Hmdb loader
Identification
HMDB Protein ID HMDBP08674
Secondary Accession Numbers
  • 14393
Name Probable imidazolonepropionase
Synonyms
  1. Amidohydrolase domain-containing protein 1
Gene Name AMDHD1
Protein Type Unknown
Biological Properties
General Function Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Specific Function Not Available
Pathways
  • Histidine metabolism
  • Histidine metabolism
  • Histidinemia
  • L-histidine degradation into L-glutamate
Reactions
4-Imidazolone-5-propionic acid + Water → Formiminoglutamic acid + Hydrogen Ion details
4-Imidazolone-5-propionic acid + Water → Formiminoglutamic acid details
GO Classification
Biological Process
histidine catabolic process to glutamate and formamide
histidine catabolic process to glutamate and formate
histidine catabolic process
Cellular Component
cytosol
Component
cell part
intracellular part
cytoplasm
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Molecular Function
imidazolonepropionase activity
metal ion binding
Process
glutamate metabolic process
metabolic process
cellular metabolic process
glutamine family amino acid metabolic process
histidine catabolic process to glutamate and formamide
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location 12
Locus 12q23.1
SNPs AMDHD1
Gene Sequence
>1281 bp
ATGGCAGGCGGCCACAGCCTCCTGCTGGAGAACGCGCAGCAAGTGGTGTTGGTGTGCGCC
CGCGGCGAGCGCTTCCTGGCGCGGGATGCGCTGCGCAGCCTGGCGGTGCTGGAAGGCGCC
AGCCTGGTGGTGGGCAAAGATGGATTTATAAAAGCTATTGGTCCTGCTGATGTTATTCAA
AGACAGTTTTCTGGAGAAACTTTTGAAGAAATAATTGACTGCTCTGGGAAATGTATCCTA
CCAGGTTTGGTGGATGCACACACACATCCAGTATGGGCTGGTGAAAGAGTTCACGAATTT
GCAATGAAGTTGGCAGGAGCCACCTACATGGAAATTCACCAGGCCGGAGGAGGGATCCAC
TTTACCGTGGAGCGCACGCGCCAAGCCACAGAGGAGGAGCTGTTCCGCTCCTTGCAGCAA
CGGCTCCAGTGCATGATGAGGGCTGGCACCACGCTGGTGGAGTGCAAGAGTGGATATGGC
CTCGACCTGGAGACCGAGCTCAAGATGCTGCGCGTGATTGAGCGCGCCCGGCGGGAGCTG
GACATCGGCATCTCGGCTACCTACTGCGGGGCTCATTCAGTGCCTAAAGGAAAAACTGCT
ACTGAAGCTGCTGATGACATCATCAATAACCACCTCCCAAAGCTGAAGGAACTTGGCAGA
AATGGGGAAATACACGTGGACAATATAGACGTATTTTGTGAGAAAGGTGTCTTTGATCTC
GATTCCACCAGAAGGATTCTTCAACGTGGAAAAGATATAGGGTTACAGATTAACTTCCAT
GGGGATGAACTCCACCCGATGAAGGCTGCTGAGCTTGGGGCTGAACTGGGAGCGCAGGCA
ATCAGCCACCTGGAAGAAGTGAGTGATGAAGGCATCGTTGCCATGGCAACGGCCAGGTGC
TCTGCCATCCTTCTGCCCACCACAGCCTACATGCTGAGACTGAAACAACCTCGAGCCAGG
AAGATGTTAGATGAAGGAGTAATAGTTGCTCTGGGAAGTGATTTCAACCCCAATGCATAT
TGCTTTTCAATGCCAATGGTCATGCATCTGGCCTGTGTAAACATGAGAATGTCCATGCCT
GAGGCCTTGGCCGCTGCCACCATCAATGCAGCTTATGCACTGGGAAAGTCTCACACACAC
GGATCGTTGGAAGTTGGCAAACAGGGAGATCTCATTATCATCAATTCATCCCGATGGGAG
CATTTGATTTACCAGTTCGGAGGCCATCATGAATTAATTGAATATGTTATAGCTAAAGGA
AAACTCATCTATAAAACATGA
Protein Properties
Number of Residues 426
Molecular Weight 46742.505
Theoretical pI 6.611
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Probable imidazolonepropionase
MAGGHSLLLENAQQVVLVCARGERFLARDALRSLAVLEGASLVVGKDGFIKAIGPADVIQ
RQFSGETFEEIIDCSGKCILPGLVDAHTHPVWAGERVHEFAMKLAGATYMEIHQAGGGIH
FTVERTRQATEEELFRSLQQRLQCMMRAGTTLVECKSGYGLDLETELKMLRVIERARREL
DIGISATYCGAHSVPKGKTATEAADDIINNHLPKLKELGRNGEIHVDNIDVFCEKGVFDL
DSTRRILQRGKDIGLQINFHGDELHPMKAAELGAELGAQAISHLEEVSDEGIVAMATARC
SAILLPTTAYMLRLKQPRARKMLDEGVIVALGSDFNPNAYCFSMPMVMHLACVNMRMSMP
EALAAATINAAYALGKSHTHGSLEVGKQGDLIIINSSRWEHLIYQFGGHHELIEYVIAKG
KLIYKT
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q96NU7
UniProtKB/Swiss-Prot Entry Name HUTI_HUMAN
PDB IDs Not Available
GenBank Gene ID AK054617
GeneCard ID AMDHD1
GenAtlas ID AMDHD1
HGNC ID HGNC:28577
References
General References
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