Hmdb loader
Identification
HMDB Protein ID HMDBP08721
Secondary Accession Numbers
  • 14444
Name Eyes absent homolog 2
Synonyms Not Available
Gene Name EYA2
Protein Type Unknown
Biological Properties
General Function Involved in catalytic activity
Specific Function Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. Together with SIX1 and DACH2 seem to be involved in myogenesis. May be involved in development of the eye. Interaction with GNAZ and GNAI2 prevents nuclear translocation and transcriptional activity.
Pathways Not Available
Reactions
Protein tyrosine phosphate + Water → protein tyrosine + Phosphate details
GO Classification
Biological Process
apoptotic process
DNA repair
histone dephosphorylation
striated muscle tissue development
mesodermal cell fate specification
regulation of transcription, DNA-dependent
transcription, DNA-dependent
Cellular Component
mitochondrion
nucleus
Function
catalytic activity
Molecular Function
magnesium ion binding
protein tyrosine phosphatase activity
Process
metabolic process
multicellular organismal process
multicellular organismal development
Cellular Location
  1. Nucleus
  2. Cytoplasm
Gene Properties
Chromosome Location 20
Locus 20q13.1
SNPs EYA2
Gene Sequence
>1617 bp
ATGGTAGAACTAGTGATCTCACCCAGCCTCACTGTAAACAGCGATTGTCTGGATAAACTG
AAGTTTAACCGTGCTGACGCTGCTGTGTGGACTCTGAGTGACAGACAAGGCATCACCAAA
TCGGCCCCCCTGAGAGTGTCCCAGCTCTTCTCCAGATCTTGCCCACGTGTCCTCCCCCGC
CAGCCTTCCACAGCCATGGCAGCCTACGGCCAGACGCAGTACAGTGCGGGGATCCAGCAG
GCTACCCCCTATACAGCTTACCCACCTCCAGCACAAGCCTATGGAATCCCTTCCTACAGC
ATCAAGACAGAAGACAGCTTGAACCATTCCCCTGGCCAGAGTGGATTCCTCAGCTATGGC
TCCAGCTTCAGCACCTCACCCACTGGACAGAGCCCATACACCTACCAGATGCACGGCACA
ACAGGGTTCTATCAAGGAGGAAATGGACTGGGCAACGCAGCCGGTTTCGGGAGTGTGCAC
CAGGACTATCCTTCCTACCCCGGCTTCCCCCAGAGCCAGTACCCCCAGTATTACGGCTCA
TCCTACAACCCTCCCTACGTCCCGGCCAGCAGCATCTGCCCTTCGCCCCTCTCCACGTCC
ACCTACGTCCTCCAGGAGGCATCTCACAACGTCCCCAACCAGAGTTCCGAGTCACTTGCT
GGTGAATACAACACACACAATGGACCTTCCACACCAGCGAAAGAGGGAGACACAGACAGG
CCGCACCGGGCCTCCGACGGGAAGCTCCGAGGCCGGTCTAAGAGGAGCAGTGACCCGTCC
CCGGCAGGGGACAATGAGATTGAGCGTGTGTTCGTGTGGGACTTGGATGAGACAATAATT
ATTTTTCACTCCTTACTCACGGGGACATTTGCATCCAGATACGGGAAGGACACCACGACG
TCCGTGCGCATTGGCCTTATGATGGAAGAGATGATCTTCAACCTTGCAGATACACATCTG
TTCTTCAATGACCTGGAGGATTGTGACCAGATCCACGTTGATGACGTCTCATCAGATGAC
AATGGCCAAGATTTAAGCACATACAACTTCTCCGCTGACGGCTTCCACAGTTCGGCCCCA
GGAGCCAACCTGTGCCTGGGCTCTGGCGTGCACGGCGGCGTGGACTGGATGAGGAAGCTG
GCCTTCCGCTACCGGCGGGTGAAGGAGATGTACAATACCTACAAGAACAACGTTGGTGGG
TTGATAGGCACTCCCAAAAGGGAGACCTGGCTACAGCTCCGAGCTGAGCTGGAAGCTCTC
ACAGACCTCTGGCTGACCCACTCCCTGAAGGCACTAAACCTCATCAACTCCCGGCCCAAC
TGTGTCAATGTGCTGGTCACCACCACTCAACTAATTCCTGCCCTGGCCAAAGTCCTGCTA
TATGGCCTGGGGTCTGTGTTTCCTATTGAGAACATCTACAGTGCAACCAAGACAGGGAAG
GAGAGCTGCTTCGAGAGGATAATGCAGAGATTCGGCAGAAAAGCTGTCTACGTGGTGATC
GGTGATGGTGTGGAAGAGGAGCAAGGAGCGAAAAAGCACAACATGCCTTTCTGGCGGATA
TCCTGCCACGCAGACCTGGAGGCACTGAGGCACGCCCTGGAGCTGGAGTATTTATAG
Protein Properties
Number of Residues 538
Molecular Weight 59231.645
Theoretical pI 6.479
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Eyes absent homolog 2
MVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFSRSCPRVLPR
QPSTAMAAYGQTQYSAGIQQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYG
SSFSTSPTGQSPYTYQMHGTTGFYQGGNGLGNAAGFGSVHQDYPSYPGFPQSQYPQYYGS
SYNPPYVPASSICPSPLSTSTYVLQEASHNVPNQSSESLAGEYNTHNGPSTPAKEGDTDR
PHRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTT
SVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAP
GANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEAL
TDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGK
ESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL
GenBank ID Protein 26667227
UniProtKB/Swiss-Prot ID O00167
UniProtKB/Swiss-Prot Entry Name EYA2_HUMAN
PDB IDs
GenBank Gene ID NM_005244.4
GeneCard ID EYA2
GenAtlas ID EYA2
HGNC ID HGNC:3520
References
General References
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  3. Abdelhak S, Kalatzis V, Heilig R, Compain S, Samson D, Vincent C, Weil D, Cruaud C, Sahly I, Leibovici M, Bitner-Glindzicz M, Francis M, Lacombe D, Vigneron J, Charachon R, Boven K, Bedbeder P, Van Regemorter N, Weissenbach J, Petit C: A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family. Nat Genet. 1997 Feb;15(2):157-64. [PubMed:9020840 ]
  4. Fougerousse F, Durand M, Lopez S, Suel L, Demignon J, Thornton C, Ozaki H, Kawakami K, Barbet P, Beckmann JS, Maire P: Six and Eya expression during human somitogenesis and MyoD gene family activation. J Muscle Res Cell Motil. 2002;23(3):255-64. [PubMed:12500905 ]
  5. Duncan MK, Kos L, Jenkins NA, Gilbert DJ, Copeland NG, Tomarev SI: Eyes absent: a gene family found in several metazoan phyla. Mamm Genome. 1997 Jul;8(7):479-85. [PubMed:9195991 ]
  6. Zimmerman JE, Bui QT, Steingrimsson E, Nagle DL, Fu W, Genin A, Spinner NB, Copeland NG, Jenkins NA, Bucan M, Bonini NM: Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene. Genome Res. 1997 Feb;7(2):128-41. [PubMed:9049631 ]
  7. Borsani G, DeGrandi A, Ballabio A, Bulfone A, Bernard L, Banfi S, Gattuso C, Mariani M, Dixon M, Donnai D, Metcalfe K, Winter R, Robertson M, Axton R, Brown A, van Heyningen V, Hanson I: EYA4, a novel vertebrate gene related to Drosophila eyes absent. Hum Mol Genet. 1999 Jan;8(1):11-23. [PubMed:9887327 ]
  8. Fan X, Brass LF, Poncz M, Spitz F, Maire P, Manning DR: The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins. J Biol Chem. 2000 Oct 13;275(41):32129-34. [PubMed:10906137 ]
  9. Krishnan N, Jeong DG, Jung SK, Ryu SE, Xiao A, Allis CD, Kim SJ, Tonks NK: Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent. J Biol Chem. 2009 Jun 12;284(24):16066-70. doi: 10.1074/jbc.C900032200. Epub 2009 Apr 7. [PubMed:19351884 ]