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Identification
HMDB Protein ID HMDBP08790
Secondary Accession Numbers
  • 14513
Name Pyridoxal phosphate phosphatase PHOSPHO2
Synonyms Not Available
Gene Name PHOSPHO2
Protein Type Unknown
Biological Properties
General Function Involved in phosphatase activity
Specific Function Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate.
Pathways
  • Vitamin B6 metabolism
Reactions
Pyridoxal 5'-phosphate + Water → Pyridoxal + Phosphate details
Pyridoxine + Phosphate → Pyridoxine 5'-phosphate + Water details
Pyridoxamine + Phosphate → Pyridoxamine 5'-phosphate + Water details
GO Classification
Biological Process
dephosphorylation
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
Molecular Function
metal ion binding
pyridoxal phosphatase activity
Process
metabolic process
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location 2
Locus 2q31.1
SNPs PHOSPHO2
Gene Sequence
>726 bp
ATGAAAATTTTGCTAGTTTTTGACTTTGACAATACAATCATAGATGACAATAGTGACACT
TGGATTGTACAATGTGCTCCCAACAAAAAGCTTCCTATTGAACTACGTGATTCTTATCGA
AAAGGATTTTGGACAGAATTTATGGGCAGAGTCTTTAAGTATTTGGGAGATAAGGGTGTA
AGAGAACATGAAATGAAAAGAGCAGTGACATCATTGCCTTTCACTCCAGGGATGGTGGAA
CTCTTCAACTTTATAAGAAAGAATAAGGATAAATTTGACTGCATTATTATTTCAGATTCA
AATTCGGTCTTCATAGATTGGGTTTTAGAAGCTGCCAGTTTTCATGACATATTTGATAAA
GTGTTTACAAATCCAGCAGCTTTTAATAGCAATGGTCATCTCACTGTTGAAAATTATCAT
ACTCATTCTTGCAATAGATGCCCAAAGAATCTTTGCAAAAAGGTAGTTTTGATAGAATTT
GTAGATAAACAGTTACAACAGGGAGTGAATTATACACAAATTGTTTATATTGGTGATGGT
GGAAATGATGTCTGTCCAGTCACCTTTTTAAAGAATGATGATGTTGCCATGCCACGGAAA
GGATATACCTTACAGAAAACTCTTTCCAGAATGTCTCAAAATCTTGAGCCTATGGAATAT
TCTGTTGTAGTTTGGTCCTCAGGTGTTGATATAATTTCTCATTTACAATTTCTAATAAAG
GATTAA
Protein Properties
Number of Residues 241
Molecular Weight 27768.72
Theoretical pI 6.781
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Pyridoxal phosphate phosphatase PHOSPHO2
MKILLVFDFDNTIIDDNSDTWIVQCAPNKKLPIELRDSYRKGFWTEFMGRVFKYLGDKGV
REHEMKRAVTSLPFTPGMVELFNFIRKNKDKFDCIIISDSNSVFIDWVLEAASFHDIFDK
VFTNPAAFNSNGHLTVENYHTHSCNRCPKNLCKKVVLIEFVDKQLQQGVNYTQIVYIGDG
GNDVCPVTFLKNDDVAMPRKGYTLQKTLSRMSQNLEPMEYSVVVWSSGVDIISHLQFLIK
D
GenBank ID Protein 56606064
UniProtKB/Swiss-Prot ID Q8TCD6
UniProtKB/Swiss-Prot Entry Name PHOP2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001008489.2
GeneCard ID PHOSPHO2
GenAtlas ID PHOSPHO2
HGNC ID HGNC:28316
References
General References
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  4. Roberts SJ, Stewart AJ, Schmid R, Blindauer CA, Bond SR, Sadler PJ, Farquharson C: Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2. Biochim Biophys Acta. 2005 Aug 31;1752(1):73-82. [PubMed:16054448 ]