Hmdb loader
Identification
HMDB Protein ID HMDBP08730
Secondary Accession Numbers
  • 14453
Name DNA helicase B
Synonyms
  1. hDHB
Gene Name HELB
Protein Type Unknown
Biological Properties
General Function Replication, recombination and repair
Specific Function Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress.
Pathways Not Available
Reactions
Adenosine triphosphate + Water → ADP + Phosphate details
GO Classification
Biological Process
DNA replication, synthesis of RNA primer
Molecular Function
ATP binding
ATP-dependent 5'-3' DNA helicase activity
single-stranded DNA-dependent ATP-dependent DNA helicase activity
Cellular Location Not Available
Gene Properties
Chromosome Location 12
Locus 12q
SNPs HELB
Gene Sequence
>3264 bp
ATGGCCAGGTCGAGTCCGTACCTGCGTCAACTTCAGGGACCTCTGCTCCCACCCAGGGAT
CTGGTGGAGGAGGACGACGACTACCTAAACGACGACGTGGAGGAGGATGAAGAGTCCGTG
TTCATCGACGCCGAGGAGCTCTGCAGTGGGGGCGTAAAGGCTGGCAGCCTCCCCGGGTGC
CTCCGCGTTTCTATTTGTGATGAAAACACACAAGAGACATGTAAAGTGTTTGGACGTTTT
CCGATAACAGGTGCTTGGTGGAGAGTGAAGGTACAAGTAAAGCCTGTGGTGGGATCAAGG
AGCTATCAATATCAAGTTCAAGGATTTCCGTCTTACTTTTTGCAGTCTGATATGTCACCA
CCAAATCAAAAACATATCTGTGCTCTCTTTCTTAAAGAGTGTGAGGTCTCCAGTGATGAT
GTTAATAAATTTTTAACATGGGTAAAGGAGGTATCAAACTACAAAAACCTAAACTTTGAA
AATCTTAGGGAAACACTAAGAACTTTCCACAAGGAAACTGGAAGGAAAGATCAAAAGCAG
CCTACACAGAATGGTCAGGAAGAGTTGTTCCCAGACAATGAGATGAGTCTTCCTCTGGAA
AACACAATTCCATTTAGAAATGTAATGACAGCTTTGCAGTTTCCGAAGATAATGGAATTC
CTTCCAGTTCTTCTGCCTCGACACTTTAAATGGATCATAGGGTCAGGTTCTAAAGAGATG
TTGAAAGAGATAGAAGAGATTTTAGGTACACATCCGTGGAAACTTGGATTTAGTAAAATA
ACCTACAGAGAGTGGAAACTCCTGCGATGTGAGGCAAGTTGGATAGCATTTTGTCAGTGT
GAGTCTCTTCTCCAGCTGATGACTGATTTGGAGAAGAATGCATTAATAATGTATTCCAGA
CTGAAGCAGATATGTAGAGAAGATGGGCACACATATGTTGAAGTGAATGACTTAACTTTG
ACATTGTCAAATCATATGTCATTTCATGCTGCTTCAGAGTCTCTGAAGTTTTTGAAGGAT
ATTGGTGTGGTGACATATGAGAAGTCCTGTGTCTTCCCTTATGACCTTTACCATGCTGAA
AGAGCCATCGCCTTTTCAATTTGTGACCTGATGAAGAAACCTCCTTGGCATTTATGTGTC
GATGTCGAAAAGGTGCTTGCCTCTATTCACACCACAAAACCTGAGAATTCAAGCGATGAT
GCATTGAATGAGAGCAAACCTGATGAAGTAAGATTAGAAAATCCTGTGGATGTTGTGGAC
ACACAGGACAATGGTGACCATATTTGGACTAATGGTGAAAATGAAATTAATGCAGAAATA
AGTGAAGTTCAGCTGGATCAGGATCAGGTTGAAGTTCCACTGGATCGGGATCAGGTGGCT
GCTTTGGAAATGATTTGCTCCAATCCTGTGACAGTCATAAGTGGGAAAGGTGGATGTGGG
AAGACCACAATCGTTAGCCGTCTTTTTAAGCATATAGAGCAGTTGGAAGAAAGAGAAGTA
AAAAAAGCCTGTGAAGATTTTGAACAAGACCAGAATGCTTCAGAAGAATGGATTACCTTT
ACTGAGCAAAGTCAACTAGAGGCGGACAAGGCTATAGAAGTTTTGCTCACAGCACCTACA
GGGAAAGCAGCTGGCTTACTAAGACAGAAAACTGGTCTTCATGCCTACACACTGTGTCAG
GTCAATTATAGCTTCTATTCATGGACTCAAACAATGATGACCACAAACAAACCATGGAAA
TTTTCTTCGGTTAGAGTTCTGGTTGTGGATGAAGGGAGTTTGGTATCTGTAGGGATCTTC
AAATCGGTCTTAAATTTATTGTGTGAGCACTCCAAACTTTCTAAGCTTATTATCCTTGGT
GACATTAGACAGTTACCCAGTATTGAACCTGGTAACTTGCTGAAAGATCTTTTTGAGACT
CTTAAGTCAAGAAATTGTGCTATTGAGCTAAAGACAAACCATAGAGCAGAATCTCAGCTC
ATTGTGGACAATGCTACAAGAATCTCAAGACGCCAATTTCCAAAATTTGATGCAGAACTA
AATATCTCTGATAATCCAACATTACCCATCTCAATTCAAGATAAGACATTTATTTTTGTC
AGGCTCCCAGAAGAGGATGCCAGTTCTCAGTCATCTAAAACTAATCATCACTCTTGTTTA
TATTCTGCAGTTAAAACTTTACTACAAGAAAATAACTTACAAAATGCAAAAACATCACAA
TTTATTGCATTTAGAAGGCAAGACTGTGATCTAATTAATGACTGCTGCTGCAAACACTAC
ACAGGCCACCTCACCAAAGACCATCAGAGTAGACTTGTTTTTGGAATTGGTGATAAAATT
TGTTGTACCAGGAATGCATACCTCTCAGACTTACTACCTGAAAATATCTCTGGAAGTCAG
CAAAATAATGATCTAGATGCCAGTAGTGAAGACTTTTCTGGTACGCTTCCTGATTTTGCT
AAAAATAAGCGTGACTTTGAAAGTAACGTTCGACTGTGCAATGGAGAGATATTTTTCATA
ACAAATGATGTAACTGATGTAACTTTTGGAAAGAGAAGATCTTTGACCATTAATAATATG
GCTGGCCTGGAAGTAACTGTGGATTTTAAGAAACTAATGAAATATTGTCGCATAAAACAT
GCATGGGCAAGAACTATTCACACTTTTCAGGGGTCCGAGGAGCAAACAGTTGTCTATGTG
GTGGGGAAGGCGGGCCGCCAGCACTGGCAGCATGTCTACACCGCCGTGACCAGGGGCCGC
TGCCGAGTGTATGTGATTGCAGAGGAGTCTCAGCTCCGGAATGCCATTATGAAAAACAGT
TTTCCTAGAAAAACTCGTTTGAAACATTTCTTGCAAAGTAAGCTCTCCTCTAGCGGCGCA
CCTCCAGCAGATTTTCCGTCCCCACGGAAGAGCTCTGGAGACAGTGGAGGACCCAGCACA
CCGTCAGCATCTCCACTCCCTGTAGTCACAGACCACGCCATGACAAATGATGTCACCTGG
AGCGAGGCCTCTTCGCCTGATGAGAGGACACTCACCTTTGCTGAAAGATGGCAATTATCT
TCACCTGATGGAGTAGATACAGATGATGATTTACCAAAATCGCGAGCATCCAAAAGAACC
TGTGGTGTGAATGATGATGAAAGTCCAAGCAAAATTTTTATGGTGGGAGAATCTCCACAA
GTGTCTTCCAGACTTCAGAATTTGAGACTGAATAATTTAATTCCCAGGCAACTTTTCAAG
CCCACCGATAATCAAGAAACTTAG
Protein Properties
Number of Residues 1087
Molecular Weight 123251.38
Theoretical pI 5.867
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>DNA helicase B
MARSSPYLRQLQGPLLPPRDLVEEDDDYLNDDVEEDEESVFIDAEELCSGGVKAGSLPGC
LRVSICDENTQETCKVFGRFPITGAWWRVKVQVKPVVGSRSYQYQVQGFPSYFLQSDMSP
PNQKHICALFLKECEVSSDDVNKFLTWVKEVSNYKNLNFENLRETLRTFHKETGRKDQKQ
PTQNGQEELFLDNEMSLPLENTIPFRNVMTALQFPKIMEFLPVLLPRHFKWIIGSGSKEM
LKEIEEILGTHPWKLGFSKITYREWKLLRCEASWIAFCQCESLLQLMTDLEKNALIMYSR
LKQICREDGHTYVEVNDLTLTLSNHMSFHAASESLKFLKDIGVVTYEKSCVFPYDLYHAE
RAIAFSICDLMKKPPWHLCVDVEKVLASIHTTKPENSSDDALNESKPDEVRLENPVDVVD
TQDNGDHIWTNGENEINAEISEVQLDQDQVEVPLDRDQVAALEMICSNPVTVISGKGGCG
KTTIVSRLFKHIEQLEEREVKKACEDFEQDQNASEEWITFTEQSQLEADKAIEVLLTAPT
GKAAGLLRQKTGLHAYTLCQVNYSFYSWTQTMMTTNKPWKFSSVRVLVVDEGSLVSVGIF
KSVLNLLCEHSKLSKLIILGDIRQLPSIEPGNLLKDLFETLKSRNCAIELKTNHRAESQL
IVDNATRISRRQFPKFDAELNISDNPTLPISIQDKTFIFVRLPEEDASSQSSKTNHHSCL
YSAVKTLLQENNLQNAKTSQFIAFRRQDCDLINDCCCKHYTGHLTKDHQSRLVFGIGDKI
CCTRNAYLSDLLPENISGSQQNNDLDASSEDFSGTLPDFAKNKRDFESNVRLCNGEIFFI
TNDVTDVTFGKRRSLTINNMAGLEVTVDFKKLMKYCRIKHAWARTIHTFQGSEEQTVVYV
VGKAGRQHWQHVYTAVTRGRCRVYVIAEESQLRNAIMKNSFPRKTRLKHFLQSKLSSSGA
PPADFPSPRKSSGDSGGPSTPSASPLPVVTDHAMTNDVTWSEASSPDERTLTFAERWQLS
SPDGVDTDDDLPKSRASKRTCGVNDDESPSKIFMVGESPQVSSRLQNLRLNNLIPRQLFK
PTDNQET
GenBank ID Protein 21666081
UniProtKB/Swiss-Prot ID Q8NG08
UniProtKB/Swiss-Prot Entry Name HELB_HUMAN
PDB IDs Not Available
GenBank Gene ID AF319995
GeneCard ID HELB
GenAtlas ID HELB
HGNC ID HGNC:17196
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  3. Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP: Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12130-5. Epub 2004 Aug 9. [PubMed:15302935 ]
  4. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  5. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007 May 25;316(5828):1160-6. [PubMed:17525332 ]
  6. Taneja P, Gu J, Peng R, Carrick R, Uchiumi F, Ott RD, Gustafson E, Podust VN, Fanning E: A dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replication. J Biol Chem. 2002 Oct 25;277(43):40853-61. Epub 2002 Aug 13. [PubMed:12181327 ]