Human Metabolome Database: Showing Protein Receptor-type tyrosine-protein phosphatase O (HMDBP08948)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 metabolites

Identification

HMDB Protein ID

HMDBP08948

Secondary Accession Numbers

14677

Name

Receptor-type tyrosine-protein phosphatase O

Synonyms

Glomerular epithelial protein 1
PTP-U2
PTPase U2
Protein tyrosine phosphatase U2
R-PTP-O

Gene Name

PTPRO

Protein Type

Enzyme

Biological Properties

General Function

Involved in phosphatase activity

Specific Function

Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).

Pathways

Not Available

Reactions

Protein tyrosine phosphate + Water → protein tyrosine + Phosphate

details

GO Classification

Biological Process
axon guidance
glomerular visceral epithelial cell differentiation
lamellipodium assembly
monocyte chemotaxis
negative regulation of canonical Wnt receptor signaling pathway
negative regulation of cell-substrate adhesion
negative regulation of neuron projection development
negative regulation of glomerular filtration
negative regulation of retinal ganglion cell axon guidance
slit diaphragm assembly
Cellular Component
growth cone
dendritic spine
lamellipodium
lateral plasma membrane
apical plasma membrane
axon
integral to plasma membrane
Function
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
Molecular Function
transmembrane receptor protein tyrosine phosphatase activity
protein homodimerization activity
Wnt-protein binding
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process

Cellular Location

Membrane
Single-pass type I membrane protein

Gene Properties

Chromosome Location

Locus

12p13-p12

SNPs

PTPRO

Gene Sequence

>3651 bp
ATGGGGCACCTGCCCACGGGGATACACGGCGCCCGCCGCCTCCTGCCTCTGCTCTGGCTC
TTTGTGCTGTTCAAGAATGCTACAGCTTTCCATGTAACTGTCCAAGATGATAATAACATC
GTTGTCTCATTAGAAGCTTCAGACGTCATCAGTCCAGCATCTGTGTATGTTGTGAAGATA
ACTGGTGAATCCAAAAATTATTTCTTCGAATTTGAGGAATTCAACAGCACTTTGCCTCCT
CCTGTTATTTTCAAGGCCAGTTATCATGGCCTTTATTATATAATCACTCTGGTAGTGGTA
AATGGAAATGTGGTGACCAAGCCATCCAGATCAATCACTGTGTTAACAAAACCTCTACCT
GTAACCAGTGTTTCCATATATGACTATAAACCTTCTCCTGAAACAGGAGTCCTGTTTGAA
ATACATTATCCAGAAAAATATAACGTTTTCACAAGAGTGAACATTAGCTACTGGGGAGGT
AAAGACTTCCGGACAATGCTATATAAAGATTTCTTTAAGGGAAAAACAGTATTTAATCAC
TGGCTGCCAGGAATGTGTTATAGTAATATCACCTTTCAGCTGGTATGTGAGGCAACTTTT
AATAAAAGTACCGTTGTTGAGTACAGTGGTGTCAGTCACGAACCCAAACAGCACAGAACT
GCCCCTTATCCACCTCAAAACATTTCCGTTCGTATCGTAAACTTGAACAAAAACAACTGG
GAAGAACAGAGTGGCAATTTCCCAGAAGAATCCTTCATGAGATCACAAGATACAATAGGA
AAAGAAAAACTCTTCCATTTTACAGAAGAAACCCCTGAAATTCCCTCGGGCAACATTTCT
TCCGGTTGGCCTGATTTTAATAGCAGTGACTATGAAACTACGTCTCAGCCATATTGGTGG
GACAGTGCATCTGCAGCTCCTGAAAGTGAAGATGAATTTTTCAGCGTACTTCCCATGGAA
TACGAAAATAACAGTACACTCAGTGAGACAGAGAAGTCAACATCAGGCTCTTTCTCCTTT
TTCCCTGTGCAAATGATATTGACCTGGTTACCACCCAAACCACCCACTGCTTTTGATGGG
TTCCATATCCATATTGAACGAGAAGAGAACTTTACTGAATATTTGATGGTGGATGAAGAA
GCACATGAATTTGTTGCAGAACTGAAGGAACCTGGGAAATATAAGTTATCTGTGACAACC
TTTAGTTCCTCAGGATCTTGTGAAACTCGAAAAAGTCAGTCAGCAAAATCACTCAGCTTT
TATATCAGTCCTTCAGGAGAGTGGATTGAAGAACTGACCGAGAAGCCGCAGCACGTGAGT
TTCCACGTTTTAAGCTCAACCACTGCCTTGATGTCCTGGACATCTTCCCAAGAGAACTAC
AACAGCACCATTGTGTCTGTGGTGTCGCTGACCTGCCAGAAACAAAAGGAGAGCCAGAGG
CTTGAAAAGCAGTACTGCACTCAGGTGAACTCAAGCAAACCTATTATTGAAAATCTGGTT
CCTGGTGCCCAGTACCAGGTTGTAATATACCTAAGGAAAGGCCCTTTGATTGGACCACCT
TCAGATCCTGTGACATTTGCTATTGTTCCCACAGGAATAAAGGATTTAATGCTCTATCCT
TTGGGTCCTACGGCCGTGGTTCTGAGCTGGACCAGACCTTATTTAGGCGTGTTCAGAAAA
TACGTGGTTGAAATGTTTTATTTCAACCCTGCTACAATGACATCAGAGTGGACCACCTAC
TATGAAATAGCAGCAACTGTTTCCTTAACTGCATCCGTGAGAATAGCTAATCTGCTGCCA
GCATGGTACTACAACTTCCGGGTTACCATGGTGACGTGGGGAGATCCAGAACTGAGCTGC
TGTGACAGCTCTACCATCAGCTTCATAACAGCCCCAGTGGCTCCGGAAATCACTTCTGTG
GAATATTTCAACAGTCTGTTATATATCAGTTGGACATATGGGGATGATACAACGGACTTG
TCCCATTCTAGAATGCTTCACTGGATGGTGGTTACAGAAGGAAAAAAGAAAATTAAAAAG
AGTGTAACACGCAATGTCATGACTGCAATTCTCAGCTTGCCTCCAGGCGACACCTATAAC
CTCTCAGTAACTACTTGTACTGAAAGAGGAAGTAATACCTCCATGCTCCGCCTTGTCAAG
CTAGAACCAGCTCCACCCAAATCACTCTTCGCAGTGAACAAAACCCAGACTTCAGTGACT
TTGCTGTGGGTGGAAGAGGGAGTAGCTGATTTCTTTAAAGTTTTCTTTCAACACGTTGGC
TCCAGTCAGAAAACCAAACTTCAGGAACCAGTTGCTGTTTCTCCCCATGTGGTGACCATC
TCCAGCCTTCTTCCTGCCACTGCCTACAGTTGTAGTGTCACCAGCTTTAGCCATGACAGC
CCCAGTGTCCCTACGTTCATAGCCGTCTCAACAATGGTTACAGAGATGAATCCCAATGTG
GTAGTGATCTCCGTGCTGGCCATCCTTAGCACACTTTTAATTGGACTGTTGCTTGTTACC
CTCATTATTCTTAGGAAAAAGCATCTGCAGATGGCTAGGGAGTGTGGAGCTGGTACATTT
GCCAATTGTGCATCCTTAGAGAGGGATGGAAAGCTTCCATACAACTGCCGTAGGAGTATA
TTTGCTTTCTTAACCCTGCTACCATCATGTCTTTGGACTGATTATCCTTTGGCATTTTAT
ATTAATCCTTGGAGTAAAAATGGTTTAAAGAAGAGGAAACTGACAAACCCGGTTCAACTG
GATGACTTTGATGCCTATATTAAGGATATGGCCAAAGACTCTGACTATAAATTTTCTCTT
CAGTTTGAGGAGTTGAAATTGATTGGACTGGATATCCCACACTTTGCTGCAGATCTTCCA
CTGAATCGATGTAAAAACCGTTACACAAACATCCTACCATATGACTTCAGCCGTGTGAGA
TTAGTCTCCATGAATGAAGAGGAAGGTGCAGACTACATCAATGCCAACTATATTCCTGGA
TACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCCACTGCCTGAAACCAGAAATGAC
TTCTGGAAGATGGTCCTGCAACAAAAGTCTCAGATTATTGTCATGCTCACTCAGTGTAAT
GAGAAAAGGAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAGCCTAT
GGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCAGGACGACTGGGCCTGTAGACAC
TTCCGGATCAACTATGCTGACGAGATGCAGGATGTGATGCATTTTAACTACACTGCATGG
CCTGATCATGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTACACATG
GTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGATCATTCACTGCAGTGCTGGCGTG
GGACGGACAGGAACATTCATTGCCCTGGACAGGCTCTTGCAGCACATTCGGGATCATGAG
TTTGTTGACATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGGTACAG
ACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAG
CAGCAGTTCTGCATCAGTGATGTCATATACGAGAATGTTAGCAAGTCCTAG

Protein Properties

Number of Residues

1216

Molecular Weight

134939.865

Theoretical pI

5.955

Pfam Domain Function

fn3 (PF00041 )
Y_phosphatase (PF00102 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Receptor-type tyrosine-protein phosphatase O
MGHLPTGIHGARRLLPLLWLFVLFKNATAFHVTVQDDNNIVVSLEASDVISPASVYVVKI
TGESKNYFFEFEEFNSTLPPPVIFKASYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLP
VTSVSIYDYKPSPETGVLFEIHYPEKYNVFTRVNISYWEGKDFRTMLYKDFFKGKTVFNH
WLPGMCYSNITFQLVSEATFNKSTLVEYSGVSHEPKQHRTAPYPPQNISVRIVNLNKNNW
EEQSGNFPEESFMRSQDTIGKEKLFHFTEETPEIPSGNISSGWPDFNSSDYETTSQPYWW
DSASAAPESEDEFVSVLPMEYENNSTLSETEKSTSGSFSFFPVQMILTWLPPKPPTAFDG
FHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSSSGSCETRKSQSAKSLSF
YISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQR
LEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYP
LGPTAVVLSWTRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLP
AWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDDTTDL
SHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVK
LEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTI
SSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLVT
LIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWRRSIFAFLTLLPSCLWTDYLLAFY
INPWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLP
LNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRND
FWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRH
FRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGV
GRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK
QQFCISDVIYENVSKS

External Links

GenBank ID Protein

963059

UniProtKB/Swiss-Prot ID

Q16827

UniProtKB/Swiss-Prot Entry Name

PTPRO_HUMAN

PDB IDs

2G59
2GJT

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Muller S, Knapp S: Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell. 2009 Jan 23;136(2):352-63. doi: 10.1016/j.cell.2008.11.038. [PubMed:19167335 ]
Seimiya H, Sawabe T, Inazawa J, Tsuruo T: Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents. Oncogene. 1995 May 4;10(9):1731-8. [PubMed:7753550 ]
Wiggins RC, Wiggins JE, Goyal M, Wharram BL, Thomas PE: Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13. Genomics. 1995 May 1;27(1):174-81. [PubMed:7665166 ]