Hmdb loader
Identification
HMDB Protein ID HMDBP08513
Secondary Accession Numbers
  • 14225
Name Rab GTPase-binding effector protein 2
Synonyms
  1. Rabaptin-5beta
Gene Name RABEP2
Protein Type Unknown
Biological Properties
General Function Involved in GTPase activator activity
Specific Function Plays a role in membrane trafficking and in homotypic early endosome fusion
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
enzyme regulator activity
protein binding
receptor binding
growth factor activity
enzyme activator activity
gtpase activator activity
Cellular Location
  1. Cytoplasm
  2. Early endosome
Gene Properties
Chromosome Location Chromosome:1
Locus 16p11.2
SNPs RABEP2
Gene Sequence
>1710 bp
ATGGCGGCAGCTGCGCCGGTGGCCGCGGACGACGATGAGCGGCGGCGGCGGCCGGGGGCT
GCACTGGAGGACTCCCGGTCCCAGGAAGGGGCAAATGGTGAGGCCGAGTCAGGTGAGCTC
AGCCGGCTTCGGGCTGAGCTGGCAGGCGCCCTGGCAGAAATGGAAACCATGAAGGCTGTG
GCAGAGGTGAGCGAGAGCACGAAGGCCGAGGCTGTGGCTGCGGTGCAGCGGCAGTGCCAA
GAGGAGGTGGCCTCGCTGCAGGCCATCCTGAAAGACTCCATCAGCAGCTATGAAGCCCAG
ATCACCGCCCTGAAGCAGGAGCGACAGCAGCAGCAGCAGGACTGTGAGGAGAAGGAGCGG
GAGCTGGGCCGCCTGAAGCAGCTGCTGTCCCGGGCCTACCCCCTGGACTCCCTGGAGAAG
CAGATGGAAAAGGCCCACGAGGACTCGGAGAAGCTGCGGGAGATCGTACTGCCCATGGAA
AAGGAGATCGAGGAGCTGAAGGCGAAGCTGCTGAGGGCCGAGGAGCTGATTCAGGAGATC
CAGAGACGTCCCCGGCATGCCCCTTCCCTGCACGGCTCCACGGAGTTGCTGCCCCTGTCC
CGGGATCCATCGCCCCCGCTGGAGCCTCTGGAGGAGCTGAGCGGAGATGGGGGTCCAGCC
GCTGAGGCCTTCGCTCACAACTGCGATGACAGCGCCTCCATCTCCTCCTTCTCCCTTGGC
GGTGGGGTCGGCAGCAGCTCCTCCCTGCCCCAAAGCCGCCAGGGCCTGAGCCCTGAACAG
GAAGAGACGGCCTCGCTGGTGTCTACGGGCACCCTGGTTCCCGAGGGCATCTACCTGCCC
CCTCCTGGCTACCAGCTCGTCCCAGACACTCAGTGGGAGCAGCTGCAGACAGAGGGCCGA
CAGCTGCAGAAGGACCTGGAGAGCGTCAGTCGCGAGCGGGACGAGCTCCAAGAGGGCCTG
AGACGGAGCAATGAGGACTGTGCCAAGCAGATGCAGGTGCTCCTGGCCCAGGTCCAGAAC
TCAGAGCAGCTGCTGCGGACCCTGCAAGGGACCGTGAGCCAGGCCCAGGAGCGGGTGCAG
CTGCAGATGGCGGAGCTGGTCACCACCCACAAGTGCCTGCACCATGAGGTAAAGCGGTTG
AATGAGGAAAACCAAGGGCTCCGGGCCGAGCAGCTGCCATCCTCAGCCCCCCAGGGCTCG
CAGCAGGAGCAGGGCGAGGAGGAATCACTGCCCAGCTCTGTGCCAGAGCTGCAGCAGCTG
CTGTGCTGCACGCGGCAAGAGGCGAGGGCCCGGCTGCAGGCCCAGGAGCACGGGGCCGAG
CGCCTGCGGATCGAGATCGTGACGCTGCGGGAGGCTCTGGAGGAGGAGACAGTGGCCAGG
GCCAGCCTGGAGGGGCAGCTGAGGGTGCAGCGGGAGGAGACAGAGGTGCTGGAGGCCTCC
CTGTGCAGCCTGAGGACAGAGATGGAGCGGGTGCAGCAGGAACAGAGCAAGGCCCAGCTC
CCAGACCTCCTCTCAGAACAGAGGGCCAAGGTGCTGCGGCTGCAGGCAGAGCTGGAGACC
AGTGAGCAGGTGCAGAGGGATTTCGTGCGACTGTCCCAGGCCCTGCAGGTGCGCCTAGAG
CGGATCCGCCAGGCTGAGACCCTGGAGCAAGTGCGCAGCATCATGGATGAGGCGCCACTC
ACGGACGTCAGGGACATCAAGGACACCTGA
Protein Properties
Number of Residues 569
Molecular Weight 63542.2
Theoretical pI 4.45
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Rab GTPase-binding effector protein 2
MAAAAPVAADDDERRRRPGAALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAV
AEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKER
ELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEI
QRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLG
GGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGR
QLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQ
LQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQL
LCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEAS
LCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLE
RIRQAETLEQVRSIMDEAPLTDVRDIKDT
GenBank ID Protein 117956403
UniProtKB/Swiss-Prot ID Q9H5N1
UniProtKB/Swiss-Prot Entry Name RABE2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_024816.2
GeneCard ID RABEP2
GenAtlas ID RABEP2
HGNC ID HGNC:24817
References
General References
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  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  4. Gournier H, Stenmark H, Rybin V, Lippe R, Zerial M: Two distinct effectors of the small GTPase Rab5 cooperate in endocytic membrane fusion. EMBO J. 1998 Apr 1;17(7):1930-40. [PubMed:9524116 ]