Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP08365
Secondary Accession Numbers
  • 14077
Name Dynamin-3
Synonyms
  1. Dynamin, testicular
  2. T-dynamin
Gene Name DNM3
Protein Type Unknown
Biological Properties
General Function Involved in GTP binding
Specific Function Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity).
Pathways
  • Bacterial invasion of epithelial cells
  • Endocrine and other factor-regulated calcium reabsorption
  • Endocytosis
  • Fc gamma R-mediated phagocytosis
  • Synaptic vesicle cycle
Reactions
Guanosine triphosphate + Water → Guanosine diphosphate + Phosphate details
GO Classification
Biological Process
synapse assembly
endocytosis
filopodium assembly
Cellular Component
mitochondrion
perinuclear region of cytoplasm
postsynaptic density
microtubule
Function
purine nucleotide binding
binding
nucleotide binding
catalytic activity
hydrolase activity
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
gtpase activity
nucleoside-triphosphatase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
Molecular Function
GTPase activity
phospholipid binding
GTP binding
Cellular Location
  1. Cytoplasm
  2. Cytoplasm (Potential)
  3. cytoskeleton (Potential)
Gene Properties
Chromosome Location 1
Locus 1q24.3
SNPs DNM3
Gene Sequence
>2580 bp
ATGGGGAACCGGGAGATGGAGGAGCTGATCCCGCTGGTGAACCGTCTGCAGGACGCGTTT
TCGGCGCTGGGACAGAGCTGCCTGCTGGAGCTGCCGCAGATCGCCGTGGTGGGCGGCCAG
AGCGCCGGCAAGAGCTCGGTGCTCGAGAACTTCGTGGGCAGGGACTTTCTCCCTCGAGGG
TCGGGCATTGTAACAAGACGACCTCTTGTGCTGCAGCTTGTTACTTCTAAAGCAGAATAT
GCCGAGTTTCTACATTGCAAAGGAAAGAAATTTACAGATTTTGATGAAGTTCGCCTTGAG
ATTGAAGCAGAAACAGATCGCGTGACTGGAATGAATAAAGGCATTTCCTCCATACCCATT
AATTTACGAGTCTATTCCCCACACGTGTTAAATCTAACCCTTATTGATCTACCTGGAATA
ACTAAAGTGCCTGTGGGAGATCAGCCACCAGATATCGAGTATCAGATCAGAGAAATGATT
ATGCAGTTCATCACGAGGGAGAACTGTCTGATTTTAGCTGTTACTCCAGCCAACACTGAT
CTTGCAAACTCAGATGCGCTGAAGCTAGCTAAAGAAGTTGATCCTCAAGGTCTGAGAACC
ATTGGAGTTATCACCAAACTGGACCTTATGGATGAAGGAACGGATGCCAGGGATGTTCTA
GAGAACAAACTGTTGCCTCTTCGCAGGGGTTACGTGGGGGTGGTAAACAGAAGCCAGAAG
GACATAGATGGGAAGAAGGACATAAAGGCAGCCATGCTGGCAGAGAGGAAGTTTTTCCTT
TCCCACCCGGCTTACAGACATATCGCTGACCGAATGGGAACCCCACACCTGCAGAAGGTC
CTTAATCAGCAACTTACCAACCACATTCGGGATACCCTACCAAACTTCAGGAACAAACTA
CAGGGACAGTTGCTCTCCATAGAACATGAAGTAGAAGCCTACAAAAATTTCAAACCAGAA
GACCCAACAAGGAAGACCAAAGCATTGCTGCAGATGGTTCAGCAATTTGCTGTGGACTTT
GAGAAGAGAATTGAAGGGTCAGGGGATCAAGTAGATACCCTGGAACTCTCAGGTGGTGCT
AAAATCAATCGTATTTTTCATGAACGCTTTCCTTTTGAGATAGTAAAGATGGAGTTCAAT
GAGAAAGAATTGCGAAGAGAAATAAGCTATGCAATCAAAAACATACATGGTATCAGGACA
GGGTTGTTTACTCCAGACATGGCATTTGAAGCGATAGTCAAGAAACAGATTGTAAAGTTG
AAAGGGCCTTCCTTGAAGAGTGTGGATCTGGTAATACAAGAATTAATCAACACTGTGAAG
AAGTGTACCAAAAAACTGGCAAACTTCCCCAGACTCTGCGAGGAAACGGAAAGGATTGTT
GCTAACCACATTCGTGAGCGAGAAGGGAAGACAAAGGACCAGGTATTGCTATTGATTGAC
ATTCAAGTCTCTTACATCAACACCAACCATGAAGACTTCATTGGCTTCGCAAATGCTCAG
CAGAGGAGCAGTCAGGTTCACAAGAAAACCACAGTTGGAAATCAGGTGATTCGCAAGGGG
TGGCTCACCATCAGCAACATTGGCATCATGAAAGGCGGCTCGAAGGGATACTGGTTCGTC
CTTACTGCGGAAAGCTTGTCCTGGTATAAAGATGATGAGGAAAAAGAAAAGAAGTACATG
CTTCCCTTGGACAACCTGAAAGTTCGGGATGTGGAAAAGAGCTTTATGTCTAGCAAGCAC
ATCTTTGCACTCTTTAATACAGAGCAAAGGAATGTATACAAAGACTATCGCTTCCTTGAG
CTGGCATGTGATTCCCAGGAGGATGTCGACAGCTGGAAGGCATCTCTACTAAGAGCTGGG
GTCTATCCTGACAAATCTGTAGCTGAAAATGATGAGAATGGACAAGCAGAAAACTTTTCC
ATGGACCCACAATTGGAGAGGCAAGTGGAGACCATTCGCAACCTCGTAGACTCCTACATG
TCCATTATCAACAAATGTATCCGAGATCTAATTCCAAAAACAATAATGCACCTTATGATC
AATAACGTTAAAGATTTCATAAATTCCGAGCTCCTAGCACAGTTGTATTCTTCAGAGGAC
CAAAATACCCTGATGGAGGAATCTGCTGAGCAGGCTCAGCGCCGGGATGAGATGCTTCGA
ATGTATCAAGCACTGAAAGAAGCCCTTGGGATAATTGGGGACATCAGCACAGCCACCGTG
TCCACTCCGGCACCCCCTCCAGTGGATGACTCCTGGATACAGCACTCTCGCAGGTCACCT
CCTCCAAGCCCCACAACCCAAAGGAGGCCAACACTAAGTGCTCCCCTCGCAAGGCCCACA
TCCGGCCGAGGACCAGCTCCTGCCATTCCCTCTCCTGGCCCCCACTCTGGGGCTCCTCCA
GTCCCATTCCGTCCAGGCCCATTACCTCCTTTCCCCAGCAGCAGTGACTCCTTCGGAGCC
CCTCCACAAGTTCCATCTAGGCCTACGAGGGCCCCGCCCAGTGTCCCAAGCCGGAGACCA
CCCCCATCACCAACTCGTCCCACTATAATCCGCCCACTAGAATCCTCCCTGTTAGACTAA
Protein Properties
Number of Residues 869
Molecular Weight 96681.0
Theoretical pI 8.228
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Dynamin-3
MGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRG
SGIVTRRPLVLQLVTSKAEYAEFLHCKGKKFTDFDEVRLEIEAETDRVTGMNKGISSIPI
NLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLILAVTPANTD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYVGVVNRSQK
DIDGKKDIKAAMLAERKFFLSHPAYRHIADRMGTPHLQKVLNQQLTNHIRDTLPNFRNKL
QGQLLSIEHEVEAYKNFKPEDPTRKTKALLQMVQQFAVDFEKRIEGSGDQVDTLELSGGA
KINRIFHERFPFEIVKMEFNEKELRREISYAIKNIHGIRTGLFTPDMAFEAIVKKQIVKL
KGPSLKSVDLVIQELINTVKKCTKKLANFPRLCEETERIVANHIREREGKTKDQVLLLID
IQVSYINTNHEDFIGFANAQQRSSQVHKKTTVGNQGTNLPPSRQIVIRKGWLTISNIGIM
KGGSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKSFMSSKHIFALFNTEQR
NVYKDYRFLELACDSQEDVDSWKASLLRAGVYPDKSVAENDENGQAENFSMDPQLERQVE
TIRNLVDSYMSIINKCIRDLIPKTIMHLMINNVKDFINSELLAQLYSSEDQNTLMEESAE
QAQRRDEMLRMYQALKEALGIIGDISTATVSTPAPPPVDDSWIQHSRRSPPPSPTTQRRP
TLSAPLARPTSGRGPAPAIPSPGPHSGAPPVPFRPGPLPPFPSSSDSFGAPPQVPSRPTR
APPSVPSRRPPPSPTRPTIIRPLESSLLD
GenBank ID Protein 209915561
UniProtKB/Swiss-Prot ID Q9UQ16
UniProtKB/Swiss-Prot Entry Name DYN3_HUMAN
PDB IDs
GenBank Gene ID NM_001136127
GeneCard ID DNM3
GenAtlas ID DNM3
HGNC ID HGNC:29125
References
General References
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