
Protein Type Unknown
Biological Properties
General Function Involved in catalytic activity
Specific Function Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs
Pathways Not Available
Reactions Not Available
GO Classification
Function
oxidoreductase activity, acting on the ch-ch group of donors
binding
catalytic activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
oxidoreductase activity
fad or fadh2 binding
trna dihydrouridine synthase activity
Process
rna metabolic process
ncrna metabolic process
trna metabolic process
trna processing
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
oxidation reduction
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:7
Locus 7q22-q31
SNPs DUS4L
Gene Sequence
>954 bp
ATGAAGAGTGACTGCATGCAAACGACAATATGTCAGGAAAGAAAAAAAGATCCCATAGAA
ATGTTTCATTCTGGACAGCTGGTAAAAGTCTGTGCCCCAATGGTTCGATATTCAAAGTTG
GCTTTTAGGACACTAGTAAGAAAATATAGTTGTGATCTGTGTTACACACCAATGATTGTT
GCCGCTGATTTTGTCAAATCTATAAAAGCCAGAGACAGCGAATTTACCACAAATCAAGGT
GATTGCCCATTGATTGTTCAGTTTGCTGCTAACGATGCAAGACTTTTATCTGATGCTGCT
CGTATAGTCTGTCCTTATGCGAATGGAATAGACATTAACTGTGGTTGCCCTCAGAGGTGG
GCAATGGCAGAAGGTTATGGGGCTTGCTTAATAAACAAGCCAGAGCTTGTTCAAGACATG
GTGAAACAAGTAAGAAATCAAGTGGAAACCCCTGGATTTTCAGTTTCTATTAAAATAAGG
ATCCATGATGACCTTAAAAGAACTGTAGATCTTTGTCAAAAGGCTGAAGCAACAGGAGTT
TCATGGATTACAGTCCATGGAAGAACTGCTGAAGAAAGACATCAGCCAGTGCACTATGAT
TCCATTAAAATAATTAAGGAAAATATGTCTATACCTGTAATTGCTAATGGAGACATCAGA
AGCTTAAAGGAAGCAGAAAATGTGTGGCGGATTACTGGGACAGATGGTGTGATGGTTGCA
AGAGGACTCTTAGCAAACCCGGCCATGTTTGCTGGATATGAGGAAACCCCACTGAAATGC
ATCTGGGACTGGGTTGACATTGCTCTTGAACTCGGGACTCCTTACATGTGTTTCCATCAA
CATTTAATGTACATGATGGAAAAGATAACTTCAAGGCAGGAAAAAAGGGTATTTAATGCT
CTGTCAAGCACATCAGCAATCATAGATTACCTTACAGACCATTATGGCATTTGA
Protein Properties
Number of Residues 317
Molecular Weight 35816.2
Theoretical pI 7.37
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>tRNA-dihydrouridine synthase 4-like
MKSDCMQTTICQERKKDPIEMFHSGQLVKVCAPMVRYSKLAFRTLVRKYSCDLCYTPMIV
AADFVKSIKARDSEFTTNQGDCPLIVQFAANDARLLSDAARIVCPYANGIDINCGCPQRW
AMAEGYGACLINKPELVQDMVKQVRNQVETPGFSVSIKIRIHDDLKRTVDLCQKAEATGV
SWITVHGRTAEERHQPVHYDSIKIIKENMSIPVIANGDIRSLKEAENVWRITGTDGVMVA
RGLLANPAMFAGYEETPLKCIWDWVDIALELGTPYMCFHQHLMYMMEKITSRQEKRVFNA
LSSTSAIIDYLTDHYGI
GenBank ID Protein 31742496
UniProtKB/Swiss-Prot ID O95620
UniProtKB/Swiss-Prot Entry Name DUS4L_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_181581.1
GeneCard ID DUS4L
GenAtlas ID DUS4L
HGNC ID HGNC:21517
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]